期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 99, 期 5, 页码 512-527出版社
WILEY
DOI: 10.1002/cpt.343
关键词
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资金
- Robert Bosch Foundation (Stuttgart, Germany)
- Federal Ministry for Education and Research (BMBF, Berlin, Germany) [FKZ 031L0037, 01EK1509A]
- Horizon PHC [U-PGx 668353]
- German Cancer Consortium (DKTK)
- German Cancer Research Center (DKFZ, Heidelberg, Germany)
- ICEPHA Graduate School Tuebingen-Stuttgart
The epigenetic regulation of expression of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs contributes to interindividual variability in drug response. Epigenetic mechanisms include DNA methylation, histone modifications, and miRNAs. This review systematically outlines the influence of DNA methylation on ADME gene expression and highlights the consequences for interindividual variability in drug response or drug-induced toxicity and the implications for personalized medicine.
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