Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait

Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia

(2016) Chengcheng Liu et al.   JOURNAL OF CLINICAL ONCOLOGY

InheritedNUDT15Variant Is a Genetic Determinant of Mercaptopurine Intolerance in Children With Acute Lymphoblastic Leukemia

(2015) Jun J. Yang et al.   JOURNAL OF CLINICAL ONCOLOGY

Systemic Exposure to Thiopurines and Risk of Relapse in Children With Acute Lymphoblastic Leukemia

(2015) Smita Bhatia et al.   JAMA Oncology

Considerations for rare variants in drug metabolism genes and the clinical implications

(2014) Britt I Drögemöller et al.   Expert Opinion on Drug Metabolism & Toxicology

Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes

(2014) Alice Matimba et al.   PHARMACOGENOMICS

Pharmacogenomic diversity in Singaporean populations and Europeans

(2014) L R Brunham et al.   PHARMACOGENOMICS JOURNAL

Changes in Gene Expression Associated with FTO Overexpression in Mice

(2014) Myrte Merkestein et al.   PLoS One

Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset

(2013) A. S. Gordon et al.   HUMAN MOLECULAR GENETICS

PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity

(2012) Gabriele Stocco et al.   HUMAN MOLECULAR GENETICS

The effects of EBV transformation on gene expression levels and methylation profiles

(2011) Minal Çalışkan et al.   HUMAN MOLECULAR GENETICS

Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia

(2011) Jun J Yang et al.   NATURE GENETICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease

(2009) Noritaka Takatsu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Treating Childhood Acute Lymphoblastic Leukemia without Cranial Irradiation

(2009) Ching-Hon Pui et al.   NEW ENGLAND JOURNAL OF MEDICINE

ThiopurineS-methyltransferase pharmacogenetics in a large-scale healthy Italian–Caucasian population: differences in enzyme activity

(2009) Loredana Serpe et al.   PHARMACOGENOMICS

Individualization of thiopurine therapy: thiopurineS-methyltransferase and beyond

(2009) Natasa Karas-Kuzelicki et al.   PHARMACOGENOMICS

Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study

(2008) K Schmiegelow et al.   LEUKEMIA

Ethnic variation of thiopurine S-methyltransferase activity: a large, prospective population study

(2008) Sheldon C Cooper et al.   PHARMACOGENOMICS

Genetic Analysis of Human Traits In Vitro: Drug Response and Gene Expression in Lymphoblastoid Cell Lines

(2008) Edwin Choy et al.   PLoS Genetics