期刊
SEMINARS IN IMMUNOPATHOLOGY
卷 42, 期 4, 页码 469-486出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-020-00801-4
关键词
Galectins; Preterm birth; Microbial infections; Glycans
资金
- Projekt DEAL
- Deutsche Forschungsgemeinschaft [BL1115/2-1, BL1115/4-1, BL1115/7-1]
- March of Dimes European Preterm Birth Research Centre at Imperial College London
Growing evidence suggests that galectins, an evolutionarily conserved family of glycan-binding proteins, fulfill key roles in pregnancy including blastocyst implantation, maternal-fetal immune tolerance, placental development, and maternal vascular expansion, thereby establishing a healthy environment for the growing fetus. In this review, we comprehensively present the function of galectins in shaping cellular circuits that characterize a healthy pregnancy. We describe the current understanding of galectins in term and preterm labor and discuss how the galectin-glycan circuits contribute to key immunological pathways sustaining maternal tolerance and preventing microbial infections. A deeper understanding of the glycoimmune pathways regulating early events in preterm birth could offer the broader translational potential for the treatment of this devastating syndrome.
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