期刊
SCIENCE TRANSLATIONAL MEDICINE
卷 12, 期 551, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.aay4068
关键词
-
资金
- JSPS KAKENHI [26713038, 16H06252, 16K15272, 18H02832]
- MEXT KAKENHI [16K18671, 16H06279]
- Naito Foundation
- Takeda Science Foundation
- AMED [JP16ek0410029h0001, JP18gm6010016h0002, 19gm0910002h0105]
- Intramural Research Program of the National Institute of Allergy and Infectious Diseases, NIH [ZIA AI000904-16]
- NIH [AR069303]
- University of Michigan Host Microbiome Initiative
- Environmental Restoration and Conservation Agency of Japan
- Institute for Global Prominent Research, Chiba University
- Joint Usage/Research Program of Medical Mycology Research Center, Chiba University [20-19]
- Grants-in-Aid for Scientific Research [26713038, 16K18671, 16H06252, 16K15272, 18H02832] Funding Source: KAKEN
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [ZIAAI000904] Funding Source: NIH RePORTER
Atopic dermatitis (AD) is commonly associated with colonization by Staphylococcus aureus in the affected skin. To understand the role of S. aureus in the development of AD, we performed whole-genome sequencing of S. aureus strains isolated from the cheek skin of 268 Japanese infants 1 and 6 months after birth. About 45% of infants were colonized with S. aureus at 1 month regardless of AD outcome. In contrast, skin colonization by S. aureus at 6 months of age increased the risk of developing AD. Acquisition of dysfunctional mutations in the S. aureus Agr quorum-sensing (QS) system was primarily observed in strains from 6-month-old infants who did not develop AD. Expression of a functional Agr system in S. aureus was required for epidermal colonization and the induction of AD-like inflammation in mice. Thus, retention of functional S. aureus agr virulence during infancy is associated with pathogen skin colonization and the development of AD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据