Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid–binding residues

PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments

(2019) Chen-Yu Wang et al.   Nature Communications

The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms

(2018) Madhusudhan Srinivasan et al.   CELL

SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X

(2018) Chen-Yu Wang et al.   CELL

The invasin D protein fromYersinia pseudotuberculosisselectively binds the Fab region of host antibodies and affects colonization of the intestine

(2018) Pooja Sadana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FSHD2- and BAMS-associated mutations confer opposing effects on SMCHD1 function

(2018) Alexandra D. Gurzau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters

(2018) Natasha Jansz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome

(2018) Michal R. Gdula et al.   Nature Communications

Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway

(2018) Natasha Jansz et al.   Cell Reports

De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development

(2017) Christopher T Gordon et al.   NATURE GENETICS

SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome

(2017) Natalie D Shaw et al.   NATURE GENETICS

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

(2017) Jeongyoon Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Overall Shapes of the SMC-ScpAB Complex Are Determined by Balance between Constraint and Relaxation of Its Structural Parts

(2017) Katsuhiko Kamada et al.   STRUCTURE

The Epigenetic Regulator SMCHD1 in Development and Disease

(2017) Natasha Jansz et al.   TRENDS IN GENETICS

Specialized interfaces of Smc5/6 control hinge stability and DNA association

(2017) Aaron Alt et al.   Nature Communications

DNA binding by PHF1 prolongs PRC2 residence time on chromatin and thereby promotes H3K27 methylation

(2017) Jeongyoon Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The hinge domain of the epigenetic repressor Smchd1 adopts an unconventional homodimeric configuration

(2016) K. Chen et al.   BIOCHEMICAL JOURNAL

The epigenetic regulator Smchd1 contains a functional GHKL-type ATPase domain

(2016) K. Chen et al.   BIOCHEMICAL JOURNAL

Dali server update

(2016) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

Structural Insights into Ring Formation of Cohesin and Related Smc Complexes

(2016) Thomas Gligoris et al.   TRENDS IN CELL BIOLOGY

Jarid2 regulates hematopoietic stem cell function by acting with polycomb repressive complex 2

(2015) S. A. Kinkel et al.   BLOOD

Structural Basis for Dimer Formation of Human Condensin Structural Maintenance of Chromosome Proteins and Its Implications for Single-stranded DNA Recognition

(2015) Susumu Uchiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Independent Mechanisms Target SMCHD1 to Trimethylated Histone H3 Lysine 9-Modified Chromatin and the Inactive X Chromosome

(2015) Nicholas J. Brideau et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Basis for SMC Rod Formation and Its Dissolution upon DNA Binding

(2015) Young-Min Soh et al.   MOLECULAR CELL

Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation

(2015) Kelan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

The FSHD2 Gene SMCHD1 Is a Modifier of Disease Severity in Families Affected by FSHD1

(2013) Sabrina Sacconi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

(2013) James M. Murphy et al.   BIOCHEMICAL JOURNAL

A low-background-intensity focusing small-angle X-ray scattering undulator beamline

(2013) Nigel M. Kirby et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway

(2013) Ryu-Suke Nozawa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

High-Throughput Thermal Scanning for Protein Stability: Making a Good Technique More Robust

(2013) Shane A. Seabrook et al.   ACS Combinatorial Science

Exploiting structure similarity in refinement: automated NCS and target-structure restraints inBUSTER

(2012) Oliver S. Smart et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2

(2012) Richard J L F Lemmers et al.   NATURE GENETICS

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion

(2010) Alexander Kurze et al.   EMBO JOURNAL

Decision-making in structure solution using Bayesian estimates of map quality: thePHENIX AutoSolwizard

(2009) Thomas C. Terwilliger et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Crystal Structure of the Hinge Domain of the Escherichia coli Structural Maintenance of Chromosomes Protein MukB

(2009) Yinyin Li et al.   JOURNAL OF MOLECULAR BIOLOGY

SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation

(2008) Marnie E Blewitt et al.   NATURE GENETICS

Polycomb Repressive Complex 2 (PRC2) Restricts Hematopoietic Stem Cell Activity

(2008) Ian J Majewski et al.   PLOS BIOLOGY