4.7 Article

Prenatal exposure to organic pollutants in northwestern Spain using non-invasive matrices (placenta and meconium)

期刊

SCIENCE OF THE TOTAL ENVIRONMENT
卷 731, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.scitotenv.2020.138341

关键词

Organic pollutants; Prenatal exposure; Non-invasive samples; Placenta; Meconium

资金

  1. Xunta de Galicia (Conselleria de Cultura, Educacion e Ordenacion Universitaria) [EM2013/004]

向作者/读者索取更多资源

Human exposure to environmental organic pollutants (OPs) begins in the uterine life period by trans-placental transfer. Epidemiological studies have consistently demonstrated the vulnerability of human fetuses and infants to the effects of OPs because of their rapid growth and organ development, cell differentiation, and immaturity of metabolism. The aim of the present study was to evaluate the prenatal exposure to OPs characterized by different physicochemical properties using non-invasive biological samples (meconium and placenta). A total of 88 placenta and 53 meconium samples were collected in Ourense, a city located in northwestern Spain, at the delivery and after birth from mothers and their infants from the University Hospital of Ourense, respectively. Selective pressurized liquid extraction (SPLE) methodologies were used to determine the targeted OPs in the selected biological samples. Cleanup of extracts was performed by solid-phase extraction (SPE) using EZ-POP cartridges and detection by gas chromatography (GC) coupled to tandem mass spectrometry (QqQ-MS/MS). The targeted OPs were detected with the following mean level total concentration order polycyclic aromatic hydrocarbons (PAHs) > organophosphorus pesticides (OPPs) > non-dioxin like polychlorinated biphenyls (NDLPCBs) > pyrethroids (PYRs) > polybrominated diphenyl ethers (PBDEs) > dioxin like polychlorinated biphenyls (DLPCBs) > organochlorine pesticides (OCPs) for placenta and Sigma NDLPCBs > Sigma PAHs > Sigma OCPs > Sigma PYRs > Sigma OPPs > Sigma DLPCBs > Sigma Sigma PBDEs for meconium, respectively. Significant correlations (p < .050) between the socio-demographic characteristics of the selected population (mother's parity, age, weight increase during pregnancy, place of living and smoking habits) and log transformed concentration of some of the targeted OPs (OCPs, PBDEs, PYRs, OPPs and PAHs) were detected. The results obtained shown the complementary information given by both biological samples selected. Nevertheless, additional research will be needed to gain an understanding of the trans-placental transfer of OPs, to choose the best biological matrix to evaluate the prenatal exposure to OPs in a correct way and to know their health implications. (C) 2020 Elsevier B.V. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Review Food Science & Technology

Impacts of nutritive and bioactive compounds on cancer development and therapy

Sabira Sultana, Abdelhakim Bouyahya, Maksim Rebezov, Mohammad Ali Shariati, Abdelaali Balahbib, Aya Khouchlaa, Ouadie Mohamed El Yaagoubi, Adnan Khaliq, Nasreddine El Omari, Saad Bakrim, Gokhan Zengin, Muhammad Akram, Mars Khayrullin, Irina Bogonosova, Shafi Mahmud, Jesus Simal-Gandara

Summary: For individuals living with progressive cancer, nutritional therapy and exercise are important factors in improving health and quality of life. Cancer survivors and patients are encouraged to seek knowledge on diet, exercise, and supplements to maintain treatment outcomes, living quality, and survival. A healthy diet plays a significant role in cancer treatment.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

Review Chemistry, Medicinal

Promising Marine Natural Products for Tackling Viral Outbreaks: A Focus on Possible Targets and Structure-activity Relationship

Mirnawati Salampe, Sukamto Salang Mamada, Yayu Mulsiani Evary, Saikat Mitra, Talha Bin Emran, Harapan Harapan, Firzan Nainu, Jesus Simal-Gandara

Summary: Recently, there have been outbreaks of various viruses around the world, such as HIV, Zika, Ebola, and the current SARS-CoV-2 virus. Unfortunately, there are limited drugs that can effectively treat these diseases. Therefore, there is a need to explore potential compounds that can combat these viruses. The review highlights the antiviral potential of marine natural products, including seaweeds, seagrasses, sponges, and marine bacteria, and discusses their mechanisms of action.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2023)

Article Food Science & Technology

HPLC-DAD Analysis, Antimicrobial and Antioxidant Properties of Aromatic Herb Melissa officinalis L., Aerial Parts Extracts

Fahima Abdellatif, Samir Begaa, Mohammed Messaoudi, Adel Benarfa, Hamza Ouakouak, Aicha Hassani, Barbara Sawicka, Jesus Simal Gandara

Summary: This study investigated the chemical composition of Melissa officinalis extracts and evaluated their antioxidant and antimicrobial activities. The results showed the presence of phenolic acids, flavonic aglycones, and heterosides, as well as good antioxidant and antimicrobial activities of the flavonoid extracts.

FOOD ANALYTICAL METHODS (2023)

Article Agricultural Engineering

Fatty acids in seed oil of wild and cultivated rosehip (Rosa canina L.) from different locations in Serbia

Jelena Popovic-Djordjevic, Bojana Spirovic-Trifunovic, Ilinka Pecinar, Luiz Fernando Cappa de Oliveira, Durda Krstic, Dragana Mihajlovic, Milica Fotiric Aksic, Jesus Simal-Gandara

Summary: This study evaluated the fatty acid composition of seed oil from wild and cultivated rosehip collected in different locations in Serbia. The results showed that unsaturated fatty acids were dominant in most samples, with linoleic acid, alpha-linolenic acid, and oleic acid as the most abundant components. Raman spectroscopy analysis revealed significantly higher content of unsaturated fatty acids in two seed samples. Ratios of UFAs/SFAs, omega-6/omega-3, and LA/ALA, as well as desirable fatty acids, indicated good quality in most rosehip seed oils. Genetic characteristics and agro-ecological conditions likely affected the fatty acid composition of seed oils.

INDUSTRIAL CROPS AND PRODUCTS (2023)

Review Food Science & Technology

Classification, application, multifarious activities and production improvement of lipopeptides produced by Bacillus

Zhimin Wang, Chao Liu, Yingying Shi, Mingming Huang, Zunyang Song, Jesus Simal-Gandara, Ningyang Li, Jingying Shi

Summary: Lipopeptides are compounds produced by Bacillus spp. with a peptide ring and a fatty acid chain. They are widely used in various industries due to their hydrophilic and oleophilic properties. However, the complex metabolic network and strict synthesis pathway of lipopeptides result in high cost and low production efficiency, limiting their large-scale application. This review explores the types and biosynthetic pathways of Bacillus-produced lipopeptides, as well as methods to improve their production, such as genetic engineering and fermentation optimization.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

Review Food Science & Technology

Oleuropein: Chemistry, extraction techniques and nutraceutical perspectives-An update

Anees Ahmed Khalil, Md. Mominur Rahman, Abdur Rauf, Md. Rezaul Islam, Sultana Juhara Manna, Ammar Ahmed Khan, Samee Ullah, Muhammad Nadeem Akhtar, Abdullah S. M. Aljohani, Waleed Abdulmonem, Jesus Simal-Gandara

Summary: The olive family, particularly Olea europaea L., is widely used for olive oil production. Different parts of the olive tree contain bioactive compounds such as oleuropein, apigenin, hydroxytyrosol, etc. Researchers have utilized various extraction methods to increase oleuropein yield, including maceration, soxhlet, microwave-assisted, ultrasonication, and supercritical fluid methods. This review focuses on in vitro and in vivo studies exploring the nutraceutical properties of oleuropein, revealing its potential in treating obesity, diabetes, cardiovascular complications, neurodegenerative diseases, cancer, inflammation, microbial infections, and oxidation. The comprehensive literature provided in this review contributes to the scientific community's understanding of oleuropein's absorption, metabolism, bioavailability, extraction techniques, and nutraceutical perspectives.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

Review Plant Sciences

Traditional use, phytochemistry, toxicology, and pharmacological properties of Lavandula dentata L.: A comprehensive review

Abdelhakim Bouyahya, Imane Chamkhi, Naoual El Menyiy, Hamza El Moudden, Hicham Harhar, Zineb Lakhlifi El Idrissi, Aya Khouchlaa, Imane Jouadi, Aicha El Baaboua, Doaue Taha, Abdelaali Balahbib, Asaad Khalid, Ashraf N. Abdalla, Gokhan Zengin, Jesus Simal-Gandara, Nasreddine El Omari

Summary: This article explores the medicinal plant Lavandula dentata L., which is frequently used in traditional medicine for the treatment of diabetes, inflammation, microbial infections, and other disorders. It highlights the plant's phytochemical characteristics, pharmacological properties, and its potential therapeutic pathways. The findings demonstrate the importance and effectiveness of L. dentata in traditional remedies, although further pharmacokinetic validation and toxicological examinations are needed.

SOUTH AFRICAN JOURNAL OF BOTANY (2023)

Article Food Science & Technology

Ice cream supplemented with roasted and grilled corn powders: Physical properties, rheology, antioxidant activity, color, sensory evaluation, and production cost

Ahmed Mohamed Abdeldaiem, Abdelmoneim H. Ali, Ahmed Hassan Mousa, Wael F. Elkot, Jesus Simal-Gandara

Summary: The study aimed to assess the impact of replacing milk fat with roasted and grilled corn powders on ice cream characteristics. The results indicated that using different concentrations of corn powders led to significant changes in the physical and rheological properties of the ice cream mixture. The addition of roasted or grilled corn powders increased the total phenolic compounds and antioxidant activity, with varying effects over time. Furthermore, ice cream treatments with corn powders demonstrated improved melting resistance and sensory evaluation scores compared to other treatments. Additionally, these treatments exhibited lower production cost than the control sample.

INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE (2023)

Article Food Science & Technology

Exploration of Indian Traditional recipe ?Tarvaani? from the drained rice gruel for nutritional and probiotic potential

Anwesha Chowdhury, Monika Choudhary, Vidushi Sharma, Anil Kant, Jitendraa Vashistt, Vijay Kumar Garlapati, Jesus Simal-Gandara

Summary: This study explores the nutritional and probiotic potential of an Indian traditional recipe, Tarvaani, and finds that it contains lactic acid bacteria and supports bacterial growth at various pH levels. The Tarvaani culture also exhibits antimicrobial activity and can be used as a formulation ingredient in traditional functional foods.

INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE (2023)

Article Food Science & Technology

Method development and validation for acrylamide in potato cutlet by UHPLC-MS/MS

Alka Kumari, Bhaswati Bhattacharya, Tripti Agarwal, Vijay Paul, Vaibhav Kumar Maurya, S. Chakkaravarthi, J. Simal-Gandara

Summary: To address the increasing demand for healthy and safe foods, researchers developed a sensitive and precise method for the detection and quantification of food contaminants like acrylamide, even in trace amounts.

FOOD CONTROL (2023)

Article Food Science & Technology

Integrative analysis of metabolome and genome-wide transcriptome reveal the flavor changes in apple (Malus pumila Mill) after the novel acaricide cyflumetofen application

Minmin Li, Lin Li, Zhiqiang Kong, Noel Gregoire, Rui Quan, Zisheng Luo, Xingyu Lin, Jesus Simal-Gandara, Bei Fan, Fengzhong Wang

Summary: Residues of pesticides were found to have an adverse effect on the nutrition and flavor of fruits. This study investigated the changes in apple flavor after the application of cyflumetofen and found that it significantly altered the nutritional composition and flavor formation of the apples. The study also revealed that cyflumetofen mainly affected pathways related to amino acid, organic acid, polyphenol, and lipid metabolism, resulting in altered nutritional and flavor characteristics.

LWT-FOOD SCIENCE AND TECHNOLOGY (2023)

Article Food Science & Technology

Perception into the binding of soy protein isolate with essential oils using multispectroscopic and QuickVina-W

Mohammad Noshad, Behrooz Alizadeh Behbahani, Zahra Nikfarjam, Farshid Zargari, Jesus Simal-Gandara

Summary: This study investigated the binding of soy protein isolate (SPI) with cumin and coriander essential oils and its impact on protein conformation. The results showed that stable ternary complexes were formed between SPI and the oils, and this binding significantly enhanced the ability of small molecules to scavenge ABTS.

LWT-FOOD SCIENCE AND TECHNOLOGY (2023)

Meeting Abstract Gastroenterology & Hepatology

Increased Primary Bile Acids with Ileocolonic Resection Impact Ileal Inflammation and Gut Microbiota in Inflammatory Bowel Disease

R. Battat, E. Scherl, D. Lukin, P. Charilaou, P. Mahtani, J. Gerber, J. Gandara, F. Dundar, P. Zumbo, D. Betel, C. J. Guo, R. Longman

JOURNAL OF CROHNS & COLITIS (2023)

Review Food Science & Technology

Challenges for future food systems: From the Green Revolution to food supply chains with a special focus on sustainability

A. Soria-Lopez, P. Garcia-Perez, M. Carpena, P. Garcia-Oliveira, Paz Otero, M. Fraga-Corral, Hui Cao, M. A. Prieto, J. Simal-Gandara

Summary: Finding a sustainable food system to feed the growing global population is a challenge due to the depletion of natural resources. The long food supply chain (LFSC) has shown limitations in feeding the population and has negative ecological, environmental, logistical, and nutritional impacts. Therefore, new efficient food systems, such as the short food supply chain (SFSC), are needed to address current environmental and consumer demands.

FOOD FRONTIERS (2023)

Article Gastroenterology & Hepatology

Epithelioid Hemangioendothelioma in a Liver Transplant Recipient: A Case Report of an Extremely Rare Tumor

Margarida Goncalves, Helena Pessegueiro, Judit Gandara, Jose Ramon Vizcaino, Vitor Lopes, Sofia Ferreira

Summary: Epithelioid hemangioendothelioma is a rare vascular neoplasm that often presents as multifocal or metastatic lesions. A liver transplant recipient developed hepatic cholestasis and a proliferative hepatic lesion with infiltrative growth, which was diagnosed as epithelioid hemangioendothelioma through histological examination and immunohistochemical study. Although pulmonary micronodules were detected, they were stable and no neoplastic recurrence was observed after liver re-transplantation and 8 years of follow-up.

GE PORTUGUESE JOURNAL OF GASTROENTEROLOGY (2023)

Article Environmental Sciences

Comparing nearshore and embayment scale assessments of submarine groundwater discharge: Significance of offshore groundwater discharge as a nutrient pathway

Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto

Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.

SCIENCE OF THE TOTAL ENVIRONMENT (2024)

Article Environmental Sciences

Impact of NO2 emissions from household heating systems with wall-mounted gas stoves on indoor and ambient air quality in Chinese urban areas

Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li

Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.

SCIENCE OF THE TOTAL ENVIRONMENT (2024)

Letter Environmental Sciences

Letter to the editor regarding Collard et al. (2023): Persistence and mobility (defined as organic-carbon partitioning) do not correlate to the detection of substances found in surface and groundwater: Criticism of the regulatory concept of persistent and mobile substances

Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann

SCIENCE OF THE TOTAL ENVIRONMENT (2024)

Article Environmental Sciences

Harnessing the composition of dissolved organic matter in lagoon sediment in association with rare earth elements using fluorescence and UV-visible absorption spectroscopy

Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu

Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.

SCIENCE OF THE TOTAL ENVIRONMENT (2024)

Article Environmental Sciences

An advanced global soil erodibility (K) assessment including the effects of saturated hydraulic conductivity

Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell

Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.

SCIENCE OF THE TOTAL ENVIRONMENT (2024)

Article Environmental Sciences

Comparison of adsorption-extraction (AE) workflows for improved measurements of viral and bacterial nucleic acid in untreated wastewater

Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed

Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.

SCIENCE OF THE TOTAL ENVIRONMENT (2024)

Article Environmental Sciences

Insights the dominant contribution of biomass burning to methanol-soluble PM2.5 bounded oxidation potential based on multilayer perceptron neural network analysis in Xi'an, China

Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen

Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.

SCIENCE OF THE TOTAL ENVIRONMENT (2024)

Article Environmental Sciences

A macroplastic vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i

Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro

Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.

SCIENCE OF THE TOTAL ENVIRONMENT (2024)

Article Environmental Sciences

Anthropic disturbances impact the soil microbial network structure and stability to a greater extent than natural disturbances in an arid ecosystem

Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso

Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.

SCIENCE OF THE TOTAL ENVIRONMENT (2024)

Article Environmental Sciences

Adsorption of metal ions by oceanic manganese nodule and deep-sea sediment: Behaviour, mechanism and evaluation

Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang

Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.

SCIENCE OF THE TOTAL ENVIRONMENT (2024)

Article Environmental Sciences

Advanced oxidation process of valsartan by activated peroxymonosulfate: Chemical characterization and ecotoxicological effects of its byproducts

Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli

Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.

SCIENCE OF THE TOTAL ENVIRONMENT (2024)

Article Environmental Sciences

Photodegradation of typical pharmaceuticals changes toxicity to algae in estuarine water: A metabolomic insight

Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng

Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.

SCIENCE OF THE TOTAL ENVIRONMENT (2024)

Article Environmental Sciences

Association of ambient air pollution and pregnancy rate among women undergoing assisted reproduction technology in Fujian, China: A retrospective cohort study

Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang

Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.

SCIENCE OF THE TOTAL ENVIRONMENT (2024)

Article Environmental Sciences

The predictive machine learning model of a hydrated inverse vulcanized copolymer for effective mercury sequestration from wastewater

Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi

Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.

SCIENCE OF THE TOTAL ENVIRONMENT (2024)

Article Environmental Sciences

Aluminium bioaccumulation in colon cancer, impinging on epithelial-mesenchymal-transition and cell death

Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca

Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.

SCIENCE OF THE TOTAL ENVIRONMENT (2024)