Article
Environmental Sciences
Xinying Wang, Ming Gao, Zihan Wang, Weiqi Cui, Jingxian Zhang, Weijie Zhang, Yu Xia, Bo Wei, Youcai Tang, Xia Xu
Summary: This study revealed that oridonin exerts a protective effect on BPA-induced liver injury by restoring oxidative stress and XOD activity, reducing organ damage. Metabolomics analysis identified alterations in purine metabolism, amino acid biosynthesis, and phenylalanine metabolism as potential underlying mechanisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Shenglan Jia, Caixia Li, Mingliang Fang, Mauricius Marques Dos Santos, Shane A. Snyder
Summary: In this study, metabolomics and XF analysis were used to investigate the effects of Bisphenol analogues (BPs) on liver metabolism. The results showed significant alterations in metabolite profiles associated with energy metabolism, oxidative stress, and cell proliferation after exposure to BPs. Different BPs also interfered with different metabolic pathways.
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Food Science & Technology
Yuzhen Hong, Mingyue Shen, Qiang Yu, Yi Chen, Jianhua Xie
Summary: The aim of this study was to investigate the improvement effect of Mesona chinensis Benth polysaccharide (MP) on cyclophosphamide (CTX) induced liver injury in mice. The results showed that MP could alleviate liver injury and promote the production of short chain fatty acids (SCFAs).
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Pharmacology & Pharmacy
Pin Li, Lin Zhang, Zhaojuan Guo, Qianjun Kang, Cong Chen, Xiaoyao Liu, Quantao Ma, Jingxuan Zhang, Yujie Hu, Ting Wang
Summary: This study investigated the mechanism of hepatotoxicity of Epimedium koreanum Nakai using untargeted metabolomics analysis of serum and liver tissue. The results demonstrated that Epimedium koreanum Nakai caused significant liver damage, possibly through the induction of ferroptosis in hepatocytes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Huoyan Liang, Heng Song, Xiaojuan Zhang, Gaofei Song, Yuze Wang, Xianfei Ding, Xiaoguang Duan, Lifeng Li, Tongwen Sun, Quancheng Kan
Summary: The study suggests that metformin may improve liver injury by modulating the gut microbiota and alleviating colon barrier dysfunction in septic-aged rats.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Food Science & Technology
Pengyao Tian, Yu Chen, Jiarong Hang, Ruonan Yu, ChunJie Zhao, Min Zhao, Miao Wang
Summary: Gypenosides (GPs) treatment improves liver function disorder, inflammation, and oxidative damage induced by liver injury. Metabolomic analysis and gut microbiota analysis reveal the therapeutic mechanism of GPs.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Ruoyue Huang, Chunyan Wang, Zhanxuan E. Wu, Qi Zhao, Jingyi Duan, Wen Huang, Yan Cheng, Beiwei Zhu, Fei Li
Summary: This study investigated the hepatotoxicity of colchicine in vivo and found that it causes liver injury by inhibiting SULT1 and reducing the production of sulfated metabolites. Supplementation of endogenous sulfated metabolites can alleviate colchicine-induced liver injury.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Review
Immunology
Yan-zhong Han, Zhi-tao Ma, Ming-xi Zhou, Ming Niu, Xu Zhao, Yu-ming Guo, Xin-hua Song, Ya-wen Lu, Zhao-fang Bai, Zhen Li, Han Gao, Yong-kang Zhao, Jia-bo Wang, Xiao-he Xiao, Jing Jing
Summary: By using metabolomics analysis, it has been found that drug-induced liver injury with autoantibodies may not be a homogeneous group in terms of pathogenesis, including a subset with autoimmune hepatitis tendencies. This finding calls for further investigation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Zhiyong Guo, Jinghong Xu, Shanzhou Huang, Meixian Yin, Qiang Zhao, Weiqiang Ju, Dongping Wang, Ningxin Gao, Changjun Huang, Lu Yang, Maogen Chen, Zhiheng Zhang, Zebin Zhu, Linhe Wang, Caihui Zhu, Yixi Zhang, Yunhua Tang, Haitian Chen, Kunpeng Liu, Yuting Lu, Yi Ma, Anbin Hu, Yinghua Chen, Xiaofeng Zhu, Xiaoshun He
Summary: Ischemia-free liver transplantation can avoid graft ischemia-reperfusion injury and has the potential to improve transplant outcomes and organ utilization.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kohei Omachi, Shota Kaseda, Tsubasa Yokota, Misato Kamura, Keisuke Teramoto, Jun Kuwazuru, Haruka Kojima, Hirofumi Nohara, Kosuke Koyama, Sumio Ohtsuki, Shogo Misumi, Toru Takeo, Naomi Nakagata, Jian-Dong Li, Tsuyoshi Shuto, Mary Ann Suico, Jeffrey H. Miner, Hirofumi Kai
Summary: Metformin is commonly used for treating type 2 diabetes, and recent studies have suggested its potential in ameliorating tumor progression, inflammatory diseases, and fibrosis. This study found that metformin not only improved non-diabetic glomerular diseases and chronic kidney disease phenotypes, but also influenced metabolic and inflammatory pathways in the transcriptome analysis.
SCIENTIFIC REPORTS
(2021)
Retraction
Chemistry, Multidisciplinary
Qi Zhao, Rui Yang, Fang Liu, Jing Wang, Dan-Dan Hu, Xiu-Wei Yang, Fei Li
Summary: The study initially found that PPAR alpha activation can protect the liver from drug-induced injury, but later discovered errors in the study and retracted it.
Article
Environmental Sciences
Xiangyu Meng, Shifeng Su, Xiyi Wei, Shangqian Wang, Tao Guo, Junjian Li, Huaidong Song, Mengjing Wang, Zengjun Wang
Summary: We found that BPA, commonly found in household products, is inversely correlated with blood testosterone levels in children. BPA replacements like BHPF and BPAF were found to cause delayed gonadal migration and reduced germ cell lineage in zebrafish larvae. Additionally, these replacements bind strongly to androgen receptors, leading to the downregulation of meiosis-related genes and the overexpression of inflammatory markers. Further research on the toxicological effects of BHPF and BPAF on human health is needed and BPA replacements should be investigated for their anti-estrogenic action.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Pharmacology & Pharmacy
Lisheng Chen, Xu Zhao, Shizhang Wei, Xiao Ma, Honghong Liu, Jianyu Li, Manyi Jing, Min Wang, Yanling Zhao
Summary: The study demonstrates the modulatory properties of PF treatment on cholestatic liver injury through metabolomics and network pharmacology analyses. PF shows a favorable pharmacological effect by regulating metabolites and key targets, providing a new and effective approach for the treatment of cholestatic liver injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Heng Song, Xiaojuan Zhang, Ruiqing Zhai, Huoyan Liang, Gaofei Song, Yangyang Yuan, Yanan Xu, Yan Yan, Lingxiao Qiu, Tongwen Sun
Summary: This study investigated the therapeutic effects of metformin on sepsis-associated liver injury in aged mice. The results showed that metformin could alleviate liver inflammation and apoptosis, reduce liver function markers ALT and AST, and attenuate inflammatory responses by regulating the AMPK-PGC1α axis.
Article
Chemistry, Applied
Wen-Chao Han, Nian Shi, Xin-Ying Wang, Zi-Han Wang, Kai-Li Wang, Ming Gao, Lei Yu, Di Chen, Xia Xu
Summary: The study developed an effective method using natural cotton fibers and an in-syringe extraction device to determine trans-resveratrol in peanut oils. By optimizing the extraction conditions, satisfactory results were obtained and successfully applied to commercial peanut oils and other edible oils.
Article
Biochemical Research Methods
Di Chen, Man-Yu Zhang, Xin-Miao Bu, Bin Wang, Xin-Li Xu, Sen Yang, Zhi Sun, Xia Xu
Summary: This study introduces a novel method of dynamic liquid-phase microextraction using natural cotton fiber as the supporter of water for extracting polar components in low-polar edible oils. The method was successfully applied to extract free 3-MCPD in edible oils, demonstrating its efficiency, simplicity, low-cost, and easy automation.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Biochemical Research Methods
Di Chen, Xin-Miao Bu, Man-Yu Zhang, Xin-Li Xu, Bin Wang, Yu-Mei Gan, Kai-Xuan Li, Xia Xu, Jun Han, Nian Shi
Summary: This study developed a tissue chemical labeling method for visualizing the distribution of three catecholamine compounds in porcine adrenal gland. The on-tissue labeling with pyrene-1-boronic acid greatly improved detection specificity and sensitivity, enabling successful imaging of the compounds. The proposed method offers a robust, easy-to-use, and low-cost approach for simultaneous molecular imaging.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Biochemical Research Methods
Di Chen, Bin Wang, Xin-Li Xu, Man-Yu Zhang, Xin-Miao Bu, Sen Yang, Yanbo Luo, Xia Xu
Summary: A novel kapok fiber-supported liquid extraction (KF-SLE) method was developed for convenient extraction of analytes from oil samples. The method offers low cost, environmental friendliness, high sample processing throughput, and ease of automation.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)