Article
Sport Sciences
Emeric Chalchat, Keyne Charlot, Sebastian Garcia-Vicencio, Pierre Hertert, Stephane Bauge, Stephanie Bourdon, Julie Bompard, Cedric Farges, Vincent Martin, Cyprien Bourrilhon, Julien Siracusa
Summary: Ultra-endurance sports can lead to exercise-induced muscle damage and exertional rhabdomyolysis, with circulating miRNAs potentially useful in assessing the degree of muscle damage. Following a 24-h run, significant increases in muscle damage markers were observed, with elevated levels of myomiRs correlating with reduced muscle height and a diagnosis of exertional rhabdomyolysis in elite ultramarathon runners.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2021)
Review
Medical Laboratory Technology
Yudong Wu, Qian Li, Renshuai Zhang, Xiaoli Dai, Wujun Chen, Dongming Xing
Summary: MicroRNAs, approximately 20-24 nucleotides in length, are considered reliable diagnostic and prognostic biomarkers for various diseases due to their reflection of disease progression and drug resistance. They play a crucial role in the diagnosis, prognosis, and treatment response prediction of diseases, potentially improving cure rates.
CLINICA CHIMICA ACTA
(2021)
Article
Multidisciplinary Sciences
Abraham Nilsson, Anna Maria Nerhall, Ivan Vechetti, Lotta Fornander, Simon Wiklund, Bjorn Alkner, Jorg Schilcher, Ferdinand von Walden
Summary: This study aimed to investigate whether low-molecular-weight heparin tinzaparin affects qPCR-based quantification of circulating miRNAs. Synthetic miRNAs were added to samples from tinzaparin-treated patients and untreated controls to control for the effect of tinzaparin on miRNA analysis. The results showed that prophylactic dose of 4500 IU tinzaparin does not seem to affect cDNA synthesis or qRT-PCR-based quantification of circulating miRNAs.
Review
Endocrinology & Metabolism
Josie L. Fullerton, Josephine M. Thomas, Laura Gonzalez-Trueba, Cara Trivett, Josie C. van Kralingen, Stuart M. Allan, Terence J. Quinn, Lorraine M. Work
Summary: This systematic review aimed to assess the range and quality of clinical and preclinical evidence supporting the association of individual microRNAs and their use in the diagnosis and prognosis of ischaemic or haemorrhagic stroke. The findings highlighted specific microRNAs that consistently showed differential expression in both clinical and preclinical samples following stroke. However, further studies with larger populations and consistent methodologies are needed to confirm the clinical value of circulating microRNAs as biomarkers for stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Sport Sciences
Manuel Fernandez-Sanjurjo, Angel E. Diaz-Martinez, Sergio Diez-Robles, Felipe Gonzalez-Gonzalez, David De Gonzalo-Calvo, Manuel Rabadan, Alberto Davalos, Benjamin Fernandez-Garcia, Eduardo Iglesias-Gutierrez
Summary: This study analyzed the response of circulating miRNA to a maximal incremental exercise test and identified specific functional subsignatures of miRNA related to different exercise markers. The findings provide novel evidence about the potential regulatory role of miRNA in exercise response and adaptation.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Article
Endocrinology & Metabolism
Simone Ciuffi, Francesca Marini, Caterina Fossi, Simone Donati, Francesca Giusti, Annalisa Botta, Laura Masi, Giancarlo Isaia, Claudio Marcocci, Silvia Migliaccio, Salvatore Minisola, Ranuccio Nuti, Umberto Tarantino, Teresa Iantomasi, Maria Luisa Brandi
Summary: This study investigated the expression of circulating microRNAs (miRNAs) in osteoporotic patients using next-generation sequencing (NGS) and droplet digital polymerase chain reaction (ddPCR). The study identified differentially expressed miRNAs, including miR-23a-3p, miR-21-5p, and miR-320a-3p, which could distinguish osteoporotic patients from individuals with normal bone mineral density (BMD). Increased expression of c-miR-320a-3p was specifically associated with fractures, suggesting it as a potential prognostic indicator of fracture risk in osteoporotic patients. These findings need to be further validated in prospective studies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Davida Mirra, Erika Cione, Giuseppe Spaziano, Renata Esposito, Mario Sorgenti, Elisabetta Granato, Ida Cerqua, Lucia Muraca, Pasquale Iovino, Luca Gallelli, Bruno D'Agostino
Summary: This study compares the serum expression of microRNAs between asthmatic patients, obese patients (the most common comorbidity in asthma), and healthy controls, and identifies the specific involvement of microRNAs in the regulation of lung inflammatory response. It highlights the potential of microRNAs as a clinical marker for asthma evaluation and management.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Physiology
Tamara Iturriaga, Thomas Yvert, Isabel M. Sanchez-Lorente, Ignacio Diez-Vega, Valentin E. Fernandez-Elias, Lara Sanchez-Barroso, Diego Dominguez-Balmaseda, Mar Larrosa, Margarita Perez-Ruiz, Catalina Santiago
Summary: The study compared the acute S alpha Kl response to different exercise interventions in healthy, physically active men, and found that while plasma alpha-klotho levels increased in response to a single bout of cardiorespiratory exercise, they decreased immediately after strength exercise with levels being elevated again after 24 hours, indicating different klotho protein responses to different forms of exercise.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Jody Vykoukal, Johannes F. Fahrmann, Nikul Patel, Masayoshi Shimizu, Edwin J. Ostrin, Jennifer B. Dennison, Cristina Ivan, Gary E. Goodman, Mark D. Thornquist, Matt J. Barnett, Ziding Feng, George A. Calin, Samir M. Hanash
Summary: Blood-based cancer biomarkers, including miRNA and four protein marker panel, have shown utility in improving the assessment and early detection of lung cancer.
Review
Endocrinology & Metabolism
Lingli Ma, Yan Wen, Zimeng Li, Nan Wu, Qing Wang
Summary: This study found that miRNAs can be used as potential diagnostic markers for DR, with high accuracy of diagnoses observed with the detection of miRNAs in plasma and serum.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Grzegorz Procyk, Dominika Klimczak-Tomaniak, Grazyna Sygitowicz, Mariusz Tomaniak
Summary: MicroRNAs play an important role in the regulation of gene expression in cardiovascular diseases (CVD), with miR-126 and miR-223 being of particular interest. Despite numerous studies, there is still no conclusive evidence on the clinical utility of miRNA expression levels. This review critically appraises the association between miRNA expression, cardiovascular risk, and on-treatment platelet reactivity, and provides insights on future developments in the field.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Sara Reis Moura, Hugo Abreu, Carla Cunha, Claudia Ribeiro-Machado, Carla Oliveira, Mario Adolfo Barbosa, Herlander Marques, Maria Ines Almeida
Summary: This study examines the expression of circulating microRNAs in multiple myeloma (MM) patients and their correlation with clinicopathological features, including bone lesions. Results suggest that certain miRNAs could serve as potential molecular markers for MM diagnosis, with correlations to disease stage, treatment, and other clinical indicators. Additionally, circulating miRNAs show promise as biomarkers for MM diagnosis and correlate with myeloma bone disease and osteolytic lesions.
Article
Environmental Sciences
Matthew C. Cave, Christina M. Pinkston, Shesh N. Rai, Banrida Wahlang, Marian Pavuk, Kimberly Z. Head, Gleta K. Carswell, Gail M. Nelson, Carolyn M. Klinge, Douglas A. Bell, Linda S. Birnbaum, Brian N. Chorley
Summary: This study suggests that environmental exposure to PCBs is associated with liver injury in humans and provides insights into the potential modes of PCB action. MiR-derived liquid liver biopsy represents a promising new technique for environmental hepatology cohort studies.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Multidisciplinary Sciences
Yasmina Chouik, Fanny Lebosse, Marie-Laure Plissonnier, Jean-Christophe Lega, Pierre Pradat, Teresa Antonini, Miroslava Subic, Kerstin Hartig-Lavie, Domitille Erard, Francois Villeret, Celine Guichon, Audrey Payance, Sylvie Radenne, Pierre-Emmanuel Rautou, Fabien Zoulim, Massimo Levrero
Summary: Bacterial infections are a common and dangerous complication in patients with acute decompensation of cirrhosis. This study investigated the potential of circulating microRNAs to diagnose bacterial infections and predict survival in these patients. The analysis found that certain miRNAs can be used as biomarkers to accurately diagnose bacterial infections, and a combination of other miRNAs can help predict survival. Circulating miRNAs show dysregulation in patients with acute decompensation of cirrhosis, suggesting their potential as diagnostic and prognostic tools.
Review
Clinical Neurology
Jimin He, Yao Jiang, Liang Liu, Zhihua Zuo, Chun Zeng
Summary: A meta-analysis was conducted on 24 studies involving a total of 2,170 glioma patients and 1,456 healthy participants, which revealed the potential of circulating miRNAs as diagnostic biomarkers for gliomas, pending validation through large prospective studies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Sport Sciences
Victor M. Alfaro-Magallanes, Nuria Romero-Parra, Laura Barba-Moreno, Beatriz Rael, Pedro J. Benito, Angel E. Diaz, Rocio Cupeiro, Ana B. Peinado
Summary: This study measured serum iron markers in naturally menstruating and oral contraceptive athletes. The results showed that naturally menstruating athletes had lower levels of serum iron compared to OC athletes during bleeding phase. However, the differences disappeared when comparing the different phases of the menstrual cycle with the withdrawal phase of the OC cycle.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Francisco R. Marin, Alberto Davalos, Dylan Kiltschewskij, Maria C. Crespo, Murray Cairns, Eduardo Andres-Leon, Cristina Soler-Rivas
Summary: Although genomes from many edible mushrooms have been sequenced, studies on fungal micro RNAs (miRNAs) are rare. This study investigated the RNA-seq of the white button mushroom and identified potential novel miRNA-like small RNAs that were found in the edible parts. The results suggest that these small RNAs are involved in fungal metabolic regulation and may interfere with important biological processes in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medical Laboratory Technology
Paivi Lakkisto, Louise Torp Dalgaard, Thalia Belmonte, Sara-Joan Pinto-Sietsma, Yvan Devaux, David De Gonzalo-Calvo
Summary: The implementation of cell-free microRNAs as biomarkers is limited due to lack of reproducibility. Technical variability and analytical caveats make the interpretation of miRNA data challenging. Standardization efforts and consideration of specific aspects in sample handling and data analysis are important for reproducibility. Providing a checklist can facilitate the control of miRNA quantification and analysis.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Yan Qiu, Benjamin Fernandez-Garcia, H. Immo Lehmann, Li Guoping, Guido Kroemer, Carlos Lopez-Otin, Xiao Junjie
Summary: Exercise plays an active role in improving physical fitness and sustaining health. It has been widely accepted as a preventative and therapeutic strategy for various diseases. Exercise maintains and restores homeostasis at multiple levels to stimulate positive physiological adaptations that protect against pathological conditions.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Pablo Muela, Elisa Cintado, Patricia Tezanos, Benjamin Fernandez-Garcia, Cristina Tomas-Zapico, Eduardo Iglesias-Gutierrez, Angel Enrique Diaz Martinez, Ray G. Butler, Victor Cuadrado-Penafiel, Ricardo De la Vega, Vanesa Soto-Leon, Antonio Oliviero, Laura Lopez-Mascaraque, Jose Luis Trejo
Summary: Spatial navigation is a crucial aspect of human behavior that is still not completely understood. Researchers have developed hardware and protocols to evaluate freely moving humans' spatial navigation abilities in a real space circular arena, providing a flexible and adaptable way to access information about these abilities.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Jessica Ares Blanco, Carmen Lambert, Manuel Fernandez-Sanjurjo, Paula Morales-Sanchez, Pedro Pujante, Paola Pinto-Hernandez, Eduardo Iglesias-Gutierrez, Edelmiro Menendez Torre, Elias Delgado
Summary: The aim of this study was to investigate the glucose tolerance status after 15 years of pregnancy in women diagnosed with gestational diabetes mellitus (GDM) and to assess the long-term effect of GDM on circulating miRNA profile. The study included 30 randomly selected women diagnosed with GDM during 2005-2006, and glucose tolerance was measured using the National Diabetes Data Group criteria. Four miRNAs were analyzed in the plasma of women 15 years after the diagnosis of GDM. The study found that 50% of women had some degree of glucose intolerance 15 years after the diagnosis of GDM, which was directly related to body weight and body mass index during pregnancy. Dysglycemic women also showed significantly increased levels of circulating hsa-miR-24-3p. Thus, initial weight and BMI, along with circulating expression levels of hsa-miR-24-3p, could be good predictors of the future development of dysglycemia in women with a previous diagnosis of GDM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Andrea del Saz-Lara, Hatim Boughanem, Maria-Carmen Lopez de las Hazas, Carmen Crespo, Alicia Saz-Lara, Francesco Visioli, Manuel Macias-Gonzalez, Alberto Davalos
Summary: The Mediterranean diet is associated with lower incidence of cardio-vascular and cerebrovascular diseases as well as cancer. Extra virgin olive oil, with its phenolic components such as hydroxytyrosol, has been attributed with many healthful effects. Recent studies show that extra virgin olive oil and hydroxytyrosol modulate epigenetic mechanisms, specifically DNA methylation, in human tissues. In this study, colorectal cancer cells treated with hydroxytyrosol demonstrated an increase in global DNA methylation, suggesting a potential gene target for this compound.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Marina Redruello-Requejo, Maria de Lourdes Samaniego-Vaesken, Ana M. Puga, Ana Montero-Bravo, Mar Ruperto, Paula Rodriguez-Alonso, Teresa Partearroyo, Gregorio Varela-Moreiras
Summary: The dietary intake of omega-3 polyunsaturated fatty acids among the Spanish population is inadequate, especially in children, adolescents, and younger women. The intake of omega-6 polyunsaturated fatty acids is relatively acceptable, but the ratio of omega-6 to omega-3 is high. Meat and meat products are the main source of essential fatty acids, while fish and shellfish are the only sources of EPA and DHA. The combined degree of inadequacy for omega-3 PUFA, folic acid, vitamin B-12, and choline is 21.3% in the ANIBES population.
Article
Medicine, Research & Experimental
Guido Rossi-Herring, Thalia Belmonte, Andrea Rivas-Urbina, Sonia Benitez, Noemi Rotllan, Javier Crespo, Vicenta Llorente-Cortes, Jose Luis Sanchez-Quesada, David de Gonzalo-Calvo
Summary: This study examined the expression profiles of miRNAs in lipoprotein fractions (VLDL, LDL, and HDL) isolated from the serum through various methods. The results showed stable detection of different miRNAs in each fraction, with VLDL-specific miRNAs detected for the first time. Functional enrichment analysis indicated the potential roles of lipoprotein-carried miRNAs in cardiovascular disease-related mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Luke C. McIlvenna, Hannah-Jade Parker, Alex P. Seabright, Benedict Sale, Genevieve Anghileri, Samuel R. C. Weaver, Samuel J. E. Lucas, Martin Whitham
Summary: Small extracellular vesicles (sEVs) are released and participate in the intercellular exchange of proteins, lipids, metabolites, and nucleic acids. Proteomic, flow cytometry, and nanoparticle tracking analyses suggest that sEVs are released into circulation with exercise. HIIT leads to a decrease in the number of platelets and CD9, CD63, and CD41a positive sEVs in platelet-free plasma, supporting the concept of sEV release with exercise. Platelet-free plasma is the preferred sample to study sEV dynamics and phenotype during exercise.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Nutrition & Dietetics
Natalia Ubeda, Maria Purificacion Gonzalez, Maria Achon, Angela Garcia-Gonzalez, Catalina Ballestero-Fernandez, Violeta Fajardo, Elena Alonso-Aperte
Summary: This study assessed the ingredients and nutrient composition of gluten-free and gluten-containing breakfast products, and analyzed the nutritional quality of breakfast in Spanish children and adolescents with celiac disease. The results showed that breakfast in celiac disease patients was balanced in terms of energy and key food groups, but their fruit intake needed improvement. Compared to the control group, breakfast in the celiac disease group had less protein and saturated fat, similar carbohydrates and fiber, and more salt. Overall, breakfast on a gluten-free diet can be adequate but can be improved through product reformulation and reducing consumption of processed foods.
Article
Sport Sciences
Irene Torres-Aguilera, Paola Pinto-Hernandez, Eduardo Iglesias-Gutierrez, Nicolas Terrados, Manuel Fernandez-Sanjurjo
Summary: This study aimed to analyze the predictive value of plasma miR-106b-5p levels on sports performance in elite female and male kayakers. Results showed that miR-106b-5p levels correlated negatively with performance in men, while the miR-106b-5p/progesterone ratio correlated negatively with performance in women. The study highlights the importance of analyzing the molecular response to exercise separately in men and women, taking into account the stage of the menstrual cycle in women as a relevant factor.
FRONTIERS IN SPORTS AND ACTIVE LIVING
(2023)
Article
Agriculture, Dairy & Animal Science
Ester Perez-Martin, Almudena Coto-Vilcapoma, Juan Castilla-Silgado, Maria Rodriguez-Canon, Catuxa Prado, Gabriel Alvarez, Marco Antonio Alvarez-Vega, Benjamin Fernandez-Garcia, Manuel Menendez-Gonzalez, Cristina Tomas-Zapico
Summary: Stereotaxic surgeries are important for drug delivery to specific brain regions, but their long-term use poses challenges for animal welfare. This study proposes an optimized method for safe implantation of intrathecal devices, focusing on preoperative, intraoperative, and postoperative procedures. The refinements include modifications to device dimensions, the use of cyanoacrylate tissue adhesive and UV light-curing resin, and the development of a welfare assessment scoresheet. These refinements positively impacted animal welfare and can enhance experimental data quality and reproducibility.
Article
Mathematical & Computational Biology
Sergio Romero-Tapiador, Blanca Lacruz-Pleguezuelos, Ruben Tolosana, Gala Freixer, Roberto Daza, Cristina M. Fernandez-Diaz, Elena Aguilar-Aguilar, Jorge Fernandez-Cabezas, Silvia Cruz-Gil, Susana Molina, Maria Carmen Crespo, Teresa Laguna, Laura Judith Marcos-Zambrano, Ruben Vera-Rodriguez, Julian Fierrez, Ana Ramirez de Molina, Javier Ortega-Garcia, Isabel Espinosa-Salinas, Aythami Morales, Enrique Carrillo de Santa Pau
Summary: The increasing prevalence of diet-related diseases has led to a demand for improved nutritional advice. Personalized nutrition aims to meet this demand by tailoring dietary and lifestyle guidelines to each individual. The AI4Food database (AI4FoodDB) is introduced as a valuable resource for research in precision health, as it centralizes data from a nutritional weight loss intervention, including food images, wearable sensors, questionnaires, and biological samples.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2023)
