Review
Medicine, General & Internal
Isabela Landsteiner de Sampaio Amendola, Jonathan Aires Pinheiro, Pedro Povoa, Vicente Ces de Souza Dantas, Rodrigo Bernardo Serafim
Summary: This study found that rheumatic patients who chronically use hydroxychloroquine or chloroquine have significantly lower all-cause mortality and hospitalization rates after developing a COVID-19 infection. These findings suggest that these drugs may have a positive impact on the outcomes of COVID-19 patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Pierre Nouvellet, Sangeeta Bhatia, Anne Cori, Kylie E. C. Ainslie, Marc Baguelin, Samir Bhatt, Adhiratha Boonyasiri, Nicholas F. Brazeau, Lorenzo Cattarino, Laura V. Cooper, Helen Coupland, Zulma M. Cucunuba, Gina Cuomo-Dannenburg, Amy Dighe, Bimandra A. Djaafara, Ilaria Dorigatti, Oliver D. Eales, Sabine L. van Elsland, Fabricia F. Nascimento, Richard G. FitzJohn, Katy A. M. Gaythorpe, Lily Geidelberg, William D. Green, Arran Hamlet, Katharina Hauck, Wes Hinsley, Natsuko Imai, Benjamin Jeffrey, Edward Knock, Daniel J. Laydon, John A. Lees, Tara Mangal, Thomas A. Mellan, Gemma Nedjati-Gilani, Kris V. Parag, Margarita Pons-Salort, Manon Ragonnet-Cronin, Steven Riley, H. Juliette T. Unwin, Robert Verity, Michaela A. C. Vollmer, Erik Volz, Patrick G. T. Walker, Caroline E. Walters, Haowei Wang, Oliver J. Watson, Charles Whittaker, Lilith K. Whittles, Xiaoyue Xi, Neil M. Ferguson, Christl A. Donnelly
Summary: In response to the COVID-19 pandemic, countries around the world have used mobility data as an important proxy measure of social distancing to control the transmission of SARS-CoV-2. While there is a correlation between reduced mobility and decreased transmission, this relationship weakens over time as strict control measures are relaxed.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Juan Macias, Paz Gonzalez-Moreno, Esther Sanchez-Garcia, Ramon Morillo-Verdugo, Jose J. Perez-Venegas, Ana Pinilla, Ma Mar Macho, Ma Victoria Martinez, Alejandro Gonzalez-Serna, Anais Corma, Luis M. Real, Juan A. Pineda
Summary: A retrospective study comparing COVID-19 incidence in Spanish patients with autoimmune rheumatic diseases treated with and without hydroxychloroquine showed that there was no significant difference in the incidence and severity of COVID-19 between the two groups.
Article
Rheumatology
Ummusen Kaya Akca, Erdal Atalay, Muserref Kasap Cuceoglu, Zeynep Balik, Seher Sener, Yasemin Ozsurekci, Ozge Basaran, Ezgi Deniz Batu, Yelda Bilginer, Seza Ozen
Summary: During the COVID-19 pandemic, there was a 42% decrease in the annual number of pediatric rheumatic disease patients, with multisystem inflammatory syndrome in children (MIS-C) being the most common new diagnosis. There were significant decreases in diagnoses of certain diseases, suggesting a potential role of infections in their pathogenesis.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Health Care Sciences & Services
Amara Tariq, Leo Anthony Celi, Janice M. Newsome, Saptarshi Purkayastha, Neal Kumar Bhatia, Hari Trivedi, Judy Wawira Gichoya, Imon Banerjee
Summary: The study demonstrated that a fusion model utilizing medical history and current treatment data can predict the need for hospitalization for patients infected with COVID-19. Factors such as history of cardiovascular disease, emergency room visits, and demographic factors were predictive of disease trajectory. The early fusion model showed the best predictive performance.
NPJ DIGITAL MEDICINE
(2021)
Review
Rheumatology
Rebecca Grainger, Pedro M. Machado, Philip C. Robinson
Summary: This review discusses the risk of infection, outcomes, and risk factors for poor outcomes in patients with rheumatic disease in the context of COVID-19. It also explores data from other immune-mediated diseases, limitations of current research efforts, translation of knowledge into practice guidance, and future research agenda.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Bente Glintborg, Dorte Vendelbo Jensen, Lene Terslev, Oliver Hendricks, Mikkel Ostergaard, Simon Horskjaer Rasmussen, Mogens Pfeiffer Jensen, Thomas Adelsten, Ada Colic, Kamilla Danebod, Malene Kildemand, Anne Gitte Loft, Heidi Lausten Munk, Jens Kristian Pedersen, Rene Drage Ostgard, Christian Moller Sorensen, Niels Steen Krogh, Jette Norgaard Agerbo, Connie Ziegler, Merete Lund Hetland
Summary: A survey conducted on patients with inflammatory rheumatic disease (IRD) showed that levels of anxiety and self-isolation decreased after the initial lockdown period of the COVID-19 pandemic. However, in May 2021, half of the patients reported self-isolation, a phase that included the widespread reopening of society and large-scale vaccination.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Oncology
Noha Sharafeldin, Benjamin Bates, Qianqian Song, Vithal Madhira, Yao Yan, Sharlene Dong, Eileen Lee, Nathaniel Kuhrt, Yu Raymond Shao, Feifan Liu, Timothy Bergquist, Justin Guinney, Jing Su, Umit Topaloglu
Summary: The largest multicenter cohort of cancer patients with COVID-19 to date was constructed by the U.S. N3C collaboration. It was found that COVID-19 positivity significantly increased the risk of all-cause mortality in cancer patients. Factors such as age, gender, region, comorbidities, and specific cancer types were associated with increased mortality risk in cancer patients with COVID-19.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Peter W. Horby, Martin J. Landray
Summary: Tocilizumab improved survival and other clinical outcomes in hospitalized COVID-19 patients with hypoxia and systemic inflammation, regardless of the level of respiratory support, and provided additional benefits on top of systemic corticosteroid therapy.
Review
Biochemistry & Molecular Biology
Susana Furman, Kim Green, Thomas E. Lane
Summary: COVID-19 has the potential to affect the brain and may contribute to the onset or worsening of Alzheimer's disease. The shared pathological features and risk factors between COVID-19 and AD, along with their global impact, could have significant public health consequences.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Medicine, General & Internal
T. Avni, L. Leibovici, I Cohen, A. Atamna, D. Guz, M. Paul, A. Gafter-Gvili, D. Yahav
Summary: Interleukin-6 inhibitor tocilizumab reduces 28-30 days all-cause mortality, mechanical ventilation risk, ICU admission rate, and superinfection risk in COVID-19 patients. However, no mortality benefit was found in critically ill patients and those who were predominantly treated with steroids. Further research is needed to determine sub-groups that benefit most and the optimal timing of TCZ administration in severe COVID-19.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2021)
Article
Psychology, Multidisciplinary
Sanjay Kumar, Alfred Veldhuis, Tina Malhotra
Summary: COVID-19 may have long-term mental health effects on patients, necessitating global recognition and planning to address mental health issues. Research indicates that patients may develop neurological symptoms and the virus could potentially cause damage to the nervous system, leading to long-term neuropsychiatric sequelae.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Oncology
Dax Kurbegov, Suanna S. Bruinooge, Xiudong Jennifer Lei, M. Kelsey Kirkwood, Natalie Dickson, Trupti Hattiangadi, Kathryn F. Mileham, Alicia Patrick, Jen Hanley Williams, Melinda Kaltenbaugh, Julie R. Gralow, Elizabeth Garrett-Mayer
Summary: The study found that age, cancer type, comorbidity, area-level education attainment, and unemployment rates were associated with differential COVID-19 vaccine uptake rates. These findings should be applied to strategies to communicate about vaccine safety and efficacy to patients with cancer.
Article
Immunology
Fadi Kharouf, Tali Eviatar, Maya Braun, Elisheva Pokroy-Shapira, Michal Brodavka, Yair Zloof, Nancy Agmon-Levin, Kochava Toledano, Shirly Oren, Merav Lidar, Devy Zisman, Yonit Tavor, Mirit Amit-Vazina, Firas Sabbah, Gabriel S. Breuer, Amir Dagan, Rima Beshara-Garzuzi, Doron Markovits, Muna Elias, Joy Feld, Oshrat Tayer-Shifman, Tal Gazitt, Tatiana Reitblatt, Limor Rubin, Amir Haddad, Sami Giryes, Daphna Paran, Hagit Peleg, Yair Molad, Ori Elkayam, Dror Mevorach, Alexandra Balbir-Gurman, Yolanda Braun-Moscovici
Summary: This study aimed to characterize the course of COVID-19 in autoimmune inflammatory rheumatic disease (AIIRD) patients in Israel, considering the outcomes of different outbreaks, the effect of vaccination campaigns, and AIIRD activity post-recovery. The results showed that COVID-19 is more severe and has increased mortality in active AIIRD patients. Vaccination with 3 doses of the mRNA vaccine protected against severe COVID-19 during the outbreak.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Elnaz Gholipour, Bela Vizvari, Tareq Babaqi, Szabolcs Takacs
Summary: With the rapid spread of the COVID-19, elderly and individuals with underlying medical issues are at higher risk of developing serious illness; a study conducted in Hungary focuses on exploring patterns of COVID-19 victims with underlying conditions, using age, gender, and medical problems for clustering; results can predict similar cases and serve as a warning for public health professionals to address this deadly disease.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Letter
Rheumatology
Pedro M. Machado, Martin Schaefer, Anja Strangfeld, Laure Gossec, Milena Gianfrancesco, Saskia Lawson-Tovey, Elsa F. Mateus, Loreto Carmona, Kimme L. Hyrich, Philip C. Robinson, Jinoos Yazdany
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Martin Schaefer, Anja Strangfeld, Kimme L. Hyrich, Loreto Carmona, Milena Gianfrancesco, Saskia Lawson-Tovey, Elsa F. Mateus, Laure Gossec, Philip C. Robinson, Jinoos Yazdany, Pedro M. Machado
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Kimme L. Hyrich, Martin Schaefer, Anja Strangfeld, Loreto Carmona, Laure Gossec, Elsa F. Mateus, Saskia Lawson-Tovey, Milena Gianfrancesco, Philip C. Robinson, Jinoos Yazdany, Pedro M. Machado
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Stefanie D. Wade, Jason A. Freed, Vasileios C. Kyttaris, Staci Saunders, Jonathan S. Hausmann
Summary: This study aimed to evaluate the use of active learning strategies in graduate medical education through a faculty development workshop and transitioning to a virtual flipped classroom. The results showed an increase in active learning scores and high faculty satisfaction within the Introductory Rheumatology Curriculum.
ARTHRITIS CARE & RESEARCH
(2023)
Letter
Rheumatology
Ricardo J. O. Ferreira, Paco M. J. Welsing, Johannes W. G. Jacobs, Laure Gossec, Mwidimi Ndosi, Pedro M. Machado, Desiree van der Heijde, Jose A. P. Da Silva
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Mikhail Protopopov, Fabian Proft, Stephanie Wichuk, Pedro M. Machado, Robert G. Lambert, Ulrich Weber, Susanne Juhl Pedersen, Mikkel Ostergaard, Joachim Sieper, Martin Rudwaleit, Xenofon Baraliakos, Walter P. Maksymowych, Denis Poddubnyy
Summary: This study compares the ability of MRI and conventional radiography to detect structural lesions indicative of axSpA.
Article
Rheumatology
Sarah Ringold, Anne C. Dennos, Yukiko Kimura, Timothy Beukelman, Peter Shrader, Thomas A. Phillips, Melanie Kohlheim, Laura E. Schanberg, Rae S. M. Yeung, Daniel B. Horton
Summary: The outcomes of disease recapture in children with well-controlled JIA after medication discontinuation were characterized in this study. The study found that approximately half of the patients experienced a flare within 6 months. The use of biologic drugs and a history of flares were associated with increased odds of successful recapture, while limited range of motion in the joints was associated with decreased odds.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Emily A. Smitherman, Rouba A. Chahine, Nicole Bitencourt, A. K. M. Fazlur Rahman, Erica F. Lawson, Joyce C. Chang
Summary: This study evaluates the care utilization and outcomes of young adults with JIA, and explores factors associated with complete transfer to adult rheumatology. The study finds that respondents with complete transfer to adult rheumatology are slightly older and report higher disease activity, morning stiffness, and pain. Biologic use is high and does not differ by transfer status. Respondents who completed the transfer are more likely to have private insurance and be pursuing postsecondary education. Majority of the cohort reports problems with pain or discomfort and anxiety or depression.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Health Care Sciences & Services
Helena Santos, Ana Rita Henriques, Jaime Branco, Pedro M. Machado, Helena Canhao, Fernando M. Pimentel-Santos, Ana Maria Rodrigues
Summary: The study found that both spondyloarthritis and chronic low back pain have similar impacts on health-related quality of life (HRQoL), including mental, physical, and social domains. Patients with spondyloarthritis and chronic low back pain reported significantly lower HRQoL compared to those without rheumatic diseases. Modifiable factors such as multimorbidity, active disease, obesity, and regular physical exercise were associated with HRQoL in these conditions.
QUALITY OF LIFE RESEARCH
(2023)
Article
Rheumatology
Manuel F. Ugarte-Gil, Graciela S. Alarcon, Andrea M. Seet, Zara Izadi, Anna D. Montgomery, Ali Duarte-Garcia, Emily L. Gilbert, Maria O. Valenzuela-Almada, Leanna Wise, Jeffrey A. Sparks, Tiffany Y. -T. Hsu, Kristin M. D'Silva, Naomi J. Patel, Emily Sirotich, Jean W. Liew, Jonathan S. Hausmann, Paul Sufka, Rebecca Grainger, Suleman Bhana, Zachary Wallace, Lindsay Jacobsohn, Anja Strangfeld, Elsa F. Mateus, Kimme L. Hyrich, Laure Gossec, Loreto Carmona, Saskia Lawson-Tovey, Lianne Kearsley-Fleet, Martin Schaefer, Pedro M. Machado, Philip C. Robinson, Milena Gianfrancesco, Jinoos Yazdany
Summary: A study on individuals with SLE in the US found that Black and Hispanic patients had higher odds of experiencing more severe COVID-19 outcomes compared to White patients, which may be attributed to socioeconomic and health disparities.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Sarah Patterson, Laura Trupin, Wendy Hartogensis, Kimberly DeQuattro, Cristina Lanata, Caroline Gordon, Kamil E. E. Barbour, Kurt J. J. Greenlund, Maria Dall'Era, Jinoos Yazdany, Patricia Katz
Summary: Several studies have shown a potential link between traumatic experiences, psychological stress, and autoimmunity. However, the impact of stress on disease activity and symptom severity in systemic lupus erythematosus (SLE) has not been fully understood. This study aimed to examine whether increases in perceived stress independently associate with worse SLE disease outcomes over a 3-year follow-up period. The results suggest that an increase in stress is associated with greater disease activity and symptom burden in individuals with SLE.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Medical Informatics
Suzanne Tamang, Marie Humbert-Droz, Milena Gianfrancesco, Zara Izadi, Gabriela Schmajuk, Jinoos Yazdany
Summary: Experts highlight the gap between clinical NLP research and real-world applications, offering practical considerations for developing NLP systems that can support clinical needs and improve health outcomes. These considerations involve assessing data and compute resources readiness, organizational incentives, and feasibility of implementation. They are beneficial for the design of future clinical NLP projects in various settings, including large health systems and clinical practices with electronic medical records.
JMIR MEDICAL INFORMATICS
(2023)
Review
Rheumatology
Brooke Conley, Samantha Bunzli, Jonathan Bullen, Penny O'Brien, Jennifer Persaud, Tilini Gunatillake, Mandana Nikpour, Rebecca Grainger, Cheryl Barnabe, Ivan Lin
Summary: This study conducted a systematic review to evaluate the quality of clinical practice guidelines for rheumatoid arthritis (RA) management and provided a synthesis of high-quality recommendations. The review identified 13 eligible guidelines that highlighted the importance of both non-pharmacological and pharmacological care for RA management. This synthesis offers clear evidence-based guidance for healthcare providers.
CLINICAL RHEUMATOLOGY
(2023)
Article
Rheumatology
Sebastian Bruera, Xiudong Lei, Hui Zhao, Jinoos Yazdany, Mariana Chavez-MacGregor, Sharon H. Giordano, Maria E. Suarez-Almazor
Summary: This study compared the outcomes of patients with or without systemic lupus erythematosus (SLE) who were diagnosed with COVID-19 and evaluated factors associated with severe outcomes in SLE patients. The results showed that patients with SLE had significantly higher rates of mortality, mechanical ventilation, and hospitalization compared to matched controls. Severe disease activity in SLE and prior use of corticosteroids were associated with worse outcomes.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Education, Scientific Disciplines
Rebecca Grainger, Qian Liu, Tehmina Gladman
Summary: In this article, the authors discuss the transformative capacity of learning technology in health professions education (HPE). Through a synthesis of current research, they find that most studies focus on substituting or augmenting learning through technology, with few using technology to modify or redefine HPE. The lack of theoretical justification for pedagogical improvement is also concerning.