Article
Environmental Sciences
Emin Sengul, Volkan Gelen, Serkan Yildirim, Irfan Cinar, Emrah Hicazi Aksu
Summary: In this study, we aimed to investigate the protective effect of naringin against the damage of acrylamide on testicular tissue and the reproductive system in rats. The results showed that naringin alone did not cause tissue damage, and the co-administration of naringin with acrylamide significantly reduced acrylamide-induced testis toxicity.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zirui Zhao, Shilei Yang, Yawen Deng, Liang Wang, Yifen Zhang, Zhenyu Feng, Han Li, Zhongchao Chi, Yunpeng Xie, Deshi Dong
Summary: The study found that Naringin can prevent DOX-related cardiac injury and inhibit oxidative stress, inflammation, and apoptosis in the heart both in vivo and in vitro. These findings suggest that Naringin may serve as a novel approach to prevent cardiac toxicity induced by anthracycline drugs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Andrology
Min Chul Cho, Junghoon Lee, Juhyun Park, Soo Woong Kim
Summary: The study showed that chronic inhibition of JNK and LIMK2 can restore cavernous veno-occlusive function by reducing cavernous apoptosis and fibrosis, similar to the results found with PDE5 inhibitors.
WORLD JOURNAL OF MENS HEALTH
(2021)
Article
Endocrinology & Metabolism
Soo Woong Kim, Junghoon Lee, Sohee Oh, Hwancheol Son, Min Chul Cho
Summary: The study found that the combined administration of a JNK inhibitor and medium or high-dose HGF in nerve-injured rats after CNCI may restore erectile function by suppressing cavernosal apoptosis and preserving the integrity of smooth muscle or endothelium through the cJun and cMet/eNOS pathways.
Article
Immunology
Xiaoping Liang, Yujie Liu, Ling Chen, Suyu Chen
Summary: The study demonstrated that Puerarin (Pue) can alleviate symptoms of preeclampsia (PE) in vitro and in vivo, suppress inflammation and apoptosis, and improve placental pathology change.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Urology & Nephrology
Junghoon Lee, Hwancheol Son, Soo Woong Kim, Min Chul Cho
Summary: The combination treatment of JNK inhibitor and HGF can reduce apoptosis and promote tissue regeneration, thus preserving erectile function after radical prostatectomy.
JOURNAL OF SEXUAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Chen Wang, Haoyu Wu, Yuanming Xing, Yulan Ye, Fangzhou He, Qian Yin, Yujin Li, Fenqing Shang, John Y. -J. Shyy, Zu-Yi Yuan
Summary: Endothelial dysfunction and vascular smooth muscle cell plasticity play a critical role in the pathogenesis of hypertension and arterial stiffness. This study found that endothelial-derived microRNA-92a (miR-92a) promotes arterial stiffness by regulating the communication between endothelial cells and smooth muscle cells. Inhibition of miR-92a can ameliorate arterial stiffness and impaired vasodilation induced by Angiotensin II.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Yinghao Yin, Yihong Zhou, Jun Zhou, Liangyu Zhao, Hongji Hu, Ming Xiao, Bin Niu, Jingxuan Peng, Yingbo Dai, Yuxin Tang
Summary: This study investigated the effect of CDDP on erectile function and its possible mechanism. The results showed that CDDP treatment could induce erectile dysfunction by affecting the content of endothelial and smooth muscle and causing cellular senescence and cell death. Clinicians should pay more attention to the erectile function of cancer patients who receive CDDP treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Bingbing Zhu, Yangjiu Niu, Haoqiang Guo, Xiufang Jin, Fengxia Liu
Summary: Erectile dysfunction (ED) is a common disease that results in sexual dysfunction in men. Inflammation-induced endothelial dysfunction, influenced by cell death, plays a critical role in the pathophysiology of ED. Pyroptosis, a type of programmed cell death mediated by the inflammasome, has been discovered in inflammatory disorders. However, the role of pyroptosis in ED is not fully understood. Research on pyroptosis aims to enhance the understanding of ED pathogenesis and develop new therapeutic options. This review discusses the literature on pyroptosis mechanisms and summarizes its role in the development and progression of inflammation-mediated ED.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Chemistry, Medicinal
Lidan Gu, Fei Wang, Yilin Wang, Deen Sun, Yiming Sun, Tingting Tian, Qiang Meng, Lianhong Yin, Lina Xu, Xiaolong Lu, Jinyong Peng, Yuan Lin, Pengyuan Sun
Summary: Naringin ameliorates ischemia/reperfusion-induced intestinal injury by deactivating the cGAS-STING signaling pathway, reducing inflammation and oxidative stress, and inhibiting apoptosis. The study emphasizes the crucial role of the cGAS-STING signaling pathway in intestinal injury and highlights the potential therapeutic effects of naringin in this condition.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pediatrics
Alberto Toso, Oscar Aranguiz, Carlos Cespedes, Orieta Navarrete, Cherie Hernandez, Carlos P. Vio, Matias Luco, Paola Casanello, Javier Kattan
Summary: This study evaluated the effects of antenatal sildenafil and ABH on lung development in a CDH rat model. The results showed that the combined treatment improved lung volume, pulmonary vascular development, and NO synthesis, while preventing smooth muscle cell hyperproliferation. This study highlights the importance of Arginase inhibition as a therapeutic target and the role of prenatal treatment in improving lung development in CDH.
PEDIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Junghoon Lee, Soo Woong Kim, Min Chul Cho
Summary: The combined treatment with JNK-inhibitors and HGF can effectively restore erectile function in a rat model of CNCI by anti-apoptosis and preservation of endothelium or smooth muscle, showing superior therapeutic effects compared to using each agent alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Huiqing Lu, Lili Gong, Huangfang Xu, Qiongjie Zhou, Huanqiang Zhao, Suwen Wu, Rong Hu, Xiaotian Li
Summary: Preeclampsia can have long-term adverse effects on the cognitive abilities of offspring. This study found that environmental enrichment in early life improved the cognitive ability of rat offspring with preeclampsia. The improvement may be due to increased hippocampal neurogenesis and synaptic plasticity, as well as decreased apoptosis and inflammatory cytokine levels.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mustafa Ileriturk, Duygu Ileriturk, Ozge Kandemir, Nurhan Akaras, Hasan Simsek, Ender Erdogan, Fatih M. Kandemir
Summary: This study investigated the activity of naringin in oxaliplatin-induced hepatorenal toxicity. The results showed that naringin has antioxidant and anti-inflammatory effects, and can alleviate oxidative stress, inflammation, and cell apoptosis in liver and kidney tissues induced by oxaliplatin. Furthermore, naringin can reduce endoplasmic reticulum stress caused by oxaliplatin.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Review
Andrology
Solomon Hayon, Evan J. Panken, Nelson E. Bennett
Summary: Low-intensity shockwave therapy (LiSWT) is gaining popularity for the treatment of erectile dysfunction (ED). Current studies show that LiSWT has low risk and positive improvements in erectile function. However, there is still debate over its clinical utility and optimal treatment protocol.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)