Article
Chemistry, Multidisciplinary
Yi Ding, Jie Yu, Xingyu Chen, Shaoyun Wang, Zhaoxu Tu, Guangxia Shen, Huixue Wang, Renbing Jia, Shengfang Ge, Jing Ruan, Kam W. Leong, Xianqun Fan
Summary: This study investigates the effects of carbon dots on uveal melanoma cell metabolomics, growth, invasiveness, and tumorigenicity, demonstrating that moderate doses of carbon dots can promote tumorigenicity in cancer cells.
Article
Biochemistry & Molecular Biology
Jing Li, Fangzheng Qi, Huishan Su, Chuanshan Zhang, Qing Zhang, Ying Chen, Ping Chen, Linjia Su, Yanan Chen, Yuqi Yang, Zhesheng Chen, Sihe Zhang
Summary: GRP75-faciliated MAM formation is enriched in cisplatin-resistant ovarian cancer cells. Diminishing MAM integrity by GRP75-deficiency reduces ER-to-mitochondrial Ca2+ transfer, accelerates mitochondrial dysfunction and ROS accumulation, and enhances cisplatin-triggered apoptotic cell death.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Xianlei Cai, Chao Liang, Miaozun Zhang, Yuan Xu, Yihui Weng, Xueying Li, Weiming Yu
Summary: N6-methyladenosine (m6A) modification plays a significant role in the metabolic reprogramming of digestive system malignancies.
Article
Cell & Tissue Engineering
Yu Liu, Xiangxian Zhang, Wei Wang, Ting Liu, Jun Ren, Siyuan Chen, Tianqi Lu, Yan Tie, Xia Yuan, Fei Mo, Jingyun Yang, Yuquan Wei, Xiawei Wei
Summary: Ammonia plays an important role in cellular metabolism but is considered toxic. Bone marrow-derived mesenchymal stem cells can convert ammonia and glutamate to glutamine via glutamine synthetase activity, supporting cell proliferation. Glutamine activates signaling pathways to stimulate cell proliferation.
Article
Biochemistry & Molecular Biology
Sarah Hartwick Bjorkman, Renata Oliveira Pereira
Summary: Mitochondria-derived reactive oxygen species (mtROS) can disrupt cellular redox homeostasis, but moderate mitochondrial stress may enhance the organism's ability to cope with stress. By regulating different signaling pathways, mtROS play a key role in maintaining cardiometabolic health.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Food Science & Technology
Sicong Tian, Peng Lei, Jing Zhang, Yao Sun, Baolong Li, Yujuan Shan
Summary: The study revealed that SFN balances Ca2+ homeostasis in the MAM by regulating Ca2+ flux through the Ca2+ channels IP3R and MCU. SFN widens the distance between ER and mitochondria, down-regulates MAM tether protein mitofusin-2, alleviates Ca2+ overload in mitochondria, increases mitochondrial DNA quantities and membrane potential, inhibits ROS production, and enhances mitochondria complexes IV content and ATP synthesis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Valeria Scalcon, Alessandra Folda, Maria Giovanna Lupo, Federica Tonolo, Naixuan Pei, Ilaria Battisti, Nicola Ferri, Giorgio Arrigoni, Alberto Bindoli, Arne Holmgren, Lucia Coppo, Maria Pia Rigobello
Summary: This study reveals the specific role of mitochondrial Grx2 in the regulation of cell metabolism and highlights an unknown association between Grx2 and metabolic dysfunction-associated fatty liver disease (MAFLD).
Review
Chemistry, Multidisciplinary
Xuemei Yao, Wei Li, De Fang, Chuyu Xiao, Xiao Wu, Menghuan Li, Zhong Luo
Summary: Ferroptosis is a new form of cell death characterized by iron-dependent accumulation of lethal lipid peroxides, with tumor cells activating adaptive metabolic responses to inhibit it; targeting tumor energy metabolism may disrupt redox homeostasis and induce ferroptosis for potential therapeutic strategies.
Article
Multidisciplinary Sciences
Benedikt Feuerecker, Philipp Biechl, Christof Seidl, Frank Bruchertseifer, Alfred Morgenstern, Markus Schwaiger, Wolfgang Eisenreich
Summary: This study utilized Bi-213-anti-EGFR-MAb to treat bladder and glioma cancer cells, revealing an early treatment response in bladder cancer cells but not in glioma cells.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Kuan-Hao Tsui, Chia-Jung Li
Summary: The aim of this study was to investigate the ability of MitoQ to resist ROS-induced apoptosis in human granulosa cells and mouse oocytes. The results showed that MitoQ treatment reduced ROS production, balanced mitochondrial membrane potential, and prevented excessive mitochondrial fragmentation. MitoQ also regulated intracellular energy metabolism and reduced the expressions of AIFM1 and PGAM5.
Article
Biology
Maria Sol Herrera-Cruz, Megan C. Yap, Nasser Tahbaz, Keelie Phillips, Laurel Thomas, Gary Thomas, Thomas Simmen
Summary: Rab32 promotes degradation of mitochondrial-proximal ER membranes via autophagy with the help of its effector RTN3L, a process proposed to be termed MAM-phagy.
Article
Pharmacology & Pharmacy
Javier Moral-Sanz, Manuel A. Fernandez-Rojo, Gonzalo Colmenarejo, Sergey Kurdyukov, Andreas Brust, Lotten Ragnarsson, Asa Andersson, Sabela F. Vila, Pablo Cabezas-Sainz, Patrick Wilhelm, Ana Vela-Sebastian, Isabel Fernandez-Carrasco, Yanni K. Y. Chin, Yaiza Lopez-Mancheno, Taylor B. Smallwood, Richard J. Clark, Bryan G. Fry, Glenn F. King, Grant A. Ramm, Paul F. Alewood, Richard J. Lewis, Jason P. Mulvenna, Glen M. Boyle, Laura E. Sanchez, G. Gregory Neely, John J. Miles, Maria P. Ikonomopoulou
Summary: This study demonstrates that Octpep-1 selectively reduces the proliferative capacity of BRAF-mutated melanoma cells and inhibits tumor progression in vivo. Octpep-1 increases ROS levels, promotes non-mitochondrial and mitochondrial respiration, and exhibits enhanced efficacy when truncated at the C-terminal region.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jones Gyamfi, Jinyoung Kim, Junjeong Choi
Summary: Cancer is not only a genetic disease but also a result of metabolic dysregulation. Metabolic alterations in cancer cells, including key changes in glucose, glutamine, and fatty acid metabolism, are more common among different subtypes and types of cancer. Recognizing cancer as a metabolic disorder can reveal important diagnostic and treatment markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Parash Prasad, Sampurna Ghosh, Sib Sankar Roy
Summary: Glutamine deficiency in the core of tumors can increase the cancer stem cell population, and the combination therapy with MDiVi-1 and L-DON is an effective approach to reduce CSCs population in tumor. The study reveals the association between glutamine deprivation and stemness in cancer cells, highlighting the potential of targeting glutamine metabolism for cancer therapy. The findings suggest that metabolic reprogramming induced by glutamine starvation plays a key role in promoting the stem cell characteristics in tumor cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Chen Yang, Yanchun Li, Wanye Hu, Xu Wang, Jiayu Hu, Chen Yuan, Chaoting Zhou, Hairui Wang, Jing Du, Ying Wang, Xiangmin Tong
Summary: TEOA inhibits proliferation and migration of pancreatic cancer cells by inducing mitochondrial dysfunction and ROS-dependent autophagic cell death, suggesting its potential as a promising therapeutic agent for pancreatic cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xin Zhang, Tian Yuan, Xuhui Chen, Xuebo Liu, Jun Hu, Zhigang Liu
Summary: The prevalence of Alzheimer's disease is increasing due to aging population, and ApoE4 allele is identified as the primary genetic risk factor. However, emerging research suggests that dietary factors, such as DHA, can modify the risk of AD. The interplay between DHA and ApoE genotype within the brain needs further investigation. Early DHA supplementation may benefit cognitively normal older adults carrying the ApoE4 gene, while its effectiveness for AD patients is limited.
PROGRESS IN LIPID RESEARCH
(2024)
Review
Biochemistry & Molecular Biology
Chen Wu, Haiqin Chen, Yongchao Mei, Bo Yang, Jianxin Zhao, Catherine Stanton, Wei Chen
Summary: This review summarizes the recent advances in microbial conjugated linoleic acid (CLA) production, including the mechanisms of linoleic acid conversion to CLA, factors influencing CLA production and isomer composition, and strategies for enhancing CLA content and nutritional value in fermented products using microorganisms. The review aims to serve as a reference for microbial CLA production and expand the understanding of the potential probiotic role of microbial CLA producers.
PROGRESS IN LIPID RESEARCH
(2024)