期刊
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
卷 153, 期 -, 页码 35-41出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2020.03.002
关键词
Connexin; Cell growth; Cell death
资金
- Fund for Scientific Research-Flanders (FWO-Vlaanderen)
- University Hospital of the Vrije Universiteit Brussel-Belgium (Willy Gepts Fonds UZ-Brussel)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP-FWO) [18/10953-9]
- FWO/SNSF Lead Agency project funding (SNSF) [310030E_176050]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [18/10953-9] Funding Source: FAPESP
- Swiss National Science Foundation (SNF) [310030E_176050] Funding Source: Swiss National Science Foundation (SNF)
Gap junctions mediate cellular communication and homeostasis by controlling the intercellular exchange of small and hydrophilic molecules and ions. Gap junction channels are formed by the docking of 2 hemichannels of adjacent cells, which in turn are composed of 6 connexin subunits. Connexin proteins as such can also control the cellular life cycle independent of their channel activities. This has been most demonstrated in the context of cell growth and cell death. Different mechanisms are involved mainly related to direct interaction with cell growth or cell death regulators, but also implying effects on the expression of cell growth and cell death regulators. The present paper focuses on these atypical roles of connexin proteins. (C) 2020 Elsevier Ltd. All rights reserved.
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