Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases

Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression

(2019) Russell E. Ericksen et al.   Cell Metabolism

DEGS1-associated aberrant sphingolipid metabolism impairs nervous system function in humans

(2019) Gergely Karsai et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

(2019) Rubina Tabassum et al.   Nature Communications

FADS3 is a Δ14Z sphingoid base desaturase that contributes to gender differences in the human plasma sphingolipidome

(2019) Gergely Karsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and characterization of some atypical sphingoid bases

(2018) Essa M. Saied et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Interorgan Metabolic Crosstalk in Human Insulin Resistance

(2018) Sofiya Gancheva et al.   PHYSIOLOGICAL REVIEWS

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues

(2018) Martina Wallace et al.   Nature Chemical Biology

The ORMs interact with transmembrane domain 1 of Lcb1 and regulate serine palmitoyltransferase oligomerization, activity and localization

(2018) Gongshe Han et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingolipids and Lipoproteins in Health and Metabolic Disorders

(2017) Jahangir Iqbal et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Structure and conserved function of iso-branched sphingoid bases from the nematode Caenorhabditis elegans

(2017) J. Thomas Hannich et al.   Chemical Science

ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase

(2016) Assem Zhakupova et al.   FASEB JOURNAL

Biological Effects of Naturally Occurring Sphingolipids, Uncommon Variants, and Their Analogs

(2016) Mitchell K. P. Lai et al.   NEUROMOLECULAR MEDICINE

A series of ceramide analogs modified at the 1-position with potent activity against the intracellular growth of Chlamydia trachomatis

(2015) Essa M Saied et al.   Future Medicinal Chemistry

HSAN1 mutations in serine palmitoyltransferase reveal a close structure–function–phenotype relationship

(2015) Heiko Bode et al.   HUMAN MOLECULAR GENETICS

Hepatic expression of the Sptlc3 subunit of serine palmitoyltransferase is associated with the development of hepatocellular carcinoma in a mouse model of nonalcoholic steatohepatitis

(2015) YOZO YOSHIMINE et al.   ONCOLOGY REPORTS

Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration

(2015) Lihong Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

(2014) Patrick Essletzbichler et al.   GENOME RESEARCH

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasingde novosynthesis of long-chain ceramides

(2013) Resat Cinar et al.   HEPATOLOGY

Myristate-derived d16:0 Sphingolipids Constitute a Cardiac Sphingolipid Pool with Distinct Synthetic Routes and Functional Properties

(2013) Sarah Brice Russo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Arabidopsis 56-Amino Acid Serine Palmitoyltransferase-Interacting Proteins Stimulate Sphingolipid Synthesis, Are Essential, and Affect Mycotoxin Sensitivity

(2013) A. N. Kimberlin et al.   PLANT CELL

Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations

(2012) Ayşe Demirkan et al.   PLoS Genetics

Plasma deoxysphingolipids: a novel class of biomarkers for the metabolic syndrome?

(2011) A. Othman et al.   DIABETOLOGIA

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae

(2011) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

Concentration-dependent exchange accelerates turnover of proteins bound to double-stranded DNA

(2010) J. S. Graham et al.   NUCLEIC ACIDS RESEARCH

Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The SPTLC3 Subunit of Serine Palmitoyltransferase Generates Short Chain Sphingoid Bases

(2009) Thorsten Hornemann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A genome-wide perspective of genetic variation in human metabolism

(2009) Thomas Illig et al.   NATURE GENETICS

Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities

(2009) G. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Determinants of Circulating Sphingolipid Concentrations in European Populations

(2009) Andrew A. Hicks et al.   PLoS Genetics

Thematic Review Series: Sphingolipids.Biodiversity of sphingoid bases (“sphingosines”) and related amino alcohols

(2008) Sarah T. Pruett et al.   JOURNAL OF LIPID RESEARCH