Article
Multidisciplinary Sciences
Wei-Chen Lo, Ching-Hsiang Fan, Yi-Ju Ho, Chia-Wei Lin, Chih-Kuang Yeh
Summary: The AVT technique, inspired by tornadoes, successfully captures and increases the local concentration of MBs. This compact, easy-to-use, and biocompatible method enables systemic drug administration with extremely low doses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Physics, Applied
Jie Huang, Qinxin Zhou, Xuemei Ren, Zheng Xu, Xiaojun Liu
Summary: Non-diffracting Bessel acoustic beams with self-healing, self-bending, and self-acceleration properties have potential applications for directional transportation of microbubbles. By adjusting the acoustic frequency, the maximum point of acoustic intensity on the beam mainlobe can be changed, and the curved trajectory and adjustable destination of microbubble transportation have been experimentally proven. The proposed method utilizes the conservative part of the radiation force to control the trajectory of microbubbles, making it suitable for in vivo applications.
APPLIED PHYSICS LETTERS
(2021)
Review
Physics, Applied
Shifang Guo, Zhen Ya, Pengying Wu, Mingxi Wan
Summary: Acoustic vortices offer a single-beam approach for manipulating objects ranging from nanometers to millimeters in size. They can stably trap particles in three dimensions using helical beams and utilize orbital angular momentum for object rotation and data transmission. Their applications are particularly significant in the biomedical field.
JOURNAL OF APPLIED PHYSICS
(2022)
Review
Chemistry, Analytical
Yuting Zhou, Liguo Dai, Niandong Jiao
Summary: Microbubbles have been widely used in the field of microrobots due to their unique properties. They can serve as power sources, manipulation tools, or even microrobots themselves. This review provides a comprehensive overview of bubble applications in microrobotics, including propulsion, manipulation, and assembly, highlighting the advantages and challenges.
Article
Chemistry, Multidisciplinary
Mingxin Xu, William S. Harley, Zhichao Ma, Peter V. S. Lee, David J. Collins
Summary: Acoustic metasurfaces with complex 3D structures complicate their fabrication and applicability to higher frequencies, but an ultrathin metasurface approach utilizing planarized micropillars in a discretized phase array is demonstrated here. This subwavelength metasurface can be easily produced via a single-step etching process and is suitable for megahertz-scale applications. The flexibility of this approach is further demonstrated in the production of complex acoustic patterns via acoustic holography. This metasurface approach, combined with predictive models, has broad potential for robust, high-frequency acoustic manipulation in various applications.
ADVANCED MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
Sonia Marrara, David Bronte Ciriza, Alessandro Magazzu, Roberto Caruso, Giuseppe Lupo, Rosalba Saija, Antonino Foti, Pietro Giuseppe Gucciardi, Andrea Mandanici, Onofrio Maria Marago, Maria Grazia Donato
Summary: Recently, acoustic tweezers inspired by holographic optical tweezers have been developed. The calibration of optical trap stiffnesses is essential in the latter technique, but seldom carried out in acoustic tweezers. In this work, the calibration protocols used in optical tweezers are adapted for acoustic tweezers based on ultrasonic transducer arrays. The measured trap stiffnesses are consistent with theoretical estimates, providing a common framework for optical and acoustic manipulation communities and enabling consistent calibration of hybrid acoustooptical setups.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Chemistry, Multidisciplinary
Adnan Shakoor, Bin Wang, Lei Fan, Lingchi Kong, Wendi Gao, Jiayu Sun, Kwan Man, Gang Li, Dong Sun
Summary: The study introduces a novel method of controlling the transfer of mitochondria to single cells using an automated optical tweezer-based micromanipulation system. By transferring healthy mitochondria to cells automatically, accurately, and efficiently, the method can enhance antiaging and metabolic gene expression in cells, potentially reversing aging-related phenotypes.
Article
Multidisciplinary Sciences
Ye Yang, Teng Ma, Sinan Li, Qi Zhang, Jiqing Huang, Yifei Liu, Jianwei Zhuang, Yongchuan Li, Xuemin Du, Lili Niu, Yang Xiao, Congzhi Wang, Feiyan Cai, Hairong Zheng
Summary: Acoustic tweezers show great potential for applications in nontransparent media, with the ability to guide and monitor the process using real-time 3D ultrasound images, and correct phase and amplitude distortions using the time reversal principle for 3D particle manipulation in heterogeneous media.
Article
Optics
Rui Ma, Lian-gang Zhang, Y. Zeng, Gui-dong Liu, Ling-ling Wang, Qi Lin
Summary: We investigated the enhanced optical force in acoustic graphene plasmon (AGP) cavities with ultra-small mode volumes. The AGP mode provides stronger field confinement and higher momentum, thus allowing for giant optical force without polarization preference. We demonstrated high trapping potential and force applied on polystyrene nanoparticles in AGP cavities, with values of -13.6 x 10(2) kBT/mW and 2.5 nN/mW, respectively. The effect of rounded corners and gap distance of AGP cavities on optical force was studied, and the results show that larger radius of rounded corners leads to smaller trapping potential and force provided by AGP cavities. Our findings open up new possibilities for studying optical field and force through acoustic plasmon mode.
Article
Physics, Applied
Hongqing Dai, Baizhan Xia, Dejie Yu
Summary: Acoustic topological insulators enable non-contact particle manipulations, such as microparticle trapping and separation. Based on the SSH model, we can separate particles of the same size and density.
APPLIED PHYSICS LETTERS
(2021)
Article
Materials Science, Multidisciplinary
Menyang Gong, Xin Xu, Yupei Qiao, Zhonghan Fei, Yuanyuan Li, Jiehui Liu, Aijun He, Xiaozhou Liu
Summary: This article presents a theoretical solution for the acoustic radiation force of an arbitrary beam on spherical particles in a spherical shell structure. Finite element simulation with specific parameters was conducted using bladder and urinary calculus as a background to verify the accuracy and feasibility of the theoretical solution. The study investigates the variation of the acoustic radiation force on the particles with particle radius, incident wave spectrum, viscosity coefficient of the medium inside the spherical shell structure, and distance from the center of the particle to the center of the spherical shell structure. This scheme provides a design idea and theoretical basis for the non-contact manipulation of particles inside the spherical shell structure, with a wide range of applications in industrial and life sciences.
RESULTS IN PHYSICS
(2023)
Article
Physics, Multidisciplinary
J. J. Hernandez-Sarria, Osvaldo N. Oliveira Jr, J. R. Mejia-Salazar
Summary: Researchers have designed an all-dielectric platform to optically trap small dielectric nanoparticles without heating the nanostructure in the infrared regime. By creating a strong electromagnetic hot spot, nanoparticles as small as 20 nm can be captured without heating.
PHYSICAL REVIEW LETTERS
(2021)
Article
Biochemical Research Methods
Shujie Yang, Joseph Rufo, Ruoyu Zhong, Joseph Rich, Zeyu Wang, Luke P. P. Lee, Tony Jun Huang
Summary: Acoustic tweezers offer an efficient and contact-free way to manipulate individual cells and particles. Its application in next-generation cellular assays can enhance our understanding of biological systems. With acoustic tweezers, users can conduct a variety of experiments involving trapping, patterning, pairing, and separating single cells in the field of biological sciences.
Article
Biochemical Research Methods
Yanqi Wu, Alastair G. Stewart, Peter V. S. Lee
Summary: This study developed a high-throughput microfluidic compressibility cytometry approach using multi-tilted-angle surface acoustic wave for rapid measurement of thousands of single-cell compressibility. Experimental validation and characterization of tumor cells showed the potential utility of high-throughput mechanophenotyping.
Article
Chemistry, Multidisciplinary
Mingxin Xu, Jizhen Wang, William S. S. Harley, Peter V. S. Lee, David J. J. Collins
Summary: Acoustic holography enables the generation of designed acoustic fields for manipulating microscale objects. However, the limitations of static 3D printed acoustic holographic phase plates or large aperture sizes prevent rapid alteration of the generated fields. In this study, a programmable acoustic holography approach is demonstrated, allowing for the creation of multiple discrete or continuously variable acoustic targets. By modifying the sound speed of an intervening fluid media, the desired acoustic fields can be produced. This approach has the advantages of flexibility in generating various acoustic patterns and has broad potential in areas such as microfluidics, cell/tissue engineering, real-time sensing, and medical ultrasound.
Article
Chemistry, Multidisciplinary
Axel Huerre, Fernando Cacho-Nerin, Vincent Poulichet, Christiana E. Udoh, Marco De Corato, Valeria Garbin
Article
Biochemical Research Methods
Shamim M. Ahmmed, Naureen S. Suteria, Valeria Garbin, Siva A. Vanapalli
Article
Multidisciplinary Sciences
Axel Huerre, Marco De Corato, Valeria Garbin
NATURE COMMUNICATIONS
(2018)
Article
Chemistry, Multidisciplinary
Akaki Jamburidze, Axel Huerre, Diego Baresch, Vincent Poulichet, Marco De Corato, Valeria Garbin
Article
Physics, Fluids & Plasmas
Marco De Corato, Brice Saint-Michel, George Makrigiorgos, Yannis Dimakopoulos, John Tsamopoulos, Valeria Garbin
PHYSICAL REVIEW FLUIDS
(2019)
Article
Chemistry, Multidisciplinary
Saikat Saha, Francis Pagaud, Bernard P. Binks, Valeria Garbin
Summary: Oil foams stabilized by crystallizing agents have excellent stability and potential applications in consumer products. The behavior of the interfacial layer at different time scales plays a crucial role in product shelf life and processing conditions. Experimental investigation reveals that the dynamics of deformation significantly affect the fate of the interfacial layer.
Article
Chemistry, Physical
Brice Saint-Michel, George Petekidis, Valeria Garbin
Summary: The dynamics of a deformable inclusion, such as a bubble, can be used to locally tune the microstructure of a colloidal gel. Bubble dissolution leads to the formation of a solvent pocket, while ultrasound-induced bubble oscillations rearrange the gel particles into a microstructure with increased local ordering.
Article
Physics, Applied
Jhon F. Pazos Ospina, Victor Contreras, Jordan Estrada-Morales, Diego Baresch, Joao Luis Ealo, Karen Volke-Sepulveda
Summary: The behavior of particles in an ultrasonic wave depends on their size. Particles within certain size ranges are trapped on the axis, while particles in other size ranges are trapped off the axis. This behavior is related to the sign of the radiation force, which can result in maximum or zero force and trapping stiffness for specific sizes.
PHYSICAL REVIEW APPLIED
(2022)
Article
Multidisciplinary Sciences
Di Wu, Diego Baresch, Colin Cook, Zhichao Ma, Mengtong Duan, Dina Malounda, David Maresca, Maria P. Abundo, Justin Lee, Shirin Shivaei, David R. Mittelstein, Tian Qiu, Peer Fischer, Mikhail G. Shapiro
Summary: Ultrasound can manipulate cells with high precision through acoustic radiation force (ARF), but this ability is disconnected from cellular genetic programs due to the similar acoustic properties of most cells. Gas vesicles (GVs), a unique class of gas-filled protein nanostructures, can serve as genetically encodable actuators for selective acoustic manipulation. GVs experience strong ARF with opposite polarity to most other materials due to their lower density and higher compressibility relative to water. When expressed inside cells, GVs invert the cells' acoustic contrast and amplify their ARF, enabling selective manipulation of cells based on their genotype. GVs provide a direct link between gene expression and acoustomechanical actuation, opening up a paradigm for selective cellular control in a broad range of contexts.
Article
Chemistry, Physical
Yanyan Liu, Mingjun Xu, Luis M. Portela, Valeria Garbin
Summary: Emulsions stabilized by nanoparticles, known as Pickering emulsions, show remarkable stability and have various applications. The layer of nanoparticles at the interface of Pickering droplets acts as a semi-permeable barrier, affecting the release rate of encapsulates and the interfacial transfer of reactants. However, our understanding of diffusion in multiphase systems with particle-laden interfaces is limited.
Article
Chemistry, Physical
Brice Saint-Michel, Valeria Garbin
Article
Chemistry, Physical
Christiana E. Udoh, Valeria Garbin, Joao T. Cabral
Article
Engineering, Biomedical
Shengtao Lin, Ge Zhang, Akaki Jamburidze, Melisse Chee, Chee Hau Leow, Valeria Garbin, Meng-Xing Tang
PHYSICS IN MEDICINE AND BIOLOGY
(2018)