期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 117, 期 26, 页码 15200-15208出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1911778117
关键词
ventral striatum; reward; expected value of information; fMRI; Bayesian optimal experimental design (OED)
资金
- NIH [NIH T32 MH020002-04, NIH MH57075-08]
- NSF [SBE-0542013]
- Deutsche Forschungsgemeinschaft, part of the New Frameworks of Rationality priority program [NE 1713/1, NE 1713/2, SPP 1516]
- University of California, San Diego Academic Senate Grant [RH094G-COTTRELL]
Do dopaminergic reward structures represent the expected utility of information similarly to a reward? Optimal experimental design models from Bayesian decision theory and statistics have proposed a theoretical framework for quantifying the expected value of information that might result from a query. In particular, this formulation quantifies the value of information before the answer to that query is known, in situations where payoffs are unknown and the goal is purely epistemic: That is, to increase knowledge about the state of the world. Whether and how such a theoretical quantity is represented in the brain is unknown. Here we use an event-related functional MRI (fMRI) task design to disentangle information expectation, information revelation and categorization outcome anticipation, and response-contingent reward processing in a visual probabilistic categorization task. We identify a neural signature corresponding to the expectation of information, involving the left lateral ventral striatum. Moreover, we show a temporal dissociation in the activation of different reward-related regions, including the nucleus accumbens, medial prefrontal cortex, and orbitofrontal cortex, during information expectation versus reward-related processing.
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