期刊
POLYHEDRON
卷 183, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2020.114532
关键词
Gold(I); Phosphanes; Dithiocarbamates; X-ray structure; Anticancer activity
资金
- King Fahd University of Petroleum and Minerals [IN171005]
Phosphane gold(I) complexes, [Au(ACP)Cl] (1) and [Au(ACP)(S2CNR2)] (2-4) where ACP = 2-(diphenyl-phosphanyl)-1-aminocyclohexane or (2-aminocyclohexyl)diphenylphosphane, and R = methyl, ethyl, benzyl, were synthesized and characterized by elemental analysis, FTIR and multinuclear NMR spectroscopy. The molecular structure of one of the compounds, [Au(ACP)Cl] (1), was determined by single crystal X-ray diffraction analysis, which revealed a linear geometry around the Au(I) center. The crystal structure is stabilized by N-H center dot center dot center dot Cl hydrogen bonding interactions. The in vitro cytotoxicity of the complexes was evaluated against three cancer cells, A549 (human lung cancer), HeLa (human cervical cancer) and HepG2 (human liver cancer) cell lines. Three of the four complexes showed excellent in vitro cytotoxicity; their inhibition effect is much greater than that of cisplatin. (C) 2020 Elsevier Ltd. All rights reserved.
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