News Item
Biochemistry & Molecular Biology
Grant M. Landwehr, Michael C. Jewett
Summary: Inspired by nature, a synthetic carbon fixation cycle is able to build complex molecules directly from CO2. Several innovative advancements are required to build metabolism from the ground up, and now a strategy to balance carbon demands in a complex metabolic network is being explored.
NATURE CHEMICAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Joshua R. Brickner, Jada L. Garzon, Karlene A. Cimprich
Summary: R-loops, non-B DNA structures formed during transcription, can cause genomic instability but also have regulatory roles in maintaining genome integrity. They contribute to genomic instability during DNA replication and double-strand break repair, but also participate as intermediates in repair and influence pathway choice. Additionally, R-loops may be linked to disease.
Review
Immunology
Hongwei Jiang, Jingting Jiang
Summary: NK cells are fundamental components of innate immunity and have regulatory functions in both innate and adaptive immunity. This review integrates multiple studies to illuminate the regulatory function of NK cells in the adaptive immune responses of B cells and T cells, with a focus on viral infections and the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Xujun Cao, Anthony F. Cordova, Lingyin Li
Summary: The innate immune system is crucial in human diseases and therapies targeting it are relatively lacking. This review discusses the innate immune pathways, therapeutic strategies, and potential novel approaches.
Editorial Material
Multidisciplinary Sciences
Agnieszka A. Kendrick, Jenna R. Christensen
Summary: Recent research revealed that ARL8 acts as an adaptor protein, connecting lysosomes to both kinesin for anterograde movement and dynein for retrograde movement, providing crucial insights into the regulation of bidirectional organelle movement in cells.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Hematology
Carlos Chiattone, Alvaro J. Alencar
Summary: This study evaluated a measurable residual disease-driven model for individualized treatment of relapsed/refractory CLL. Combination therapy with Bruton's tyrosine kinase and BCL2 inhibitors was successful, and monotherapy also achieved deep responses, minimizing the risk of added toxicity.
Editorial Material
Hematology
Deepa Manwani
Summary: The study found that the absence of genetic P-selectin in SCD mice resulted in a welcome attenuation of liver ischemia due to the inhibition of multicellular adhesive interactions. However, this improvement was offset by an increase in liver senescence, leading to a lack of protection from progressive liver damage.
Editorial Material
Anesthesiology
Elizabeth L. Whitlock, Eric R. Gross, C. Ryan King, Michael S. Avidan
Summary: The study found that targeting deep anesthesia in patients undergoing major noncardiac surgery was not associated with significantly increased postoperative death or major morbidity, but it significantly increased delirium incidence. The findings may be affected by subpopulation-based differences in patients.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Editorial Material
Cell Biology
Grant S. Mastick, Lauren E. Jones, Thomas Kidd
Summary: Axons crossing the midline of the CNS adjust their responsiveness to attractive and repulsive cues. Dailey-Krempel et al. discover different actions of DCC isoforms and provide evidence against the silencing model of axon guidance.
Review
Oncology
Diogo Estevao, Miguel da Cruz-Ribeiro, Ana P. Cardoso, Angela M. Costa, Maria J. Oliveira, Tiago L. Duarte, Tania B. da Cruz
Summary: This review discusses the complex role of iron in colorectal cancer (CRC), particularly the consequences of iron excess or deprivation on tumor development and progression. The regulation of cellular iron metabolism in the CRC microenvironment and the role of hypoxia and oxidative stress (e.g. ferroptosis) in CRC are also highlighted. Furthermore, potential therapeutic targets against CRC malignancy related to iron are identified.
Review
Cell Biology
Ron Benyair, Avital Eisenberg-Lerner, Yifat Merbl
Summary: The Golgi apparatus plays a central role in cellular protein trafficking and signaling, with its structure and function tightly coupled and dynamically changing in health and disease. Recent studies have revealed various mechanisms by which the Golgi apparatus degrades aberrant proteins, including autophagy, retrograde trafficking to the ER, and Golgi apparatus-related degradation.
Article
Ecology
Chelsea J. Little
Summary: This study investigates the population regulation of stream insects through larval density dependence. The researchers found that density manipulation of larvae had minimal effects on the number of emergent adults and egg masses, which may be due to stochasticity in the dispersal of flying adults. However, there was evidence of density-dependent population regulation among larval stages, potentially controlled by resource availability.
JOURNAL OF ANIMAL ECOLOGY
(2022)
Review
Immunology
Amrita Basu, Ganesan Ramamoorthi, Gabriella Albert, Corey Gallen, Amber Beyer, Colin Snyder, Gary Koski, Mary L. Disis, Brian J. Czerniecki, Krithika Kodumudi
Summary: This review highlights the importance of T-H cells in cancer immunotherapy, discussing the regulation of different subtypes by various immune cells and the impact of contradictory signals on treatment outcomes. Understanding the complexities of CD4(+) T-H cells and balancing anti- vs pro-tumorigenic subtypes is crucial for designing effective immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Plant Sciences
Annelie Carlsbecker, Frauke Augstein
Summary: The study reveals how hormones auxin and gibberellic acid regulate the activity of the vascular cambium, promoting xylem formation in Arabidopsis hypocotyls.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Cell Biology
Elina Ikonen, Xin Zhou
Summary: This article summarizes the asymmetric distribution of cholesterol in mammalian cells and its co-transport with other lipids, discussing lipid transfer proteins at membrane contacts and membrane transport. It also reviews the physiological evidence related to this process.
DEVELOPMENTAL CELL
(2021)
Article
Paleontology
David J. Peterman, Christopher C. Barton
Article
Paleontology
David J. Peterman, Nicholas Hebdon, Charles N. Ciampaglio, Margaret M. Yacobucci, Neil H. Landman, Tom Linn
Article
Biodiversity Conservation
David J. Peterman, Margaret M. Yacobucci, Neal L. Larson, Charles Ciampaglio, Tom Linn
Article
Marine & Freshwater Biology
David J. Peterman, Ryan Shell, Charles N. Ciampaglio, Margaret M. Yacobucci
JOURNAL OF MOLLUSCAN STUDIES
(2020)
Article
Ecology
Tomoyuki Mikami, Wataru Iwasaki
Summary: An organism cannot be fully optimized for all tasks for its survival due to inherent trade-offs, and the general theory of Pareto theory has been proposed to explain the rules of phenotypic evolution under such trade-offs. However, the statistical method used to test this theory has been found to have serious flaws, leading to a high false-positive rate. By developing a new flipping t-ratio test, researchers are able to more accurately test the Pareto theory and confirm whether phenotype datasets truly fit this theory.
METHODS IN ECOLOGY AND EVOLUTION
(2021)
Article
Biodiversity Conservation
Erynn H. Johnson, Briana M. DiMarco, David J. Peterman, Aja M. Carter, Warren D. Allmon
Summary: The authors conducted the first physical compression experiments on model ammonoid septa and found that increasing complexity of septal margins does not increase compression resistance. They also proposed the hypothesis that the evolution of septal shape may be closely tied to the placement of the siphuncle foramen.
Article
Multidisciplinary Sciences
David J. Peterman, Kathleen A. Ritterbush, Charles N. Ciampaglio, Erynn H. Johnson, Shinya Inoue, Tomoyuki Mikami, Thomas J. Linn
Summary: The study shows that the relationship between septal complexity of ammonoids and liquid retention capacity through surface tension provides a simple yet powerful functional explanation for buoyancy manipulation.
SCIENTIFIC REPORTS
(2021)
Article
Geology
Yusuke Muramiya, Hidekazu Yoshida, Masayo Minami, Tomoyuki Mikami, Toshinori Kobayashi, Kousuke Sekiuchi, Nagayoshi Katsuta
Summary: This study presents detailed observations and analyses of the formation process of glendonite concretions and proposes a growth model controlled by phosphate concentration. The results demonstrate that organic matter in dead organisms served as a carbon source for both ikaite crystals and the surrounding concretions.
SEDIMENTARY GEOLOGY
(2022)
Article
Paleontology
Tomoyuki Mikami, Takafumi Ikeda, Yusuke Muramiya, Tatsuya Hirasawa, Wataru Iwasaki
Summary: Tullimonstrum gregarium, known as the Tully monster, is a well-known enigma in phylogenetics, with fossils found only in the Mazon Creek Lagerstatte. Its unique morphology, including stalked eyes and a proboscis, makes it difficult to compare with known animal morphotypes. Recent research suggests that Tullimonstrum may not be a vertebrate as previously believed, but instead a non-vertebrate chordate or a protostome.
Article
Biology
David J. Peterman, Kathleen A. Ritterbush
Summary: Stability-maneuverability tradeoffs impose constraints on aquatic locomotion. Externally shelled cephalopods are good targets for studying these tradeoffs because of their diverse conch morphologies. Neutrally buoyant biomimetic models were used to investigate the tradeoff between hydrostatic stability and maneuverability. The results showed that stability influenced the life habits of these animals. Different conch morphologies presented functional opportunities and consequences. The study highlights the relationship between functional diversity and morphological disparity in aquatic ecosystems.
INTEGRATIVE ORGANISMAL BIOLOGY
(2022)
Article
Paleontology
Daniel A. Moron-Alfonso, David J. Peterman, Marcela Cichowolski, Rene Hoffmann, Robert E. Lemanis
ACTA PALAEONTOLOGICA POLONICA
(2020)
Article
Paleontology
David J. Peterman, Christopher C. Barton, Margaret M. Yacobucci
PALAEONTOLOGIA ELECTRONICA
(2019)