Article
Immunology
Namrata Prasad, Tiffany A. Walker, Ben Waite, Tim Wood, Adrian A. Trenholme, Michael G. Baker, Colin McArthur, Conroy A. Wong, Cameron C. Grant, Q. Sue Huang, E. Claire Newbern
Summary: The study reveals that adults with certain chronic medical conditions are at a higher risk of RSV-related hospitalizations, with CHF and COPD patients having the highest risk. Age plays a role in the relationship between certain chronic conditions and RSV risk.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
Summary: Studying the economic burden of RSV-associated illness can help inform decisions on the implementation of maternal vaccines and monoclonal antibodies. A costing study conducted in South Africa estimated the cost of RSV-associated illness in infants and found that the highest cost burden was in the youngest infants.
Article
Immunology
Richard Osei-Yeboah, Peter Spreeuwenberg, Marco Del Riccio, Thea K. Fischer, Amanda Marie Egeskov-Cavling, Hakon Boas, Michiel van Boven, Xin Wang, Toni Lehtonen, Mathieu Bangert, Harry Campbell, John Paget
Summary: Respiratory syncytial virus causes a high number of hospital admissions in adults in the European Union, with 92% of the admissions occurring in adults aged 65 years and older. The study's analysis showed that the average annual hospitalization estimate in adults for respiratory syncytial virus was similar to the estimate in young children (0-4 years).
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Marco Del Riccio, Peter Spreeuwenberg, Richard Osei-Yeboah, Caroline K. Johannesen, Liliana Vazquez Fernandez, Anne C. Teirlinck, Xin Wang, Terho Heikkinen, Mathieu Bangert, Saverio Caini, Harry Campbell, John Paget
Summary: This study estimated that an average of 245,244 children aged under 5 years are hospitalized annually due to RSV in the EU, with the highest hospitalization rates in children aged less than 2 months (71.6 per 1000 children).
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
C. Demont, N. Petrica, I Bardoulat, S. Duret, L. Watier, A. Chosidow, M. Lorrot, A. Kieffer, M. Lemaitre
Summary: RSV is a significant cause of child hospitalization in France, with an average of 45,225 RSV-associated hospitalizations reported per season. The economic burden is mainly driven by infants under 1 year old, representing 80% of the cost. Preventive strategies should be implemented before the first RSV season.
BMC INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
Summary: Based on a study in South African children, the burden of RSV-associated illness was estimated, with newborns and infants being the most affected group. Implementing maternal vaccination and monoclonal antibody products for this group can help reduce the disease burden.
Article
Infectious Diseases
Tobias Tenenbaum, Maren Doenhardt, Natalie Diffloth, Reinhard Berner, Jakob P. Armann
Summary: Public health measures implemented to mitigate the effects of the COVID-19 pandemic disrupted the worldwide transmission of endemic respiratory viruses such as RSV, as well as other typical, seasonal, and viral respiratory pathogens. German pediatric hospitals monitored RSV cases from October 18, 2021 to March 31, 2022 using a newly established national Clinician-Led Reporting System.
Article
Medicine, General & Internal
Malou Bourdeau, Nirma Khatri Vadlamudi, Nathalie Bastien, Joanne Embree, Scott A. Halperin, Taj Jadavji, Kescha Kazmi, Joanne M. Langley, Marc H. Lebel, Nicole Le Saux, Dorothy Moore, Shaun K. Morris, Jeffrey M. Pernica, Joan Robinson, Manish Sadarangani, Julie A. Bettinger, Jesse Papenburg
Summary: This study provides an overview of the epidemiology and burden of RSV-associated hospitalizations among children and adolescents in Canadian tertiary pediatric hospitals from 2017 to 2022. The findings show that the number of RSV hospitalizations increased during this period, particularly during the COVID-19 pandemic. However, the severity of illness did not change compared to the prepandemic period.
Article
Immunology
Mina Suh, Naimisha Movva, Xiaohui Jiang, Lauren C. Bylsma, Heidi Reichert, Jon P. Fryzek, Christopher B. Nelson
Summary: This study demonstrates that acute bronchiolitis due to RSV is the leading cause of hospitalizations in US infants, especially during the winter months.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Yanxia Lu, Bao-Peng Liu, Crystal T. Y. Tan, Fang Pan, Anis Larbi, Tze Pin Ng
Summary: The link between pathogen exposure and mental health has been investigated in a study of over 800 participants in the Singapore Longitudinal Ageing Studies. The study found that high pathogen burden is associated with increased prevalence of depressive symptoms and impaired mental health. Certain infections and inflammatory markers were found to mediate this association. These findings highlight the potential impact of pathogens on mental health.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Immunology
Ting Shi, Sophie Vennard, Francis Jasiewicz, Rory Brogden, Harish Nair
Summary: RSV-ARI in adults with comorbidities is a significant burden, with limited data available. This study estimated the incidence, hospitalization rate, and in-hospital case fatality ratio of RSV-ARI in this population, and found an association between the disease and any comorbidity.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Maarten J. Postma, Chih-Yuan Cheng, Nasuh C. Buyukkaramikli, Luis Hernandez Pastor, Ine Vandersmissen, Thierry Van Effelterre, Peter Openshaw, Steven Simoens
Summary: This study used a decision-tree model to estimate the impact of RSV vaccination on public health and economy in older adults in Belgium. The results demonstrated that a longer duration of vaccine protection could effectively reduce the cases and costs associated with RSV.
Article
Immunology
Caroline K. Johannesen, Maarten van Wijhe, Sabine Tong, Liliana Fernandez, Terho Heikkinen, Michiel van Boven, Xin Wang, Hakon Boas, You Li, Harry Campbell, John Paget, Luca Stona, Anne Teirlinck, Toni Lehtonen, Hanna Nohynek, Mathieu Bangert, Thea K. Fischer
Summary: This study aimed to estimate the burden of RSV-associated hospital admissions in different age groups based on national health registers and laboratory databases in 6 European countries. The results showed a clear association between respiratory infections and RSV in children, with the highest proportions observed in children younger than 3 months. The study also found that the annual incidence of RSV-associated hospitalizations was high in infants aged 0-2 months, while incidence rates were low in adults older than 85 years.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Teresa Bandeira, Mafalda Carmo, Hugo Lopes, Catarina Gomes, Margarida Martins, Carlos Guzman, Mathieu Bangert, Fernanda Rodrigues, Gustavo Januario, Teresa Tome, Ines Azevedo
Summary: This study evaluated the hospitalizations related to respiratory syncytial virus (RSV) in children in Portugal. The results showed that RSV is a leading cause of hospitalizations in children, especially during their first year of life. This highlights the need for a comprehensive RSV surveillance system to guide prevention strategies.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)
Article
Immunology
Koos Korsten, Niels Adriaenssens, Samuel Coenen, Chris C. Butler, Theo J. M. Verheij, Louis J. Bont, Joanne G. Wildenbeest
Summary: The accuracy of the influenza-like illness (ILI) case definition from the World Health Organization (WHO) in identifying acute respiratory tract infections (ARTI) caused by respiratory syncytial virus (RSV) in older adults is uncertain. The ILI definition, which includes fever, underestimates the occurrence of RSV-ARTI. There is a need for a better approach to measure RSV disease occurrence and the impact of future RSV vaccine introduction.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Namrata Prasad, Tiffany A. Walker, Ben Waite, Tim Wood, Adrian A. Trenholme, Michael G. Baker, Colin McArthur, Conroy A. Wong, Cameron C. Grant, Q. Sue Huang, E. Claire Newbern
Summary: The study reveals that adults with certain chronic medical conditions are at a higher risk of RSV-related hospitalizations, with CHF and COPD patients having the highest risk. Age plays a role in the relationship between certain chronic conditions and RSV risk.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Q. Sue Huang, Tim Wood, Lauren Jelley, Tineke Jennings, Sarah Jefferies, Karen Daniells, Annette Nesdale, Tony Dowell, Nikki Turner, Priscilla Campbell-Stokes, Michelle Balm, Hazel C. Dobinson, Cameron C. Grant, Shelley James, Nayyereh Aminisani, Jacqui Ralston, Wendy Gunn, Judy Bocacao, Jessica Danielewicz, Tessa Moncrieff, Andrea McNeill, Liza Lopez, Ben Waite, Tomasz Kiedrzynski, Hannah Schrader, Rebekah Gray, Kayla Cook, Danielle Currin, Chaune Engelbrecht, Whitney Tapurau, Leigh Emmerton, Maxine Martin, Michael G. Baker, Susan Taylor, Adrian Trenholme, Conroy Wong, Shirley Lawrence, Colin McArthur, Alicia Stanley, Sally Roberts, Fahimeh Rahnama, Jenny Bennett, Chris Mansell, Meik Dilcher, Anja Werno, Jennifer Grant, Antje van der Linden, Ben Youngblood, Paul G. Thomas, Richard J. Webby
Summary: New Zealand has successfully controlled COVID-19 by implementing strict non-pharmaceutical interventions, leading to a significant decline in reports of influenza and other non-influenza respiratory pathogens during the winter months when these interventions were in place.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Kathryn E. Lafond, Rachael M. Porter, Melissa J. Whaley, Zhou Suizan, Zhang Ran, Mohammad Abdul Aleem, Binay Thapa, Borann Sar, Viviana Sotomayor Proschle, Zhibin Peng, Luzhao Feng, Daouda Coulibaly, Edith Nkwembe, Alfredo Olmedo, William Ampofo, Siddhartha Saha, Mandeep Chadha, Amalya Mangiri, Vivi Setiawaty, Sami Sheikh Ali, Sandra S. Chaves, Dinagul Otorbaeva, Onechanh Keosavanh, Majd Saleh, Antonia Ho, Burmaa Alexander, Hicham Oumzil, Kedar Prasad Baral, Q. Sue Huang, Adedeji A. Adebayo, Idris Al-Abaidani, Marta von Horoch, Cheryl Cohen, Stefano Tempia, Vida Mmbaga, Malinee Chittaganpitch, Mariana Casal, Duc Anh Dang, Paula Couto, Harish Nair, Joseph S. Bresee, Sonja J. Olsen, Eduardo Azziz-Baumgartner, J. Pekka Nuorti, Marc-Alain Widdowson
Summary: This study aimed to estimate the global burden of influenza-associated hospitalizations among adults worldwide. The researchers conducted a systematic review and meta-analysis, finding that influenza was associated with 14% of acute respiratory hospitalizations in adults, with over 5 million cases annually. The findings emphasize the importance of influenza vaccination, especially for older adults, in preventing severe disease and hospitalizations.
Article
Infectious Diseases
Lisa Staadegaard, Saverio Caini, Sonam Wangchuk, Binay Thapa, Walquiria Aparecida Ferreira de Almeida, Felipe Cotrim de Carvalho, Rodrigo A. Fasce, Patricia Bustos, Jan Kyncl, Ludmila Novakova, Alfredo Bruno Caicedo, Domenica Joseth de Mora Coloma, Adam Meijer, Mariette Hooiveld, Q. Sue Huang, Tim Wood, Raquel Guiomar, Ana Paula Rodrigues, Vernon Jian Ming Lee, Li Wei Ang, Cheryl Cohen, Jocelyn Moyes, Amparo Larrauri, Concepcion Delgado-Sanz, Clarisse Demont, Mathieu Bangert, Michel Duckers, Jojanneke van Summeren, John Paget
Summary: The study found that RSV epidemics mainly occur in winter in most temperate countries, lasting 10-21 weeks. More variation in seasonality was observed in (sub)tropical countries, with substantial differences at a subnational level. There was no clear association between epidemic timing and the dominant RSV subtype.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2021)
Article
Immunology
Namrata Prasad, M. Jonathan Read, Christopher Jewell, Ben Waite, A. Adrian Trenholme, Q. Sue Huang, C. Cameron Grant, E. Claire Newbern, B. Alexandra Hogan
Summary: The study found that both maternal RSV vaccine and mAb could effectively reduce RSV hospitalizations in New Zealand, with seasonal mAb showing a greater impact on disease prevention.
Article
Multidisciplinary Sciences
Marcos C. Vieira, Celeste M. Donato, Philip Arevalo, Guus F. Rimmelzwaan, Timothy Wood, Liza Lopez, Q. Sue Huang, Vijaykrishna Dhanasekaran, Katia Koelle, Sarah Cobey
Summary: Based on statistical modeling of surveillance data from New Zealand, historical changes and cross-protection between different strains of the same lineage were found to explain the contrasting age distributions of influenza B cases. Additional protection against B/Yamagata was observed in individuals with first-time influenza B infections, resembling immune imprinting seen in influenza A. While data did not show evidence of B/Victoria imprinting, B/Yamagata imprinting could explain the fewer cases in certain cohorts and the bimodal age distribution. Longitudinal studies are needed to validate these findings across different populations and more recent strains.
NATURE COMMUNICATIONS
(2021)
Article
Infectious Diseases
William Davis, Jazmin Duque, Q. Sue Huang, Natalie Olson, Cameron C. Grant, E. Claire Newbern, Mark Thompson, Ben Waite, Namrata Prasad, Adrian Trenholme, Eduardo Azziz-Baumgartner
Summary: This study evaluates the usefulness of four influenza surveillance case definitions for influenza and RSV surveillance. The results show that different case definitions have varying sensitivity and specificity, and SARI has lower sensitivity among children under three months.
JOURNAL OF INFECTION
(2022)
Article
Multidisciplinary Sciences
Lauren Jelley, Jordan Douglas, Xiaoyun Ren, David Winter, Andrea McNeill, Sue Huang, Nigel French, David Welch, James Hadfield, Joep de Ligt, Jemma L. Geoghegan
Summary: New Zealand's COVID-19 elimination strategy shifted to a suppression strategy after a large outbreak caused by the Delta variant. The role of genomics changed from tracking and tracing to population-level surveillance.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Namrata Prasad, Julia Rhodes, Li Deng, Natalie L. McCarthy, Heidi L. Moline, James Baggs, Sujan C. Reddy, John A. Jernigan, Fiona P. Havers, Daniel M. Sosin, Ann Thomas, Ruth Lynfield, William Schaffner, Arthur Reingold, Kari Burzlaff, Lee H. Harrison, Susan Petit, Monica M. Farley, Rachel Herlihy, Srinivas Nanduri, Tamara Pilishvili, Lucy A. McNamara, Stephanie J. Schrag, Katherine E. Fleming-Dutra, Miwako Kobayashi, Melissa Arvay
Summary: The incidence of invasive bacterial diseases (IBD) such as Streptococcus pneumoniae, Haemophilus influenzae, group A Streptococcus (GAS), and group B Streptococcus (GBS) significantly declined in the United States during the COVID-19 pandemic in 2020. The decline was likely due to COVID-19-related nonpharmaceutical interventions (NPIs), and not driven by reductions in testing. Blood and cerebrospinal fluid (CSF) culture testing rates during the pandemic remained comparable to previous years.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Namrata Prasad, Charles Stoecker, Wei Xing, Bo-Hyun Cho, Andrew J. Leidner, Miwako Kobayashi
Summary: Although PCV13 has reduced the incidence of pneumococcal disease, there is still a considerable burden. PCV15, a new vaccine, includes additional serotypes compared to PCV13. Replacing PCV13 with PCV15 and providing a supplementary dose to fully vaccinated children could have significant health benefits, cost saving, but also additional costs.
Letter
Immunology
Lisa Staadegaard, Adam Meijer, Ana Paula Rodrigues, Sue Huang, Cheryl Cohen, Clarisse Demont, Jojanneke van Summeren, Saverio Caini, John Paget
Summary: After analyzing data from 4 countries in both the Northern and Southern Hemispheres, it was found that the dominant RSV subtype did not appear to affect the temporal variation of RSV epidemics.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Cell Biology
Sook-San Wong, Christine M. Oshansky, Xi-Zhi J. Guo, Jacqui Ralston, Timothy Wood, Gary E. Reynolds, Ruth Seeds, Lauren Jelley, Ben Waite, Trushar Jeevan, Mark Zanin, Marc-Alain Widdowson, Q. Sue Huang, Paul G. Thomas, Richard J. Webby
Summary: The study identified immunologic markers associated with robust antibody responses after influenza virus infection. Seroconversion failure after infection is a definable immunological phenomenon, associated with quantifiable cellular markers that can be used to improve diagnostics, vaccine efficacy, and epidemiologic efforts.
CELL REPORTS MEDICINE
(2021)
Article
Immunology
Tara Swadi, Jemma L. Geoghegan, Tom Devine, Caroline McElnay, Jillian Sherwood, Phil Shoemack, Xiaoyun Ren, Matt Storey, Sarah Jefferies, Erasmus Smit, James Hadfield, Aoife Kenny, Lauren Jelley, Andrew Sporle, Andrea McNeill, G. Edwin Reynolds, Kip Mouldey, Lindsay Lowe, Gerard Sonder, Alexei J. Drummond, Sue Huang, David Welch, Edward C. Holmes, Nigel French, Colin R. Simpson, Joep de Ligt
Summary: Since March 2020, New Zealand has required citizens and permanent residents returning to undergo 14 days of managed isolation and quarantine, along with mandatory testing for SARS-CoV-2. Analysis of 7 cases of SARS-CoV-2 infection on a flight from Dubai revealed that these passengers had nearly identical genomes, suggesting multiple instances of in-flight virus transmission.
EMERGING INFECTIOUS DISEASES
(2021)