Article
Horticulture
Laxman Jat, Shreedhar Singh Lakhawat, Virendra Singh, Ramhari Meena, Jagdish Lal Choudhary, Suman Gathala
Summary: Gamma irradiation increased the antioxidant potential of jujube fruit, enhancing its beneficial health effects.
SCIENTIA HORTICULTURAE
(2022)
Review
Chemistry, Multidisciplinary
Bharat Singh, Ram A. Sharma
Summary: According to Ayurvedic medicine, Indian Ficus plants are used for treating various diseases. These plants have specific inflorescence called syconia and are distributed in different states of India. The Ficus species in India have various pharmacological properties and contain alkaloids, triterpenoids, flavonoids, furanocoumarins, and polyphenolic compounds. This review focuses on 31 Indian Ficus species, summarizing their ethnomedicinal uses, phytochemistry, pharmacological activities, bioavailability, pharmacokinetic profiles, as well as clinical and toxicological studies.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Plant Sciences
Ying Yang, Zhong-Yuan Li, Jun-Jing Shao, Gang Wang, Rou Wen, Jing-Zhen Tian, Lin Hou
Summary: Callicarpa nudiflora, a traditional Chinese herbal medicine, has been found to contain various compounds with anti-inflammatory, anti-thrombotic, hepatoprotective, anticancer, and antioxidant effects, contributing to its potential medicinal properties. Additionally, studies have shown significant antiviral activities of Callicarpa nudiflora against RSV, EV71, COXB5, and HSV-1.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pingya He, Yi Zhang, Ning Li
Summary: This review comprehensively summarizes the isolation, characterization, and bioactivities of secondary metabolites from the fungi of the genus Phellinus, focusing on studies published up to April 2020. Over 300 compounds from 13 Phellinus species, their isolation, characterization, chemistry, pharmacological activities, and relevant molecular mechanisms are covered in this review.
Review
Plant Sciences
Shi-Jun Liu, Yan-Ping Lv, Zhi-Shu Tang, Yu Zhang, Hong-Bo Xu, Dong-Bo Zhang, Chun-Li Cui, Hong-Bo Liu, Huan-Huan Sun, Zhong-Xing Song, Si-Min Wei
Summary: Jujubae Fructus (ZJF) is the fruit of Ziziphus jujuba Mill., used in China as both food and traditional medicine. Over 278 compounds have been isolated from ZJ, with scientific investigations confirming its potential pharmacological effects, including anti-inflammatory, antioxidant, antimicrobial, gastrointestinal protective, cardiovascular, neuroprotective, anticancer, sedative-hypnotic, and anxiolytic effects. Further studies are needed to explore the relationship between modern applications and traditional uses, as well as unresolved issues related to processing, pharmacokinetics, efficacy, and toxicology.
PHYTOCHEMISTRY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Bharat Singh, Sheenu Nathawat, Ram A. Sharma
Summary: This study summarized the detailed information on the botany, ethnomedicinal uses, phytochemistry, and pharmacological attributes of Indian Tinospora species, discussing their potential uses in the pharmaceutical industry.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Review
Plant Sciences
Shujuan Chen, Lin Dong, Hongfeng Quan, Xirong Zhou, Jiahua Ma, Wenxin Xia, Hao Zhou, Xueyan Fu
Summary: Coltsfoot, known as a vital folk medicine, has diverse uses in traditional medicine, particularly for relieving inflammatory conditions and respiratory diseases. Many traditional uses are supported by modern pharmacological studies, but adverse events have resulted from the collection of the wrong plant containing toxic alkaloids.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Plant Sciences
Bingcong Xing, Shuailing Li, Jiaxin Yang, Ding Lin, Yue Feng, Jiangjie Lu, Qingsong Shao
Summary: Saffron, the dried stigma of the herb Crocus sativus L., is used in traditional Chinese medicine for various purposes such as promoting blood circulation and relieving depression. Over 150 chemical compounds have been identified in saffron, with pharmacological activities including antioxidant, antiinflammatory, and antidepressant effects. Clinical trials are needed to further explore its efficacy in treating various conditions such as hypertension, hyperlipidemia, and cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Plant Sciences
Arpita Paul, Md Kamaruz Zaman
Summary: This paper provides a comprehensive and updated report on ten Garcinia plants of south-east Asia, covering their diverse range of phytochemicals, traditional uses, nutritional values, major pharmacological attributes, and toxicological findings. The study found a myriad of natural products in Garcinia sp., including organic acids, xanthones, benzophenones, flavonoids, phloroglucinols, fatty acids, and terpenoids. Additionally, important pharmacological properties and toxicological studies of the Garcinia sp. were discussed.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Review
Plant Sciences
Wenqian Xu, Hongkang Zhu, Bin Hu, Yuliang Cheng, Yahui Guo, Weirong Yao, He Qian
Summary: Echinacea, with its anti-inflammatory and immunomodulatory activities, plays an important role in the treatment of liver diseases, with main ingredients like caffeic acid derivatives, alkylamides, and polysaccharides. Studies have shown that Echinacea exhibits good efficacy in regulating various liver diseases induced by different factors.
Review
Plant Sciences
Hanze Liu, Changhong Wang
Summary: Genus Asarum has been widely used as herbal medicine, particularly Asari Radix et Rhizoma, with functions of dispelling cold, relieving pain and reducing phlegm. Over 277 compounds have been identified from genus Asarum, with volatile oil and lignans as major active constituents. Modern studies have shown pharmacological effects including analgesic, anti-inflammatory, neuroprotective, cardiovascular protection, antitussive, immunosuppressive, anti-tumor, and microbicidal activities, indicating therapeutic potential in various conditions.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Plant Sciences
Consolata Nanjala, Wyclif Ochieng Odago, Peninah Cheptoo Rono, Emmanuel Nyongesa Waswa, Elizabeth Syowai Mutinda, Millicent Akinyi Oulo, Felix Wambua Muema, Vincent Okelo Wanga, Elijah Mbandi Mkala, Josiah Kuja, Moses Mucugi Njire, Guang-Wan Hu
Summary: The genus Didymocarpus is widely used in traditional medicine in Asian countries and has shown various pharmacological activities, including antiurolithiatic, nephro-protective, antimicrobial, anticancer, antidiabetic, cytotoxic, wound healing, and antioxidant activities. However, further studies on the pharmacology and toxicology of these species are needed to ensure their safety, efficacy, and quality.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yueru Chen, Lu Wang, Xue Liu, Fulin Wang, Ying An, Wei Zhao, Jinli Tian, Degang Kong, Wenru Zhang, Yang Xu, Yahui Ba, Honglei Zhou
Summary: This review systematically investigates the phytochemistry and pharmacology of the Broussonetia genus, summarizes its applications, discusses the limitations of research, and explores potential directions.
Review
Plant Sciences
Cai Chen, Xiaojie Li, Yoshihiro Kano, Dan Yuan, Jialin Qu
Summary: This review summarizes the research progress on Pueraria Flos in ethnopharmacology, phytochemistry, pharmacology and toxicology, metabolism, and therapeutic application, aiming to provide a strong basis for future clinical treatment and scientific research.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Widad Ben Bakrim, Amine Ezzariai, Fadoua Karouach, Mansour Sobeh, Mulugeta Kibret, Mohamed Hafidi, Lamfeddal Kouisni, Abdelaziz Yasri
Summary: Water hyacinth, also known as Eichhornia crassipes, is a highly invasive aquatic plant with versatile applications in industries and pharmacology. It is rich in various active compounds and exhibits pharmacological activities such as anticancer, antioxidant, and antimicrobial properties.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Nadeem Rais, Rizwan Ahmad, Akash Ved, Kehkashan Parveen, Darakhshan Gazala Bari, Om Prakash
Summary: Diabetes mellitus and steroid medication, coincided with COVID-19, weaken the immune system and increase the risk of opportunistic infections such as mucormycosis. High blood sugar and decreased insulin levels in DKA patients can lead to the development of mucormycosis. Managing hyperglycemia is crucial in the treatment of mucormycosis in DKA patients.
CURRENT DIABETES REVIEWS
(2023)
Review
Chemistry, Medicinal
Sonu Kumar Mahawer, Ravendra Kumar, Om Prakash, Sushila Arya, Shailja Singh, Mozaniel Santana de Oliveira, Dharmendra Singh Rawat
Summary: Medicinal and aromatic plants have been used in ethnopharmacology since ancient times and continue to be of interest to researchers for developing plant-based medicines. Zingiberaceae is a well-known plant family, and Zingiber roseum is a medicinal and aromatic species in this family. It has a wide range of medicinal properties and bioactive compounds such as terpenes and terpenoids, phenols, flavonoids, alkaloids, saponins, ascorbic acid, and unique constituents like zerumbone. This review discusses the botanical descriptions, phytochemistry, ethnopharmacological uses, and medicinal properties of Z. roseum as reported by researchers.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Pringal Upadhyay, Sonu Kumar Mahawer, Ravendra Kumar, Om Prakash, Himani Karakoti, Tanuja Kabdal, Dharamendra Singh Rawat
Summary: In this study, the chemical composition and biological activities of essential oils from five Strobilanthes species were investigated. The essential oils showed significant antioxidant, anti-inflammatory, and antidiabetic activities. This suggests that the essential oils from these Strobilanthes species can be used as ecofriendly antioxidants, anti-inflammatory agents, and antidiabetic agents.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Akanksha Malhotra, Avneesh Rawat, Om Prakash, Ravendra Kumar, R. M. Srivastava, Satya Kumar
Summary: This study investigated the variation of essential oil composition from Artemisia annua L. aerial parts harvested in rainy and winter seasons. The GC-MS analysis identified different major constituents between the two essential oils. Both oils showed antifeedant and nematocidal activities. In silico tests revealed that the major components had good docking scores with acetylcholinesterase compared to carbofuran.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Plant Sciences
Kirti Nagarkoti, Om Prakash, Avneesh Rawat, Chenesh Patel, Ravendra Kumar, R. M. Srivastava, Satya Kumar, D. S. Rawat
Summary: Micromeria biflora Benth. is an important medicinal herb used for treating various ailments. The essential oil of Micromeria biflora exhibited insecticidal, antimicrobial, and antioxidant activities.
JOURNAL OF ESSENTIAL OIL BEARING PLANTS
(2023)
Article
Food Science & Technology
Sushila Arya, Sonu Kumar Mahawer, Himani Karakoti, Ravendra Kumar, Om Prakash, Satya Kumar, Mamta Latwal, Ganesh Panday, Ravi Mohan Srivastava, Mozaniel Santana de Oliveira, Dharmendra Singh Rawat
Summary: The current study aimed to evaluate the altitudinal variability in chemical compounds, nematicidal, insecticidal, herbicidal, and antifungal activity of the essential oils of H. coronarium collected from different habitats in Uttarakhand. The major compounds identified through GC-MS analysis included 1, 8-cineole, coronarin E, alpha-terpineol, terpinen-4-ol, alpha-pinene, Z-caryophyllene, and linalool. Heat map clustering, Venn diagram, and principal component analysis (PCA) were performed to observe the variation in oil composition. The essential oils showed significant nematicidal, insecticidal, herbicidal, and antifungal activity against tested organisms.
JOURNAL OF FOOD QUALITY
(2023)
Article
Plant Sciences
Soni Chauhan, Touseef Fatima, Amita Dubey, Puneet Singh Chauhan, Om Prakash, Poonam C. Singh
Summary: The aim of this study was to investigate the persistence of pesticides in different soil conditions and their effects on soil microbial diversity. The researchers conducted experiments in pots under net house conditions and used Biolog to analyze substrate utilization patterns. HPLC analysis was used to study the persistence of carbendazim in fallow soil, maize rhizosphere, and plant parts with and without Trichoderma. The results showed that fallow conditions increased the persistence of carbendazim in soil and affected the soil microbial community, while the application of Trichoderma enhanced its degradation.
JOURNAL OF SOIL SCIENCE AND PLANT NUTRITION
(2023)
Review
Pharmacology & Pharmacy
Akib Nisar, Suresh Jagtap, Suresh Vyavahare, Manasi Deshpande, Abhay Harsulkar, Prabhakar Ranjekar, Om Prakash
Summary: Advances in biomedical research have revealed that inflammation and its associated diseases pose the biggest threat to public health. While inflammation is a natural response of the body to external stimuli, prolonged activation of detrimental pathways can lead to chronic low-grade inflammation, which is linked to various degenerative disorders and chronic health issues. Current anti-inflammatory drugs often have undesirable side effects, necessitating the development of drugs that target chronic inflammation with fewer side effects. Medicinal plants contain bioactive compounds that possess potent anti-inflammatory properties and can regulate molecular mechanisms to alleviate inflammation-associated diseases. This review focuses on the anti-inflammatory properties of these phytochemicals and their mechanisms of action, with an emphasis on those that have been evaluated in preclinical and clinical studies. The review also discusses recent trends and gaps in the development of phytochemical-based anti-inflammatory drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Monu Kumar Kashyap, Akash Ved, Rajiv Ratan Singh Yadav, Akhand Pratap Singh, Mahima Kushwaha, Karuna S. Shukla
Summary: Colorectal carcinogenesis (CRC) is a significant health issue in underdeveloped nations, ranking as the third most common cause of cancer death. More research is needed to develop new medications that can effectively reduce the severity of this condition. Adenomatous polyps in the colon, especially in older patients, are the main cause of CRC, but inflammatory polyps are also gaining attention due to their role in the disease. Experimental models such as mouse models and combination of sulfated polysaccharides have been used to study CRC, which involves various signal transduction pathways and cell death mechanisms. Our study provides a summary of the pathogenesis of CRC, as well as the associated cell death and cell signalling pathways.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Vijay Kumar Juyal, Shweta Chand Thakuri, Mohit Panwar, Om Prakash, Viveka Nand
Summary: A bidentate hydroxy alpha-aminophosphonates ligand and its Mn(II), Fe(III), and Zn(II) metal complexes were prepared and characterized by various methods. Thermal analysis revealed the thermal decomposition behavior of the metal complexes. The antibacterial and antioxidant activities of the compounds were tested, and molecular docking studies showed good interaction with the target protein.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2023)
Article
Food Science & Technology
Nadeem Rais, Akash Ved, Rizwan Ahmad, Manoj Kumar, Mrunal Deepak Barbhai, Radha, Deepak Chandran, Abhijit Dey, Sangram Dhumal, Marisennayya Senapathy, Vishal P. Deshmukh, T. Anitha, V. Balamurugan, Jose M. Lorenzo
Summary: SAC, found in aged garlic extract, has antioxidant and anti-inflammatory properties, making it a more favorable option for those seeking the health benefits of garlic without unpleasant side effects. It protects against oxidative stress and damage caused by free radicals, which is beneficial for chronic diseases such as cardiovascular disease, diabetes, and cancer. Additionally, its anti-inflammatory effects may help prevent or manage conditions associated with chronic inflammation. SAC is a fascinating substance with multiple pharmacological qualities and may gain popularity as a dietary supplement.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Chemistry, Medicinal
Monu Kumar Kashyap, Shubhada V. Mangrulkar, Sapana Kushwaha, Akash Ved, Mayur B. Kale, Nitu L. Wankhede, Brijesh G. Taksande, Aman B. Upaganlawar, Milind J. Umekar, Sushruta Koppula, Spandana Rajendra Kopalli
Summary: Cardiotoxicity is a well-known adverse effect of cancer-related therapy, and it significantly affects patient outcomes and quality of life. The use of antineoplastic drugs to treat colorectal cancers (CRCs) can result in cardiac complications. The mechanisms underlying cardiotoxicity associated with CRC treatment are complex and involve the modulation of various signaling pathways, ultimately damaging cardiac tissue. Therefore, the identification and management of cardiotoxicity associated with CRC drug therapy have become increasingly important.
Article
Chemistry, Analytical
Avneesh Rawat, Om Prakash, Ravendra Kumar, A. K. Verma, Satya Kumar, Kirti Nagarkoti, R. M. Srivastava
Summary: A chemical study on the rhizomes of Hedychium spicatum led to the discovery of labdane diterpenes, hedychilactone A and B. The chemical structures of these compounds were determined through spectral data analysis and comparison with literature data. The compounds were evaluated for their pesticidal activities and their bioactivity was predicted using computational studies. These compounds show potential as natural pesticidal agents and further research is needed to understand their mechanisms and conduct field trials.
ANALYTICAL CHEMISTRY LETTERS
(2023)
Article
Multidisciplinary Sciences
Avneesh Rawat, Om Prakash, Kirti Nagarkoti, Ravendra Kumar, Ashok K. Verma, Satya Kumar, Ravi M. Srivastava, Mamta Latwal, Ganesh Pandey
Summary: The study identified the active constituents in the chloroform extract of H. spicatum rhizomes (HS-RCLE) and validated its in-vitro pesticidal activities using molecular docking techniques. GC/MS analysis revealed 14 compounds, contributing to 84.1% of the total composition, with oxygenated sesquiterpenes as the dominant compounds. The extract showed significant inhibition of egg hatchability, immobility of Meloidogyne incognita, insecticidal activity on Spodoptera litura, phytotoxic activity on Raphanus raphanistrum seeds, and anti-fungal activity on Curvularia lunata.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2023)