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Medicine, General & Internal
Laura Sophie Tribian, Maximilian Lennartz, Doris Hoeflmayer, Noemi de Wispelaere, Sebastian Dwertmann Rico, Clara von Bargen, Simon Kind, Viktor Reiswich, Florian Viehweger, Florian Lutz, Veit Bertram, Christoph Fraune, Natalia Gorbokon, Soeren Weidemann, Claudia Hube-Magg, Anne Menz, Ria Uhlig, Till Krech, Andrea Hinsch, Eike Burandt, Guido Sauter, Ronald Simon, Martina Kluth, Stefan Steurer, Andreas H. Marx, Patrick Lebok, David Dum, Sarah Minner, Frank Jacobsen, Till S. Clauditz, Christian Bernreuther
Summary: Prostate-specific acid phosphatase (PSAP) is a marker for prostate cancer and its expression is limited in normal tissues but higher in prostate cancers. The expression level of PSAP is associated with clinical characteristics and prognosis of prostate cancer, making it a potential marker for prognostic evaluation.
Article
Biochemistry & Molecular Biology
Mourad Assidi, Fatimah M. Yahya, Maryam H. Al-Zahrani, Razan Elkhatib, Ali Zari, Aisha Elaimi, Jaudah Al-Maghrabi, Ashraf Dallol, Abdelbaset Buhmeida, Muhammad Abu-Elmagd
Summary: This study investigated the expression pattern and methylation profiles of leptin (LEP) in ovarian cancer (OC), and found that high LEP protein expression is associated with better survival outcomes. The results suggest that LEP expression in OC may be regulated by promoter hypermethylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Alexandros Lalos, Ornella Neri, Caner Ercan, Alexander Wilhelm, Sebastian Staubli, Alberto Posabella, Benjamin Weixler, Luigi Terracciano, Salvatore Piscuoglio, Sylvia Stadlmann, Giulio C. Spagnoli, Raoul A. Droeser, Gad Singer
Summary: Ovarian cancer is the most aggressive and fatal malignancy of the female reproductive system. The tumor microenvironment plays a critical role in tumorigenesis, progression, prognosis, and response to chemotherapy. High density of CD16-expressing tumor-infiltrating immune cells in recurrent ovarian cancer is associated with better recurrence-free survival and overall survival, indicating a potential interaction between standard chemotherapy and immune cell infiltration.
Article
Oncology
Zheng Fang, Hong-yu Shen, Qi Xu, Hong-lei Zhou, Lei Li, Si-Yuan Yang, Zhen Zhu, Jin-hai Tang
Summary: Breast cancer patients with high expression of PUS1 have poor prognosis and shorter survival time. Knockdown of PUS1 suppresses the proliferation, colony formation, and invasion abilities of breast cancer cells. PUS1 may serve as a promising biomarker and treatment target for breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Mourad Assidi
Summary: This study investigates the expression patterns of N-CAD protein in ovarian cancer (OC) patients and its correlations with clinicopathological features. The study finds that N-CAD protein is often overexpressed in OC and its cytoplasmic overexpression is significantly correlated with tumor grade, subtype, necrosis, and age at menarche. Patients with cytoplasmic N-CAD overexpression have a shorter disease-free survival and higher recurrence rate. These findings highlight the poor prognostic role of N-CAD in OC and its involvement in EMT and distant metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tingting Yang, Xuan Gu, Lizhou Jia, Jiaojiao Guo, Qi Tang, Jin Zhu, Wei Zhao, Zhenqing Feng
Summary: Immunohistochemical testing revealed lower DSG2 expression in colon cancer tissues compared to pericarcinomatous tissues, and this low expression is associated with poor survival in colon cancer patients. Bioinformatics analysis indicated that low DSG2 expression affects protein activation, regulates the P53-related pathway in colon cancer, and activates the EGFR pathway.
BMC GASTROENTEROLOGY
(2021)
Article
Oncology
Qian-xin Chen, Yuan-zhong Yang, Zhuo-zhi Liang, Jia-li Chen, Yue-lin Li, Zi-yi Huang, Zi-jin Weng, Xiao-fang Zhang, Jie-xia Guan, Lu-ying Tang, Jing-ping Yun, Ze-fang Ren
Summary: The study revealed a time-varying effect of FOXA1 on breast cancer prognosis, with the impact of FOXA1 expression levels on prognosis changing over time. Patients with higher FOXA1 expression levels had a higher risk of death compared to those with lower levels, with a crossover point around 36 months.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Biochemistry & Molecular Biology
Kun Li, Guangqing Tan, Xin Zhang, Weiyu Lu, Jingyi Ren, Yuewen Si, Enoch Appiah Adu-Gyamfi, Fangfang Li, Yingxiong Wang, Biao Xie, Meijiao Wang
Summary: EIF4G1 is identified as a potential prognostic biomarker and therapeutic target for breast cancer, as it may regulate the tumor microenvironment and affect metastasis and overall survival in breast cancer patients.
Article
Oncology
Mourad Assidi
Summary: This study investigated the expression patterns of SLAMF7 in breast cancer patients using tissue microarray and immunohistochemistry techniques. The results showed a significant association between SLAMF7 overexpression and clinicopathological parameters, as well as improved survival outcomes. Therefore, elotuzumab may be a promising targeted therapy option for breast cancer.
Article
Reproductive Biology
Mina Sharbatoghli, Parisa Shamshiripour, Fahimeh Fattahi, Elham Kalantari, Zohre Habibi Shams, Mahshid Panahi, Mehdi Totonchi, Zeynab Asadi-Lari, Zahra Madjd, Leili Saeednejad Zanjani
Summary: The co-expression of SALL4/ALDH1A1 is significantly associated with clinicopathological parameters and prognosis in serous ovarian carcinoma patients, suggesting its potential as a prognostic biomarker for cancer progression.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Immunology
Yue-Yu Shi, Xing-Lei Chen, Qian-Xin Chen, Yuan-Zhong Yang, Meng Zhou, Yue-Xiang Ren, Lu-Ying Tang, Ze-Fang Ren
Summary: This study assessed the prognostic effect of ENO1 in breast cancer and considered potential confounders and modification effects. The results showed that ENO1 protein had a protective effect on OS in stage I/II patients but not in stage III patients. The study also found a positive correlation between ENO1 and several antitumor immune cells, which may explain its favorable prognosis in early-stage breast cancer.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Juan Gu, Shu Zhang, Xin He, Sufang Chen, Yan Wang
Summary: High expression of PIG11 is associated with unfavorable prognosis in patients with gastric cancer, serving as a potential diagnostic and prognostic biomarker for gastric cancer.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Su-Wen Zhu, Shuo Wang, Zhi-Zhong Wu, Qi-Chao Yang, De-Run Chen, Shu-Cheng Wan, Zhi-Jun Sun
Summary: This study revealed the overexpression of CD168 in oral squamous cell carcinoma (OSCC) tissues, which was associated with worse patient survival and pathological grade. Additionally, CD168 expression was positively correlated with other marker expression in OSCC.
Article
Oncology
Philipp Kohn, Alexandros Lalos, Alberto Posabella, Alexander Wilhelm, Athanasios Tampakis, Ercan Caner, Uwe Guth, Sylvia Stadlmann, Giulio C. Spagnoli, Salvatore Piscuoglio, Sabine Richarz, Tarik Delko, Raoul A. Droeser, Gad Singer
Summary: High expression of CXCL12 in immune cells is associated with better chemosensitivity, overall survival, and longer recurrence-free survival in patients with high-grade serous ovarian carcinoma. Additionally, combined high density of CXCL12 and CD66b immune cells is an independent favorable predictor of recurrence-free survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Cristian Carrasco, Andres Tittarelli, Natalia Paillaleve, Maeva Del Pozo, Daniel Rojas-Sepulveda, Omar Barria, Paula Fluxa, Melissa Hott, Carolina Martin, Claudia Quezada, Flavio Salazar-Onfray
Summary: Gallbladder cancer is a highly lethal disease with low global incidence, but a significant health problem in certain regions. New tumor-associated markers, such as MUC6, CK17, and CD10, show potential as prognosis markers for gallbladder cancer, with different expressions associated with different patient prognosis.strconv
Article
Pathology
Xiaobo Zhang, Chen Wang, Danhua Shen
Summary: This study investigated the Clinicopathological features and FH mutation in FH-dUL. FH-dUL is rare and the combination of predictive Clinicopathological evaluation, FH and 2SC IHC test, and molecular test were helpful for the screening of FH-dUL or even HLRCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Gaurav Dubey, Mithilesh Singh, Himmat Singh, Mohit Agarwal, Shailendra Singh Chandel, Anurag Mishra, Ravindra Pal Singh, Neelima Kukreti
Summary: SnoRNAs play a crucial role in autoimmune diseases, influencing gene expression, immune cell development, and immune regulation. They have the potential to be biomarkers or therapeutic targets for disease management. However, further research is needed to elucidate their precise molecular mechanisms.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
P. Suhaj, D. Do, T. Olejar, R. Pichova, O. Lang, R. Matej
Summary: Pancreatic polypeptide cell hyperplasia (PPY-H) is a multiplication of neuroendocrine cells producing pancreatic polypeptide (PPY). The development and role of PPY-H still need to be further elucidated. This study analyzed 12 cases of PPY-H accompanying pancreatic neuroendocrine neoplasias (NEN) and found that gastrointestinal symptoms may be more related to PPY-H rather than NEN hormonal production. Strong SSTR2 expression in PPY-H suggests the potential utility of radiotracers in clinical diagnostics, but further studies are needed.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ruyun Zhang, Xiaofei Liao, Bin Zhang, Xiaohong Huang, Guanjie Qin, Xiangyun Kong, Yuan Xie, Yunyan Mo, Jinxuan Dai, Chunqiao Gan, Zan Luo, Jingyan Lu, Wei Jiang
Summary: This study found that patients with high COV+TIL score had worse prognosis in nasopharyngeal carcinoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Waleed Hassan Almalki
Summary: Understanding the molecular pathways behind cardiovascular illnesses is crucial. Recent studies have revealed the role of Xist RNA in cardiovascular diseases, including epigenetic changes, gene expression, cellular identity, and sex chromosomal inactivation. Dysregulation of Xist RNA expression is associated with conditions such as atherosclerosis, hypertrophy, and cardiac fibrosis.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Yanxin Dong, Boshi Fan, Mingyang Li, Jiale Zhang, Shun Xie, Shouyin Dia, Qingge Jia, Taiqian Gong
Summary: Tescalcin (TESC) is upregulated in esophageal squamous carcinoma (ESCC) and is associated with poor prognosis, tumor infiltration, staging, and lymph node metastasis. TESC promotes proliferation, invasion, migration, and epithelial-mesenchymal transition (EMT) progression in ESCC, as well as activates the AKT pathway. TESC may serve as a prognostic factor and provide a new therapeutic strategy for ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Article
Pathology
Ozge Sukruoglu Erdogan, Demet Akdeniz Odemis, Zubeyde Yalniz Kayim, Orkun Gurbuz, Seref Bugra Tuncer, Seda Kilic, Betul Celik, Samuray Tuncer, Sema Buyukkapu Bay, Rejin Kebudi, Hulya Yazici
Summary: This study found that methylation of the RB1 gene promoter does not influence the hereditary transmission of familial retinoblastoma.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
Review
Pathology
Syam Mohan, Mohammed Ageeli Hakami, Hamad Ghaleb Dailah, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Maryam A. Halawi, Thaifallah Munahi Alotaibi
Summary: Cancer is a complex disease caused by multiple factors, and miR-155 plays a significant role as a regulator of the NF-kappa B signaling pathway, contributing to cancer development and progression.
PATHOLOGY RESEARCH AND PRACTICE
(2024)
