Review
Clinical Neurology
Sabrina Poonja, K. Ray Chaudhuri, Janis M. Miyasaki
Summary: This review outlines the impact of the COVID-19 pandemic on holistic care for movement disorders, particularly in the care of people with Parkinson disease. It discusses the challenges of recognizing infection in patients, the loss of community-based team care, and the inequalities amplified by the pandemic, such as the "digital divide".
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Clinical Neurology
Marta Magrico, Miguel Serodio, Rita Ventura, Paulo Bugalho
Summary: This study investigated the satisfaction of Parkinson's disease patients with telemedicine visits during the COVID-19 pandemic. The majority of the patients reported being satisfied with telemedicine visits. Male gender and employment status were associated with higher satisfaction. Clear therapeutic changes and not considering the absence of neurological examination were positively associated with higher satisfaction with telemedicine.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Review
Public, Environmental & Occupational Health
Sanjana Fatema Chowdhury, Syed Muktadir Al Sium, Saeed Anwar
Summary: The COVID-19 pandemic has made the lives of patients with rare diseases more vulnerable and marginalized, while clinicians and researchers working on rare genetic diseases are facing extra challenges. Despite the obstacles, telehealth and virtual consultations have provided hope for rare disease patients.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Computer Science, Information Systems
Ran Sun, Douglas W. Blayney, Tina Hernandez-Boussard
Summary: Telemedicine was rapidly implemented during the COVID-19 pandemic to protect patients and healthcare providers. While it offers many opportunities, challenges related to technology interoperability, the digital divide, and usability still exist. Evidence is needed to support the paradigm shift in care delivery via telemedicine to ensure quality and efficacy.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Review
Public, Environmental & Occupational Health
Steven Yu, Rongjun Wan, Lu Bai, Bingrong Zhao, Qiaoling Jiang, Juan Jiang, Yuanyuan Li
Summary: Adults with chronic diseases often face a decline in quality of life and frequent exacerbations, which can cause anxiety and impose a significant economic burden. Self-management outside of the hospital is crucial for improving quality of life and reducing the financial burden of unexpected hospitalizations. With the COVID-19 pandemic, telehealth has become essential, as in-person appointments have been canceled, leading to increased reliance on online resources. This article discusses traditional self-management and modern telehealth strategies for chronic disease management, compares before and after the COVID-19 outbreak, and highlights emerging challenges.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Sarah Nouri, Courtney R. Lyles, Elizabeth B. Sherwin, Magdalene Kuznia, Anna D. Rubinsky, Kathryn E. Kemper, Oanh K. Nguyen, Urmimala Sarkar, Dean Schillinger, Elaine C. Khoong
Summary: This study evaluated the changes over time in visits and between-visit interactions among patients with diabetes receiving primary care at two health care systems. The results showed an increase in total encounters during the hybrid-PHE period, driven by growth in between-visit interactions. Differential utilization based on patient characteristics was observed, indicating potential disparities in care.
Article
Clinical Neurology
Alessandra Calculli, Tommaso Bocci, Mattia Porcino, Micol Avenali, Chiara Casellato, Sebastiano Arceri, Simone Regalbuto, Alberto Priori, Antonio Pisani
Summary: This case series describes six patients who developed Parkinson's disease after COVID-19 infection. The average time window for developing PD after SARS-CoV-2 infection was 4-7 weeks. There was no apparent relationship with COVID-19 severity and no structural brain abnormalities were found. All patients experienced unilateral resting tremor and responded well to dopaminergic treatment.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Avner Abrami, Steven Gunzler, Camilla Kilbane, Rachel Ostrand, Bryan Ho, Guillermo Cecchi
Summary: The study demonstrates that computer vision techniques can effectively detect hypomimia in Parkinson's disease patients, classify drug states, and play an important role in telemedicine.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Kamal Sharma, Zeel Patel, Smeet Patel, Kalpen Patel, Shweta Dabhi, Jinish Doshi, MohmadSabir Amdani, Darshini Shah, Dhyanee Patel, Ashwati Konat
Summary: During the COVID-19 pandemic, telemedicine has emerged as a rapidly expanding service solution that provides efficient, cost-effective, and time-saving healthcare. Remote monitoring, virtual consultations, and other high-end technologies have revolutionized the traditional forms of care delivery and helped manage cardiovascular disease risk factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Rehabilitation
Min-Yong Lee, Byung-Mo Oh, Han Gil Seo
Summary: COVID-19 may have a significant impact on patients with Parkinson's disease, potentially leading to severe dysphagia and complications such as pneumonia. Healthcare providers should be aware of these risks and monitor patients closely for any signs of swallowing difficulties.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Biochemistry & Molecular Biology
Aria Jahanimoghadam, Hadis Abdolahzadeh, Niloofar Khoshdel Rad, Javad Zahiri
Summary: This study aimed to identify common signatures between COVID-19 and Parkinson's disease (PD) through transcriptome analysis and found 81 common differentially expressed genes (DEGs). The functional analysis of these DEGs revealed their involvement in various pathways related to PD. Protein-protein interaction network analysis identified 10 hub genes associated with molecular mechanisms such as inflammation and microglia activation. Transcription factors and miRNAs regulating these hub genes were also investigated. The study provides important insights into the possible mechanisms linking COVID-19 and PD.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Gastroenterology & Hepatology
Ryan C. Ungaro, Erica J. Brenner, Richard B. Gearry, Gilaad G. Kaplan, Michele Kissous-Hunt, James D. Lewis, Siew C. Ng, Jean-Francois Rahier, Walter Reinisch, Flavio Steinwurz, Fox E. Underwood, Xian Zhang, Jean-Frederic Colombel, Michael D. Kappelman
Summary: Combination therapy and thiopurines may be associated with an increased risk of severe COVID-19, while no significant differences were observed when comparing classes of biologicals. These findings warrant confirmation in large population-based cohorts.
Article
Oncology
EunMee Yang, Weidong Lu, Anna M. Tanasijevic, Jennifer A. Ligibel
Summary: After the outbreak of COVID-19, virtual acupressure sessions were implemented to provide continuing supportive care for cancer patients. The findings suggest that remotely delivered acupressure can significantly reduce symptom burden in cancer patients, highlighting its importance.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Pediatrics
Lily Payvandi, Emily Trudell Correa, Jonathan Hatoun, Heather O'Donnell, Louis Vernacchio
Summary: During the coronavirus disease 2019 pandemic, telehealth antibiotic prescribing increased, but the proportion varied among different diagnosis categories. Clearer guidelines are needed for the appropriate use of antibiotics prescribed during telehealth encounters.
Article
Medicine, General & Internal
Neal Yuan, Joshua M. Pevnick, Patrick G. Botting, Yaron Elad, Shaun J. Miller, Susan Cheng, Joseph E. Ebinger
Summary: The COVID-19 pandemic has caused a shift in cardiovascular ambulatory care from in-person to remote visits. This study analyzed data from an urban, multisite health system in Los Angeles County to compare patient characteristics, medication ordering, and diagnostic testing frequencies between pre-COVID and COVID-era periods. Patients accessing remote visits in the COVID-era were more likely to be Asian, Black, or Hispanic individuals, have private insurance, and have cardiovascular comorbidities. Clinician ordering of medications and diagnostic tests consistently decreased in remote visits compared to in-person visits.
Article
Medicine, Research & Experimental
Zi H. Su, Salil Patel, Bronwyn Gavine, Tim Buchanan, Marko Bogdanovic, Nagaraja Sarangmat, Alexander L. Green, Bastiaan R. Bloem, James J. FitzGerald, Chrystalina A. Antoniades
Summary: This study compared the effects of dopaminergic medication and subthalamic nucleus deep brain stimulation (STN DBS) on gait variability in Parkinson disease patients. The results showed that STN DBS reduced short-term variability in lower limb gait parameters, while medication did not have this effect. In addition, STN DBS had no effect on arm swing and trunk motion variability, while medication increased them.
Review
Geriatrics & Gerontology
Lily Man Lee Chan, Oliver Yongyang Yan, Jay Jung Jae Lee, Wendy Wing Tak Lam, Chia-Chin Lin, Man Auyeung, Bastiaan R. Bloem, Jojo Yan Yan Kwok
Summary: Palliative care is associated with lower symptom burden and higher caregiver and patient satisfaction in patients with progressive neurologic diseases. However, the associations are not significant after excluding studies with high risk of bias. The effects of palliative care on caregiver burden and patient quality of life are inconclusive.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Clinical Neurology
Amir H. Talebi, Jan H. L. Ypinga, Nienke M. De Vries, Jorik Nonnekes, Marten Munneke, Bas R. Bloem, Tom Heskes, Yoav Ben-Shlomo, Sirwan K. L. Darweesh
Summary: Specialized physiotherapy and occupational therapy can reduce the incidence rate of Parkinson's disease-related complications. There may be a synergistic effect among multiple specialized allied health disciplines. The findings of this study support the introduction of specialized allied health therapy expertise in Parkinson's disease care.
MOVEMENT DISORDERS
(2023)
Editorial Material
Neurosciences
Bastiaan R. Bloem, Lorraine V. Kalia
JOURNAL OF PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Pierre-Emmanuel Sugier, Elise A. Lucotte, Cloe Domenighetti, Matthew H. Law, Mark M. Iles, Kevin Brown, Christopher Amos, James D. McKay, Rayjean J. Hung, Mojgan Karimi, Delphine Bacq-Daian, Anne Boland-Auge, Robert Olaso, Jean-francois Deleuze, Fabienne Lesueur, Evgenia Ostroumova, Ausrele Kesminiene, Florent de Vathaire, Pascal Guenel, Ashwin Ashok Kumar Sreelatha, Claudia Schulte, Sandeep Grover, Patrick May, Dheeraj R. Bobbili, Milena Radivojkov-Blagojevic, Peter Lichtner, Andrew B. Singleton, Dena G. Hernandez, Connor Edsall, George D. Mellick, Alexander Zimprich, Walter Pirker, Ekaterina Rogaeva, Anthony E. Lang, Sulev Koks, Pille Taba, Suzanne Lesage, Alexis Brice, Jean-Christophe Corvol, Marie-Christine Chartier-Harlin, Eugenie Mutez, Kathrin Brockmann, Angela B. Deutschlaender, Georges M. Hadjigeorgiou, Efthimios Dardiotis, Leonidas Stefanis, Athina Maria Simitsi, Enza Maria Valente, Simona Petrucci, Letizia Straniero, Anna Zecchinelli, Gianni Pezzoli, Laura Brighina, Carlo Ferrarese, Grazia Annesi, Andrea Quattrone, Monica Gagliardi, Hirotaka Matsuo, Akiyoshi Nakayama, Nobutaka Hattori, Kenya Nishioka, Sun Ju Chung, Yun Joong Kim, Pierre Kolber, Bart P. C. van de Warrenburg, Bastiaan R. Bloem, Jan Aasly, Mathias Toft, Lasse Pihlstrom, Leonor Correia Guedes, Joaquim J. Ferreira, Soraya Bardien, Jonathan Carr, Eduardo Tolosa, Mario Ezquerra, Pau Pastor, Monica Diez-Fairen, Karin Wirdefeldt, Nancy Pedersen, Caroline Ran, Andrea C. Belin, Andreas Puschmann, Emil Ygland Roedstroem, Carl E. Clarke, Karen E. Morrison, Manuela Tan, Dimitri Krainc, Lena F. Burbulla, Matt J. Farrer, Rejko Kruger, Thomas Gasser, Manu Sharma, Therese Truong, Alexis Elbaz
Summary: By using genome-wide association studies, this study found that Parkinson's disease (PD) is genetically correlated with melanoma and prostate cancer, while it is inversely correlated with ovarian cancer. These findings suggest that pleiotropic genes contribute to the association between PD and specific cancers.
MOVEMENT DISORDERS
(2023)
Review
Clinical Neurology
Jesco Streumer, Ashok K. Selvaraj, Erkan Kurt, Bastiaan R. Bloem, Rianne A. J. Esselink, Ronald H. M. A. Bartels, Dejan Georgiev, R. Saman Vinke
Summary: Axial disability, including gait disturbances, is common in Parkinson's disease (PD), especially in advanced stages. Epidural spinal cord stimulation (SCS) has been investigated as a treatment option for gait disorders in PD. This review examines the literature on SCS in PD and evaluates its efficacy, optimal stimulation parameters, optimal electrode locations, possible effects of concurrent deep brain stimulation, and possible working mechanisms on gait.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Irene Gottgens, Linda Modderkolk, Corine Jansen, Sirwan K. L. Darweesh, Bastiaan R. Bloem, Sabine Oertelt-Prigione
Summary: This study explores the salience of gender-related aspects in the illness experiences and care provision preferences of people with Parkinson's disease (PD). Most participants did not consider gender-related aspects salient towards their illness experiences, but some described stereotypical views related to visibility of PD, emotional experiences, help seeking, role patterns, and physical appearance. While most participants did not express specific gender-related preferences for their healthcare providers, those that did preferred women as healthcare providers, citing attributed feminine traits relevant in physical examinations of people with PD.
SOCIAL SCIENCE & MEDICINE
(2023)
Review
Neurosciences
Anouk Tosserams, Bastiaan R. Bloem, Kaylena Ehgoetz A. Martens, Rick C. Helmich, Roy P. C. Kessels, James M. Shine, Natasha L. Taylor, Gabriel Wainstein, Simon J. G. Lewis, Jorik Nonnekes
Summary: In stressful situations, individuals with Parkinson's disease (PD) may experience worsening of motor symptoms, including gait impairments. However, some patients report benefits from stressful or high-arousal situations. A study with 4324 PD patients shows that they use various mental strategies to cope with gait impairments, which can either increase or decrease overall sympathetic tone. This suggests that arousal can have both detrimental and alleviating effects on gait control in PD.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Neurosciences
Martin E. Johansson, Nina M. van Lier, Roy P. C. Kessels, Bastiaan R. Bloem, Rick C. Helmich
Summary: Heterogeneity in Parkinson's disease (PD) makes it difficult to understand the disease and develop treatments. Stratifying patients into subtypes based on clinical characteristics may help overcome this challenge. A recent study classified de novo PD patients into three subtypes and found that the diffuse-malignant subtype had more severe symptoms and faster progression compared to the mild-motor predominant subtype. These findings suggest different pathophysiological mechanisms underlie distinct PD subtypes.
NPJ PARKINSONS DISEASE
(2023)
Editorial Material
Clinical Neurology
Jules M. Janssen Daalen, Thomas H. Oosterhof, Bastiaan R. Bloem, Sirwan K. L. Darweesh
MOVEMENT DISORDERS
(2023)
Editorial Material
Neurosciences
Federica Albanese, Bastiaan R. Bloem, Lorraine V. Kalia
Summary: Metascience emphasizes the importance of replication, reproducibility, and rigor in research, particularly in studying major diseases like Parkinson's disease.
JOURNAL OF PARKINSONS DISEASE
(2023)
Review
Clinical Neurology
Carlo Alberto Artusi, Christian Geroin, Jorik Nonnekes, Camila Aquino, Divyani Garg, Marian L. Dale, Darbe Schlosser, Yijie Lai, Mohammad Al-Wardat, Mehri Salari, Robin Wolke, Valery Tsinda Labou, Gabriele Imbalzano, Serena Camozzi, Marcelo Merello, Bastiaan R. Bloem, Tamine Capato, Ruth Djaldetti, Karen Doherty, Alfonso Fasano, Houyam Tibar, Leonardo Lopiano, Nils G. Margraf, Caroline Moreau, Yoshikazu Ugawa, Roongroj Bhidayasiri, Michele Tinazzi
Summary: Axial postural abnormalities are common in patients with Parkinson's disease and atypical parkinsonism, and have a significant impact on the patients' quality of life. However, there is limited understanding of the pathophysiology and clinical predictors of these symptoms, highlighting the need for further research in this area.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Milan Beckers, Peter J. Koehler, Geert J. A. Wanten, Bastiaan R. Bloem
Summary: There is a hypothesis suggesting that Adolf Hitler had Parkinson's disease and suffered from gastrointestinal symptoms, possibly linked to small-intestinal bacterial overgrowth (SIBO), serving as an early indication of Parkinson's.
EUROPEAN NEUROLOGY
(2023)
Letter
Clinical Neurology
Rui Araujo, Jos J. Kole, Joaquim J. Ferreira, Bastiaan R. Bloem
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Francisco Cardoso, Christopher G. Goetz, Tiago A. Mestre, Cristina Sampaio, Charles H. Adler, Daniela Berg, Bastiaan R. Bloem, David J. Burn, Michael S. Fitts, Thomas Gasser, Christine Klein, Marina A. J. de Tijssen, Anthony E. Lang, Shen-Yang Lim, Irene Litvan, Wassilios G. Meissner, Brit Mollenhauer, Njideka Okubadejo, Michael S. Okun, Ronald B. Postuma, Per Svenningsson, Louis C. S. Tan, Taiji Tsunemi, Sarah Wahlstrom-Helgren, Oscar S. Gershanik, Victor S. C. Fung, Claudia Trenkwalder
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
