期刊
ORGANIC LETTERS
卷 22, 期 15, 页码 6214-6219出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02367
关键词
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资金
- Major National Science and Technology Projects of water pollution control and treatment [2017ZX07402003]
- Natural Science Foundation of Tianjin [19JCYBJC20200]
- Tianjin University
Tetrahydroxydiboron has previously been used as a borylation or reducing reagent in organic synthesis. Herein, we present a novel tetrahydroxydiboron-promoted radical addition of internal alkynes followed by intramolecular oxidation of alcohol through 1,5-hydrogen atom transfer. Preliminary mechanistic studies showed that the process might be initiated through N,N-dimethylformamideassisted homolytic cleavage of tetrahydroxydiboron. This process provides a convenient synthesis of fluoroalkyl-substituted alkenes with a pendant aldehyde or ketone moiety.
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