期刊
ORGANIC LETTERS
卷 22, 期 16, 页码 6414-6419出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02229
关键词
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资金
- National Key Research and Development Program of China [2019YFA0905100]
- National Natural Science Foundation of China [21772142, 21901181, 21961142015]
- Tianjin Municipal Science & Technology Commission [19JCQNJC04700]
A general and practical cross-dehydrogenative coupling protocol between readily available trisubstituted alpha,beta-dehydro alpha-amino carboxylic esters and H-phosphites is described. This C(sp(2))-H phosphorylation reaction proceeds with absolute Z-selectivity promoted by silver salt in a radical relay manner. The bulky tetrasubstituted beta-phosphonodehydroamino acids were obtained in grams and added new modules to the toolkit for peptide modifications.
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