Article
Nutrition & Dietetics
In Young Cho, Kyung Min Lee, Yoojin Lee, Chuel Min Paek, Ha Jin Kim, Ju Young Kim, Kiheon Lee, Jong Soo Han, Woo Kyung Bae
Summary: This study evaluated the dietary habits of CCVD patients using the Diet Quality Index-International and found that the quality of dietary habits of CCVD patients was lower than non-CCVD subjects. Evaluation and education of adequate dietary habits are needed in the management of CCVD patients.
Review
Biochemistry & Molecular Biology
Roland Gal, Laszlo Deres, Kalman Toth, Robert Halmosi, Tamas Habon
Summary: Resveratrol, a natural polyphenol, has been extensively studied for its beneficial effects on the cardiovascular system, including signal transduction pathways, energy metabolism, anti-inflammatory, and antioxidant properties. Research indicates its potential protective role in cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Heather L. Petrick, Leslie M. Ogilvie, Henver S. Brunetta, Avery Robinson, Aleah J. Kirsh, Pierre-Andre Barbeau, Rachel M. Handy, Bridget Coyle-Asbil, Connor Gianetto-Hill, Kaitlyn M. J. H. Dennis, Luc J. C. van Loon, Adrian Chabowski, Jonathan D. Schertzer, Emma Allen-Vercoe, Jeremy A. Simpson, Graham P. Holloway
Summary: Impaired heart function in diabetes patients can be caused by factors other than hypertension, such as gut dysbiosis. Dietary nitrate and fecal microbial transplantation have been found to prevent high-fat diet-induced cardiac abnormalities by mitigating gut dysbiosis.
Article
Nutrition & Dietetics
Weiting Lyu, Thamer Omar, Harna Patel, David Rodriguez, Mario G. Ferruzzi, Giulio M. Pasinetti, James W. Murrough, Fernando J. Muzzio, James E. Simon, Qingli Wu
Summary: The study developed methods for dissolution analysis of grape polyphenol dietary supplements using ultra-high performance liquid chromatography/triple quadrupole mass spectrometry, following USP guidance. Results indicated that while RSV capsules met USP standards in both dissolution media, further improvement is needed for GSE capsules in acetate buffer. This suggests the need to enhance the dissolution of GSE over a wider range of pH environments to improve bioavailability and efficacy.
FRONTIERS IN NUTRITION
(2021)
Review
Medicine, Research & Experimental
Ali Mohammad Pourbagher-Shahri, Tahereh Farkhondeh, Milad Ashrafizadeh, Marjan Talebi, Saeed Samargahndian
Summary: Curcumin, the main ingredient of turmeric, has been shown to modulate multiple signaling pathways and protect against cardiovascular diseases. However, more research is still needed to discover the exact molecular targets of Curcumin in the treatment of CVDs.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Physiology
Fulye Argunhan, Susan D. Brain
Summary: The treatment of hypertension and heart failure is a major challenge, with over 26 million people affected worldwide. CGRP has been found to have beneficial effects in hypertensive and heart failure patients. However, due to its short half-life, the beneficial effects of CGRP are often acute and transient. Recently developed long-lasting CGRP agonists may provide a solution for further studying CGRP in cardiovascular disease.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Peripheral Vascular Disease
Hainan Li, Huong Nguyen, Sai Pranathi Meda Venkata, Jia Yi Koh, Anjaneyulu Kowluru, Li Li, Noreen F. Rossi, Wei Chen, Jie-Mei Wang
Summary: Inhibition of GPR35 was found to enhance endothelial cell functions and promote angiogenesis while reducing intracellular superoxide levels, resulting in improved vasodilation and decreased blood pressure in male mice. These findings suggest that antagonizing GPR35 activity could be a potential therapeutic approach to restore endothelial function and maintain hemodynamic homeostasis, particularly in the context of hypertension.
Review
Pharmacology & Pharmacy
Aisha Rasool, Fernanda Alvarado-Flores, Perrie O'Tierney-Ginn
Summary: Appropriate use of supplements may have positive therapeutic effects on maternal and fetal outcomes. Probiotics may serve as a therapeutic modality by improving inflammation and lipid metabolism. Omega-3 fatty acids from fish oil supplementation may be beneficial for obese mothers but have little placental impact on healthy lean women.
CLINICAL THERAPEUTICS
(2021)
Review
Hematology
Simon Kraler, Peter Libby, Paul C. Evans, Alexander Akhmedov, Martin O. Schmiady, Michael Reinehr, Giovanni G. Camici, Thomas F. Luscher
Summary: Atherosclerotic cardiovascular disease has become a global epidemic, with the internal mammary artery's unique biological properties providing resilience against atherosclerotic plaque formation. Shifting the perspective from risk to resilience may help decipher the mechanisms of atheroresistance and identify new therapeutic targets.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ricardo Carnicer, Drew Duglan, Klemen Ziberna, Alice Recalde, Svetlana Reilly, Jillian N. Simon, Simona Mafrici, Ritu Arya, Esther Rosello-Lleti, Surawee Chuaiphichai, Damian Tyler, Craig A. Lygate, Keith M. Channon, Barbara Casadei
Summary: Myocardial BH4 was found to prevent and reverse left ventricular diastolic and systolic dysfunction associated with diabetes by increasing insulin-independent myocardial glucose uptake and utilization. This mechanism highlights the potential for GCH1/BH4-based therapeutics in human diabetic cardiomyopathy.
CIRCULATION RESEARCH
(2021)
Review
Nutrition & Dietetics
Phiwayinkosi V. Dludla, Khanyisani Ziqubu, Sihle E. Mabhida, Sithandiwe E. Mazibuko-Mbeje, Sidney Hanser, Bongani B. Nkambule, Albertus K. Basson, Carmen Pheiffer, Luca Tiano, Andre P. Kengne
Summary: Cardiovascular diseases are the leading cause of death in people with diabetes, and low glutathione levels are consistently linked with the pathological features of diabetes. Dietary supplements, such as coenzyme Q(10), selenium, curcumin, omega-3 fatty acids, and vitamin E or D, may potentially improve cardiometabolic health in patients with diabetes by enhancing glutathione levels and reducing cholesterol. However, more clinical studies are needed to validate these findings.
Review
Biochemistry & Molecular Biology
Anna Janaszak-Jasiecka, Anna Siekierzycka, Agata Ploska, Iwona T. Dobrucki, Leszek Kalinowski
Summary: Hypoxia plays a crucial role in the pathogenesis of cardiovascular diseases by affecting NO bioavailability and leading to eNOS uncoupling, resulting in oxidative stress and endothelial dysfunction.
Review
Biochemistry & Molecular Biology
Roland Gal, Robert Halmosi, Ferenc Gallyas Jr, Michael Tschida, Pornthira Mutirangura, Kalman Toth, Tamas Alexy, Laszlo Czopf
Summary: Cardiovascular diseases (CVDs) are a major cause of illness and death worldwide. Unhealthy dietary habits have been shown to contribute to the development of CVDs. Natural polyphenols, found in fruits, vegetables, and red wine, play a clear role in improving cardiovascular health. This review summarizes the results of pre-clinical and clinical trials on important natural polyphenols such as resveratrol and flavonoids, their sources and biosynthesis, and their regulatory effect on signal transduction pathways. Additionally, scientific evidence is provided regarding the cardiovascular benefits of moderate, long-term red wine consumption.
Article
Cardiac & Cardiovascular Systems
Sarah E. Basehore, Samantha Bohlman, Callie Weber, Swathi Swaminathan, Yuji Zhang, Cholsoon Jang, Zoltan Arany, Alisa Morss Clyne
Summary: The study found that steady laminar flow reduces eNOS O-GlcNAcylation by limiting glycolysis and the availability of UDP-GlcNAc, leading to increased eNOS phosphorylation and NO production. This research demonstrates for the first time that O-GlcNAcylation is regulated by mechanical stimuli, which has implications for cardiovascular disease.
CIRCULATION RESEARCH
(2021)
Article
Nutrition & Dietetics
You-Lin Tain, Chi- Chang, Chih-Yao Hou, Guo-Ping Chang-Chien, Sufan Lin, Chien-Ning Hsu
Summary: In this study, the protective effects of resveratrol butyrate monoester (RBM) on kidney dysfunction and hypertension in a CKD model were examined. RBM supplementation improved NO bioavailability, balanced the renin-angiotensin system, reduced oxidative stress, and altered gut microbiota composition. These findings suggest that RBM supplementation holds promise for improving CKD outcomes and hypertension treatment.