Designer Cathinones N-Ethylhexedrone and Buphedrone Show Different In Vitro Neurotoxicity and Mice Behaviour Impairment

New/emerging psychoactive substances and associated psychopathological consequences

(2019) F. Schifano et al.   PSYCHOLOGICAL MEDICINE

Structure-cytotoxicity relationship profile of 13 synthetic cathinones in differentiated human SH-SY5Y neuronal cells

(2019) Jorge Soares et al.   NEUROTOXICOLOGY

Secretome from SH-SY5Y APP Swe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling

(2018) Adelaide Fernandes et al.   BIOCHIMIE

LysoTracker and MitoTracker Red are transport substrates of P-glycoprotein: implications for anticancer drug design evading multidrug resistance

(2018) Benny Zhitomirsky et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Automated Morphological Analysis of Microglia After Stroke

(2018) Steffanie Heindl et al.   Frontiers in Cellular Neuroscience

A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration

(2018) Meng-meng Jin et al.   Frontiers in Aging Neuroscience

Different Patterns of Neurodegeneration and Glia Activation in CA1 and CA3 Hippocampal Regions of TgCRND8 Mice

(2018) Filippo Ugolini et al.   Frontiers in Aging Neuroscience

Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging

(2017) Ainhoa Plaza-Zabala et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Of Mice and Men: Comparative Analysis of Neuro-Inflammatory Mechanisms in Human and Mouse Using Cause-and-Effect Models

(2017) Alpha Tom Kodamullil et al.   JOURNAL OF ALZHEIMERS DISEASE

Activity-Dependent Exocytosis of Lysosomes Regulates the Structural Plasticity of Dendritic Spines

(2017) Zahid Padamsey et al.   NEURON

α-Pyrrolidinononanophenone provokes apoptosis of neuronal cells through alterations in antioxidant properties

(2017) Toshiyuki Matsunaga et al.   TOXICOLOGY

Characterizing microglia activation: a spatial statistics approach to maximize information extraction

(2017) Benjamin M. Davis et al.   Scientific Reports

Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aβ-Mediated Microglial Inflammation

(2016) Ana S. Falcão et al.   ACS Chemical Neuroscience

The new designer drug buphedrone produces rewarding properties via dopamine D1 receptor activation

(2016) Ji-Hwan Oh et al.   ADDICTION BIOLOGY

Neurobiology of 3,4-methylenedioxypyrovalerone (MDPV) and α-pyrrolidinovalerophenone (α-PVP)

(2016) Richard A. Glennon et al.   BRAIN RESEARCH BULLETIN

Identification and analytical characterization of nine synthetic cathinone derivatives N -ethylhexedrone, 4-Cl-pentedrone, 4-Cl-α -EAPP, propylone, N -ethylnorpentylone, 6-MeO-bk-MDMA, α -PiHP, 4-Cl-α -PHP, and 4-F-α -PHP

(2016) Cuimei Liu et al.   Drug Testing and Analysis

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization

(2016) Carolina Cunha et al.   MEDIATORS OF INFLAMMATION

The new psychoactive substances 5-(2-aminopropyl)indole (5-IT) and 6-(2-aminopropyl)indole (6-IT) interact with monoamine transporters in brain tissue

(2016) Julie A. Marusich et al.   NEUROPHARMACOLOGY

Cytotoxic Activity of Pyrovalerone Derivatives, an Emerging Group of Psychostimulant Designer Cathinones

(2016) Jakub Wojcieszak et al.   NEUROTOXICITY RESEARCH

Pharmacological effects of methamphetamine and alpha-PVP vapor and injection

(2016) Julie A. Marusich et al.   NEUROTOXICOLOGY

Neurobiology of rodent self-grooming and its value for translational neuroscience

(2015) Allan V. Kalueff et al.   NATURE REVIEWS NEUROSCIENCE

Comparative pharmacological evaluation of the cathinone derivatives, mephedrone and methedrone, in mice

(2015) Priscilla B. Pail et al.   NEUROTOXICOLOGY

TRPC1-mediated Ca2+ entry is essential for the regulation of hypoxia and nutrient depletion-dependent autophagy

(2015) P Sukumaran et al.   Cell Death & Disease

Mitochondrial respiratory dysfunction due to the conversion of substituted cathinones to methylbenzamides in SH-SY5Y cells

(2015) Bjørnar den Hollander et al.   Scientific Reports

Mephedrone, Methylone and 3,4-Methylenedioxypyrovalerone (MDPV) Induce Conditioned Place Preference in Mice

(2014) Louise Karlsson et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Analytical profiles of “legal highs” containing cathinones available in the area of Lisbon, Portugal

(2014) Victor M.R. Zancajo et al.   FORENSIC SCIENCE INTERNATIONAL

Baths Salts, Spice, and Related Designer Drugs: The Science Behind the Headlines

(2014) M. H. Baumann et al.   JOURNAL OF NEUROSCIENCE

Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV)

(2014) Julie A. Marusich et al.   NEUROPHARMACOLOGY

Dose and Time-Dependent Selective Neurotoxicity Induced by Mephedrone in Mice

(2014) José Martínez-Clemente et al.   PLoS One

Keto Amphetamine Toxicity—Focus on the Redox Reactivity of the Cathinone Designer Drug Mephedrone

(2014) Bjørnar den Hollander et al.   TOXICOLOGICAL SCIENCES

Microglia centered pathogenesis in ALS: insights in cell interconnectivity

(2014) Dora Brites et al.   Frontiers in Cellular Neuroscience

Microglia change from a reactive to an age-like phenotype with the time in culture

(2014) Cláudia Caldeira et al.   Frontiers in Cellular Neuroscience

Khat and synthetic cathinones: a review

(2013) Maria João Valente et al.   ARCHIVES OF TOXICOLOGY

Animal models of the serotonin syndrome: A systematic review

(2013) Robert Haberzettl et al.   BEHAVIOURAL BRAIN RESEARCH

Two Fatal Intoxications with the New Designer Drug Methedrone (4-Methoxymethcathinone)

(2013) Maria Wikström et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Hypothesizing that designer drugs containing cathinones (“bath salts”) have profound neuro-inflammatory effects and dangerous neurotoxic response following human consumption

(2013) Kenneth Blum et al.   MEDICAL HYPOTHESES

Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice

(2013) Y. Tanaka et al.   NEUROSCIENCE

Lysosomal dysfunction in neurodegeneration

(2012) Marija Usenovic et al.   Autophagy

Hyperstimulation of macropinocytosis leads to lysosomal dysfunction during exposure to methamphetamine in SH-SY5Y cells

(2012) Akina Nara et al.   BRAIN RESEARCH

Mephedrone (‘bath salt’) elicits conditioned place preference and dopamine-sensitive motor activation

(2012) Renata Lisek et al.   DRUG AND ALCOHOL DEPENDENCE

Detection of buphedrone in biological and non-biological material – Two case reports

(2012) Dariusz Zuba et al.   FORENSIC SCIENCE INTERNATIONAL

Effects of synthetic cathinones contained in “bath salts” on motor behavior and a functional observational battery in mice

(2012) Julie A. Marusich et al.   NEUROTOXICOLOGY

Regulation and Function of Autophagy during Cell Survival and Cell Death

(2012) G. Das et al.   Cold Spring Harbor Perspectives in Biology

Clinical experience with and analytical confirmation of “bath salts” and “legal highs” (synthetic cathinones) in the United States

(2011) Henry A. Spiller et al.   CLINICAL TOXICOLOGY

Interleukin 4 induces the apoptosis of mouse microglial cells by a caspase-dependent mechanism

(2011) Javier A. Soria et al.   NEUROBIOLOGY OF DISEASE

Depressive behavior and vascular dysfunction: a link between clinical depression and vascular disease?

(2010) Alexandre C. d'Audiffret et al.   JOURNAL OF APPLIED PHYSIOLOGY

Roles for nigrostriatal—not just mesocorticolimbic—dopamine in reward and addiction

(2009) Roy A. Wise   TRENDS IN NEUROSCIENCES

Neurochemical responses to antidepressants in the prefrontal cortex of mice and their efficacy in preclinical models of anxiety-like and depression-like behavior: a comparative and correlational study

(2008) Tomohiro Kobayashi et al.   PSYCHOPHARMACOLOGY

Neurotoxic-related changes in tyrosine hydroxylase, microglia, myelin, and the blood-brain barrier in the caudate-putamen from acute methamphetamine exposure

(2007) John F. Bowyer et al.   SYNAPSE