Article
Neurosciences
Qiuting Wen, Shannon L. Risacher, Linhui Xie, Junjie Li, Jaroslaw Harezlak, Martin R. Farlow, Frederick W. Unverzagt, Sujuan Gao, Liana G. Apostolova, Andrew J. Saykin, Yu-Chien Wu
Summary: The study explored the spatial pattern of tau-white matter (WM) associations across the whole brain and found a distinct spatial pattern resembling the typical propagation of tau pathology in Alzheimer's disease (AD). The association between tau and WM degeneration highlights the important role of WM alterations in the AD pathological cascade.
Article
Biochemistry & Molecular Biology
Johanna Seitz-Holland, Suheyla Cetin-Karayumak, Joanne D. Wojcik, Amanda Lyall, James Levitt, Martha E. Shenton, Ofer Pasternak, Carl-Fredrik Westin, Madhura Baxi, Sinead Kelly, Raquelle Mesholam-Gately, Mark Vangel, Godfrey Pearlson, Carol A. Tamminga, John A. Sweeney, Brett A. Clementz, David Schretlen, Petra Verena Viher, Katharina Stegmayer, Sebastian Walther, Jungsun Lee, Tim Crow, Anthony James, Aristotle Voineskos, Robert W. Buchanan, Philip R. Szeszko, Anil K. Malhotra, Yogesh Rathi, Matcheri Keshavan, Marek Kubicki
Summary: White matter abnormalities in schizophrenia patients are associated with illness duration and antipsychotic medication dose. The study also shows gender-specific relationships between white matter pathology and symptom severity in males and females.
MOLECULAR PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Hedok Lee, Feng Xu, Xiaodan Liu, Sunil Koundal, Xiaoyue Zhu, Judianne Davis, David Yanez, Joseph Schrader, Aleksandra Stanisavljevic, Douglas L. Rothman, Joanna Wardlaw, William E. Van Nostrand, Helene Benveniste
Summary: It was found that under the influence of CAA type 1 pathology, the transgenic rats exhibited a distinct pattern of WM loss.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Neurosciences
Carissa N. Weis, Ashley A. Huggins, Tara A. Miskovich, Jacklynn M. Fitzgerald, Kenneth P. Bennett, Jessica L. Krukowski, E. Kate Webb, Terri A. DeRoon-Cassini, Christine L. Larson
Summary: This study investigated acute brain structural integrity in individuals being treated for traumatic injuries and found that acute white matter integrity after trauma is not robustly related to the development of chronic PTSD symptoms, highlighting the importance of timing in evaluating white matter integrity and PTSD.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Christopher E. Bauer, Valentinos Zachariou, Elayna Seago, Brian T. Gold
Summary: This study investigated the associations between three potential early markers of white matter hyperintensity volume and found that white matter microstructure may be a better predictor of WMH volume compared to brain iron concentration and cerebral blood flow. It also highlighted that some early WMH markers may be location-specific.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Ali Baran Tanrikulu, Ikbal Inanli, Serdar Arslan, Ali Metehan Caliskan, Ismet Esra Cicek, Ibrahim Eren
Summary: This study aimed to investigate the white matter (WM) integrity within different stages of bipolar disorder (BD) and its potential as a biomarker for clinical staging. The results suggest that WM integrity in the corpus callosum genu and right sagittal stratum may serve as biomarkers for clinical staging of BD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Aleksi J. Sihvonen, Paula Virtala, Anja Thiede, Marja Laasonen, Teija Kujala
Summary: This study utilized a hodological approach to investigate the relationships between structural white matter connectivity and reading skills and phonological processing. The findings revealed specific brain regions associated with reading skills and phonological processing, as well as structural connectivity anomalies in dyslexics.
Article
Clinical Neurology
Daniel Ta, Abdullah Ishaque, Ojas Srivastava, Chris Hanstock, Peter Seres, Dean T. Eurich, Collin Luk, Hannah Briemberg, Richard Frayne, Angela L. Genge, Simon J. Graham, Lawrence Korngut, Lorne Zinman, Sanjay Kalra
Summary: The study found that ALS patients have reduced NAA ratios in the motor cortex, which are associated with more rapid disease progression and greater UMN signs. Prefrontal cortex NAA ratios were only reduced in cognitively impaired patients. The use of standardized imaging protocols may play a role in clinical trials for patient selection or subgrouping.
Article
Urology & Nephrology
Rebecca J. Lepping, Robert N. Montgomery, Palash Sharma, Jonathan D. Mahnken, Eric D. Vidoni, In-Young Choi, Mark J. Sarnak, William M. Brooks, Jeffrey M. Burns, Aditi Gupta
Summary: This study investigated the effects of kidney transplantation on cerebral abnormalities in ESKD patients. The results showed that kidney transplantation can reverse certain brain abnormalities, including improvements in cerebral blood flow, neurochemical concentrations, and white matter integrity. Further studies are needed to understand the mechanisms underlying these brain abnormalities and explore interventions to mitigate them.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Clinical Neurology
Mykyta Smirnov, Christophe Destrieux, Igor Lima Maldonado
Summary: This review provides a structured presentation of the existing knowledge of the vascularization of the human cerebral white matter from seminal historical studies to the current literature, emphasizing the transition in conceptions of white matter vascularization and the need for further research on deep white matter vascularization, especially regarding the arterial supply of white matter fibre tracts.
Article
Clinical Neurology
Zeinab Gharaylou, Mohammad Ali Sahraian, Mahmoudreza Hadjighassem, Mohsen Kohanpour, Rozita Doosti, Shima Nahardani, Abdorreza Naser Moghadasi
Summary: This study utilized DTI and NODDI techniques to compare different groups of multiple sclerosis patients and their family members, revealing widespread white matter impairment in familial patients, while changes in sporadic patients and their healthy relatives were not significant.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Steven L. Meisler, John D. E. Gabrieli
Summary: Reading involves a widely distributed brain network and white matter tracts play an important role in transmitting information between constituent network nodes. A study with a large dataset of 686 children found that while white matter FA increased with age, there were no significant correlations between overall reading abilities and tract FAs. However, higher FA in specific tracts was associated with better nonword reading skills in older children.
Article
Geriatrics & Gerontology
Mustapha Bouhrara, Alexandru V. Avram, Matthew Kiely, Aparna Trivedi, Dan Benjamini
Summary: Using the MAP-MRI framework, this study found that older adults exhibited higher non-Gaussianity and lower propagator anisotropy in white matter, indicating axonal degradation. In gray matter, these two indices were consistent and showed regional heterogeneity, suggesting fewer neuronal projections across cortical layers and increased glial concentration. Regional variations in age-related microstructural differences were also observed, consistent with the posterior-anterior shift in aging paradigm.
NEUROBIOLOGY OF AGING
(2023)
Article
Clinical Neurology
Heather M. Clark, Nirubol Tosakulwong, Stephen D. Weigand, Farwa Ali, Hugo Botha, Nha Trang Thu Pham, Christopher G. Schwarz, Robert Reid, Matthew L. Senjem, Clifford R. Jack, Val J. Lowe, J. Eric Ahlskog, Keith A. Josephs, Jennifer L. Whitwell
Summary: This study found that impairments in swallowing function were associated with specific brain regions' reduced gray matter volumes and abnormal white matter integrity. The impairments in the oral and pharyngeal phases of swallowing corresponded to different regions of neuroanatomical impairment.
MOVEMENT DISORDERS
(2021)
Article
Neuroimaging
Ivana Kancheva, Floor Buma, Gert Kwakkel, Angelina Kancheva, Nick Ramsey, Mathijs Raemaekers
Summary: This study aimed to assess secondary white matter degeneration after ischemic stroke and found that it spreads along the entire damaged tract and worsens over time.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Sarah Treit, Julia N. Rickard, Emily Stolz, Kevin Solar, Peter Seres, Derek Emery, Christian Beaulieu
Summary: The goal of this study was to create a normative brain MRI database for comparisons with various neurological disorders across the lifespan. A sample of 378 neurotypical controls completed brain MRI and other assessments, providing valuable insight into healthy brain development and aging.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Vincent Picher-Martel, Claire Magnussen, Mathieu Blais, Tania Bubela, Samir Das, Annie Dionne, Alan C. Evans, Angela Genge, Russell Greiner, Yasser Iturria-Medina, Wendy Johnston, Kelvin Jones, Hannah Kaneb, Jason Karamchandani, Sara Moradipoor, Janice Robertson, Ekaterina Rogaeva, David M. Taylor, Christine Vande Velde, Yana Yunusova, Lorne Zinman, Sanjay Kalra, Nicolas Dupre
Summary: The paper presents the CAPTURE ALS platform, a Canadian-based initiative aimed at accelerating ALS research through comprehensive clinical and biological characterization, leading to the development of effective treatments and disease progression monitoring biomarkers.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Clinical Neurology
Julie Ottoy, Miracle Ozzoude, Katherine Zukotynski, Sabrina Adamo, Christopher Scott, Vincent Gaudet, Joel Ramirez, Walter Swardfager, Hugo Cogo-Moreira, Benjamin Lam, Aparna Bhan, Parisa Mojiri, Min Su Kang, Jennifer S. Rabin, Alex Kiss, Stephen Strother, Christian Bocti, Michael Borrie, Howard Chertkow, Richard Frayne, Robin Hsiung, Robert Laforce, Michael D. Noseworthy, Frank S. Prato, Demetrios J. Sahlas, Eric E. Smith, Phillip H. Kuo, Vesna Sossi, Alexander Thiel, Jean-Paul Soucy, Jean-Claude Tardif, Sandra E. Black, Maged Goubran
Summary: This study investigated the association between cerebrovascular burden and cognitive function, and found that the relationship was mainly mediated by localized neurodegeneration rather than amyloid beta deposition. The results suggest an amyloid-independent pathway through which vascular burden affects cognitive function.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Florian Philipp Raber, Florian Vincent Gmeiner, Jens Dreyhaupt, Armin Wolf, Albert Christian Ludolph, Jens Ulrich Werner, Jan Kassubek, Katharina Althaus
Summary: This study aimed to investigate the feasibility, efficacy, and safety of intravenous thrombolysis (IVT) in functionally blind patients with non-arteritic central retinal artery occlusion (NA-CRAO). The results showed that early IVT therapy within 4.5 hours of symptom onset might be a potential treatment option for NA-CRAO. MRI should be performed in all patients for optimized treatment and secondary stroke prevention.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Nabeela Nathoo, Myrlene Gee, Krista Nelles, Jacqueline Burt, Hongfu Sun, Peter Seres, Alan H. Wilman, Christian Beaulieu, Fang Ba, Richard Camicioli
Summary: This study found that susceptibilities in basal ganglia and extra-basal ganglia structures are related to qualitative measures of gait impairment and freezing of gait in Parkinson's disease.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Avyarthana Dey, Collin C. Luk, Abdullah Ishaque, Daniel Ta, Ojas Srivastava, Dennell Krebs, Peter Seres, Chris Hanstock, Christian Beaulieu, Lawrence Korngut, Richard Frayne, Lorne Zinman, Simon Graham, Angela Genge, Hannah Briemberg, Sanjay Kalra
Summary: This study aimed to identify the structural and neurochemical properties that contribute to functional connectivity impairments in the primary motor cortex (PMC) in amyotrophic lateral sclerosis (ALS), and to understand the clinical implications of these findings. The analysis of multimodal data revealed reduced functional connectivity between the PMC and other regions in the brain, as well as alterations in neurochemical markers and diffusion metrics. Furthermore, there were correlations between neurochemical markers, diffusion metrics, and upper motor neuron function. These findings suggest that in vivo neurochemistry may serve as an effective imaging marker for assessing functional connectivity impairments in ALS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Seyed Amir Ali Adel, Sarah Treit, Wasan Abd Wahab, Graham Little, Laura Schmitt, Alan H. Wilman, Christian Beaulieu, Donald W. Gross
Summary: This study found stable volume, MD, and T2 changes in sclerotic hippocampi of TLE patients over time, with good sensitivity and specificity in detecting subfield neuron loss on postsurgical histology using MD and T2 maps. Therefore, high-resolution hippocampal DTI and T2 may have the potential to diagnose HS subtype before surgery.
Review
Clinical Neurology
Martin Regensburger, Chi Wang Ip, Zacharias Kohl, Christoph Schrader, Peter P. Urban, Jan Kassubek, Wolfgang H. Jost
Summary: Inhibitors of monoamine oxidase B (MAO-B) and catechol-O-methyltransferase (COMT) are important strategies in Parkinson's disease treatment. Several drugs have been available on the market for more than a decade, while others have been approved more recently. Various post-authorization studies have provided comprehensive data on their use and characteristics in real-life clinical practice. This article summarizes the current knowledge on these medications and discusses their clinical value in Parkinson's disease, as well as practical considerations and ongoing studies.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Hans-Peter Mueller, Anna Behler, Maximilian Muench, Johannes Dorst, Albert C. C. Ludolph, Jan Kassubek
Summary: This study investigates the association between the sequential alteration pattern and disease severity in patients with ALS using diffusion tensor imaging (DTI). The results show that the progression of white matter alterations across tracts is associated with clinical disease severity, suggesting the use of staging-based DTI as a technical marker for disease progression.
JOURNAL OF NEUROLOGY
(2023)
Article
Biophysics
Diana Valdes Cabrera, Gregg Blevins, Penelope Smyth, Derek Emery, Kevin Grant Solar, Christian Beaulieu
Summary: High-resolution DTI and T2 mapping revealed abnormalities in the hippocampus of patients with multiple sclerosis. In patients with cognitive impairment, higher MD and T2 values and lower FA and volume were observed. These abnormalities may be associated with demyelination, neuron loss, and/or inflammation.
NMR IN BIOMEDICINE
(2023)
Article
Neurosciences
Wolfgang Becker, Anna Behler, Olga Vintonyak, Jan Kassubek
Summary: The characteristics of microsaccades and square wave jerks (SWJs) have been found to follow common patterns in different neurodegenerative disorders. The amplitude of microsaccades is related to the frequency of SWJ-like patterns. This suggests that there are differences in microsaccade characteristics between different diseases, possibly due to different underlying mechanisms.
EXPERIMENTAL BRAIN RESEARCH
(2023)
Article
Behavioral Sciences
Tanushka Anand, Abdullah Ishaque, Daniel Ta, Muhammad Umer Khan, Komal Bharti, Andrew Wu, Dennell Krebs, Christian Beaulieu, Peter Seres, Sanjay Kalra
Summary: DKI can provide complementary information to DTI for understanding the pathology and microstructural alterations in patients with motor neuron disease and UMN dysfunction. Abnormalities in the CST and CC were observed, with higher mean and radial diffusivity and lower FA, kurtosis anisotropy, MK, and RK in patients compared to controls. The changes were concentrated in specific areas and correlated with disease progression rate and UMN burden.
BRAIN AND BEHAVIOR
(2023)
Article
Genetics & Heredity
Sarah Jesse, Hans-Peter Mueller, Hans-Juergen Huppertz, Stephanie Andres, Albert C. Ludolph, Michael Schoen, Tobias M. Boeckers, Jan Kassubek
Summary: Alterations of CSF markers in Phelan-McDermid syndrome patients were found to be correlated with structural connectivity losses. These findings have important implications for further clinical diagnostics and basic research.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Clinical Neurology
Jan Kassubek, Fabrizio Stocchi, Ernest Balaguer Martinez, Rajesh Pahwa, William Ondo, Yi Zhang, Alyssa Bowling, Eric Pappert, Stuart Isaacson, Stacy Wu
Summary: Most patients with Parkinson's disease were able to optimize the dosage of sublingual apomorphine at home and find their optimal dosage.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2023)
Article
Neuroimaging
Maximilian Wiesenfarth, Hans-Juergen Huppertz, Johannes Dorst, Dorothee Lule, Albert C. Ludolph, Hans-Peter Mueller, Jan Kassubek
Summary: This study explores the MRI characteristics of C9orf72-associated ALS and finds significant alterations in both white matter and gray matter in the early stages of the disease.
NEUROIMAGE-CLINICAL
(2023)