Article
Behavioral Sciences
Laura Canafoglia, Ilaria Vigano, Edoardo Ferlazzo, Elisa Visani, Tiziana Granata, Aglaia Vignoli, Francesca Ragona, Sara Gasparini, Umberto Aguglia, Maria Paola Canevini, Giulia Varotto, Ferruccio Panzica, Silvana Franceschetti
Summary: The study compared EEG signals of drug-naive patients with juvenile myoclonic epilepsy (JME) and juvenile absence epilepsy (JAE) and found different network dysfunctions, potentially leading to distinct presentations of the two syndromes. JME showed regional network changes in alpha and beta bands, while JAE exhibited reduced Global/Local Efficiency and Clustering Coefficient in the gamma band.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Magnus Spangsberg Boesen, Malene Landbo Borresen, Soren Kirchhoff Christensen, Amalie Wandel Klein-Petersen, Sahla El Mahdaoui, Malini Vendela Sagar, Emilie Schou, Anna Korsgaard Eltvedt, Maria Jose Miranda, Alfred Peter Born, Peter Vilhelm Uldall, Lau Caspar Thygesen, Melita Cacic Hribljan
Summary: The study found that juvenile absence epilepsy and juvenile myoclonic epilepsy had slightly poorer school performance compared to the control group, with absence epilepsy having an increased risk for special education needs. Both types of epilepsy patients had higher use of sleep medication.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Lorenzo Caciagli, Corey Ratcliffe, Fenglai Xiao, Louis A. A. van Graan, Karin Trimmel, Christian Vollmar, Maria Centeno, John S. S. Duncan, Pamela J. J. Thompson, Sallie Baxendale, Matthias J. J. Koepp, Britta Wandschneider
Summary: The objective of this study was to characterize the cognitive profile of juvenile absence epilepsy (JAE), identify familial cognitive traits, determine the clinical significance of JAE-associated cognitive traits, compare JAE with juvenile myoclonic epilepsy (JME) to identify shared or syndrome-specific cognitive traits, and identify relationships between cognitive abilities and clinical characteristics.
Article
Clinical Neurology
Ali A. Asadi-Pooya, Mohsen Farazdaghi
Summary: The study aimed to differentiate childhood absence epilepsy (CAE) from juvenile absence epilepsy (JAE) based on their clinical characteristics. The age at onset of seizures was found to be an important indicator for distinguishing between the two syndromes, with significant implications for treatment strategy and outcome prediction.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2022)
Article
Clinical Neurology
Tianhua Yang, Yingying Zhang, Tianyu Zhang, Huanyu Zhou, Menghan Yang, Jiechuan Ren, Lei Li, Du Lei, Qiyong Gong, Dong Zhou
Summary: The objective of this study was to investigate the changes in dynamic functional connectivity (dFC) of striatal-cortical circuits in juvenile myoclonic epilepsy (JME). The results showed increased dFC variability in fronto-striatal and striatal-thalamic networks and decreased dFC variability between striatum subdivisions and the default mode network (DMN) in JME patients compared with healthy controls. Furthermore, the hypervariability between specific regions of the striatum and cortex was positively correlated with the frequency of myoclonic seizures in JME patients.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2022)
Article
Behavioral Sciences
Dong Ah Lee, Junghae Ko, Ho-Joon Lee, Hyung Chan Kim, Bong Soo Park, Sihyung Park, Il Hwan Kim, Jin Han Park, Yoo Jin Lee, Kang Min Park
Summary: The study found no significant volume differences in the nuclei of the amygdala and hippocampal subfields between patients with JME and healthy controls. However, there were significant differences in the global network, with decreased mean clustering coefficient in JME patients. Specific regions in the hippocampal subfields also showed increased betweenness centrality in patients with JME compared to healthy controls.
BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Anatolie Vataman, Dumitru Ciolac, Vitalie Chiosa, Daniela Aftene, Pavel Leahu, Yaroslav Winter, Stanislav A. Groppa, Gabriel Gonzalez-Escamilla, Muthuraman Muthuraman, Sergiu Groppa
Summary: In this study, the temporal and spatial organization of functional networks and their dynamic properties in juvenile myoclonic epilepsy (JME) patients were characterized using high-density EEG (hdEEG) recordings and MRI data. It was found that the flexibility and controllability of network modules exhibit antagonistic dynamics during SWD generation in JME. The flexibility and controllability of the fronto-temporal module were found to be related to seizure frequency and cognitive performance in JME patients. These findings have implications for the diagnosis and treatment of JME.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Christina Stier, Adham Elshahabi, Yiwen Li Hegner, Raviteja Kotikalapudi, Justus Marquetand, Christoph Braun, Holger Lerche, Niels K. Focke
Summary: The study aimed to assess the heritability of neuronal signals in patients with genetic generalized epilepsy (GGE) by examining magnetoencephalography resting-state recordings in patients and their healthy siblings. The results showed that the imaging metrics in GGE patients were heritable in certain brain regions, mainly in beta frequencies, and that high power and connectivity levels co-segregated in patients with GGE and healthy siblings. This suggests that brain oscillations in GGE are likely related to genetic factors and represent an endophenotype of the disorder.
Article
Clinical Neurology
Ali A. Asadi-Pooya, Mohsen Farazdaghi
Summary: This study applied Two-step cluster analysis on a large dataset of patients with juvenile myoclonic epilepsy (JME) to identify distinct subgroups with similar clinical characteristics and evaluate the differences in seizure outcomes between these clusters. The analysis revealed two homogeneous clusters of patients with JME and demonstrated that the response to treatment at 12 months differed between these clusters.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2023)
Article
Clinical Neurology
John M. Bernabei, Nishant Sinha, T. Campbell Arnold, Erin Conrad, Ian Ong, Akash R. Pattnaik, Joel M. Stein, Russell T. Shinohara, Timothy H. Lucas, Dani S. Bassett, Kathryn A. Davis, Brian Litt
Summary: Bernabei et al. constructed an atlas of normative interictal intracranial EEG recordings and found that brain regions generating spikes and seizures have different patterns of activity and connectivity compared to the atlas. Comparing EEG recordings to the atlas can reliably identify abnormal regions and guide invasive treatment for epilepsy.
Article
Clinical Neurology
Marinho A. Lopes, Dominik Krzeminski, Khalid Hamandi, Krish D. Singh, Naoki Masuda, John R. Terry, Jiaxiang Zhang
Summary: The study investigated the applicability of the BNI framework to resting-state MEG in patients with JME, finding that patients with JME had a higher propensity to generate seizures compared to healthy controls. The BNI framework was effective in differentiating between epilepsy patients and healthy controls.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Efrain Santiago-Rodriguez, Elba Zaldivar-Uribe
Summary: Juvenile myoclonic epilepsy (JME) is characterized by different types of seizures and various characteristics of background EEG activity and paroxysmal events. Precipitating factors include sleep deprivation, alcoholic beverage intake, and stress. Abnormalities in background EEG activity increase when quantitative analysis is used.
Article
Health Care Sciences & Services
Siew-Na Lim, Tony Wu, Wei-En Johnny Tseng, Chun-Wei Chang, Hsiang-Yao Hsieh, Mei-Yun Cheng, Hsing- Chiang, Chih-Hong Lee, Wey-Ran Lin, Chun-Jing Liu
Summary: This study aimed to investigate the clinical and social features of patients with juvenile myoclonic epilepsy (JME) and determine the factors associated with outcomes. The findings showed that despite optimal treatment with antiseizure medications, a considerable proportion of JME patients did not achieve seizure freedom. The presence of epileptiform discharges and seizures during sleep were significantly associated with worse seizure outcomes, and seizure-free patients had a higher employment rate compared to those with ongoing seizures.
Article
Clinical Neurology
Maria Vlachou, Georgios Alexandros Skrimpas, Mustafa Aykut Kural, Gija Rackauskaite, Natalya Nikanorova, Jakob Christensen, Marina Nikanorova, Sandor Beniczky
Summary: This study characterized the electroclinical features of typical absence seizures and found additional semiological features besides the hallmark manifestations. However, none of these features could predict long-term therapeutic outcome. The presence of polyspikes was the only significant predictor of an unfavorable therapeutic outcome, highlighting its importance when reporting EEGs in patients with typical absence seizures.
EPILEPTIC DISORDERS
(2022)
Article
Clinical Neurology
Jacopo Lanzone, Lorenzo Ricci, Mario Tombini, Marilisa Boscarino, Oriano Mecarelli, Patrizia Pulitano, Vincenzo Di Lazzaro, Giovanni Assenza
Summary: This study examined qEEG changes in patients with epilepsy receiving Perampanel (PER) as add-on therapy, revealing increased theta power but no significant alteration in EEG connectivity. Compared to healthy controls, patients showed differences in beta power and connectivity in delta and theta ranges. Alpha power may serve as a predictor of treatment response.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Sofia Kasradze, Giorgi Lomidze, J. Helen Cross, David Kvernadze, Maia Alkhidze, Tamar Gagoshidze
Summary: This study found that children with epilepsy in Georgia often exhibit abnormalities in various neuropsychological domains, with factors such as early age of seizure onset, epilepsy duration, and anti-seizure medication use influencing these impairments. Evaluation of cognitive functions should be an integral part of diagnosing epilepsy to ensure effective management of the disorder.
BRAIN & DEVELOPMENT
(2021)
Article
Clinical Neurology
Giorgi Japaridze, Dirk Loeckx, Tim Buckinx, Sidsel Armand Larsen, Renee Proost, Katrien Jansen, Paul MacMullin, Natalia Paiva, Sofia Kasradze, Alexander Rotenberg, Lieven Lagae, Sandor Beniczky
Summary: The study aimed to evaluate the accuracy of fully automated absence seizure detection using a wearable EEG device and test the feasibility of automated behavioral testing triggered by the detection. The algorithm analyzed real-time EEG data using artificial intelligence, and the results were compared with expert evaluation of video-EEGs.
Article
Clinical Neurology
Ana Kvernadze, Nana Tatishvili, Giorgi Lomidze, Nino Tarkhnishvili, Tamar Kipiani, Sofia Tatishvili
Summary: The study found that onset of infantile spasms before seven months, pre-existing developmental delay, low ASQ scores, and structural abnormalities on MRI are predictors of poor developmental outcomes for patients.
EPILEPTIC DISORDERS
(2022)
Article
Virology
Leila Tabatadze, Ekaterine Gabashvili, Saba Kobakhidze, George Lomidze, Jimsher Loladze, Levan Tsitskishvili, Mamuka Kotetishvili
Summary: Genetic relationships between rabies virus isolates recovered from Georgia suggest a risk of dog-to-cattle transmission and provide evidence for coinfections with different strains and transborder transmission.
ARCHIVES OF VIROLOGY
(2022)
Article
Infectious Diseases
Maia Metreveli, Salome Bulia, Liana Tevzadze, Shota Tsanava, Michael Zarske, Juan Cruz Goenaga, Sandra Preuss, Giorgi Lomidze, Stylianos Koulouris, Paata Imnadze, Kerstin Stingl
Summary: This study investigates the antimicrobial resistance and genetic diversity of Campylobacter spp. isolated from human and poultry samples in Georgia. The study reveals high resistance to tetracycline in C. coli from industrial chicken and low resistance to tetracycline in C. jejuni from clinical isolates. Point mutations in gyrA and tet (O) genes are identified as resistance determinants. The study also highlights the high variability of multi-locus sequence types in Georgian strains. This study provides important data for monitoring antibiotic resistance in Georgia.
Article
Medicine, General & Internal
Pietro Mattioli, Evy Cleeren, Levente Hadady, Alberto Cossu, Thomas Cloppenborg, Dario Arnaldi, Sandor Beniczky
Summary: This study investigated the inter-analyser agreement of ESI in presurgical evaluations of epilepsy, using the same software and analysis pipeline. The results showed that newly trained experts reached similar ESI solutions, highlighting the need for more standardization in this emerging clinical application.
Article
Public, Environmental & Occupational Health
Medea Zirakashvili, Maia Gabunia, Nana Mebonia, Tamar Mikiashvili, Giorgi Lomidze, Somer Bishop, Bennett Leventhal, Young Shin Kim
Summary: This study aimed to adapt and validate the ASSQ for use in Georgia, where data from over 15,000 parents and 13,000 teachers revealed significant differences in scores. The cutoff score of 14 showed high sensitivity for identifying children with ASD, making it a valuable tool for clinicians in school settings.
JOURNAL OF PUBLIC MENTAL HEALTH
(2022)
Article
Pediatrics
Tatia Aprasidze, Teona Shatirishvili, Gabriela Oesch, Giorgi Lomidze, Nana Tatishvili
Summary: This study aims to correlate different measurement scales and obtain long-term outcome information on children with arterial ischemic stroke. The results show that there is a correlation between PSOM scores and mRS scores, indicating that long-term neurological deficits are related to functional outcome. Therefore, early appropriate rehabilitative therapy may improve the outcome.
JOURNAL OF PEDIATRIC NEUROLOGY
(2023)
Article
Behavioral Sciences
Sofia Kasradze, Nino Gogatishvili, Marine Lazariashvili, Giorgi Lomidze, Josemir W. Sander
Summary: The study adapted and validated a Georgian version of the Stigma Scale of Epilepsy, finding it to be a valid and reliable tool for assessing epilepsy-related stigma determinants among the country's population.
EPILEPSY & BEHAVIOR
(2023)
Proceedings Paper
Computer Science, Information Systems
Giorgi Lomidze, Daniel Schuster, Chiao-Yun Li, Sebastiaan J. van Zelst
Summary: This paper presents a novel approach to convert BPMN models with exception events into reset nets, reducing the number of invisible transitions required in the transformation and reducing the computational effort for conformance checking.
ENTERPRISE DESIGN, OPERATIONS, AND COMPUTING, EDOC 2022
(2022)
Article
Neurosciences
Giorgi Japaridze, Sofia Kasradze, Harald Aurlien, Sandor Beniczky
Summary: Implementing the freeware version of the SCORE EEG system improves the quality of clinical EEG reading, as evidenced by higher usability ratings from referring physicians.
CLINICAL NEUROPHYSIOLOGY PRACTICE
(2022)
Meeting Abstract
Clinical Neurology
A. Kvernadze, N. Tatishvili, G. Lomidze, T. Kipiani, N. Tarkhnishvili, S. Tatishvili, A. Kotetishvili
Meeting Abstract
Clinical Neurology
Sofia Kasradze, Giorgi Lomidze, Lasha Ephremidze, Ilya Spitkovsky
Meeting Abstract
Clinical Neurology
Sofia Kasradze, Giorgi Lomidze, Lasha Ephremidze, Ilya Spitkovsky
Article
Pediatrics
Tatia Aprasidze, Nana Tatishvili, Teona Shatirishvili, Giorgi Lomidze
Summary: This study evaluated the long-term neurological outcome in children with arterial ischemic stroke (AIS) and found that approximately one-third of patients have long-term neurological deficits. Male gender, multiple stroke episodes, and infarctions involving a combination of cortical and subcortical areas were associated with worse neurological outcomes. Pediatric AIS carries the risk of long-term morbidity, with neuroimaging serving as a predictive factor for outcome.
JOURNAL OF PEDIATRIC NEUROLOGY
(2021)
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)
