Article
Neurosciences
Martina Bockova, Eva Vytvarova, Martin Lamos, Petr Klimes, Pavel Jurak, Josef Halamek, Sabina Goldemundova, Marek Balaz, Ivan Rektor
Summary: The response to subthalamic nucleus deep brain stimulation (STN-DBS) varies individually and is difficult to predict. While most patients did not show changes in global network organization, suboptimal responders exhibited decreased global connectivity in the 1-8 Hz frequency range and regional node strength in frontal areas. The supplementary motor area was demonstrated to play an important role in the optimal response to DBS, with good responders showing increased node strength and eigenvector centrality in this brain region.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Kay Palopoli-Trojani, Stephen L. Schmidt, Karley D. Baringer, Theodore A. Slotkin, Jennifer J. Peters, Dennis A. Turner, Warren M. Grill
Summary: This study compared the effects of temporally non-regular patterns of deep brain stimulation (DBS) to traditional regularly-spaced pulses. It found that both patterns were equally effective in modulating motor symptoms, oscillatory activity, and DBS local evoked potentials (DLEPs). Additionally, one of the novel patterns allowed for longer duration DLEPs to be recorded during clinically effective stimulation.
Article
Neurosciences
Taylor J. Bosch, Rachel C. Cole, Yarema Bezchlibnyk, Oliver Flouty, Arun Singh
Summary: This study compared the effects of very low frequency (VLF) and high frequency (HF) deep brain stimulation (DBS) on lower-limb movement and motor cortical oscillations in Parkinson’s disease (PD) patients. The results showed that both VLF-DBS and HF-DBS reduced the speed of the pedaling task and increased motor cortical oscillations in the lower frequency band.
JOURNAL OF PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Joseph W. Olson, Arie Nakhmani, Zachary T. Irwin, Lloyd J. Edwards, Christopher L. Gonzalez, Melissa H. Wade, Sarah D. Black, Mohammad Z. Awad, Daniel J. Kuhman, Christopher P. Hurt, Bart L. Guthrie, Harrison C. Walker
Summary: This study investigates the characteristics of dystonia in patients with Parkinson's disease (PD) and its relationship with brain electrophysiology. The results show significant differences in spectral power in the motor cortex and subcortical areas during repetitive limb movements, especially in PD patients with dystonia.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Matthew J. J. Georgiades, James M. M. Shine, Moran Gilat, Jacqueline McMaster, Brian Owler, Neil Mahant, Simon J. G. Lewis
Summary: Patients with Parkinson's disease experience freezing of gait during cognitive tasks, and their subthalamic nucleus recordings show abnormal firing patterns at low frequencies, which may inform the development of deep brain stimulation protocols.
MOVEMENT DISORDERS
(2023)
Article
Neurosciences
Stefanie T. Jost, Lena Strobel, Alexandra Rizos, Philipp A. Loehrer, Keyoumars Ashkan, Julian Evans, Franz Rosenkranz, Michael T. Barbe, Gereon R. Fink, Jeremy Franklin, Anna Sauerbier, Christopher Nimsky, Afsar Sattari, K. Ray Chaudhuri, Angelo Antonini, Lars Timmermann, Pablo Martinez-Martin, Monty Silverdale, Elke Kalbe, Veerle Visser-Vandewalle, Haidar S. Dafsari
Summary: Previous studies have shown that women with Parkinson's disease (PD) have less access to deep brain stimulation (DBS) compared to men. This study observed and compared a total of 505 patients and found that women with PD were less likely to be referred for DBS, but more likely to be approved for the treatment. The study also found that women and men with PD had different preoperative symptoms and characteristics. However, both genders had similar improvements in clinical outcomes after the surgery.
NPJ PARKINSONS DISEASE
(2022)
Article
Neurosciences
Jonas R. Wagner, Miriam Schaper, Wolfgang Hamel, Manfred Westphal, Christian Gerloff, Andreas K. Engel, Christian K. E. Moll, Alessandro Gulberti, Monika Poetter-Nerger
Summary: The study demonstrates that STN+SN DBS is more effective than conventional STN DBS in improving gait impairment in Parkinson's disease patients. The cortical activity of patients during resting and effective stepping shows excessive synchronization in certain frequency bands, which is reduced by DBS. Different patterns of cortical activity are observed during freezing episodes with STN DBS and STN+SN DBS.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Eileen Gulke, Leon Juarez Paz, Heleen Scholtes, Christian Gerloff, Andrea A. Kuehn, Monika Potter-Nerger
Summary: This study evaluated the feasibility of a semi-automatic algorithm-guided programming approach for beneficial stimulation settings in Parkinson's disease patients. The results showed significant improvement in clinical effectiveness compared to standard care procedures. This method represents an important step towards future closed-loop DBS optimization systems.
NPJ PARKINSONS DISEASE
(2022)
Article
Neurosciences
Peter M. Lauro, Shane Lee, Umer Akbar, Wael F. Asaad
Summary: The study discovered distinct neurophysiological characteristics of tremor onset and maintenance in Parkinson's disease. The subthalamic nucleus plays a key role in tremor onset, while control of tremor shifts to cortex in sustained tremor state. Furthermore, changes in directed functional connectivity across sensorimotor cortex distinguish the sustained tremor state.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Giulia Di Rauso, Francesco Cavallieri, Isabella Campanini, Annalisa Gessani, Valentina Fioravanti, Alberto Feletti, Benedetta Damiano, Sara Scaltriti, Elisa Bardi, Maria Giulia Corni, Francesca Antonelli, Vittorio Rispoli, Francesca Cavalleri, Maria Angela Molinari, Sara Contardi, Elisa Menozzi, Annette Puzzolante, Jessica Rossi, Stefano Meletti, Giuseppe Biagini, Giacomo Pavesi, Valerie Fraix, Mirco Lusuardi, Alessandro Fraternali, Annibale Versari, Carla Budriesi, Elena Moro, Andrea Merlo, Franco Valzania
Summary: This study evaluated the long-term effects of STN-DBS on freezing of gait (FOG) in advanced Parkinson's Disease (PD). The results showed that FOG significantly improved in the on-stimulation/off-medication condition compared to the off-stimulation/off-medication condition, highlighting the possible beneficial long-term effects of STN-DBS on FOG.
Article
Neurosciences
Nicolas A. M. Zang, Marlieke Schneider, Daniel Weiss
Summary: The study aimed to explore the cortical neuronal mechanisms underlying movement recovery after freezing episodes in Parkinson's disease patients. The findings suggest that different cortical pathways are used when re-initiating movement after freezing or voluntary stops. These findings may facilitate the development of neuromodulation strategies to counteract freezing behavior.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Neurosciences
Miranda J. Munoz, Rishabh Arora, Yessenia M. Rivera, Quentin H. Drane, Gian D. Pal, Leo Verhagen Metman, Sepehr B. Sani, Joshua M. Rosenow, Lisa C. Goelz, Daniel M. Corcos, Fabian J. David
Summary: This study found that medication worsens saccade performance and benefits reaching performance, while STN-DBS benefits both saccade and reaching performance. These findings suggest potential physiological changes due to treatment.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Marwan Hariz, Patric Blomstedtl
Summary: Parkinson's disease is a progressive neurodegenerative illness with motor and nonmotor symptoms. Deep brain stimulation is an effective symptomatic treatment that can be tailored to individual patients. DBS has significant effects on tremors, rigidity, and dyskinesias, but less responsive for axial symptoms. Specialized multidisciplinary teams are required for DBS in PD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Neurosciences
Syed M. Zafar, Roopa Rajan, Syam Krishnan, Krishnakumar Kesavapisharady, Asha Kishore
Summary: Interleaved stimulation (ILS) through two adjacent contacts of the subthalamic nucleus (STN) provided significant short-term beneficial effects on freezing of gait (FOG) in patients with advanced Parkinson's disease. This resulted in improved gait scores and reduced FOG episodes during testing.
Article
Clinical Neurology
Abteen Mostofi, Francesca Morgante, Mark J. Edwards, Peter Brown, Erlick A. C. Pereira
Summary: Pain in Parkinson's disease is often untreated due to lack of understanding of its mechanisms. Deep brain stimulation of the subthalamic nucleus has shown potential in treating pain, but the exact type of pain it benefits and how it interferes with pain processing remain unclear.
Article
Medicine, Research & Experimental
Zi H. Su, Salil Patel, Bronwyn Gavine, Tim Buchanan, Marko Bogdanovic, Nagaraja Sarangmat, Alexander L. Green, Bastiaan R. Bloem, James J. FitzGerald, Chrystalina A. Antoniades
Summary: This study compared the effects of dopaminergic medication and subthalamic nucleus deep brain stimulation (STN DBS) on gait variability in Parkinson disease patients. The results showed that STN DBS reduced short-term variability in lower limb gait parameters, while medication did not have this effect. In addition, STN DBS had no effect on arm swing and trunk motion variability, while medication increased them.
Article
Clinical Neurology
Amir H. Talebi, Jan H. L. Ypinga, Nienke M. De Vries, Jorik Nonnekes, Marten Munneke, Bas R. Bloem, Tom Heskes, Yoav Ben-Shlomo, Sirwan K. L. Darweesh
Summary: Specialized physiotherapy and occupational therapy can reduce the incidence rate of Parkinson's disease-related complications. There may be a synergistic effect among multiple specialized allied health disciplines. The findings of this study support the introduction of specialized allied health therapy expertise in Parkinson's disease care.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Eva-Juliane Vollstedt, Susen Schaake, Katja Lohmann, Shalini Padmanabhan, Alexis Brice, Suzanne Lesage, Christelle Tesson, Marie Vidailhet, Isabel Wurster, Faycel Hentati, Anat Mirelman, Nir Giladi, Karen Marder, Cheryl Waters, Stanley Fahn, Meike Kasten, Norbert Bruggemann, Max Borsche, Tatiana Foroud, Eduardo Tolosa, Alicia Garrido, Grazia Annesi, Monica Gagliardi, Maria Bozi, Leonidas Stefanis, Joaquim J. Ferreira, Leonor Correia Guedes, Micol Avenali, Simona Petrucci, Lorraine Clark, Ekaterina Y. Fedotova, Natalya Y. Abramycheva, Victoria Alvarez, Manuel Menendez-Gonzalez, Silvia Jesus Maestre, Pilar Gomez-Garre, Pablo Mir, Andrea Carmine Belin, Caroline Ran, Chin-Hsien Lin, Ming-Che Kuo, David Crosiers, Zbigniew K. Wszolek, Owen A. Ross, Joseph Jankovic, Kenya Nishioka, Manabu Funayama, Jordi Clarimon, Caroline H. Williams-Gray, Marta Camacho, Mario Cornejo-Olivas, Luis Torres-Ramirez, Yih-Ru Wu, Guey-Jen Lee-Chen, Ana Morgadinho, Teeratorn Pulkes, Pichet Termsarasab, Daniela Berg, Gregor Kuhlenbaumer, Andrea A. Kuhn, Friederike Borngraeber, Giuseppe de Michele, Anna De Rosa, Alexander Zimprich, Andreas Puschmann, George D. Mellick, Jolanta Dorszewska, Jonathan Carr, Rosangela Ferese, Stefano Gambardella, Bruce Chase, Katerina Markopoulou, Wataru Satake, Tatsushi Toda, Malco Rossi, Marcelo Merello, Timothy Lynch, Diana A. Olszewska, Shen-Yang Lim, Azlina Ahmad-Annuar, Ai Huey Tan, Bashayer Al-Mubarak, Hasmet Hanagasi, Dariusz Koziorowski, Sibel Ertan, Gencer Genc, Patricia de Carvalho Aguiar, Melinda Barkhuizen, Marcia M. G. Pimentel, Rachel Saunders-Pullman, Bart van de Warrenburg, Susan Bressman, Mathias Toft, Silke Appel-Cresswell, Anthony E. Lang, Matej Skorvanek, Agnita J. W. Boon, Rejko Kruger, Esther M. Sammler, Vitor Tumas, Bao-Rong Zhang, Gaetan Garraux, Sun Ju Chung, Yun Joong Kim, Juliane Winkelmann, Carolyn M. Sue, Eng-King Tan, Joana Damasio, Peter Klivenyi, Vladimir S. Kostic, David Arkadir, Mika Martikainen, Vanderci Borges, Jens Michael Hertz, Laura Brighina, Mariana Spitz, Oksana Suchowersky, Olaf Riess, Parimal Das, Brit Mollenhauer, Emilia M. Gatto, Maria Skaalum Petersen, Nobutaka Hattori, Ruey-Meei Wu, Sergey N. Illarioshkin, Enza Maria Valente, Jan O. Aasly, Anna Aasly, Roy N. Alcalay, Avner Thaler, Matthew J. Farrer, Kathrin Brockmann, Jean-Christophe Corvol, Christine Klein
Summary: Through a worldwide online survey, we established an international cohort of individuals with PD-linked variants, providing harmonized and quality-controlled clinical and genetic data for each participant and promoting collaboration among researchers in the field of monogenic PD.
MOVEMENT DISORDERS
(2023)
Editorial Material
Neurosciences
Bastiaan R. Bloem, Lorraine V. Kalia
JOURNAL OF PARKINSONS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Ayami Okuzumi, Taku Hatano, Gen Matsumoto, Shuko Nojiri, Shin-ichi Ueno, Yoko Imamichi-Tatano, Haruka Kimura, Soichiro Kakuta, Akihide Kondo, Takeshi Fukuhara, Yuanzhe Li, Manabu Funayama, Shinji Saiki, Daisuke Taniguchi, Taiji Tsunemi, Deborah McIntyre, Jean-Jacques Gerardy, Michel Mittelbronn, Rejko Kruger, Yasuo Uchiyama, Nobuyuki Nukina, Nobutaka Hattori
Summary: A modified assay system (IP/RT-QuIC) has been developed to detect pathogenic alpha-synuclein seeds in the serum of individuals with synucleinopathies. The system showed high diagnostic performance for differentiating Parkinson's disease and multiple system atrophy from controls.
Article
Cell & Tissue Engineering
Axel Chemla, Giuseppe Arena, Claudia Saraiva, Clara Berenguer-Escuder, Dajana Grossmann, Anne Grunewald, Christine Klein, Philip Seibler, Jens C. Schwamborn, Rejko Kruger
Summary: In this study, two Parkinson's disease patients' primary skin fibroblasts carrying distinct heterozygous mutations in the RHOT1 gene encoding Miro1 were reprogrammed into induced pluripotent stem cells (iPSCs) using episomal reprogramming. Isogenic gene-corrected lines were generated using CRISPR/Cas9 technology. Both isogenic pairs were comprehensively characterized and quality assured to study the Miro1-related molecular mechanisms underlying neurodegeneration in iPSC-derived neuronal models.
STEM CELL RESEARCH
(2023)
Review
Neurosciences
Anouk Tosserams, Bastiaan R. Bloem, Kaylena Ehgoetz A. Martens, Rick C. Helmich, Roy P. C. Kessels, James M. Shine, Natasha L. Taylor, Gabriel Wainstein, Simon J. G. Lewis, Jorik Nonnekes
Summary: In stressful situations, individuals with Parkinson's disease (PD) may experience worsening of motor symptoms, including gait impairments. However, some patients report benefits from stressful or high-arousal situations. A study with 4324 PD patients shows that they use various mental strategies to cope with gait impairments, which can either increase or decrease overall sympathetic tone. This suggests that arousal can have both detrimental and alleviating effects on gait control in PD.
TRANSLATIONAL NEURODEGENERATION
(2023)
Article
Neurosciences
Odette Fruendt, Anne-Marie Hanff, Annika Moehl, Tobias Mai, Christiane Kirchner, Ali Amouzandeh, Carsten Buhmann, Rejko Kruger, Martin Suedmeyer
Summary: Data on the use of device-aided therapies (DATs) in people with Parkinson's disease (PwP) are scarce. German DAT application rate is rather low, indicating a need for precise identification of symptoms and implementation in future treatment strategies.
Article
Neurosciences
Martin E. Johansson, Nina M. van Lier, Roy P. C. Kessels, Bastiaan R. Bloem, Rick C. Helmich
Summary: Heterogeneity in Parkinson's disease (PD) makes it difficult to understand the disease and develop treatments. Stratifying patients into subtypes based on clinical characteristics may help overcome this challenge. A recent study classified de novo PD patients into three subtypes and found that the diffuse-malignant subtype had more severe symptoms and faster progression compared to the mild-motor predominant subtype. These findings suggest different pathophysiological mechanisms underlie distinct PD subtypes.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Anne-Marie Hanff, Christopher McCrum, Armin Rauschenberger, Gloria A. Aguayo, Maurice P. Zeegers, Anja K. Leist, Rejko Kruger
Summary: This study aimed to validate the algorithm calculating the Functional Mobility Composite Score (FMCS) based on the Parkinson's Disease Questionnaire-39 (PDQ-39). The results showed that the FMCS has good convergent and discriminative validity, making it a reliable measure for assessing functional mobility through patient reports in people with Parkinson's disease.
PARKINSONISM & RELATED DISORDERS
(2023)
Editorial Material
Neurosciences
Federica Albanese, Bastiaan R. Bloem, Lorraine V. Kalia
Summary: Metascience emphasizes the importance of replication, reproducibility, and rigor in research, particularly in studying major diseases like Parkinson's disease.
JOURNAL OF PARKINSONS DISEASE
(2023)
Review
Clinical Neurology
Carlo Alberto Artusi, Christian Geroin, Jorik Nonnekes, Camila Aquino, Divyani Garg, Marian L. Dale, Darbe Schlosser, Yijie Lai, Mohammad Al-Wardat, Mehri Salari, Robin Wolke, Valery Tsinda Labou, Gabriele Imbalzano, Serena Camozzi, Marcelo Merello, Bastiaan R. Bloem, Tamine Capato, Ruth Djaldetti, Karen Doherty, Alfonso Fasano, Houyam Tibar, Leonardo Lopiano, Nils G. Margraf, Caroline Moreau, Yoshikazu Ugawa, Roongroj Bhidayasiri, Michele Tinazzi
Summary: Axial postural abnormalities are common in patients with Parkinson's disease and atypical parkinsonism, and have a significant impact on the patients' quality of life. However, there is limited understanding of the pathophysiology and clinical predictors of these symptoms, highlighting the need for further research in this area.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Milan Beckers, Peter J. Koehler, Geert J. A. Wanten, Bastiaan R. Bloem
Summary: There is a hypothesis suggesting that Adolf Hitler had Parkinson's disease and suffered from gastrointestinal symptoms, possibly linked to small-intestinal bacterial overgrowth (SIBO), serving as an early indication of Parkinson's.
EUROPEAN NEUROLOGY
(2023)
Letter
Clinical Neurology
Rui Araujo, Jos J. Kole, Joaquim J. Ferreira, Bastiaan R. Bloem
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Francisco Cardoso, Christopher G. Goetz, Tiago A. Mestre, Cristina Sampaio, Charles H. Adler, Daniela Berg, Bastiaan R. Bloem, David J. Burn, Michael S. Fitts, Thomas Gasser, Christine Klein, Marina A. J. de Tijssen, Anthony E. Lang, Shen-Yang Lim, Irene Litvan, Wassilios G. Meissner, Brit Mollenhauer, Njideka Okubadejo, Michael S. Okun, Ronald B. Postuma, Per Svenningsson, Louis C. S. Tan, Taiji Tsunemi, Sarah Wahlstrom-Helgren, Oscar S. Gershanik, Victor S. C. Fung, Claudia Trenkwalder
MOVEMENT DISORDERS
(2023)