期刊
NATURE GENETICS
卷 52, 期 7, 页码 642-643出版社
NATURE PORTFOLIO
DOI: 10.1038/s41588-020-0660-z
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资金
- NCI NIH HHS [U54 CA217376, P30 CA014089] Funding Source: Medline
- Wellcome Trust [202778/Z/16/Z] Funding Source: Medline
- Wellcome Trust [202778/Z/16/Z] Funding Source: Wellcome Trust
How 'difficult' is it for somatic evolution to produce a cell that is capable of leaving the primary tumor and growing in a distant organ? In this issue, Reiter et al. assess genetic diversity across metastatic lesions and identify a tight selective bottleneck preceding distant metastasis.
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