标题
Oncometabolites suppress DNA repair by disrupting local chromatin signalling
作者
关键词
-
出版物
NATURE
Volume 582, Issue 7813, Pages 586-591
出版商
Springer Science and Business Media LLC
发表日期
2020-06-04
DOI
10.1038/s41586-020-2363-0
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair
- (2018) Parker L. Sulkowski et al. NATURE GENETICS
- Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence
- (2017) Sevin Turcan et al. NATURE GENETICS
- 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity
- (2017) Parker L. Sulkowski et al. Science Translational Medicine
- Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self‐renewal and early development
- (2016) Marianne Terndrup Pedersen et al. EMBO JOURNAL
- A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading
- (2016) Chun-Min Shan et al. eLife
- Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents
- (2015) Pu Wang et al. Cell Reports
- DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin
- (2014) M. K. Ayrapetov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- KDM4A Lysine Demethylase Induces Site-Specific Copy Gain and Rereplication of Regions Amplified in Tumors
- (2013) Joshua C. Black et al. CELL
- What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
- (2013) J.-A. Losman et al. GENES & DEVELOPMENT
- Kdm4b Histone Demethylase Is a DNA Damage Response Protein and Confers a Survival Advantage following γ-Irradiation
- (2013) Leah C. Young et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells
- (2013) Ranjit S. Bindra et al. NUCLEIC ACIDS RESEARCH
- Quantitation of DNA double-strand break resection intermediates in human cells
- (2013) Yi Zhou et al. NUCLEIC ACIDS RESEARCH
- RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites
- (2012) Frédérick A Mallette et al. EMBO JOURNAL
- Inhibition of -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
- (2012) M. Xiao et al. GENES & DEVELOPMENT
- IDH mutation impairs histone demethylation and results in a block to cell differentiation
- (2012) Chao Lu et al. NATURE
- IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
- (2012) Sevin Turcan et al. NATURE
- Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
- (2011) Wei Xu et al. CANCER CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
- (2011) S. E. Polo et al. GENES & DEVELOPMENT
- Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
- (2009) Lenny Dang et al. NATURE
- Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
- (2009) Yingli Sun et al. NATURE CELL BIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now