Article
Neurosciences
Yifeng Shi, Mengqi Wang, Linglong Xiao, Luolan Gui, Wen Zheng, Lin Bai, Bo Su, Bin Li, Yangyang Xu, Wei Pan, Jie Zhang, Wei Wang
Summary: Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is effective for refractory obsessive-compulsive disorder (OCD). This study investigated the neurobiological mechanisms of OCD and the effect of NAc-DBS. The results showed that NAc-DBS modulated electrophysiological activities and neurotransmitter levels in the NAc, suggesting a potential therapeutic effect of NAc-DBS for OCD.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Fernando Lopez-Sosa, Blanca Reneses, Florencia Sanmartino, Ana Galarza-Vallejo, Julia Garcia-Albea, Alvaro J. Cruz-Gomez, Mar Yebra, Antonio Oliviero, Juan A. Barcia, Bryan A. Strange, Javier J. Gonzalez-Rosa
Summary: In this study, deep brain stimulation (DBS) of the nucleus accumbens (NAc) was found to significantly improve inhibitory control abilities in OCD patients, leading to increased cortical activation mainly in the right inferior frontal gyrus and medial frontal gyrus. This modulation of neuronal activity in the prefrontal regions may be triggered by reorganizing brain functions and is associated with underlying cortical thinning.
Article
Clinical Neurology
Svenja Treu, Javier J. Gonzalez-Rosa, Vanesa Soto-Leon, Diego Lozano-Soldevilla, Antonio Oliviero, Fernando Lopez-Sosa, Blanca Reneses-Prieto, Juan A. Barcia, Bryan A. Strange
Summary: This study investigated neuronal synchronization in OCD patients, revealing increased beta-gamma phase amplitude coupling in fronto-central scalp sensors compared to healthy controls, which may serve as a biomarker of OCD. The aberrant cross-frequency coupling normalized with DBS of the nucleus accumbens, suggesting a potential target for novel therapeutic approaches.
Article
Psychology, Clinical
Zhishun Wang, Martine Fontaine, Marilyn Cyr, Moira A. Rynn, Helen Blair Simpson, Rachel Marsh, David Pagliaccio
Summary: This study is the largest to date examining subcortical surface morphometry in OCD. The results show that individuals with OCD exhibit surface expansions on the right nucleus accumbens and inward left amygdala deformations, and these shape alterations are associated with OCD symptom severity. The study also found that these changes are driven by age and health status.
DEPRESSION AND ANXIETY
(2022)
Article
Neuroimaging
Thomas Schueller, Theo O. J. Gruendler, Ezra E. Smith, Juan Carlos Baldermann, Sina Kohl, Adrian G. Fischer, Veerle Visser-Vandewalle, Markus Ullsperger, Jens Kuhn, Daniel Huys
Summary: The study observed increased electromagnetic activity in the medial frontal cortex and striatum during negative performance feedback in patients with OCD, while decreased connectivity in the right lateral side was associated with symptom severity. Following DBS, electromagnetic activity in the medial frontal cortex significantly decreased.
NEUROIMAGE-CLINICAL
(2021)
Article
Clinical Neurology
Cristina Torres Diaz, Svenja Treu, Bryan Strange, Monica Lara, Marta Navas, Elena Ezquiaga, Elisa Seijo Zazo, Juncal Sevilla Vicente, Isabel Muniz, Fernando Seijo Fernandez
Summary: This study demonstrated that deep brain stimulation targeting the nucleus accumbens, internal capsule, and ventral striatum significantly improved symptoms in patients with medication-resistant obsessive-compulsive disorder. Adjustment of the stimulation site based on individual response may optimize treatment outcomes.
WORLD NEUROSURGERY
(2021)
Review
Clinical Neurology
Michael D. Staudt, Nader Pouratian, Jonathan P. Miller, Clement Hamani, Nataly Raviv, Guy M. McKhann, Jorge A. Gonzalez-Martinez, Julie G. Pilitsis
Summary: In 2020, a systematic review of literature on deep brain stimulation (DBS) for obsessive-compulsive disorder (OCD) was conducted to update the guidelines. Based on the data in the literature, recommendations were updated to include the use of bilateral subthalamic nucleus DBS or bilateral nucleus accumbens or bed nucleus of stria terminalis DBS for medically refractory OCD. There is insufficient evidence to determine the most effective target.
Editorial Material
Clinical Neurology
Trevor. W. Robbins
Summary: This scientific commentary discusses the research conducted by Kim et al. on the unbalanced fronto-pallidal neurocircuit underlying set shifting in patients with obsessive-compulsive disorder, published in the journal Brain.
Article
Clinical Neurology
Botao Xiong, Bin Li, Rong Wen, Yuan Gao, Feilong Gong, Denghui Li, Yangyang Xu, Hao Deng, Linglong Xiao, Senlin Yin, Wei Zhang, Andres M. Lozano, Wei Wang
Summary: This study investigates the effects of differential stimulation on the efficacy of DBS for OCD. By implanting a novel designed electrode and IPG that allows independent programming of different contacts, the study found that differential stimulation can significantly improve the outcomes of DBS for OCD.
JOURNAL OF NEUROSURGERY
(2023)
Article
Neurosciences
Tingting Xu, Yuan Gao, Bin Li, Jiaxin Jiang, Huirong Guo, Xianzhi Liu, Hongxing Huang, Yuqi Cheng, Hualin Yu, Jie Hu, Xi Wu, Wei Wang, Zhen Wang
Summary: This study aims to evaluate the efficacy and safety of combined ALIC- and NAcc-DBS for treatment-refractory OCD. A total of 64 patients will be recruited and randomly allocated to active and sham-stimulation groups. Primary outcome measures include treatment response rate and adverse events, while secondary outcome measures include changes in multiple scale scores.
Article
Clinical Neurology
Lorea Mar-Barrutia, Oliver Ibarrondo, Javier Mar, Eva Real, Cinto Segalas, Sara Bertolin, Marco Alberto Aparicio, Gerard Plans, Jose Manuel Menchon, Pino Alonso
Summary: This study assessed the long-term effectiveness and tolerability of Deep Brain Stimulation (DBS) in obsessive-compulsive disorder (OCD) patients. The results showed that DBS treatment significantly reduced obsessive symptoms and improved depression and functioning scores compared to the control group. The study confirms DBS as a valid option for the treatment of severe refractory OCD.
Article
Neurosciences
Lining Yin, Fang Han, Ying Yu, Qingyun Wang
Summary: Obsessive-compulsive disorder (OCD) is associated with abnormalities in brain networks, characterized by low-frequency oscillations and burst firing patterns. Dysregulation of the orbitofronto-subcortical loop may contribute to OCD and serve as a biomarker for diagnosis and treatment advancement.
COGNITIVE NEURODYNAMICS
(2023)
Article
Clinical Neurology
Matilda Naesstrom, Marwan Hariz, Lotta Stromsten, Owe Bodlund, Patric Blomstedt
Summary: DBS in the BNST shows promising clinical outcomes in severe therapy-refractory OCD, with improvements in YBOCS, MADRS, and Global Assessment of Functioning scores. However, further multidisciplinary clinical studies are needed to confirm the efficacy and safety of this treatment.
WORLD NEUROSURGERY
(2021)
Article
Neurosciences
Nozomi Asaoka, Masakazu Ibi, Hikari Hatakama, Koki Nagaoka, Kazumi Iwata, Misaki Matsumoto, Masato Katsuyama, Shuji Kaneko, Chihiro Yabe-Nishimura
Summary: The study revealed that NOX1 regulates repetitive behavior in mice by facilitating excitatory synaptic inputs in the central striatum. Deficiency or inhibition of NOX1 can significantly reduce repeated D-2 receptor stimulation-induced repetitive behavior without affecting motor responses.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Mehran Nematizadeh, Hossein Ghorbanzadeh, Hossein Sanjari Moghaddam, Mohammadreza Shalbafan, Mahsa Boroon, Amir-Abbas Keshavarz-Akhlaghi, Shahin Akhondzadeh
Summary: The main aim of this study was to investigate the additional effects of L-theanine on OCD symptoms in combination with fluvoxamine. The results suggest that L-theanine can be a relatively safe and effective adjuvant therapy for moderate to severe OCD.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)
