Review
Pharmacology & Pharmacy
Liang Han, Chen Jiang
Summary: This review focuses on nanoscale brain-targeting drug delivery strategies designed based on blood-brain barrier (BBB) alterations and their applications in various brain diseases. However, advances on optimization of small molecules for BBB crossing and non-systemic administration routes such as intranasal treatment are not included in this review.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Pharmacology & Pharmacy
Yulin Chen, Xianmin Wu, Jiadong Li, Yingying Jiang, Ke Xu, Jiacan Su
Summary: Targeted delivery of therapeutics to the bone can improve the treatment of bone metabolism diseases, and nanotechnology offers a more effective approach with reduced side effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Santosh Bashyal, Chhitij Thapa, Sangkil Lee
Summary: This article provides an overview of recent exosome-based drug delivery nanoplatforms and discusses the potential of using exosomes as drug delivery vehicles for treating brain diseases. Exosomes possess advantages such as barrier penetration, targeting capability, and stability, but also face challenges that need to be addressed through future research efforts.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Physical
Yue Jiang, Xueting Pan, Tao Yu, Hai Wang
Summary: The existence of the blood-brain barrier (BBB) poses challenges for drug delivery to the central nervous system (CNS). Intranasal administration has emerged as an alternative method for delivering drugs to the brain by bypassing the BBB. This review focuses on the mechanisms, properties, and strategies of intranasal nanosystems for brain-targeted drug delivery. Despite promising results in animal models and clinical applications, significant challenges need to be overcome for the translation of these nanosystems into clinics. The future prospects of intranasal drug delivery nanosystems are discussed, aiming to provide insights and guidance for effective neurological disease treatment.
Review
Chemistry, Multidisciplinary
Jia Li, Meng Zheng, Olga Shimoni, William A. Banks, Ashley I. Bush, Jennifer R. Gamble, Bingyang Shi
Summary: The blood-brain barrier is a crucial neurovascular unit that prevents harmful substances from entering the brain and maintains normal neuronal function. Disruption of BBB in diseases can contribute to disease progression, while restoration of BBB integrity is a biomarker for better clinical outcomes. The BBB also plays a role in facilitating communication between neuronal and circulatory systems, showing promising results for brain-targeted drug delivery.
Review
Pharmacology & Pharmacy
Jianzhuang Li, Yanhao Wei, Chunlin Zhang, Rentang Bi, Yanmei Qiu, Yanan Li, Bo Hu
Summary: Neurological diseases are a major cause of disability and death globally, and there is a need for improved treatments. Cell-membrane-coated nanoparticles have emerged as a promising drug delivery system with immune evasion and functional mimicry capabilities. This review provides an overview of single/hybrid cell-membrane-derived nanoparticles, discusses their application and safety in neurological diseases, and explores the challenges and opportunities in this field.
Article
Chemistry, Multidisciplinary
Jia Nong, Patrick M. M. Glassman, Jacob W. W. Myerson, Viviana Zuluaga-Ramirez, Alba Rodriguez-Garcia, Alvin Mukalel, Serena Omo-Lamai, Landis R. R. Walsh, Marco E. E. Zamora, Xijing Gong, Zhicheng Wang, Kartik Bhamidipati, Raisa Y. Y. Kiseleva, Carlos H. H. Villa, Colin Fred Greineder, Scott E. E. Kasner, Drew Weissman, Michael J. J. Mitchell, Silvia Muro, Yuri Persidsky, Jacob Samuel Brenner, Vladimir R. R. Muzykantov, Oscar A. A. Marcos-Contreras
Summary: The study investigated the loading of nanoparticles targeted to intercellular adhesion molecule 1 (anti-ICAM/NP) into white blood cells (WBC) in vivo, bypassing the ex vivo manipulation. The results showed successful transport of anti-ICAM/NP to pathological foci in the central nervous system (CNS) through the migration of WBCs from the lungs. This method could be clinically significant in the treatment of acute brain inflammation and reduction of brain edema.
Article
Chemistry, Multidisciplinary
Zhou Ye, Benjamin D. Gastfriend, Benjamin J. Umlauf, David M. Lynn, Eric Shusta
Summary: A receptor-mediated antibody-targeted liposomal system was developed and evaluated for targeted delivery of therapeutics into the brain. The system showed increased brain accumulation by targeting the brain vasculature through the blood-brain barrier. These findings indicate the potential of this system for transporting therapeutic molecules into the central nervous system.
PHARMACEUTICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Elena Marcello, Valeria Chiono
Summary: Intranasal drug delivery is a promising method for delivering drugs to the brain, bypassing the blood-brain barrier and reducing side effects. Drug penetration through the nasal epithelial barrier, diffusion along the olfactory or trigeminal nerves, and extracellular diffusion in the brain are involved in the drug delivery mechanism. Nanocarriers and hydrogels have been proposed to improve the effectiveness of intranasal drug delivery to the brain. This review paper discusses biomaterials-based strategies, challenges, and potential solutions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Yuzhe Sun, Edward Davis
Summary: The translation mentioned that achieving the promise of stimuli-responsive drug delivery systems for cancer treatment involves challenges like avoiding premature clearance, accumulating in tumors, and exhibiting appropriate payload release. However, the expanding toolbox of design tools from proof-of-concept studies each year helps address these requirements. Recent advances in targeting and stimuli-responsiveness, as well as challenges and potential solutions are discussed to assist researchers in overcoming interdisciplinary knowledge barriers and speeding up development in cancer therapy.
Article
Chemistry, Physical
Wenhao Zhong, Xinyu Zhang, Yunxin Zeng, Dongjun Lin, Jun Wu
Summary: Lung diseases, including COVID-19 and lung cancers, pose a significant threat to human health, with treatment and diagnosis becoming increasingly challenging. Nanotechnology, as an emerging technology, has shown promise in improving targeted drug delivery in the lungs, offering potential for enhancing therapeutic effects.
Review
Medicine, Research & Experimental
Danielle Paige Anthony, Manasa Hegde, Shreya S. Shetty, Thasneema Rafic, Srinivas Mutalik, B. S. Satish Rao
Summary: The blood-brain barrier is a complex structure composed of endothelial cells with tight junctions and regulated by various cells like astrocytes and neurons. While traditional drug delivery methods pose challenges for treating brain diseases, receptor-mediated drug delivery is considered an efficient and safe strategy that exploits the internalization of ligands by specific receptors on the blood-brain barrier.
Article
Pharmacology & Pharmacy
Nasrul Wathoni, Lisa Efriani Puluhulawa, I. Made Joni, Muchtaridi Muchtaridi, Ahmed Fouad Abdelwahab Mohammed, Khaled M. Elamin, Tiana Milanda, Dolih Gozali
Summary: Lung cancer, the second most common type of cancer, has the highest mortality rate. Nanoparticle technology is being developed for lung cancer therapies, but specific ligands are needed to enhance drug delivery precision. Monoclonal antibodies can actively target nanoparticles to cancer cells, but they have drawbacks. Formulating antibodies in nanoparticles can minimize these drawbacks and enhance drug targeting.
Article
Chemistry, Multidisciplinary
Haiyan Chen, Mengyuan Zhou, Yuteng Zeng, Tongtong Miao, Haoyuan Luo, Yang Tong, Mei Zhao, Rui Mu, Jiang Gu, Shudi Yang, Liang Han
Summary: This study proposes a biomimetic nanoparticle that utilizes the BBB invasion ability of Escherichia coli K1 (EC-K1) outer membrane for brain-targeted drug delivery. The nanoparticles penetrate the BBB through the transcellular vesicle transport pathway, which is mediated by the interactions between outer membrane protein A and gp96 on BBB endothelial cells. This nanoengineering strategy provides the loaded drugs with prolonged circulation, intracranial interstitial distribution, and extremely high biocompatibility. The study also reveals the potential of delivering therapeutics to treat gp96-overexpressing intracranial malignancies.
Review
Pharmacology & Pharmacy
Tanzeel Khan, Rashid Waseem, Zainy Zehra, Ayesha Aiman, Priyanka Bhardwaj, Jaoud Ansari, Md. Imtaiyaz Hassan, Asimul Islam
Summary: Mitochondria are essential organelles involved in various cellular functions, and their dysfunction can lead to the development of various diseases. Targeted drug delivery to mitochondria has become a promising strategy for the diagnosis, treatment, and prevention of diseases. Recent advancements in nanoformulations, such as polymeric nanoparticles and liposomes, have shown potential in overcoming the challenges associated with delivering therapeutic molecules to the mitochondria.
Article
Biochemistry & Molecular Biology
Anna Fosch, Maria Rodriguez-Garcia, Cristina Miralpeix, Sebastian Zagmutt, Maite Larranaga, Ana Cristina Reguera, Jesus Garcia-Chica, Laura Herrero, Dolors Serra, Nuria Casals, Rosalia Rodriguez-Rodriguez
Summary: Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance and disruption leads to obesity. The effects of saturated or unsaturated LCFA on hypothalamic-brown adipose tissue (BAT) axis and underlying mechanisms were investigated. Unsaturated LCFA increased BAT thermogenesis through CPT1C-mediated FA metabolism shift, while saturated LCFA did not. These findings provide new insight into neuronal circuitries activated by LCFA to drive thermogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Helena Muley, Karmele Valencia, Josefina Casas, Bea Moreno, Luis Botella, Fernando Lecanda, Rut Fado, Nuria Casals
Summary: Breast cancer is the most common malignancy in women worldwide, and chemoresistance is a major obstacle to patient survival. CPT1C expression has been found to be associated with plasma membrane remodelling and drug resistance in breast cancer cells, suggesting its potential as a predictive biomarker for breast cancer chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Rosalia Rodriguez-Rodriguez, Anna Fosch, Jesus Garcia-Chica, Sebastian Zagmutt, Nuria Casals
Summary: Tackling obesity requires uncovering new molecular pathways. The brain, especially the hypothalamus, plays a major role in regulating metabolic signals that control feeding behavior and energy expenditure. Hypothalamic lipid metabolism, particularly the CPT1 isoforms, are potential targets for obesity treatment.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Review
Cell Biology
Rut Fado, Sebastian Zagmutt, Laura Herrero, Helena Muley, Rosalia Rodriguez-Rodriguez, Huichang Bi, Dolors Serra, Nuria Casals
Summary: There is a need for reliable genetic biomarkers in the diagnosis, prognosis, and treatment of different tumor types. One potential biomarker is CPT1C, a neuronal protein involved in cancer cell adaptation to nutrient depletion and hypoxia. However, its molecular role in cancer cells is controversial. This review discusses the evidence on CPT1C in neurons and its potential role in lipid metabolism and cell adaptation to stressors in cancer cells.
CELL DEATH & DISEASE
(2023)
Review
Chemistry, Multidisciplinary
Vahideh Mohammadzadeh, Niloufar Rahiman, Horacio Cabral, Sabina Quader, Mohammad Reza Zirak, Mohammad Ehsan Taghavizadeh Yazdi, Mahmoud Reza Jaafari, Seyedeh Hoda Alavizadeh
Summary: Vaccination is an innovative strategy for cancer treatment that uses nanoparticles as carriers and adjuvants to enhance patients' anti-tumor immune response. Poly-?-glutamic acid nanoparticles have a natural origin and can be easily taken up by cells, leading to modulation of the tumor microenvironment and promotion of systemic anti-tumor immunity.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Nutrition & Dietetics
Ivonne Palacios-Marin, Dolors Serra, Josep Jimenez-Chillaron, Laura Herrero, Marijana Todorcevic
Summary: The increase in obesity worldwide has led to metabolic health complications, and understanding the cellular and lipid turnover in adipose tissue is crucial for mitigating the adverse effects of excess adiposity.
Article
Materials Science, Biomaterials
Jesus Garcia-Chica, West Kristian Dizon Paraiso, Sebastian Zagmutt, Anna Fosch, Ana Cristina Reguera, Sara Alzina, Laura Sanchez-Garcia, Shigeto Fukushima, Kazuko Toh, Nuria Casals, Dolors Serra, Laura Herrero, Jordi Garcia, Kazunori Kataoka, Xavier Ariza, Sabina Quader, Rosalia Rodriguez-Rodriguez
Summary: Targeting brain lipid metabolism is a promising strategy for regulating energy balance and combating metabolic diseases. However, it is difficult to selectively deliver drugs to the hypothalamus, which plays a crucial role in controlling metabolism. This study proposes the use of a nanomedicine that can effectively deliver a CPT1A inhibitor to the hypothalamus, leading to the modulation of food intake and peripheral metabolism in mice.
BIOMATERIALS SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Natalie E. Goeppert, Sabina Quader, Joachim F. R. Van Guyse, Christine Weber, Kazunori Kataoka, Ulrich S. Schubert
Summary: An amphiphilic block copolymer was synthesized and found to readily self-assemble into stable micelles, making it suitable for potential drug delivery applications. The encapsulation of panobinostat and imatinib into the micelles maintained their well-defined nature. The imatinib-loaded micelles showed higher cytotoxicity compared to the pure drug.
Article
Genetics & Heredity
Shihori Tanabe, Eger Boonstra, Taehun Hong, Sabina Quader, Ryuichi Ono, Horacio Cabral, Kazuhiko Aoyagi, Hiroshi Yokozaki, Edward J. Perkins, Hiroki Sasaki
Summary: This study analyzed the molecular networks of anti-cancer drugs such as cisplatin, carboplatin, oxaliplatin, and arsenic trioxide in various types of cancer to reveal the mechanism of drug resistance. The study also highlighted the significance of tumor microenvironment in the treatment of drug-resistant cancer.