期刊
NANO LETTERS
卷 20, 期 7, 页码 5367-5375出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c01723
关键词
Geometry-matching principle; spiky nanostructures; virus binding and inhibition; cellular membrane coating
类别
资金
- Deutsche Forschungsgemeinschaft (DFG) [(SFB) 765]
- China Scholarship Council (CSC)
- National Key R&D Program of China [2019YFA0110600, 2019YFA0110601]
- State Key Laboratory of Polymer Materials Engineering [sklpme2019-2-03]
- Fundamental Research Funds for the Central Universities
- Special Funds for Prevention and Control of COVID-19 of Sichuan University
- Thousand Youth Talents Plan
Geometry-matching has been known to benefit the formation of stable biological interactions in natural systems. Herein, we report that the spiky nanostructures with matched topography to the influenza A virus (IAV) virions could be used to design next-generation advanced virus inhibitors. We demonstrated that nanostructures with spikes between 5 and 10 nm bind significantly better to virions than smooth nanoparticles, due to the short spikes inserting into the gaps of glycoproteins of the IAV virion. Furthermore, an erythrocyte membrane (EM) was coated to target the IAV, and the obtained EM-coated nanostructures could efficiently prevent IAV virion binding to the cells and inhibit subsequent infection. In a postinfection study, the EM-coated nanostructures reduced >99.9% virus replication at the cellular nontoxic dosage. We predict that such a combination of geometry-matching topography and cellular membrane coating will also push forward the development of nanoinhibitors for other virus strains, including SARS-CoV-2.
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