Article
Food Science & Technology
Nazim Uddin Emon, Safaet Alam, Sajib Rudra, Susmita Roy Riya, Avi Paul, S. M. Moazzem Hossen, Ummay Kulsum, Amlan Ganguly
Summary: The research on the pharmacological potential of methanol extract of Piper nigrum demonstrated dose-dependent effects on antidepressant, anxiolytic, antipyretic, and thrombolytic activities.
FOOD SCIENCE & NUTRITION
(2021)
Article
Agricultural Engineering
Snehalata Khuntia, Bhaskar Chandra Sahoo, Jyotirmayee Lenka, Basudeba Kar, Suprava Sahoo
Summary: This study aimed to predict the in-silico interactions of C. caesia volatile constituents against the protein responsible for oxidative and microbial stress in order to investigate their potential for industrial and pharmaceutical applications. The in vitro validation of the antioxidant, antibacterial, and antifungal activity of the essential oils (EOs) derived from C. caesia rhizome and leaves confirmed the accuracy of the in-silico predictions. The major constituents in C. caesia EOs were curzerenone, camphor, eucalyptol, epicurzerenone, germacrone, viridifloral, muurola-4,10(14)-dien-1-ol, and globulol, which may be valuable sources for developing antioxidant and antimicrobial drugs.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Infectious Diseases
Crislene V. Perigo, Lenita L. Haber, Roselaine Facanali, Maria A. R. Vieira, Roseli B. Torres, Luis C. Bernacci, Elsie F. Guimaraes, Joao B. Baitello, Marcos E. G. Sobral, Vera Quecini, Marcia Ortiz M. Marques
Summary: In this study, the metabolite profiles of essential oils (EOs) from plants in the Atlantic Rainforest were determined, and their antimicrobial and biocidal activity were evaluated. The results demonstrated the antimicrobial potential of EOs and revealed novel macromolecular targets, as well as highlighted the chemical diversity of native species.
Article
Entomology
M. Shantal Rodriguez-Flores, Soraia I. Falcao, Olga Escuredo, M. Carmen Seijo, Miguel Vilas-Boas
Summary: Vespa velutina and V. crabro are eusocial insects where chemical communication plays a crucial role in social interactions. This study analyzed chemical compounds extracted from the heads of V. velutina and V. crabro using GC/MS, identifying carbohydrates, fatty acids, and hydrocarbons. The chemical profiles of both species were compared, with a differentiation made between queens and workers in V. velutina using chemometric techniques (PCA and LSD).
Article
Biochemistry & Molecular Biology
M. Shantal Rodriguez-Flores, Soraia I. Falcao, Olga Escuredo, Luis Queijo, M. Carmen Seijo, Miguel Vilas-Boas
Summary: Vespa velutina has been rapidly expanding throughout Galicia since 2012, causing human health risks and losses in the beekeeping sector. Studying insect-derived semiochemicals as an alternative to conventional pesticides could be an effective integrated pest management tool.
Article
Biochemical Research Methods
Noemi Molina-Fernandez, Sandra Rainieri, Riansares Munoz-Olivas, Paloma de Oro-Carretero, Jon Sanz-Landaluze
Summary: Antidepressant drugs are widely used for treating disorders like depression, with their presence and metabolites found in the environment. Research showed low bioaccumulation of these compounds in zebrafish, but evidence of metabolite transformation was observed after 6 hours of exposure.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Khushboo, Priyanka Kumari, Bechan Sharma, Anup Som
Summary: Depressive disorders are common psychiatric diseases globally. Chemical drugs for treatment of these disorders have undesirable effects, so there is a need to explore novel antidepressants from herbal sources. In this study, the ethanolic extract of garlic was analyzed and 35 compounds were found which may act as antidepressants. Computational analyses predicted compound 1 as a potential SSRI with strong inhibitory interaction, making it a potential antidepressant drug.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Reda F. A. Abdelhameed, Eman S. Habib, Ahmed K. Ibrahim, Koji Yamada, Maged S. Abdel-Kader, Amany K. Ibrahim, Safwat A. Ahmed, Jihan M. Badr, Mohamed S. Nafie
Summary: The study extensively investigated the chemical constituents of the nonpolar fractions of bamboo shoot skin, identifying a compound with potential anti-breast cancer properties. This compound showed significant effects in cell experiments, stimulating apoptosis in breast cancer cells and halting cell cycle progression.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Jyoti Tripathi, Sumit Gupta, Satyendra Gautam
Summary: This study found that the aqueous extract of Phaseolus vulgaris L. (common bean) has the ability to inhibit ACE enzyme, with alpha-cadinol showing the strongest binding affinity to ACE. Molecular dynamic simulation showed that the ACE:alpha-cadinol complex is stable and interacts with the hydrophobic residues of ACE's active site. This suggests that alpha-cadinol may serve as a potential drug for treating hypertension.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Medicinal
Rossella Fioravanti, Eleonora Proia, Ivan N. Tyurenkov, Denis V. Kurkin, Dmitry A. Bakulin, Nikolay S. Kovalev, Dmitry S. Sheikin, Ivan A. Kirillov, Maxim B. Nawrozkij, Andrey A. Vernigora, Leila L. Brunilina, Francesco Fiorentino, Milan Mladenovic, Dante Rotili, Rino Ragno
Summary: A series of new pyrimidine thioethers were prepared and evaluated as key intermediates in the synthesis of S-DABO antivirals. The evaluation aimed to find new structural analogues of the known antihypoxic drug Isothiobarbamine with improved pharmacological profile. In vivo studies identified compounds 5c, 5e, and 5f, which exhibited antidepressant/anxiolytic, performance enhancing, and nootropic properties. Furthermore, molecular modelling studies suggested the biomolecular mechanism of action and provided a SAR model for designing optimized compounds.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Pablo Rayff da Silva, Natalia Diniz NunesPazos, Thallita Karla Silva do Nascimento Gonzaga, Jessica Cabral de Andrade, Alefe Brito Monteiro, Anne Caroline Ribeiro Portela, Hugo Fernandes Oliveira Pires, Mayara Dos Santos Maia, Diogo Vilar da Fonseca, Marcus T. Scotti, Jose Maria Barbosa Filho, Damiao Pergentino de Sousa, Cicero Francisco Bezerra Felipe, Reinaldo Nobrega de Almeida, Luciana Scotti
Summary: This study evaluated the potential of the monoterpene tetrahydrolinalool as an anxiolytic and antidepressant through in vivo animal models and molecular docking. Results showed that tetrahydrolinalool at appropriate doses effectively reduced anxiety and depression symptoms without compromising locomotor activity or motor coordination in animals. It demonstrated promising energy values for potential pharmacological targets, indicating its potential as a drug candidate.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Plant Sciences
Ezgi Ersoy, Goncagul Suvari, Selami Ercan, Esra Eroglu Ozkan, Selim Karahan, Evin Ayguen Tuncay, Yeter Yesil Canturk, Emel Mataraci Kara, Gokhan Zengin, Mehmet Boga
Summary: This study aimed to determine the phytochemical compositions of the essential oils and ethanol extracts of Teucrium polium and Teucrium parviflorum collected from different locations in Turkiye, as well as investigate their in vitro antioxidant, anticancer, antimicrobial activities, and enzyme inhibitory activities. The results showed that these extracts were rich in various biologically important compounds and exhibited significant antioxidant and enzyme inhibitory activities. The root extract of Teucrium polium stood out with remarkable tyrosinase and urease inhibitory and cytotoxic activities.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Virginia Silveira, Karina Taciana Santos Rubio, Maria Elvira Poleti Martucci
Summary: Anxiety disorders are common mental health conditions, and essential oils may offer significant benefits in their treatment. This study evaluated the anxiolytic effects of Roman chamomile and tangerine essential oils in zebrafish and found that Roman chamomile oil exhibited anxiolytic effects, while tangerine oil showed a tendency to reduce anxiety.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dipayan Paul, Saurov Mahanta, Hui Tag, Sanjib Kumar Das, Debmalya Das Gupta, Bhaben Tanti, Rajendran Ananthan, Ranjan Das, Sanjay Jambhulkar, Pallabi Kalita Hui
Summary: Breast and stomach cancer are major causes of human mortality worldwide. The overexpression of the RTK proteins HER2 and VEGFR2 is responsible for the development and metastasis of these cancers. Natural compounds luteolin 7-O-glucoside and chlorogenic acid were identified as potential tyrosine kinase inhibitors for the treatment of these cancers.
MOLECULAR DIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
Mohamed M. Tawfik, Bassant Galal, Mohamed S. Nafie, Mona M. El Bous, Magdy El-Bana
Summary: This study investigates the cytotoxic activities of different forms of Cakile maritima ssp. aegyptiaca along the Mediterranean coast of Egypt. The results show that the extracts have selective cytotoxic activities against cancer cell lines, inducing apoptosis and regulating the expression of related genes.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Food Science & Technology
Fahima Abdellatif, Samir Begaa, Mohammed Messaoudi, Adel Benarfa, Hamza Ouakouak, Aicha Hassani, Barbara Sawicka, Jesus Simal Gandara
Summary: This study investigated the chemical composition of Melissa officinalis extracts and evaluated their antioxidant and antimicrobial activities. The results showed the presence of phenolic acids, flavonic aglycones, and heterosides, as well as good antioxidant and antimicrobial activities of the flavonoid extracts.
FOOD ANALYTICAL METHODS
(2023)
Article
Chemistry, Applied
Mahnaz Esteki, Neda Memarbashi, Jesus Simal-Gandara
Summary: The potential of FT-IR spectral fingerprinting was investigated for classifying tea samples based on their harvest season. The results demonstrated that the two harvest seasons of tea samples can be identified accurately using FT-IR spectral fingerprints. Classification and prediction of the harvest season of tea samples were achieved using PCA-LDA and PLS-LDA models.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Review
Medicine, General & Internal
Neil Patel, Yashendra Sethi, Nirja Kaka, Oroshay Kaiwan, Ishita Gupta, Rahma Sameh Shaheen, Shady Sapoor, Hitesh Chopra, Mihaela Simona Popoviciu, Talha Bin Emran, Simona Cavalu
Summary: Acute hepatitis is a growing concern with recent outbreaks affecting pediatric populations in around 35 countries, including developed nations. The outbreaks have been associated with devastating liver failure in approximately 10% of affected patients. Clinical presentation resembles typical acute hepatitis symptoms, but tests have come back negative for known hepatitis viruses, leading to the term non-HepA-E hepatitis. Adenovirus and SARS-CoV-2 have been identified as potential causes. International efforts are underway to establish diagnostic and management protocols to control these outbreaks. This comprehensive review aims to provide evidence-based conclusions to assist clinicians.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Manish Dhawan, Ali A. Rabaan, Mahmoud M. Al Fawarah, Souad A. Almuthree, Roua A. Alsubki, Amal H. Alfaraj, Mutaib M. Mashraqi, Saleh A. Alshamrani, Wesam A. Abduljabbar, Ameen S. S. Alwashmi, Fatimah Al Ibrahim, Abdulmonem A. Alsaleh, Faryal Khamis, Jameela Alsalman, Manish Sharma, Talha Bin Emran
Summary: The emergence of novel variants of SARS-CoV-2 and their ability to evade the immune response makes it essential to understand the mechanisms of interaction between the virus and the human immune system. This understanding is crucial for the development of effective vaccines against COVID-19. T cells play a critical role in reducing viral load and containing the infection, but their hyperactivation and reduced numbers are associated with severe disease. The involvement of T cells in determining the prognosis of SARS-CoV-2 infection and the strategies to enhance T cell-mediated immune responses are still not fully understood.
Review
Food Science & Technology
Anees Ahmed Khalil, Md. Mominur Rahman, Abdur Rauf, Md. Rezaul Islam, Sultana Juhara Manna, Ammar Ahmed Khan, Samee Ullah, Muhammad Nadeem Akhtar, Abdullah S. M. Aljohani, Waleed Abdulmonem, Jesus Simal-Gandara
Summary: The olive family, particularly Olea europaea L., is widely used for olive oil production. Different parts of the olive tree contain bioactive compounds such as oleuropein, apigenin, hydroxytyrosol, etc. Researchers have utilized various extraction methods to increase oleuropein yield, including maceration, soxhlet, microwave-assisted, ultrasonication, and supercritical fluid methods. This review focuses on in vitro and in vivo studies exploring the nutraceutical properties of oleuropein, revealing its potential in treating obesity, diabetes, cardiovascular complications, neurodegenerative diseases, cancer, inflammation, microbial infections, and oxidation. The comprehensive literature provided in this review contributes to the scientific community's understanding of oleuropein's absorption, metabolism, bioavailability, extraction techniques, and nutraceutical perspectives.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Medicine, Research & Experimental
Wasim Akram, Priti Tagde, Sakeel Ahmed, Swamita Arora, Talha Bin Emran, Ahmad O. Babalghith, Sherouk Hussein Sweilam, Jesus Simal-Gandara
Summary: Thousands of people worldwide die each year from various diseases, and finding innovative therapies to treat and reduce the impact of these diseases is a global concern.
Letter
Surgery
AbdulRahman A. Saied, Deepak Chandran, Hitesh Chopra, Abhijit Dey, Talha B. Emran, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Chemistry, Multidisciplinary
Yahaya Saadu Itas, Abdussalam Balarabe Suleiman, Chifu E. Ndikilar, Abdullahi Lawal, Razif Razali, Ismail Ibrahim Idowu, Mayeen Uddin Khandaker, Amina Muhammad Danmadami, Pervaiz Ahmad, Talha Bin Emran, Mohammad Rashed Iqbal Faruque
Summary: In this study, the structural, electronic, and optical properties of a combined system of carbon and boron nitride nanotubes were investigated. The results showed that the double-walled carbon boron nitride nanotube (DWCBNNT) systems exhibited high stability under different interwall distances. The electronic properties of DWCBNNTs revealed semiconducting behavior, and the optical properties demonstrated refractive capabilities in all directions, which make them suitable for use in magnifying glass materials.
JOURNAL OF CHEMISTRY
(2023)
Article
Food Science & Technology
Mohamed G. Shehata, Nourhan M. Abd El-Aziz, Taha Mehany, Jesus Simal-Gandara
Summary: In this study, two fermented milk beverages were produced using Taro leaves extract (TLE) at concentrations of 250 and 500 mg/L (FMTLE 250 and FMTLE 500). The study evaluated the polyphenolic profile, volatile compounds, antioxidant and antimicrobial activities of TLE, as well as the physicochemical properties, probiotic survival, and bio-accessibility of the supplemented beverages. The results showed that the beverages had high antioxidant and antimicrobial activities, and the probiotics remained stable during the digestion processes.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Mahema Sivakumar, Sheikh F. Ahmad, Talha Bin Emran, Paola Isabel Angulo-Bejarano, Ashutosh Sharma, Shiek S. S. J. Ahmed
Summary: This study identifies a potential therapeutic target for radioresistant breast cancer through protein network analysis and evaluates a phytochemical compound from brown algae as a promising candidate.
Article
Food Science & Technology
Lingchao Miao, Haolin Zhang, Meng Sam Cheong, Ruting Zhong, Paula Garcia-oliveira, Miguel A. Prieto, Ka-wing Cheng, Mingfu Wang, Hui Cao, Shaoping Nie, Jesus Simal-Gandara, Wai San Cheang, Jianbo Xiao
Summary: This study evaluated the anti-diabetic effect of apigenin, luteolin, and baicalein in insulin-resistant HepG2 cells. These flavonoids improved glucose consumption and glycogen synthesis abilities by activating GLUT4 and GSK-3 beta. They also inhibited the production of ROS and AGEs, which were related to the inhibition of NF-kappa B and P65 phosphorylation. The expression levels of IRS-1, IRS-2, and PI3K/Akt pathway were partially activated by the flavonoids.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Letter
Surgery
Shopnil Akash, Talha B. Emran, Hitesh Chopra, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Margarida Goncalves, Helena Pessegueiro, Judit Gandara, Jose Ramon Vizcaino, Vitor Lopes, Sofia Ferreira
Summary: Epithelioid hemangioendothelioma is a rare vascular neoplasm that often presents as multifocal or metastatic lesions. A liver transplant recipient developed hepatic cholestasis and a proliferative hepatic lesion with infiltrative growth, which was diagnosed as epithelioid hemangioendothelioma through histological examination and immunohistochemical study. Although pulmonary micronodules were detected, they were stable and no neoplastic recurrence was observed after liver re-transplantation and 8 years of follow-up.
GE PORTUGUESE JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Integrative & Complementary Medicine
Md. Faysal, Jishan Khan, Mehrukh Zehravi, Nikhil Nath, Laliteshwar Pratap Singh, Saloni Kakkar, Rajashekar Perusomula, Pathan Amanulla Khan, Firzan Nainu, Mohammed Asiri, Sharuk L. Khan, Rajib Das, Talha Bin Emran, Polrat Wilairatana
Summary: Honokiol, a bioactive molecule derived from the Magnolia plant, has potential neuroprotective properties and could be used for the treatment of various neurological diseases. Furthermore, honokiol derivatives have also been identified as potential therapeutic options for these diseases.
Article
Endocrinology & Metabolism
Md. Showkoth Akbor, Mehedi Hasan Bappi, Abdullah Al Shamsh Prottay, Mst. Farjanamul Haque, Md. Sakib Al Hasan, Shoyaeb Ahammed, Rokibul Islam Chowdhury, Md. Sabbir Hosain, Clara Mariana Goncalves Lima, Sheikh F. Ahmad, Sabry M. Attia, Talha Bin Emran, Henrique Douglas Melo Coutinho, Micheline Azevedo Lima, Muhammad Torequl Islam
Summary: The study found that SES and THY increased the duration of sleeping time and decreased the latency of sleep induction in mice. When SES, DZP, and THY were administered together, they demonstrated the greatest hypnotic activity.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)