Design, Synthesis and Anti-Tumor Activity of Novel Benzimidazole-Chalcone Hybrids as Non-Intercalative Topoisomerase II Catalytic Inhibitors
出版年份 2020 全文链接
标题
Design, Synthesis and Anti-Tumor Activity of Novel Benzimidazole-Chalcone Hybrids as Non-Intercalative Topoisomerase II Catalytic Inhibitors
作者
关键词
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出版物
MOLECULES
Volume 25, Issue 14, Pages 3180
出版商
MDPI AG
发表日期
2020-07-22
DOI
10.3390/molecules25143180
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Synthesis of substituted biphenyl methylene indolinones as apoptosis inducers and tubulin polymerization inhibitors
- (2019) Kavitha Donthiboina et al. BIOORGANIC CHEMISTRY
- Topoisomerases as anticancer targets
- (2018) Justine L. Delgado et al. BIOCHEMICAL JOURNAL
- Synthesis of carbazole derivatives containing chalcone analogs as non-intercalative topoisomerase II catalytic inhibitors and apoptosis inducers
- (2018) Peng-Hui Li et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches
- (2018) Wei Hu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, synthesis and biological evaluation of benzimidazole–rhodanine conjugates as potent topoisomerase II inhibitors
- (2018) Penghui Li et al. MedChemComm
- Increasing the distance between two monomers of topoisomerase IIβ under the action of antitumor agent 4β-sulfur-(benzimidazole) 4′-demethylepipodophyllotoxin
- (2018) Lin-Yang Sun et al. Scientific Reports
- The effects of jolkinolide B on HepG2 cells as revealed by 1H-NMR-based metabolic profiling
- (2018) Yujing Yan et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Discovery of Clinical Candidate 2-(4-(2-((1H-Benzo[d]imidazol-2-yl)thio)ethyl)piperazin-1-yl)-N-(6-methyl-2,4-bis(methylthio)pyridin-3-yl)acetamide Hydrochloride [K-604], an Aqueous-Soluble Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor
- (2018) Kimiyuki Shibuya et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Novel Quinoline–Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity
- (2018) Wenlong Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- Therapeutic evolution of benzimidazole derivatives in the last quinquennial period
- (2017) Wasim Akhtar et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Pharmacophore Hybridization To Discover Novel Topoisomerase II Poisons with Promising Antiproliferative Activity
- (2017) Jose Antonio Ortega et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nitric oxide inhibits topoisomerase II activity and induces resistance to topoisomerase II-poisons in human tumor cells
- (2016) Ashutosh Kumar et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Chalcone Derivatives Activate and Desensitize the Transient Receptor Potential Ankyrin 1 Cation Channel, Subfamily A, Member 1 TRPA1 Ion Channel: Structure-Activity Relationships in vitro and Anti-Nociceptive and Anti-inflammatory Activity in vivo
- (2016) Aniello Schiano Moriello et al. CNS & Neurological Disorders-Drug Targets
- Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo
- (2016) Jun Yan et al. JOURNAL OF MEDICINAL CHEMISTRY
- Prenylated chalcones and flavonoids for the prevention and treatment of cancer
- (2016) Sascha Venturelli et al. NUTRITION
- Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors
- (2015) Bing-Lei Yao et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors
- (2015) Peng-Hui Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Series of Novel Terpyridine-Skeleton Molecule Derivants Inhibit Tumor Growth and Metastasis by Targeting Topoisomerases
- (2015) Han-Byeol Kwon et al. JOURNAL OF MEDICINAL CHEMISTRY
- Switch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIα Catalytic Inhibitors
- (2015) Ashish T. Baviskar et al. ACS Medicinal Chemistry Letters
- Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids
- (2014) Kunal Nepali et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Recent developments in biological activities of chalcones: A mini review
- (2014) Parvesh Singh et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Structure-Based Design of New Dihydrofolate Reductase Antibacterial Agents: 7-(Benzimidazol-1-yl)-2,4-diaminoquinazolines
- (2014) Thanh Lam et al. JOURNAL OF MEDICINAL CHEMISTRY
- An Overview on Cardamonin
- (2014) Luís Moreira Gonçalves et al. JOURNAL OF MEDICINAL FOOD
- Topoisomerase as target for antibacterial and anticancer drug discovery
- (2012) Muthu K. Kathiravan et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- N-Fused Imidazoles As Novel Anticancer Agents That Inhibit Catalytic Activity of Topoisomerase IIα and Induce Apoptosis in G1/S Phase
- (2011) Ashish T. Baviskar et al. JOURNAL OF MEDICINAL CHEMISTRY
- All tangled up: how cells direct, manage and exploit topoisomerase function
- (2011) Seychelle M. Vos et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide
- (2011) C.-C. Wu et al. SCIENCE
- Second-line mitoxantrone, etoposide, and cytarabine for acute myeloid leukemia: A single-center experience
- (2010) Holbrook E. Kohrt et al. AMERICAN JOURNAL OF HEMATOLOGY
- DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs
- (2010) Yves Pommier et al. CHEMISTRY & BIOLOGY
- In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives
- (2010) Kavitha C.S. Achar et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety
- (2010) Yusuf Özkay et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- A Series of α-Heterocyclic Carboxaldehyde Thiosemicarbazones Inhibit Topoisomerase IIα Catalytic Activity
- (2010) He Huang et al. JOURNAL OF MEDICINAL CHEMISTRY
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