Hybrid Quinoline-Sulfonamide Complexes (M2+) Derivatives with Antimicrobial Activity

Two new series of hybrid quinoline-sulfonamide complexes (M2+: Zn2+, Cu2+, Co(2+)and Cd2+) derivatives (QSC) were designed, synthesized and tested for their antimicrobial activity. The synthesis is straightforward and efficient, involving two steps: acylation of aminoquinoline followed by complexation with metal acetate (Cu2+, Co(2+)and Cd2+) or chloride (Zn2+). The synthesizedQSCcompounds were characterized by FTIR and NMR spectroscopy and by X-ray diffraction on single crystal. TheQSCcompounds were preliminary screened for their antibacterial and antifungal activity and the obtained results are very promising. In this respect, the hybridN-(quinolin-8-yl)-4-chloro-benzenesulfonamide cadmium (II), considered as leading structure for further studies, has an excellent antibacterial activity againstStaphylococcus aureus ATCC25923(with a diameters of inhibition zones of 21 mm and a minimum inhibitory concentration (MIC) of 19.04 x 10(-5)mg/mL), a very good antibacterial activity againstEscherichia coli ATCC25922(with a diameters of inhibition zones of 19 mm and a MIC of 609 x 10(-5)mg/mL), and again an excellent antifungal activity againstCandida albicans ATCC10231(with a diameters of inhibition zones of 25 mm and a MIC of 19.04 x 10(-5)mg/mL).