Article
Chemistry, Physical
G. Anjali Krishna, T. M. Dhanya, A. . A. . Shanty, K. G. Raghu, P. V. Mohanan
Summary: A flexible class of Ni(II) and Zn(II) complexes were synthesized with a novel Schiff base ligand containing an imidazole moiety. The compounds were characterized structurally and tested for their biochemical properties.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Samra Farooq, Ihsan-Ul Haq, Naseem Ullah
Summary: A series of N-Mannich base derivatives of 2-phenyl-2-imidazoline with substituted amines were designed, synthesized, and evaluated for their biological activities. The compounds showed good antioxidant, antimicrobial, and anti-inflammatory responses, with SP11 and SP13 exhibiting notable activity. SP2 demonstrated significant inhibition against alpha-amylase enzyme.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Alex Zohmachhuana, Malsawmdawngliana, F. Lalnunmawia, Vabeiryureilai Mathipi, K. Lalrinzuali, N. Senthil Kumar
Summary: The aim of this study was to evaluate the phytochemical content, antioxidant and anti-cancer activities of different parts of Curcuma aeruginosa Roxb. The methanol extracts from C. aeruginosa showed cytotoxicity against lung adenocarcinoma and cervical cancer cells, induced DNA damage, and up-regulated caspase activity. Additionally, bioactive compounds identified from the plant have been found to possess anti-cancer properties.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Alfredo Torres-Benitez, Jose Erick Ortega-Valencia, Marta Sanchez, Mathias Hillmann-Eggers, Maria Pilar Gomez-Serranillos, Gabriel Vargas-Arana, Mario J. Simirgiotis
Summary: This study investigated the metabolomic characterization and biological potential of two lichen species, Cladonia chlorophaea and C. gracilis, in maritime Antarctica. Nineteen compounds were identified in each species, with better results in C. chlorophaea. The study demonstrates the potential of Cladonia species in the prevention and treatment of central nervous system pathologies, inflammatory disorders, and metabolic alterations.
Article
Chemistry, Medicinal
Swapnali Vasant Birajdar, Farhan Mazahir, Awesh K. Yadav
Summary: This study reports the preparation and characterization of Metformin-Loaded, Transferrin-Poloxamer-Functionalized Chitosan Nanoparticles (TPMC-NPs) for the treatment of Alzheimer's disease (AD) through the intranasal route, showing promising results.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Biochemistry & Molecular Biology
H. Yasemin Yenilmez, Nazli Farajzadeh, Nilgun Guler Kusculu, Dilek Bahar, Sadin Ozdemir, Gulsah Tollu, Mithat Gullu, Zehra Altuntas Bayir
Summary: Three new axially disubstituted silicon phthalocyanines (SiPc1-3) and their quaternized phthalocyanine derivatives (QSiPc1-3) were synthesized and characterized. The water-soluble silicon phthalocyanines exhibited high antioxidant, antimicrobial, antibiofilm, and microbial cell viability activities, especially against Gram (+) bacteria. They also demonstrated DNA cleavage and binding features, as well as inhibition of the human topoisomerase I enzyme. Furthermore, they displayed anticarcinogenic activity against the DLD-1 colon cancer cell line. These compounds have potential as effective biological agents and anticancer drugs.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Immunology
Ravindra Jagannath Waghole, Ashwini Vivek Misar, Neha Shashikant Kulkarni, Feroz Khan, Dattatraya Gopal Naik, Sachin Hanmant Jadhav
Summary: The present study further explored the anti-inflammatory activity and antioxidative effects of T. sulcatum and found that it significantly reduced inflammation-induced oxidative damage and the expression of pro-inflammatory cytokines. This suggests that T. sulcatum may be a potential alternative anti-inflammatory medication.
INFLAMMOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Mira Bou Dargham, Jocelyne Matar Boumosleh, Antonie Farhat, Salwa Abdelkhalek, Elias Bou-Maroun, Leina El Hosry
Summary: This study assessed the phytochemical composition, antioxidant, and anti-diabetic properties of homemade and commercial pomegranate molasses in Lebanon. The results showed that homemade samples had higher antioxidant and anti-diabetic activity compared to commercial samples, indicating their potential nutritional value.
Article
Biochemistry & Molecular Biology
Rong He, Mengting Liu, Zhipeng Zou, Mingjie Wang, Zhigao Wang, Xingrong Ju, Guangfei Hao
Summary: This study investigated the anti-inflammatory effect of millet bran peptides and found that they can reduce the levels of inflammatory factors and regulate the signaling pathways involved in inflammation.
Article
Food Science & Technology
Javier Antileo-Laurie, Cristina Theoduloz, Alberto Burgos-Edwards, Felipe Jimenez-Aspee, Katherine Marquez, Marlene Fischer, Guillermo Schmeda-Hirschmann
Summary: This study investigated the phenolic content, antioxidant capacity, and inhibitory effects on enzymes related to metabolic syndrome of the peumo fruits consumed by Mapuche Amerindians in Chile. The results showed that peumo fruits contained beneficial compounds and had significant effects on enzyme activity and antioxidant capacity. Furthermore, significant differences were observed in the fruit parts and processing methods.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Microbiology
Shahira A. A. Ahmed, Enas E. E. Eltamany, Mohamed S. S. Nafie, Sameh S. S. Elhady, Panagiotis Karanis, Amira B. B. Mokhtar
Summary: This study investigates the toxic activity of Artemisia judaica ethanolic extract (ArEx), phenolic fraction (ArPh), and terpenoid fraction (ArT) against Cryptosporidium parvum oocysts. The results show that ArPh exhibits toxic activity against C. parvum oocysts and demonstrates antioxidant activity.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
A-Mohsen M. E. Omar, Omaima M. AboulWafa, Mai E. Amr, Mai S. El-Shoukrofy
Summary: Novel benzoxazole derivatives were synthesized and evaluated for their anticancer activities, showing selectivity towards breast cancer cells and promising apoptosis-inducing properties. Compound 7a and 8e demonstrated potent inhibition of EGFR and ARO enzymes, highlighting their potential as anti-breast cancer agents.
BIOORGANIC CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Asma Bukhari, Humaira Nadeem, Muhammad Imran, Syed Aun Muhammad
Summary: The study reported 10 new oxadiazole analogs as antidiabetic agents, with two compounds (5a and 4a (a)) showing strong inhibitory potential against alpha-glucosidase enzyme, and one compound (5g) demonstrating outstanding inhibitory potential against alpha-amylase enzyme.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Chemistry, Organic
Marzieh Pourhossein Alamdary, Robabeh Baharfar, Saeed Tavakoli
Summary: A bioassay-guided study of Pulicaria gnaphalodes led to the isolation of four compounds, which were tested for their cytotoxicity and antioxidant activity. The EtOAc fraction showed significant inhibitory activity on cancer cell lines, suggesting that Pulicaria gnaphalodes may serve as a natural source of bioactive compounds.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Biochemistry & Molecular Biology
Maram B. Alhawarri, Roza Dianita, Khairul Niza Abd Razak, Suriani Mohamad, Toshihiko Nogawa, Habibah A. Wahab
Summary: This study found that ethyl acetate and methanol extracts of C. timoriensis flowers exhibited the highest antioxidant, anti-inflammatory, and anti-AChE activities, potentially containing bioactive compounds that could be beneficial in controlling neurodegenerative disorders, including Alzheimer's disease.
Article
Integrative & Complementary Medicine
Muhammad Majid, Bakht Nasir, Syeda Saniya Zahra, Muhammad Rashid Khan, Bushra Mirza, Ihsan-ul Haq
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2018)
Article
Biotechnology & Applied Microbiology
Muhammad Majid, Fatima Ijaz, Muhammad Waleed Baig, Bakht Nasir, Muhammad Rashid Khan, Ihsan-ul Haq
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Chemistry, Multidisciplinary
Samra Farooq, Aqsa Mazhar, Ihsan-Ul-Haq, Naseem Ullah
ARABIAN JOURNAL OF CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Samra Farooq, Ihsan-Ul Haq, Naseem Ullah
Summary: A series of N-Mannich base derivatives of 2-phenyl-2-imidazoline with substituted amines were designed, synthesized, and evaluated for their biological activities. The compounds showed good antioxidant, antimicrobial, and anti-inflammatory responses, with SP11 and SP13 exhibiting notable activity. SP2 demonstrated significant inhibition against alpha-amylase enzyme.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Tahira Sultana, Madiha Ahmed, Nosheen Akhtar, Mohammad K. Okla, Abdulrahman Al-Hashimi, Wahidah H. Al-Qahtani, Hamada Abdelgawad, Ihsan-ul-Haq
Summary: This study aimed to evaluate the polarity-dependent extraction efficiency and pharmacological profiling of Polygonum glabrum Willd. The results showed that the nature of pharmacological responses depends on the polarity of extraction solvents and the parts of the plant used.
Article
Biochemistry & Molecular Biology
Muhammad Majid, Anam Farhan, Muhammad Imran Asad, Muhammad Rashid Khan, Syed Shams ul Hassan, Ihsan-ul Haq, Simona Bungau
Summary: Nummularic acid (NA), a potent pentacyclic triterpenoid compound derived from sweet potato, has shown significant anti-proliferative effects against prostate cancer cells. In vitro studies demonstrated dose-dependent reductions in cell proliferation, migration, invasion, and increased apoptotic cell populations after NA treatment. Mechanistic studies revealed that NA induced apoptosis in prostate cancer cells through activation of caspases, upregulation of pro-apoptotic genes, and downregulation of anti-apoptotic genes.
Article
Biotechnology & Applied Microbiology
Bakht Nasir, Ashraf Ullah Khan, Muhammad Waleed Baig, Yusuf S. Althobaiti, Muhammad Faheem, Ihsan-Ul Haq
Summary: This study aimed to validate the potential of Datura stramonium extract as an anti-inflammatory agent. The results showed that the extract exhibited anti-inflammatory activity both in vitro and in vivo, improving liver function and histological parameters in CCl4-induced liver injury model rats.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Saira Bano, Muhammad Waleed Baig, Mohammad K. Okla, Syeda Saniya Zahra, Nosheen Akhtar, Wahidah H. Al-Qahtani, Hamada AbdElgawad, Ihsan-Ul Haq
Summary: The validation of underexplored traditional plant remedies represents a reservoir of novel leads for drug discovery. In this study, the seed extracts of Chenopodium ambrosioides were evaluated for various bioactivities, including antioxidant, antimicrobial, cytotoxicity, and protein kinase inhibition. The methanol extract showed the highest content of phenolics and flavonoids, while the ethyl acetate extract exhibited the highest cytotoxicity and the ethanol extract showed remarkable protein kinase inhibitory activity.
JOURNAL OF CHEMISTRY
(2022)
Article
Plant Sciences
Bushra Hafeez Kiani, Ihsan-Ul-Haq, Aiyeshah Alhodaib, Samra Basheer, Humaira Fatima, Iffat Naz, Tofeeq Ur-Rehman
Summary: This study highlights the significance of green synthesis of zinc nanoparticles using Withania somnifera extracts in the modern health care system. The zinc nanoparticles exhibited strong biological activities including antioxidant, antibacterial, and cytotoxic effects, as well as potential therapeutic effects against diabetes and protein kinases.
Article
Plant Sciences
Bushra Hafeez Kiani, Qudsia Ajmal, Nosheen Akhtar, Ihsan-ul Haq, Mostafa A. Abdel-Maksoud, Abdul Malik, Mohammed Aufy, Nazif Ullah
Summary: Green synthesis of zinc oxide nanoparticles from Citrullus colocynthis extracts showed antimicrobial, cytotoxic, antidiabetic, and antioxidant properties. The bioactivity of the plant suggests its potential therapeutic use. The nanoparticles can also be used for in vivo assessment of a nano-directed drug delivery system.
Article
Biochemistry & Molecular Biology
Qurat-ul Ain Fatima, Naveed Ahmed, Bazla Siddiqui, Asim Ur Rehman, Ihsan ul Haq, Gul Majid Khan, Abdelhamid Elaissari
Summary: This study aimed to develop a nanoemulsion-based cosmetotherapeutic lotion for the treatment of burn injuries. The optimized formulation showed smaller particle size and higher encapsulation efficiency. Scar massaging using the lotion improved its permeation properties. The nanoemulsion-based lotion demonstrated superior antimicrobial activity compared to commercialized burn creams.
Article
Chemistry, Medicinal
Humaira Fatima, Madiha Ahmed, Muhammad Waleed Baig, Muhammad Nawaz Tahir, Tamara P. Kondratyuk, John M. Pezzuto, Ihsan ul-Haq
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2020)
Article
Integrative & Complementary Medicine
Bakht Nasir, Muhammad Waleed Baig, Muhammad Majid, Syeda Masooma Ali, Muhammad Zafar Irshad Khan, Syeda Tayyaba Batool Kazmi, Ihsan-Ul Haq
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2020)