Metformin and/or low dose radiation reduces cardiotoxicity and apoptosis induced by cyclophosphamide through SIRT-1/SOD and BAX/Bcl-2 pathways in rats

Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis

(2019) Shashank Shrishrimal et al.   Oxidative Medicine and Cellular Longevity

Galangin Activates Nrf2 Signaling and Attenuates Oxidative Damage, Inflammation, and Apoptosis in a Rat Model of Cyclophosphamide-Induced Hepatotoxicity

(2019) Aladaileh et al.   Biomolecules

Premna integrifolia ameliorates cyclophosphamide-induced hepatotoxicity by modulation of oxidative stress and apoptosis

(2018) Chandrashekhar Singh et al.   BIOMEDICINE & PHARMACOTHERAPY

Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells

(2017) Weijin Zhang et al.   Oxidative Medicine and Cellular Longevity

Low-Dose Radiation Induces Cell Proliferation in Human Embryonic Lung Fibroblasts but not in Lung Cancer Cells

(2016) Xinyue Liang et al.   Dose-Response

Effect of metformin and sitagliptin on doxorubicin-induced cardiotoxicity in adult male albino rats

(2016) A Sheta et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Low-dose radiation may be a novel approach to enhance the effectiveness of cancer therapeutics

(2016) Guozi Yang et al.   INTERNATIONAL JOURNAL OF CANCER

Gamma-Glutamylcysteine Ethyl Ester Protects against Cyclophosphamide-Induced Liver Injury and Hematologic Alterations via Upregulation of PPARγand Attenuation of Oxidative Stress, Inflammation, and Apoptosis

(2016) Sultan Alqahtani et al.   Oxidative Medicine and Cellular Longevity

Repurposing metformin: an old drug with new tricks in its binding pockets

(2015) R. Pryor et al.   BIOCHEMICAL JOURNAL

Protective effect of N-acetylcysteine on cyclophosphamide-induced cardiotoxicity in rats

(2015) Heba H. Mansour et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease

(2015) Akshata Moghe et al.   TOXICOLOGICAL SCIENCES

Ginseng alleviates cyclophosphamide-induced hepatotoxicity via reversing disordered homeostasis of glutathione and bile acid

(2015) He Zhu et al.   Scientific Reports

Reactive oxygen species induce Cox-2 expression via TAK1 activation in synovial fibroblast cells

(2015) Yuta Onodera et al.   FEBS Open Bio

The Inhibitory Effects of Low-Dose Ionizing Radiation in IgE-Mediated Allergic Responses

(2015) Hae Mi Joo et al.   PLoS One

Anti-diabetic Drug Metformin: Challenges and Perspectives for Cancer Therapy

(2014) Kaniyampadi Snima et al.   CURRENT CANCER DRUG TARGETS

Des-acyl ghrelin protects microvascular endothelial cells from oxidative stress-induced apoptosis through sirtuin 1 signaling pathway

(2014) Takeshi Shimada et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effect of cyclophosphamide and morin-5’-sulfonic acid sodium salt, alone or in combination, on ADMA/DDAH pathway in rats

(2014) Anna Merwid-Ląd et al.   Pharmacological Reports

Metformin Protects Cardiomyocyte from Doxorubicin Induced Cytotoxicity through an AMP-Activated Protein Kinase Dependent Signaling Pathway: An In Vitro Study

(2014) Laura C. Kobashigawa et al.   PLoS One

A Novel Role for SIRT-1 in L-Arginine Protection against STZ Induced Myocardial Fibrosis in Rats

(2014) Sherine M. Rizk et al.   PLoS One

Cardioprotective effect of Saraca indica against cyclophosphamide induced cardiotoxicity in rats: A biochemical, electrocardiographic and histopathological study

(2013) A. H. M Viswanatha Swamy et al.   INDIAN JOURNAL OF PHARMACOLOGY

Crocin, a dietary colorant mitigates cyclophosphamide-induced organ toxicity by modulating antioxidant status and inflammatory cytokines

(2013) Sadashivaiah Jnaneshwari et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Low-Dose Gamma Irradiation Enhances Superoxide Anion Production by Nonirradiated Cells Through TGF-β1-Dependent Bystander Signaling

(2013) Jennifer Temme et al.   RADIATION RESEARCH

Endothelium-specific SIRT1 overexpression inhibits hyperglycemia-induced upregulation of vascular cell senescence

(2012) HouZao Chen et al.   Science China-Life Sciences

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease

(2011) Rebecca L. Smathers et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy

(2011) Y. S. Hori et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Probucol Attenuates Cyclophosphamide-induced Oxidative Apoptosis, p53 and Bax Signal Expression in Rat Cardiac Tissues

(2011) Yousif A. Asiri   Oxidative Medicine and Cellular Longevity

Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis

(2010) A. DeCensi et al.   Cancer Prevention Research

Sirt1 activation protects the mouse renal medulla from oxidative injury

(2010) Wenjuan He et al.   JOURNAL OF CLINICAL INVESTIGATION

Current Perspectives on Role of Chromatin Modifications and Deacetylases in Lung Inflammation in COPD

(2009) Saravanan Rajendrasozhan et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages

(2009) Ran Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging

(2008) Philipp Oberdoerffer et al.   CELL

Control of autophagy by oncogenes and tumor suppressor genes

(2008) M C Maiuri et al.   CELL DEATH AND DIFFERENTIATION

SIRT1 Exerts Anti-Inflammatory Effects and Improves Insulin Sensitivity in Adipocytes

(2008) T. Yoshizaki et al.   MOLECULAR AND CELLULAR BIOLOGY

Natriuretic peptide C receptor signalling in the heart and vasculature

(2007) Robert A. Rose et al.   JOURNAL OF PHYSIOLOGY-LONDON