Review
Biochemistry & Molecular Biology
Young-Su Yi
Summary: Inflammasome, activated in response to infection and damage, triggers inflammatory responses, while methylation, a critical biological process, modulates gene expression. The functional relationship between inflammasome regulation and methylation may play a key role in inflammatory responses and disease development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Heng Liu, Jianhuang Lin, Wei Zhou, Renyta Moses, Zhongping Dai, Andrew V. Kossenkov, Ronny Drapkin, Benjamin G. Bitler, Sergey Karakashev, Rugang Zhang
Summary: This study demonstrates that the extent of effector CD8+ T cell infiltration into tumors is influenced by a histone H3 demethylase (KDM5A) in epithelial ovarian cancer. KDM5A inhibits immune cell infiltration and antitumor immune responses by silencing genes involved in antigen processing and presentation. Inhibition of KDM5A restores gene expression in the antigen-presentation pathway and promotes antitumor immune responses mediated by CD8+ T cells.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Yuhua Shi, Qian Lv, Mengjie Zheng, Hongxiang Sun, Fushan Shi
Summary: INF39 is a specific inhibitor for NLRP3 inflammasome activation, without affecting other inflammasomes. It exerts its anti-inflammatory effect by inhibiting the interaction of NEK7-NLRP3 and other downstream events.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Oncology
Richard Sean Lee, Kirti Sad, Dorelle V. Fawwal, Jennifer Marie Spangle
Summary: Breast cancer is a frequent and deadly disease in women, with histone-modifying enzymes playing a role in treatment response and patient outcomes. Epigenetic changes to chromatin affect the tumor environment and can be targeted for breast cancer treatment. Understanding these mechanisms may improve therapeutic interventions and patient outcomes.
Review
Cardiac & Cardiovascular Systems
Jian Qin, Ningning Guo, Jingjing Tong, Zhihua Wang
Summary: Cardiac hypertrophy is a common pathological process in cardiovascular diseases, characterized by gene expression reprogramming largely dependent on histone modifications such as methylation and acetylation. Understanding the role of histone modifiers in cardiac hypertrophy provides potential therapeutic strategies.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Reproductive Biology
Naiara Z. Saraiva, Clara S. Oliveira, Nathalia N. C. Almeida, Marivaldo R. Figueiro, Carolina C. R. Quintao, Joaquim M. Garcia
Summary: This study investigated the epigenetic changes resulting from the use of histone deacetylase inhibitors in the maturation of bovine oocytes and subsequent embryo development. The results showed that the treatment with histone deacetylase inhibitors promoted the development of bovine oocytes and had a positive impact on embryo development.
Review
Biochemistry & Molecular Biology
Aroa Baragano Raneros, Cristian Ruiz Bernet, Aida Bernardo Florez, Beatriz Suarez-Alvarez
Summary: Aberrant activation of the NLRP3 inflammasome in innate immune cells, triggered by various danger signals, is involved in the pathogenesis of a wide range of diseases. Epigenetic dynamics play a key role in regulating inflammasome expression and activation, and targeting these mechanisms through epigenetic treatments may be a useful strategy for controlling NLRP3-related inflammatory diseases.
Article
Chemistry, Medicinal
Hideaki Niwa, Chiduru Watanabe, Shin Sato, Toshiyuki Harada, Hisami Watanabe, Ryo Tabusa, Shunsuke Fukasawa, Ayane Shiobara, Tomoko Hashimoto, Osamu Ohno, Kana Nakamura, Keiko Tsuganezawa, Akiko Tanaka, Mikako Shirouzu, Teruki Honma, Kenji Matsuno, Takashi Umehra
Summary: In this study, a total of 65 cis- and trans-PCPA derivatives were synthesized and evaluated for their inhibitory activity against LSD1 and LSD2. One derivative, 7c, showed high inhibitory activity against both LSD1 and LSD2, and increased the level of dimethylated histone H3 at K4 in cells. Additionally, a machine learning-based regression model was constructed to accurately predict LSD1 inhibitory activity.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Medicinal
Hideaki Niwa, Chiduru Watanabe, Shin Sato, Toshiyuki Harada, Hisami Watanabe, Ryo Tabusa, Shunsuke Fukasawa, Ayane Shiobara, Tomoko Hashimoto, Osamu Ohno, Kana Nakamura, Keiko Tsuganezawa, Akiko Tanaka, Mikako Shirouzu, Teruki Honma, Kenji Matsuno, Takashi Umehara
Summary: In this study, we synthesized and evaluated multiple cis- and trans-PCPA derivatives for their inhibitory activity against LSD1 and LSD2. A derivative named 7c showed high inhibitory activity against both LSD1 and LSD2, and increased a significant histone modification in cells. Furthermore, a regression model based on machine learning was constructed and demonstrated good prediction accuracy for LSD1 inhibitory activity.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Immunology
Jesus Beltran-Garcia, Rebeca Osca-Verdegal, Daniel Perez-Cremades, Susana Novella, Carlos Hermenegildo, Federico Pallardo, Jose Luis Garcia-Gimenez
Summary: This study reveals that circulating extracellular histones may contribute to endothelial dysfunction and inflammation in sepsis by activating the NLRP3 inflammasome and pyroptosis. The findings also suggest that pyroptosis is a common process in septic shock, associated with severe inflammation and endothelial dysfunction.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yeon-Ji Park, Niranjan Dodantenna, Yonghyeon Kim, Tae-Hwan Kim, Ho-Soo Lee, Young-Suk Yoo, June Heo, Jae-Ho Lee, Myung-Hee Kwon, Ho Chul Kang, Jong-Soo Lee, Hyeseong Cho
Summary: The NLRP3 inflammasome is activated through mitochondria-mediated ubiquitination by the E3 ligase MARCH5. Knockout of MARCH5 leads to an impaired secretion of IL-1β and IL-18 in myeloid cells, as well as a decreased mortality rate upon infection. MARCH5-dependent NLRP3 ubiquitination is essential for NLRP3-NEK7 complex formation and NLRP3 oligomerization.
Article
Cell Biology
Maria R. Pozo, Gantt W. Meredith, Emilia Entcheva
Summary: The epigenetic landscape and the responses to pharmacological epigenetic regulators in each human are unique. HDAC inhibitors (HDACi) are widely used in the treatment of cancer and immune diseases. However, the effects of these epigenetic modulators on cardiac tissue are not well understood. hiPSC-CM technology can be used as a high-throughput platform to study the functional electrophysiological responses of the heart and quantify the responses to HDACi.
Review
Immunology
Subhashini Brahadeeswaran, Tiasha Dasgupta, Venkatraman Manickam, Viswanathan Saraswathi, Ramasamy Tamizhselvi
Summary: The liver is responsible for important physiological processes and its role in activating the innate immune system and causing inflammation is crucial. Chronic ethanol exposure disrupts the liver's inflammatory mechanism and releases proinflammatory mediators. Activation of the NLRP3 inflammasome is involved in liver fibrosis/cirrhosis, leading to hepatocyte destruction and metabolic dysregulation. Alcohol intake also affects liver epigenetics, promoting the development of alcoholic liver disease (ALD). Understanding the role of NLRP3 inflammasome and epigenetic modifications could lead to potential therapeutic targets for ALD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yueke Lin, Xiaoting Lv, Caiyu Sun, Yanlin Sun, Min Yang, Dapeng Ma, Weiqiang Jing, Yunxue Zhao, Yeping Cheng, Haocheng Xuan, Lihui Han
Summary: This study reveals a novel regulatory mechanism of NLRP3 via TRIM50 and suggests that modulating TRIM50 might represent a therapeutic strategy for NLRP3-dependent pathologies.
Article
Chemistry, Medicinal
Guan-Jun Yang, Jia Wu, Liang Miao, Ming-Hui Zhu, Qian-Jin Zhou, Xin-Jiang Lu, Jian-Fei Lu, Chung-Hang Leung, Dik-Lung Ma, Jiong Chen
Summary: KDM5A, a demethylase that is aberrantly expressed in many cancers, plays a role in promoting cancer cell proliferation, metastasis, invasiveness, drug resistance, and poor prognosis. Pharmacological inhibition of KDM5A has been shown to significantly attenuate tumor progression and may serve as a potential drug target in cancer therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Shruti Sharma, Ujjawal Sharma
Summary: Exosomes, as important communicators between cells, play a crucial role in the protection and progression of cardiovascular diseases.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Oncology
Sanjeev K. K. Sharma, Subodh K. K. Yadav, Ujjawal Sharma, Pramod Avti, Satyavati Rana, Krishan L. L. Khanduja
Summary: The study aims to investigate the potential role of secretory phospholipase A2 (sPLA(2)) isozymes in tobacco condensate-induced colon damage. The effects of cigarette smoke condensate (CSC) on cell viability, reactive oxygen species (ROS), and gene expression of different sPLA(2) were evaluated. The findings suggest that specific sPLA(2) isozymes play a key role in controlling CSC-induced damage and may aid in the development of targeted therapeutic strategies.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2023)
Review
Endocrinology & Metabolism
Bunty Sharma, Aman Kumar, Ujjawal Sharma, Deeksha Pal, Sourabh Prashar
Summary: The gut microbiota plays a crucial role in regulating the metabolic health of host organisms. Dysbiosis of the gut microflora can lead to the development of type 2 diabetes mellitus (T2DM), and the microbial composition can also influence the host organism's epigenetics and the involvement of the innate immune system. Understanding the connection between gut microbiota and T2DM is important for better understanding the disease.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Review
Dermatology
Bunty Sharma, Anil Kumar Sharma, Ujjawal Sharma
Summary: Sporotrichosis has emerged as a leading fungal infection in animals and humans, and its increasing prevalence is attributed to changes in epidemiology, taxonomy, and outbreaks. Delayed diagnosis and limited antifungal therapy contribute to higher morbidity, highlighting the need for new treatment options. Recent studies focus on developing new drugs and identifying antigens for vaccine development. Early diagnosis, patient education, and counseling for prolonged therapy are important for the management of sporotrichosis.
CURRENT DERMATOLOGY REPORTS
(2022)
Review
Neurosciences
Bunty Sharma, Deeksha Pal, Ujjawal Sharma, Aman Kumar
Summary: Mitochondria play a crucial role in providing energy and controlling apoptosis in neurons. Defective mitochondrial function is linked to neurodegenerative diseases such as Alzheimer's disease. Mitophagy, a quality control system, helps neurons maintain their health and functionality by removing damaged mitochondria. Dysfunction of mitochondria and dysregulated mitophagy are closely associated with the onset of Alzheimer's disease. Therapeutic approaches targeting mitophagy restoration could be used to prevent disease progression.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Uttam Sharma, Hardeep Singh Tuli, Vivek Uttam, Renuka Choudhary, Bunty Sharma, Ujjawal Sharma, Hridayesh Prakash, Aklank Jain
Summary: This review provides an overview of the current research progress on how microRNAs, long non-coding RNAs, and circular RNAs regulate Hedgehog and Hippo signaling pathways in various cancers, and their potential application as targets for cancer treatment.
PHARMACOLOGICAL RESEARCH
(2022)
Review
Oncology
Hardeep Singh Tuli, Prangya Rath, Abhishek Chauhan, Katrin Sak, Diwakar Aggarwal, Renuka Choudhary, Ujjawal Sharma, Kanupriya Vashishth, Sheetu Sharma, Manoj Kumar, Vikas Yadav, Tejveer Singh, Mukerrem Betul Yerer, Shafiul Haque
Summary: Luteolin, a common flavonoid, has shown promising anticancer properties by targeting various cellular processes to inhibit tumor growth and reverse medication resistance in cancer cells.
Review
Toxicology
Hardeep Singh Tuli, Jagjit Kaur, Kanupriya Vashishth, Katrin Sak, Ujjawal Sharma, Renuka Choudhary, Tapan Behl, Tejveer Singh, Sheetu Sharma, Adesh K. Saini, Kuldeep Dhama, Mehmet Varol, Gautam Sethi
Summary: ROS plays important roles in living organisms, with moderate levels affecting disease development and excessive levels leading to cell death. Current research is focused on using chemotherapy drugs and herbal agents to induce cancer cell death, while maintaining ROS homeostasis is crucial for cell development and survival.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Masrat Mohmad, Nivedita Agnihotri, Vikas Kumar, Ujjawal Sharma, Rakesh Kumar, Sadegh Kaviani, Ashish Kumar, Raj Kamal
Summary: A concise, ingenious and expedite extractive spectrophotometric procedure for the micro-level analysis of Pt(II) using the novel synthesized Ligand of flavonoids family, 3-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one was elucidated by employing chelation as the basis of reaction between the two. The resulting brown coloured complex was extractable in non-aqueous organic solvents, the effectual and sensitive extraction and hence maximal colour intensity being exhibited in dichloromethane in the wavelength range 500-514 nm. To acquire a deeper knowledge of the complex's structural characteristics, theoretical investigations including Quantum theory of atoms in molecules and Natural bond orbital analysis were employed using Density functional theory calculations.
RESULTS IN CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Ajay Kumar, Bunty Sharma, Ujjawal Sharma, Gaurav Parashar, Nidarshana Chaturvedi Parashar, Isha Rani, Seema Ramniwas, Satwinderjeet Kaur, Shafiul Haque, Hardeep Singh Tuli
Summary: Cucurbitacins, a class of secondary metabolites produced by the Cucurbitaceae family, have significant anticancer activity by inhibiting cell proliferation, invasion, and migration, inducing apoptosis, and encouraging cell cycle arrest. They also suppress the JAK-STAT3, Wnt, PI3K/Akt, and MAPK signaling pathways, which are essential for cancer cell survival and apoptosis. This study provides a comprehensive summary of potential molecular targets for cucurbitacins in suppressing various malignant processes.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Letter
Surgery
Nirmala Sehrawat, Ujjawal Sharma, Mukesh Yadav, Varruchi Sharma, Abhijit Dey, Talha B. Emran, Anil K. Sharma, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Review
Pharmacology & Pharmacy
Priyanka Verma, Hemant Joshi, Tejveer Singh, Bunty Sharma, Ujjawal Sharma, Seema Ramniwas, Rashmi Rana, Madhu Gupta, Ginpreet Kaur, Hardeep Singh Tuli
Summary: Patients with glioblastoma and anaplastic astrocytoma are treated with temozolomide, which has been shown to increase patient survival but may also have negative immune-related effects. Flavonoids have antioxidant and chemo-preventive effects, and may reduce side effects of chemotherapy while increasing effectiveness. Exosomes have potential as drug carriers for cancer therapy due to their favorable biodistribution, biocompatibility, and low immunogenicity.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Masrat Mohmad, Nivedita Agnihotri, Vikas Kumar, Mohammad Azam, Raj Kamal, Ashish Kumar, Ujjawal Sharma, Saleem Javed, Sambantham Muthu, Kim Min
Summary: A novel benzopyran-based platinum complex was prepared and studied using UV-visible spectrophotometry. The complexation between Pt(II) and HToC resulted in the formation of a stable binary yellow complex. The analytical results showed that the complex exhibits good sensitivity, versatility, and cost-effectiveness. DFT studies revealed the molecular geometry and other structural specifics of the complex. The complex demonstrated better antiproliferative potential, antimicrobial activity, and antioxidant capacity compared to the ligand.
Review
Dermatology
Ravi Kant Sharma, Manu Rashmi Sharma, Aneet Mahendra, Ujjawal Sharma, Simranjit Singh, Seema Ramniwas, Anil Kumar Sharma
Summary: Psoriasis is a prevalent chronic inflammatory skin condition caused by abnormal immune response. It not only affects the mental health of patients, but also leads to various systemic diseases. Artificial intelligence can play an important role in the early detection and management of psoriasis.
CURRENT DERMATOLOGY REPORTS
(2023)
