Review
Medicine, General & Internal
Shuaiyu Jiang, Mengmeng Wu, Xiaoguang Lu, Yilong Zhong, Xin Kang, Yi Song, Zhiwei Fan
Summary: This study indicates that limited fluid resuscitation (LFR) is more beneficial than harmful in patients with hemorrhagic shock or septic shock, reducing mortality, multiple organ dysfunction syndrome (MODS), acute respiratory distress syndrome (ARDS), and disseminated intravascular coagulation (DIC) rates.
Article
Biochemistry & Molecular Biology
Milomir O. Simovic, Michael J. Falabella, Tuan D. Le, Jurandir J. DalleLucca, Yansong Li
Summary: This study investigated the effects of early administration of DAF on hemorrhage-induced organ damage. The results suggest that DAF treatment can alleviate organ injury and improve metabolic acidosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Mathew Geevarghese III, Krishna Patel, Anil Gulati, Amaresh K. K. Ranjan
Summary: Shock is a life-threatening condition with high mortality worldwide, and immediate intervention is crucial. Dysfunction and downregulation of adrenergic receptors (ARs) play a role in various types of shock. Centhaquine (CQ) has been shown to activate alpha 2 ARs, increasing cardiac output and reducing systemic vascular resistance in hypovolemic/hemorrhagic shock. Clinical trials have demonstrated improved survival and better blood circulation with CQ compared to standard resuscitative agents. Alpha 2 ARs could be potential targets for managing hypovolemic/hemorrhagic shock, and further understanding of ARs in shock may lead to new pharmacological targets.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Critical Care Medicine
Don Walsh, Ciara Cunning, Graham Lee, John Boylan, Paul Mcloughlin
Summary: Normal shear stress is important for the normal functioning of the microcirculation. Hemorrhagic shock and the use of current resuscitation solutions can lead to reduced shear stress, resulting in vascular dysfunction and edema formation.
Article
Biochemistry & Molecular Biology
Milomir O. O. Simovic, Zhangsheng Yang, Bryan S. S. Jordan, Tamara L. L. Fraker, Tomas S. S. Cancio, Michael L. L. Lucas, Leopoldo C. C. Cancio, Yansong Li
Summary: Trauma-related hemorrhagic shock (HS) is a major cause of death in military and civilian trauma patients. Previous studies have shown that the use of complement and HMGB1 inhibitors can reduce morbidity and mortality in a rat model of blast injury (BI) and HS. This study aimed to develop a swine model and evaluate the pathophysiological changes induced by BI+HS. The results showed evidence of multiple-organ damage, systemic innate immunological activation, and local tissue inflammation in the injured animals. This model could be helpful in assessing immunological damage control resuscitation approaches in the care of warfighters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Chemical
David Berard, Saul J. Vega, Guy Avital, Eric J. Snider
Summary: Hemorrhage remains a leading cause of preventable death in emergency situations. Closed-loop control systems can simplify hemorrhagic shock resuscitation if properly tuned. In this study, we showcased the tunability of different fuzzy logic controller designs for different hemorrhage scenarios.
Article
Chemistry, Multidisciplinary
Rajesh Kumar, Julia Garcia Mancebo, Ryan Patenaude, Kristen Sack, Maksymilian Prondzynski, Alan B. Packard, Jason L. J. Dearling, Ruihan Li, Michelle Balcarcel-Monzon, Saffron Dominguez, Sirisha Emani, John N. Kheir, Brian Polizzotti, Yifeng Peng
Summary: This study proposes a low-fouling zwitterionic polymer as an alternative volume expander for hypovolemic shock. The polymer shows improved biocompatibility and efficacy, with resistance to cell interaction and deposition in major organs. It is rapidly cleared from the body, reducing the risk of long-term side effects. In comparison to existing colloids and plasma, the polymer serves as a more potent oncotic agent for restoring intravascular volume.
ADVANCED MATERIALS
(2022)
Article
Oncology
Xiao Lu, Lan Ying, Haizhen Wang, Libing Jiang, Zhongjun Zheng
Summary: This study compared the therapeutic effect and safety of restrictive versus massive fluid resuscitation in patients with traumatic hemorrhagic shock. The results showed that restrictive fluid resuscitation can accelerate patients' resuscitation, reduce the volume of infusion, shorten the duration of mechanical ventilation and ICU stay, and promote the recovery of coagulation function.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Anesthesiology
Bulent Ergin, Tom van Rooij, Alex Lima, Yasin Ince, Patricia A. C. Specht, Bert Mik, Ugur Aksu, Berna Yavuz-Aksu, Klazina Kooiman, Nico de Jong, Can Ince
Summary: This study investigated the role of renal microcirculatory alterations in the development of renal dysfunction in a pig model of non-traumatic hemorrhagic shock-induced acute kidney injury (AKI). The results showed that despite stable renal blood flow and urine output, there were perfusion defects in the renal cortex during shock and resuscitation. The correction of systemic hemodynamic variables did not improve renal cortical perfusion, intra-renal blood volume, and renal damage following fluid resuscitation.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Multidisciplinary Sciences
Cynthia R. Muller, Vasiliki Courelli, Alfredo Lucas, Alexander T. Williams, Joyce B. Li, Fernando Dos Santos, Clayton T. Cuddington, Savannah R. Moses, Andre F. Palmer, Erik B. Kistler, Pedro Cabrales
Summary: When accompanied by hemorrhagic shock after TBI, PolyhHb may serve as an effective alternative to blood for resuscitation, restoring hemodynamics and oxygen delivery.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Akira Endo, Atsushi Senda, Yasuhiro Otomo, Matthew Firek, Mitsuaki Kojima, Raul Coimbra
Summary: This study aimed to evaluate the benefits of the concurrent use of cryoprecipitate (Cryo) in combination with fresh frozen plasma (FFP) for bleeding trauma patients. The results of propensity score-matching analysis showed that the use of Cryo combined with FFP was significantly associated with reduced in-hospital mortality and no significant difference in the occurrence rate of adverse events. Further randomized controlled trials are needed to confirm these results.
CRITICAL CARE MEDICINE
(2022)
Article
Cell Biology
Jonathan M. Preuss, Ute Burret, Michael Groeger, Sandra Kress, Angelika Scheuerle, Peter Moeller, Jan P. Tuckermann, Martin Wepler, Sabine Vettorazzi
Summary: Impaired GR signaling in GR(dim/dim) mice results in increased lung inflammation and apoptosis, leading to attenuated protection against hemorrhagic shock-induced lung damage.
Review
Cardiac & Cardiovascular Systems
Kamil Safiejko, Jacek Smereka, Krzysztof J. Filipiak, Agnieszka Szarpak, Marek Dabrowski, Jerzy R. Ladny, Milosz J. Jaguszewski, Lukasz Szarpak
Summary: This study systematically reviewed and meta-analyzed the effect of hypotensive versus conventional fluid resuscitation in traumatic hemorrhagic shock patients. The findings showed that hypotensive fluid resuscitation significantly reduced mortality and adverse events in hypovolemic shock patients.
CARDIOLOGY JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Francois Durand, John A. Kellum, Mitra K. Nadim
Summary: Fluid resuscitation is complicated in patients with cirrhosis and hypotension due to circulatory changes and hyperdynamic state. Echocardiography shows promise for assessing fluid status. Large volumes of saline should be avoided in cirrhosis patients, and albumin may be superior for controlling inflammation. Vasopressors should be initiated early in cirrhosis patients with sepsis and hypotension, with norepinephrine as the first-line option.
JOURNAL OF HEPATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lei Kuang, Yu Zhu, Yue Wu, Kunlun Tian, Xiaoyong Peng, Mingying Xue, Xinming Xiang, Billy Lau, Fei Chuen Tzang, Liangming Liu, Tao Li
Summary: YQ23 showed better outcomes compared to LR in hypotensive resuscitation by reducing blood loss and fluid demand, stabilizing hemodynamics, increasing oxygen delivery, reducing organ injury, extending survival time without significant side effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Anesthesiology
Nicole A. M. Dekker, Dennis Veerhoek, Anoek L. van Leeuwen, Alexander B. A. Vonk, Charissa E. van den Brom, Christa Boer
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2020)
Review
Engineering, Biomedical
Helga Haberfehlner, Marije Goudriaan, Laura A. Bonouvrie, Elise P. Jansma, Jaap Harlaar, R. Jeroen Vermeulen, Marjolein M. van der Krogt, Annemieke I. Buizer
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2020)
Article
Medicine, General & Internal
Chantal A. Boly, Margot Venhuizen, Nicole A. M. Dekker, Alexander B. A. Vonk, Christa Boer, Charissa E. van den Brom
Summary: Cardiac surgery with cardiopulmonary bypass impairs microcirculatory perfusion equally in metabolically healthy obese patients and lean patients, with recovery observed in both groups within three days post-surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Critical Care Medicine
Anoek L. van Leeuwen, Marieke P. Borgdorff, Nicole A. M. Dekker, Charissa E. van den Brom
Summary: The study reviewed 45 preclinical studies on therapeutic agents targeting microvascular leakage following experimental hemorrhagic shock and fluid resuscitation, with 54 different therapeutics mainly tested in pulmonary and intestinal vascular beds. Most drugs were found to be effective in reducing microvascular leakage in at least one organ, with targeting oxidative stress and apoptosis being the most effective strategy.
Article
Critical Care Medicine
Nicole A. M. Dekker, Anoek L. I. van Leeuwen, Matijs van Meurs, Jill Moser, Jeannette E. Pankras, Nicole N. van der Wel, Hans W. Niessen, Marc G. Vervloet, Alexander B. A. Vonk, Peter L. Hordijk, Christa Boer, Charissa E. van den Brom
Summary: Aprotinin treatment can reduce cremaster microcirculatory perfusion, endothelial gap formation, renal edema and fluid requirements, but did not improve renal perfusion or reduce renal injury during the first hour following experimental CPB.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2021)
Review
Surgery
Nadia A. G. Hakkenbrak, Elise P. Jansma, N. van der Wielen, Donald L. van der Peet, Jennifer Straatman
Summary: This meta-analysis aims to compare laparoscopic distal gastrectomy (LDG) and open distal gastrectomy (ODG) in terms of short-term and long-term surgical outcomes, recovery, and oncological results. The results show that LDG leads to less intraoperative blood loss, faster patient recovery, and fewer complications. Moreover, LDG meets the clinical requirements in terms of lymph node yield, adequacy of resection, and survival.
Review
Medicine, General & Internal
Dennis Visser, Elizabeth M. Wattel, Karin H. L. Gerrits, Johannes C. van der Wouden, Franka J. M. Meiland, Aafke J. de Groot, Elise P. Jansma, Cees M. P. M. Hertogh, Ewout B. Smit
Summary: Physical fitness training can be effective for adults aged over 65 years, with current existing guidelines widely applicable. However, adjustments may be necessary based on individual health conditions.
Review
Cell Biology
Qian Wang, Coert J. Zuurbier, Ragnar Huhn, Carolin Torregroza, Markus W. Hollmann, Benedikt Preckel, Charissa E. van den Brom, Nina C. Weber
Summary: Pharmacological conditioning aims to protect the heart from myocardial ischemia-reperfusion injury. This review updates the recent developments in pharmacological conditioning and summarizes the clinical evidence of these strategies in the perioperative setting. It discusses the cellular processes during ischemia and reperfusion that contribute to acute injury and explores promising interventions targeting these processes.
Review
Dermatology
B. Rook, M. J. E. van Rijn, E. P. Jansma, C. van Montfrans
Summary: Physical exercise after DVT has positive effects on patients' quality of life, pain reduction, and severity of PTS. Lifestyle interventions, such as guided individualized training programs, can be a useful supplementary therapy for both DVT patients and PTS patients.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Medicine, General & Internal
Elise Beijer, Stefan F. van Wonderen, Wietse P. Zuidema, Marieke C. Visser, Michael J. R. Edwards, Michael H. J. Verhofstad, Tjarda N. Tromp, Charissa E. van den Brom, Esther M. M. van Lieshout, Frank W. Bloemers, Leo M. G. Geeraedts Jr
Summary: This study identified an association between sex and outcomes in severe traumatic brain injury (TBI) patients, particularly favoring older females by indicating shorter hospital stays.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Anesthesiology
Nicole P. Juffermans, Charissa E. van den Brom, Derek J. B. Kleinveld
ANESTHESIA AND ANALGESIA
(2020)
Review
Critical Care Medicine
Matthijs M. den Os, Charissa E. van den Brom, Anoek L. I. van Leeuwen, Nicole A. M. Dekker
