Comparable Exogenous Carbohydrate Oxidation from Lactose or Sucrose during Exercise

Purpose Ingesting readily oxidized carbohydrates (CHO) such as sucrose during exercise can improve endurance performance. Whether lactose can be utilized as a fuel source during exercise is unknown. The purpose of this study was to investigate the metabolic response to lactose ingestion during exercise, compared with sucrose or water. Methods Eleven participants (age, 22 +/- 4 yr; V?O-2peak, 50.9 +/- 4.7 mL center dot min(-1)center dot kg(-1)) cycled at 50% W-max for 150 min on five occasions. Participants ingested CHO beverages (lactose or sucrose; 48 g center dot h(-1), 0.8 g center dot min(-1)) or water throughout exercise. Total substrate and exogenous CHO oxidation was estimated using indirect calorimetry and stable isotope techniques (naturally high C-13-abundance CHO ingestion). Naturally low C-13-abundance CHO trials were conducted to correct background shifts in breath (CO2)-C-13 production. Venous blood samples were taken to determine plasma glucose, lactate, and nonesterified fatty acid concentrations. Results Mean exogenous CHO oxidation rates were comparable with lactose (0.56 +/- 0.19 g center dot min(-1)) and sucrose (0.61 +/- 0.10 g center dot min(-1); P = 0.49) ingestion. Endogenous CHO oxidation contributed less to energy expenditure in lactose (38% +/- 14%) versus water (50% +/- 11%, P = 0.01) and sucrose (50% +/- 7%, P <= 0.05). Fat oxidation was higher in lactose (42% +/- 8%) than in sucrose (28% +/- 6%; P <= 0.01); CHO conditions were lower than water (50% +/- 11%; P <= 0.05). Plasma glucose was higher in lactose and sucrose than in water (P <= 0.01); plasma lactate was higher in sucrose than in water (P <= 0.01); plasma nonesterified fatty acids were higher in water than in sucrose (P <= 0.01). Conclusions Lactose and sucrose exhibited similar exogenous CHO oxidation rates during exercise at moderate ingestion rates. Compared with sucrose ingestion, lactose resulted in higher fat and lower endogenous CHO oxidation.