Review
Clinical Neurology
Mi Su, Xiaoxiao Ouyang, Yongyan Song
Summary: This meta-analysis supports the association between depression and inflammation, with NLR being a potential indicator of depression. However, no significant differences were found in PLR and MLR values between depressed subjects and controls. Further large-scale studies are needed to evaluate the role of PLR and MLR in depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Martha Fors, Santiago Ballaz, Hegira Ramirez, Francisco X. Mora, Mary Pulgar-Sanchez, Kevin Chamorro, Esteban Fernandez-Moreira
Summary: Sex-dependent differences exist in the contribution of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and mean platelet volume-to-platelet ratio (MPR) to COVID-19 severity and mortality. The mortality rate of COVID-19 is higher among men, and men have higher levels of NLR, MLR, and MPR compared to women. NLR, MLR, and PLR have better sensitivity for predicting pneumonia severity in men, while their specificity is enhanced in women.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Obstetrics & Gynecology
Ozlem Erte, Ysun Tekeli Taskomur
Summary: This study evaluated inflammatory parameters in pregnant women with isolated oligohydramnios, and found that serum levels of Cystatin C and hs-CRP may serve as potential biochemical markers for the diagnosis and prediction of perinatal outcomes in these cases.
GINEKOLOGIA POLSKA
(2022)
Article
Immunology
Qian Song, Song-Xiao Xu, Jun-Zhou Wu, Lin Ling, Sheng Wang, Xin-Hua Shu, Dan-Ni Ying, Wang-Wei Pei, Yu-Chen Wu, Su-Fang Sun, Yi-Ning Zhang, Si-Hang Zhou, Zhu-Yan Shao
Summary: This study analyzed data from 991 ovarian cancer patients and found that the lymphocyte to monocyte ratio (LMR) and platelet to neutrophil ratio (PNR) were independent prognostic indicators of ovarian cancer. In contrast, the platelet to lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) had limited prognostic value. In conclusion, LMR and PNR are superior prognostic indicators in ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Yanping Zhang, Aihong Zhang, Lin Wei, Kaiming Ren, Qian Wang, Bing Shao, Chen Zhao, Zhuo Ren, Jiuxu Bai, Ning Cao
Summary: This study aimed to assess whether the platelet-to-lymphocyte ratio (PLR) is independently associated with all-cause mortality and cardiovascular mortality in maintenance hemodialysis (MHD) patients. The results showed that high PLR levels can independently predict all-cause and cardiovascular mortality in MHD patients.
Article
Immunology
Ebru Yuce
Summary: The role of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in predicting spontaneous preterm birth was investigated. Retrospective data collected from hospital records between February 2018 and November 2022 showed that NLR and PLR values can predict preterm birth with high sensitivity and specificity. Predicting preterm birth allows for sensitive and smooth management of the pregnancy process.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Clinical Neurology
Yanyan Wei, Junhui Feng, Jinbao Ma, Dongning Chen, Jingxu Chen
Summary: This study examines the role of alterations in the immune-inflammation system in affective disorders, specifically major depressive disorder (MDD) and bipolar disorder (BD). The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and monocyte/lymphocyte ratio (MLR) are investigated as inflammation markers. The findings reveal elevated NLR and MLR in first-episode and recurrent MDD patients, as well as higher NLR and MLR and lower PLR in BD patients. Moreover, BD manic episode patients have significantly higher NLR and MLR compared to BD depressive episode patients or MDD patients. Overall, this study highlights the importance of systemic inflammation in the pathophysiology of MDD and BD, particularly during manic BD episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Infectious Diseases
Vanessa Bianconi, Elisabetta Schiaroli, Massimo R. Mannarino, Amirhossein Sahebkar, Francesco Paciosi, Sara Benedetti, Ettore Marini, Matteo Pirro, Daniela Francisci
Summary: In long-term ART-treated PLWH with high NLR, there is a curvilinear association between NLR and bFMD, but NLR has low discriminatory ability towards predicting endothelial dysfunction.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2022)
Article
Clinical Neurology
Fanchao Meng, Xiuping Yan, Junhui Qi, Fan He
Summary: This study aimed to investigate the association and potential non-linear relationship between neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR) with depression. Based on a cross-sectional study of US adults, it was found that only PLR was significantly associated with depression. Furthermore, the relationships between NLR, PLR, and MLR with depression were found to be non-linear.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Oncology
Qiang Hu, Weipu Mao, Tiange Wu, Zhipeng Xu, Junjie Yu, Can Wang, Saisai Chen, Shuqiu Chen, Bin Xu, Yueshuang Xu, Ming Chen
Summary: In RCC patients undergoing laparoscopic partial or radical nephrectomy, NLR and PLR were identified as biomarkers of systemic inflammation associated with increased risk of sarcopenia. The best cutoff points for predicting sarcopenia risk were NLR >2.88 and PLR >135.63, with higher levels indicating a greater risk. Adjusting for various variables, patients with NLR >2.88 and PLR >135.63 had significantly higher risks of developing sarcopenia compared to those with lower NLR or PLR levels.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pediatrics
Tan Xie, Dongliang Hou, Jiaxiang Wang, Song Zhao
Summary: This study showed that elevated NLR and PLR were poor prognostic factors in hepatoblastoma patients before treatment, and NLR was an independent prognostic factor for overall survival.
FRONTIERS IN PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Peng Ning, Fan Yang, Jun Kang, Jing Yang, Jiaxing Zhang, Yi Tang, Yanghong Ou, Haiyan Wan, Hongyi Cao
Summary: This study found that platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR) were associated with arterial stiffness in patients with diabetes. Among them, NLR showed higher accuracy in predicting arterial stiffness.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Jiali Leng, Fei Wu, Lihui Zhang
Summary: This meta-analysis found that pretreatment neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may serve as biomarkers for predicting poor prognosis in patients with endometrial cancer, while monocyte-lymphocyte ratio (MLR) is not associated with prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Siqing Wang, Lingqiu Dong, Gaiqin Pei, Zheng Jiang, Aiya Qin, Jiaxing Tan, Yi Tang, Wei Qin
Summary: The study found that a high NLR value is closely related to the deterioration of renal function, worsening of pathological lesions, renal progression, and prognosis in patients with IgAN. Patients with a high NLR value are more likely to have hypertension and a poorer prognosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Psychiatry
Yanwei Cheng, Yiwen Wang, Xiangyi Wang, Zhuoya Jiang, Lijun Zhu, Shaokuan Fang
Summary: This study found that the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are significantly higher in patients with depression. However, the monocyte-to-lymphocyte ratio (MLR) is slightly higher but not significantly different. Sensitivity and subgroup analysis revealed differences in inflammatory ratios in different regions and in patients with post-stroke depression (PSD).
FRONTIERS IN PSYCHIATRY
(2022)
Article
Urology & Nephrology
Arzu Ozdemir, Sibel Yucel Kocak, Ayse Aysim Ozagari, Murvet Yilmaz
Summary: The prevalence of kidney disease and the number of renal biopsies are increasing in the elderly population. Differences in clinical presentation and renal pathology exist between elderly and younger patients. The relatively high prevalence of potentially curative kidney diseases in the elderly emphasizes the importance of renal biopsy in this age group.
CLINICAL NEPHROLOGY
(2022)
Article
Urology & Nephrology
Arzu Ozdemir, Sibel Yucel Kocak, Semsi Nur Karabela, Murvet Yilmaza
Summary: This study found that patients with chronic kidney disease (CKD) who are infected with COVID-19 have a higher risk of severe disease and mortality. Hematological indices, including NLR, SII, PLR, and LCR, are associated with in-hospital mortality in CKD patients. Among these markers, NLR and SII have the best ability to distinguish patients at higher risk of death.
Article
Urology & Nephrology
Arzu Ozdemir, Sibel Yucel Kocak, Suheyla Apaydin, Murvet Yilmaz
Summary: This study aimed to evaluate the daily variability of bicarbonate in hemodialysis patients and identify the factors that affect this issue. The results showed that relying solely on pre-dialysis tCO2 values to define metabolic acidosis may lead to misclassification, as the agreement between pre- and post-dialysis tCO2 and HCO3- was not good.
CLINICAL NEPHROLOGY
(2022)
Article
Urology & Nephrology
Arzu Ozdemir, Murvet Yilmaz, Ayse Aysim Ozagari, Sibel Yucel Kocak
Summary: This study aimed to analyze the impact of histological characteristics on renal outcome in patients with biopsy-proven renal AA amyloidosis. The results showed that baseline renal function was closely linked to the extent of AA amyloid deposit in renal parenchyma, while only vascular amyloid load was a predictor of renal outcome in AAA patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Arzu Ozdemir, Sibel Yucel Kocak
Summary: This study investigated the incidence, causative agents, and outcomes of peritonitis episodes in patients undergoing peritoneal dialysis. The results showed that both Gram-positive and Gram-negative organisms were common causes of peritonitis, with a higher rate of catheter removals and lower resolution rate observed in Gram-negative cases. The findings suggest that knowledge of prevalent microbial agents and appropriate treatment adjustments are important in reducing the incidence of peritonitis.
MEDICAL JOURNAL OF BAKIRKOY
(2022)
Article
Urology & Nephrology
Meltem Gursu, Itir Yegenaga, Serhan Tuglular, Belda Dursun, Sibel Gokcay Bek, Simge Bardak, Engin Onan, Serap Demir, Ulver Derici, Ayhan Dogukan, Mustafa Sevinc, Ismail Kocyigit, Eda Altun, Ali Burak Haras, Mehmet Riza Altiparmak, Halil Zeki Tonbul
Summary: This study evaluated the etiologies, comorbidities, and outcomes of AKI in Turkey. The results showed that prerenal etiologies were more common, with nephrotoxic agent exposure being the most common renal etiology. A high proportion of patients required kidney replacement therapy, and the recovery rate at 6 months varied. Patients from the Eastern Anatolian region had a higher mortality rate.
Article
Urology & Nephrology
Aziz Batu, Leman Karaagac, Tuncay Sahutoglu
Summary: This is a case report on a nonendemic occurrence of leptospirosis caused by Leptospira in a 44-year-old male living in a Syrian refugee camp in the arid city of Sanliurfa. The patient presented with jaundice and renal failure. This case serves as an example of leptospirosis in a nonendemic area, and provides a brief overview of relevant literature.
HEMODIALYSIS INTERNATIONAL
(2023)
Article
Urology & Nephrology
Tuncay Sahutoglu, Yadigar Akturk Kus, Halenur Harman, Meral Beyaz
Summary: This study aimed to assess the efficacy and safety of a consistent percutaneous procedure for peritoneal dialysis (PD) catheter placement in initiating immediate-start PD in patients with end-stage kidney disease (ESKD). The results showed that it is feasible to start PD within 1 hour of catheter placement, with no cases of leakage, technique failure, or the need for hemodialysis. Although there were minor complications, it is of significant importance for initiating PD.
CLINICAL NEPHROLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Tuncay Sahutoglu, Elif Sahutoglu
EUROPEAN HEART JOURNAL
(2023)
Review
Urology & Nephrology
Ozkan Gungor, Mustafa Sevinc, Sena Ulu, Ismail Kocyigit
Summary: Cardiovascular disease is common in patients with chronic kidney disease and is the leading cause of mortality. Advanced age, hypertension, uremic toxins, and other factors contribute to increased cardiovascular disease risk. Sarcopenia, a decrease in muscle strength, is prevalent in chronic kidney disease patients and is associated with lower quality of life and increased mortality risk.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Urology & Nephrology
Serhat Karadag, Savas Ozturk, Mustafa Arici, Numan Gorgulu, Esra Akcali, Irem Pembegul, Dilek Guven Taymez, Rumeyza Kazancioglu, Yavuz Ayar, Ruya Mutluay, Arzu Ozdemir, Zeki Aydin, Yagmur Bashan, Selma Alagoz, Fatih Yilmaz, Sinan Trabulus, Ahmet Burak Dirim, Ilyas Ozturk, Ayca Inci, Alper Azak, Nimet Aktas, Tolga Kuzu, Hamad Dheir, Taner Basturk, Tuba Elif Ozler, Mevlut Tamer Dincer, Kenan Turgutalp, Sena Ulu, Ozkan Gungor, Elif Ari Bakir, Ali Riza Odabas, Nurhan Seyahi, Alaattin Yildiz, Kenan Ates
Summary: COVID-19 is associated with increased mortality, deterioration of kidney function, higher need for dialysis, and ongoing respiratory symptoms in patients with chronic kidney disease (CKD).
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Urology & Nephrology
Arzu Ozdemir, Erdem Baran, Muhammed Kutu, Selda Celik, Murvet Yilmaz
Summary: The study found that SII levels were elevated in patients with SLE, and SII was positively correlated with C-reactive protein. However, SII had lower predictive ability for SLE compared to NLR and PLR. Additionally, NLR may be a better marker for predicting SLE patients with nephritis.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Elbis Ahbap, Nuri Baris Hasbal, Mustafa Sevinc, Taner Basturk, Tamer Sakaci, Abdulkadir Unsal
Summary: This study aims to evaluate factors associated with long-term survival in stable maintenance hemodialysis patients. It was found that pre-dialysis systolic blood pressure was the sole risk factor for poor long-term survival, while malnutrition-inflammation, measures of nutrition, inflammation, and anemia had no significant impact on survival.
MEDICAL BULLETIN OF SISLI ETFAL HOSPITAL
(2022)
Article
Medicine, General & Internal
Ekrem Kara, Tuncay Sahutoglu, Sibel Demirbas, Mehmet Beyazal
Summary: Ultrasonographic temporal muscle thickness is a significant predictor of mortality in prevalent hemodialysis patients. Further studies are needed to explore its potential as a novel marker of nutritional status and mortality.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2022)
Article
Medicine, General & Internal
Hamad Dheir, Ozkan Gungor, Memnune Sena Ulu, Ebru Gok Oguz, Necmi Eren, Orcun Altunoren, Erhan Tatar, Kadir Gokhan Atilgan, Suleyman Karakose, Ibrahim Guney, Eray Eroglu, Ruya Mutluay, Ilter Bozaci, Alper Alp, Hakan Akdam, Meltem Sezis Demirci, Zeki Soypacaci, Ozger Akarsu, Saime Payda, Zafer Ercan, Ekrem Kara, Cevat Topal, Haldun Hakan Yava, Nihan Tekkarismaz, Kenan Turgutalp, Can Huzmeli, Ayca Inci, Guner Karaveli Gursoy, Ayse Jini Gunes Keskin, Bulent Huddam, Ender Hur, Abdulmecit Yildiz, Garip Bekfilavioglu, Tuncay Sahutoglu, Mehmet Tuncay, Simge Bardak, Serkan Bakirdogen, Zulfukar Yilmaz, Emrah Gunay, Onur Tunca, Sinan Kazan, Irem Pembegul Yigit, Hazen Sarita, Can Sevinc, Hakan Kaptanogullari, Sibel Gokcay Bek, Ilhan Kurultak, Ali Degirmenci, Murat Sakaci, Ilhan Kilic, Zeki Aydin, Hulya Colak, Erkan Dervisoglu, Garip Sahin, Mehmet Deniz Ayli, Savas Sipahi, Ulver Derici, Eray Eroglu
Summary: This study investigated the pregnancy frequency and factors affecting live births in hemodialysis (HD) patients. The results showed that increasing the number of HD sessions can decrease fetal and maternal complications and increase live birth rates.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2022)
