Review
Medicine, General & Internal
Li Xie, Gang Feng, Ping Zhu, Jiang Xie
Summary: This meta-analysis evaluated the relationship between PVT1 expression and prognosis, as well as clinicopathological characteristics, in breast cancer patients, providing high-quality medical evidence for related studies.
Article
Biochemistry & Molecular Biology
Zhangxiang Zhao, YingYing Guo, Yaoyao Liu, Lichun Sun, Bo Chen, Chengyu Wang, Tingting Chen, Yuquan Wang, Yawei Li, Qi Dong, Liqiang Ai, Ran Wang, Yunyan Gu, Xia Li
Summary: The study individualized lncRNA expression profiles for breast cancer using the LncRNA Individualization method, constructing an individualized differentially expressed lncRNA profile for breast cancer and investigating subtype-specific lncRNAs.
Article
Cell Biology
Yi-Tung Chen, Chia-Hua Kan, Hsuan Liu, Yu-Hao Liu, Chih-Ching Wu, Yu-Ping Kuo, Ian Yi-Feng Chang, Kai-Ping Chang, Jau-Song Yu, Bertrand Chin-Ming Tan
Summary: Recent findings have highlighted the role of long noncoding RNAs (lncRNAs) in gene regulation, particularly in pathways associated with tumorigenesis. HOXA10-AS, a tumor-biased expressed lncRNA, plays a critical role in oral cancer growth and metastasis and is also associated with drug sensitivity.
CELL DEATH & DISEASE
(2022)
Article
Medicine, Research & Experimental
Changhao Chen, Hanhao Zheng, Yuming Luo, Yao Kong, Mingjie An, Yuting Li, Wang He, Bowen Gao, Yue Zhao, Hao Huang, Jian Huang, Tianxin Lin
Summary: This study reveals that SUMOylation is a crucial mechanism promoting lymphatic metastasis in bladder cancer, by regulating the ELNAT1/UBC9/SOX18 axis to enhance lymphangiogenesis and LN metastasis. Blocking tumor cell SUMOylation could be a promising therapeutic strategy for LN metastatic BCa.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemical Research Methods
Meng Zhou, Zicheng Zhang, Siqi Bao, Ping Hou, Congcong Yan, Jianzhong Su, Jie Sun
Summary: A machine learning-based computational framework was used to identify a lncRNA signature of TIL-Bs, named TILBlncSig, which showed potential in distinguishing survival outcomes and was associated with cancer features and immunosuppressive phenotype.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Cell Biology
Qin Wang, Jiena Liu, Zilong You, Yanling Yin, Lei Liu, Yujuan Kang, Siwei Li, Shipeng Ning, Hui Li, Yajie Gong, Shouping Xu, Da Pang
Summary: The study revealed that TINCR is upregulated in human breast cancer tissues and its knockdown suppresses tumorigenesis in vitro and in vivo. Mechanistically, TINCR recruits DNMT1 to the miR-503-5p locus promoter, increasing methylation and suppressing transcriptional expression of miR-503-5p. Additionally, TINCR functions as a competing endogenous RNA to upregulate EGFR expression by sponging miR-503-5p.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Shidong Wang, Chen Qiao, Jun Li, Si Liu, Peng Li
Summary: CASC19 exerts an oncogenic effect in gastric cancer by interacting with CREB1 and enhancing its stability. These findings highlight CASC19 as a potential biomarker and therapeutic target for advanced gastric cancer.
Article
Biotechnology & Applied Microbiology
Yongzhi Li, Benkang Shi, Fengming Dong, Xingwang Zhu, Bing Liu, Yili Liu
Summary: The study demonstrates that high expression of KCNQ1OT1 in bladder cancer promotes tumor progression by regulating the miR-218-5p/HS3ST3B1 signaling pathway.
CANCER GENE THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Hongtao Hu, Hanqiu Zhang, Yue Xing, Yan Zhou, Jianing Chen, Cheng Li, Jingjing Xu, Yanyan Guo, Jie Wang, Qi He, Xinmei Liu, Jianzhong Sheng, Erwei Song, Yanting Wu, Hefeng Huang
Summary: Emerging evidence suggests that the long non-coding RNA THOR plays a critical role in the development of breast cancer. THOR interacts with hnRNPD to regulate downstream signaling pathways, promoting cell proliferation and metastasis in breast cancer. The THOR-hnRNPD-PDK1-MAPK/PI3K-AKT axis may serve as a potential therapeutic target for breast cancer treatment.
Article
Biology
Tingting Shao, Yunjin Xie, Jingyi Shi, Changbo Yang, Haozhe Zou, Yongsheng Li, Juan Xu, Xia Li
Summary: This study proposes a multiple-step model to identify lncRNA-lncRNA immune cooperation and constructs lncRNA immune cooperative networks. These networks may modulate tumor-immune microenvironment by regulating immune-related functions. The study also reveals important immune cooperative lncRNAs that play central roles in multiple cancers and are correlated with known anticancer drug targets.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuan Wang, Shun Gao, Yingkun Xu, Zhenrong Tang, Shengchun Liu
Summary: This study aimed to analyze the prognostic implications of mitochondrial function-related lncRNAs in breast cancer (BRCA) and their link to the immunological microenvironment. By analyzing clinical and transcriptome data of BRCA samples, mitochondrial function-related lncRNAs were identified and a prognostic signature was constructed. The study found that individuals in the higher-risk category had lower overall survival rates and decreased immune cell infiltration and function. This study provides new insights for the treatment and prognostic prediction of breast cancer.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Ye Feng, Ying Xu, Yongjian Gao, Yiying Chen, Xuefeng Wang, Zhi Chen
Summary: SOX2OT is an up-regulated oncogene in CRC, promoting cell proliferation, migration, and invasion. It acts as a competing endogenous RNA to upregulate SOX5 by sponging miR-194-5p, thus affecting tumorgenesis of CRC.
CELL DEATH & DISEASE
(2021)
Review
Medicine, Research & Experimental
Amirreza Mehmandar-Oskuie, Kasra Jahankhani, Arman Rostamlou, Sepideh Arabi, Zahra Sadat Razavi, Amirhossein Mardi
Summary: Bladder cancer is a prevalent and challenging malignancy worldwide. Long noncoding RNAs (lncRNAs) have been identified as playing significant roles in the development and progression of bladder cancer. Abnormal expression of lncRNAs impacts various functions related to bladder cancer, and they show potential as prognostic and diagnostic biomarkers. The use of genetic tools and anti-tumor agents has also been explored in preclinical cancer models.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Minghui Wang, Zhijun Zhang, Deng Pan, Zhigang Xin, Fan Bu, Yue Zhang, Qingwu Tian, Xiaodong Feng
Summary: This study identified two lncRNAs, UCA1 and PGM5-AS1, in the plasma of CRC patients, which have the potential to be used as diagnostic biomarkers for CRC. The diagnostic potential of these lncRNAs is even higher for early-stage CRC.
BIOSCIENCE REPORTS
(2021)
Article
Cell Biology
Wentao Ma, Weihong Zhang, Bing Cui, Jing Gao, Qiuhong Liu, Mengying Yao, Hanbing Ning, Lihua Xing
Summary: This study reveals that EPCs derived EVs transmit TUG1 to alleviate sepsis by promoting macrophage M2 polarization. Additionally, TUG1 can competitively bind to miR-9-5p to upregulate SIRT1 expression, leading to the inhibition of miR-9-5p-mediated SIRT1 inhibition, which contributes to a more comprehensive understanding of the pathogenesis of sepsis.
CELL DEATH & DISEASE
(2021)