期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 22, 期 11, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cmi.2016.07.032
关键词
Democratic Republic of Congo; Genotype 7b; Hepatitis C virus; Next-generation sequencing; Polymorphism
We report the near-full-length genome sequence of a hepatitis C virus (HCV) isolate from a man originating from Democratic Republic of Congo, the genotype of which could not be determined by the routinely used sequencing technique. The near-complete genome sequence of this variant BAK1 was obtained by the association of two next-generation sequencing technologies. Evolutionary analysis indicates that this isolate, BAK1, could be the first reported strain belonging to a new HCV-7b subtype. This new subtype has been incorrectly identified as genotype 2 by the Versant HCV Genotype 2.0 assay (LiPA). The requirement of three independent isolates has been filled, and a new subtype can be assigned. More examples of HCV-7 are required to better understand its origin, its pathogenicity and its relationship with genotype 2. M. Salmona, CMI 2016; 22: 947.e1-947.e8 (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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