Article
Endocrinology & Metabolism
Shanshan Xue, Yuzheng Zhang, Wenjing Qiao, Qianqian Zhao, Dingjie Guo, Binbin Li, Xue Shen, Lijie Feng, Fengyi Huang, Na Wang, Kemal Sherefa Oumer, Charkos Tesfaye Getachew, Shuman Yang
Summary: The study updated BMD T-score references using the most recent NHANES data, finding significant differences in the percentages of individuals classified as having osteoporosis and low bone mass between the updated and existing guidelines.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Yi Xiang J. Wang, Ben-Heng Xiao
Summary: This study estimated the prevalence of osteoporosis in Chinese men and women over the age of 50, and proposed revised T-score cutpoints for defining osteopenia and osteoporosis. The results suggest that the prevalence of osteoporosis in China is lower compared to the US, but the risk of fractures is relatively higher.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Environmental Sciences
Aroon La-up, Pranee Mahasakpan, Udomsak Saengow
Summary: This study aimed to determine the prevalence of osteoporosis after 15 years of reduced cadmium exposure and investigate the association between urinary cadmium (U-Cd) and osteoporosis. The results showed that despite discontinued cadmium exposure for over a decade, the toxic effects on bone continued, especially in women. Increasing levels of U-Cd were correlated with decreasing bone mineral density, with the association between U-Cd and osteoporosis being significant at concentrations of U-Cd >= 10 mu g/g creatinine.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Medicine, General & Internal
Yu-Cheng Liu, Tzu- Yang, Shu-Wei Huang, Yi-Jie Kuo, Yu-Ping Chen
Summary: Osteoporosis is characterized by low bone mass and increased bone fragility. Inflammation has been suggested to play a role in its development. This study found that both the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were significantly higher in the osteoporosis group compared to the normal bone mineral density group. NLR was also significantly higher in postmenopausal women with osteoporosis. These findings suggest that NLR and PLR could be potential targets for osteoporosis screening.
Article
Endocrinology & Metabolism
Barbara Stachowska, Jowita Halupczok-Zyla, Justyna Kuliczkowska-Plaksej, Joanna Syrycka, Marek Bolanowski
Summary: Patients with active Cushing's syndrome show altered bone microstructure with decreased TBS, leading to a higher risk of hip and major osteoporotic fractures. TBS appears to be a valuable tool for assessing fracture risk in endogenous hypercortisolism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Christoph Biehl, Jakob Schmitt, Sabine Stoetzel, Deeksha Malhan, Fathi Hassan, Gero Knapp, Christian Heiss, Thaqif El Khassawna
Summary: This study determined reference parameters for the skeletal system in merino land sheep, providing a standard for comparison with human studies. Results showed that bone density increases with age, with distinct peaks observed around the fourth and seventh year of life. Establishing an independent reference group is crucial for improving comparability in research using this animal model.
Article
Nutrition & Dietetics
Briana M. Nosal, Junichi R. Sakaki, Zachary Macdonald, Kyle Mahoney, Kijoon Kim, Matthew Madore, Staci Thornton, Thi Dong Binh Tran, George Weinstock, Elaine Choung-Hee Lee, Ock K. Chun
Summary: This study aimed to examine the dose-dependent effects of blackcurrant supplementation on preventing bone loss in adult women. The results showed that blackcurrant supplementation decreased the loss of whole-body bone mineral density and increased the marker of bone formation, P1NP. Further studies with larger samples and different skeletal conditions are needed to confirm these findings.
Article
Endocrinology & Metabolism
Nipith Charoenngam, Caroline M. Apovian, Chatlert Pongchaiyakul
Summary: This study aims to determine the association of lean mass and fat mass with bone mineral density in Thais. The results show that in men, lean mass index is positively correlated with lumbar spine and femoral neck bone density, while fat mass index is negatively correlated with femoral neck bone density. In women, both lean mass and fat mass index are positively correlated with lumbar spine and femoral neck bone density. These findings indicate a sex-specific influence of fat mass on bone density in Thais.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shereen M. Aleidi, Mysoon M. Al-Ansari, Eman A. Alnehmi, Abeer K. Malkawi, Ahmad Alodaib, Mohamed Alshaker, Hicham Benabdelkamel, Anas M. Abdel Rahman
Summary: The study revealed distinct lipidomics profiles between LBMD and Ctrl groups, with 322 dysregulated lipid molecules identified, primarily in subclasses such as PC, TG, and PE. These findings offer insights into lipidomics alterations associated with bone remodeling and LBMD, potentially guiding the development of therapeutic targets and nutritional strategies for managing OP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mysoon M. Al-Ansari, Shereen M. Aleidi, Afshan Masood, Eman A. Alnehmi, Mai Abdel Jabar, Maha Almogren, Mohammed Alshaker, Hicham Benabdelkamel, Anas M. Abdel Rahman
Summary: This study investigated sensitive and specific LBMD-associated protein biomarkers in patients diagnosed with ON and OP. The results identified distinctive proteomics profiles between the control, ON, and OP groups, as well as significant dysregulation in a panel of proteins common among the three groups. A comparison of proteins showed differences in their levels between ON and the control group, as well as between ON and OP. These findings provide potential protein biomarkers for further research on bone health and OP progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
William D. Leslie, Heenam Goel, Neil Binkley, Eugene McCloskey, Didier Hans
Summary: Lumbar spine trabecular bone score (TBS) is a bone mineral density (BMD)-independent risk factor for fracture, but its sensitivity to technical factors and oral antiresorptive therapies is limited. This study analyzed TBS changes over time and in response to osteoporosis treatment, and found that TBS is strongly affected by technical factors and has little effect on monitoring response to antiresorptive treatment. Therefore, the current version of the TBS algorithm has limited usefulness in untreated individuals or routine clinical practice.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Orthopedics
Yi Xiang J. Wang, Glen M. Blake, Ben-Heng Xiao, Giuseppe Guglielmi, Yi Su, Yebin Jiang, Ali Guermazi, Timothy C. Y. Kwok, James F. Griffith
Summary: This article argues that an ethnicity- and gender-specific BMD database should be used for T-score calculations for East Asians, and provides justifications for this advocacy. Using a Caucasian BMD reference database leads to lower T-scores for East Asians and overestimation of osteoporosis prevalence. Using a female BMD reference database for male patients leads to higher T-scores and underestimation of osteoporosis prevalence. Epidemiological evidence does not support using a female BMD reference database for T-score calculations in men.
SKELETAL RADIOLOGY
(2023)
Review
Clinical Neurology
Bo Liu, Guangdong Chen, Zhaohui Yu, Chenchen Ji, Ting Liang, Jiaheng He, Wangying Dai, Yijie Shao, Huaye Jiang, Wen Zhang, Huilin Yang, Zongping Luo
Summary: This meta-analysis of 17 studies found that patients with Parkinson's disease have significantly lower bone mineral density, as well as lower bone mineral density T scores and Z scores compared to non-PD controls.
WORLD NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Shereen M. Aleidi, Eman A. Alnehmi, Mohammed Alshaker, Afshan Masood, Hicham Benabdelkamel, Mysoon M. Al-Ansari, Anas M. Abdel Rahman
Summary: This study used an untargeted mass spectrometry-based metabolomics approach to analyze serum samples of patients with low BMD, finding significant differences in metabolic processes between LBMD patients and controls. Various metabolic pathways, including histidine metabolism and aminoacyl-tRNA biosynthesis, were dysregulated in LBMD. Differences in metabolite levels were also observed between osteopenia (ON) and osteoporosis (OP) groups, with certain metabolites upregulated in ON and downregulated in OP. These findings contribute to understanding metabolic alterations associated with LBMD, ON, and OP, and aid in developing prediction models for bone health and OP progression.