Article
Biochemistry & Molecular Biology
Yan-Ni Wang, Chang-E Yang, Dan-Dan Zhang, Yuan-Yuan Chen, Xiao-Yong Yu, Ying-Yong Zhao, Hua Miao
Summary: Aging is a risk factor for chronic diseases, including kidney disease. Advances in genome analyses have identified noncoding RNAs, specifically lncRNAs, that play critical roles in the regulation of gene expression and epigenetic reprogramming, and have been shown to be important in kidney disease. Targeting lncRNAs may present a precise therapeutic strategy for progressive renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Cell Biology
Dimitrios Tsitsipatis, Jennifer L. L. Martindale, Krystyna Mazan-Mamczarz, Allison B. B. Herman, Yulan Piao, Nirad Banskota, Jen-Hao Yang, Linna Cui, Carlos Anerillas, Ming-Wen Chang, Mary Kaileh, Rachel Munk, Xiaoling Yang, Ceereena Ubaida-Mohien, Chee W. W. Chia, Ajoy C. C. Karikkineth, Linda Zukley, Jarod D'Agostino, Kotb Abdelmohsen, Nathan Basisty, Supriyo De, Luigi Ferrucci, Myriam Gorospe
Summary: We identified age-associated changes in the transcriptome, including coding and noncoding RNAs, of healthy human skin fibroblasts from 82 individuals across a wide age range. The differential abundance of 1437 coding and 1177 long noncoding RNAs was observed as a function of age. Transcription factors and RNA-binding proteins were implicated in regulating the expression of differentially abundant mRNAs and age-associated lncRNAs. These findings suggest that the identified transcripts may have potential as biomarkers and therapeutic targets for aging skin.
Review
Medicine, Research & Experimental
Xiaoying Jiang
Summary: Fibrosis is a process involving excessive deposition of extracellular matrix that leads to tissue disruption and organ failure. NEAT1, a long noncoding RNA, plays a crucial role in the development of fibrosis and knockdown of NEAT1 can alleviate fibrosis.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Oncology
Yiqiao Luo, Bin Yan, Li Liu, Libo Yin, Huihui Ji, Xuefeng An, Jury Gladkich, Zhimin Qi, Carolina de la Torre, Ingrid Herr
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor with poor therapeutic responses. Sulforaphane has shown promise in targeting long noncoding RNAs (lncRNAs) to inhibit PDAC progression, notably through the downregulation of the lncRNA H19. This study identified APOBEC3G as a new therapeutic target in PDAC inhibited by sulforaphane, providing valuable insight for future research.
Article
Multidisciplinary Sciences
Yue Cui, Bozhong Shi, Zijie Zhou, Bo Chen, Xiaoyang Zhang, Cong Li, Kai Luo, Zhongqun Zhu, Jinghao Zheng, Xiaomin He
Summary: A long non-coding RNA (CFRL) associated with cardiac fibrosis has been identified, which can promote the proliferation and migration of cardiac fibroblasts. Silencing CFRL significantly alleviates cardiac fibrosis and improves ventricular function. Interfering with CFRL may be considered as a multitarget strategy for treating cardiac fibrosis and heart failure.
Article
Neurosciences
Shiqian Han, Meng Ren, Tianyin Kuang, Mao Pang, Dongwei Guan, Yesong Liu, Yong Wang, Wengeng Zhang, Zhijia Ye
Summary: This study revealed dysregulated lncRNA expression patterns in NP-C disease, potentially playing a crucial role in its pathogenesis. RNA-seq analysis showed that mRNAs coexpressed with lncRNAs are mainly associated with immune system-related processes and neuroinflammation. Knockdown of specific lncRNAs could improve intracellular ROS levels and cell viability, as well as suppress inflammatory responses in vitro.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Senxiang Chen, Da Liu, Zimo Zhou, Sen Qin
Summary: Research on the targeting of lncRNA H19 in the treatment of osteoporosis shows promising prospects due to its effects on osteogenic differentiation processes. This review summarizes the molecular pathways and mechanisms of lncRNA H19 in the pathogenesis of osteoporosis and the progress of research on targeting H19 as a treatment option, indicating emerging possibilities for more effective treatments for bone metabolism diseases with molecular targets.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Lixia Zhang, Jinning Gao, Anjing Gong, Yanhan Dong, Xiaodan Hao, Xuekang Wang, Jian Zheng, Wenmeng Ma, Yiying Song, Jie Zhang, Wenhua Xu
Summary: The study explored the role of LINC00963 in regulating corneal fibrosis, finding that its overexpression can inhibit the formation of myofibroblasts and affect the contractility and secretion of collagen I and III in corneal fibroblasts by downregulating miR-143-3p expression. The research suggests LINC00963 as a promising therapeutic target for corneal fibrosis.
DNA AND CELL BIOLOGY
(2022)
Article
Biochemical Research Methods
Yu-Jian Kang, Jing-Yi Li, Lan Ke, Shuai Jiang, De-Chang Yang, Mei Hou, Ge Gao
Summary: This study introduces the ribosome calculator, which quantitatively models the coding ability of RNAs in the human genome, and successfully predicts transcripts with different coding abilities in various cell types. This suggests that the coding ability of transcripts should be modeled as a continuous spectrum with context-dependent nature.
BRIEFINGS IN BIOINFORMATICS
(2022)
Review
Cell & Tissue Engineering
Zimo Zhou, Mohammad Showkat Hossain, Da Liu
Summary: The long noncoding RNA H19 plays a vital role in osteogenic differentiation and is recognized as a novel target for promoting bone regeneration.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Food Science & Technology
Xiaoniu Dai, Yusi Cheng, Cuifen Wang, Jie Huang, Jie Chao
Summary: CircRNAs are a novel class of noncoding RNAs with a unique circular structure that play crucial roles in the pathogenesis and progression of human diseases, particularly in fibrotic diseases across various organs.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Cell Biology
Wentao Ma, Weihong Zhang, Bing Cui, Jing Gao, Qiuhong Liu, Mengying Yao, Hanbing Ning, Lihua Xing
Summary: This study reveals that EPCs derived EVs transmit TUG1 to alleviate sepsis by promoting macrophage M2 polarization. Additionally, TUG1 can competitively bind to miR-9-5p to upregulate SIRT1 expression, leading to the inhibition of miR-9-5p-mediated SIRT1 inhibition, which contributes to a more comprehensive understanding of the pathogenesis of sepsis.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Tae Hyung Kim, Yoonseok Lee, Young-Sun Lee, Jeong-An Gim, Eunjung Ko, Sun Young Yim, Young Kul Jung, SeongHee Kang, Moon Young Kim, Hayeon Kim, Baek-hui Kim, Ji Hoon Kim, Yeon Seok Seo, Hyung Joon Yim, Jong Eun Yeon, Soon Ho Um, Kwan Soo Byun
Summary: NASH and NAFL exhibit different miRNA expression profiles, with a combination of 4 miRNAs showing significant diagnostic accuracy for NASH, serving as a novel biomarker for NASH diagnosis in NAFLD.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Meng-Zhi Wu, Yi-Chuan Yuan, Bi-Yu Huang, Jin-Xi Chen, Bin-Kui Li, Jian-Hong Fang, Shi-Mei Zhuang
Summary: This study identified an oncogenic lncRNA, lnc-UTGF, that is upregulated in HCC and transcriptionally induced by TGF-beta. Mechanistic investigations revealed a positive feedback loop between TGF-beta/SMAD signaling and lnc-UTGF, promoting hepatoma metastasis. The findings suggest lnc-UTGF as a potential therapeutic target for HCC metastasis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Yuai Xiao, Yu Xia, Yuchong Wang, Chunyu Xue
Summary: Melanoma, a dangerous type of cutaneous neoplasm, has been extensively studied to improve diagnostic and treatment options. Long noncoding RNAs (lncRNAs) have been discovered and found to play significant roles in the occurrence and progression of melanoma. Researchers have categorized melanoma-associated lncRNAs based on their cellular functions, gene expression, and signaling pathways, and discussed the possibility of lncRNA-targeted treatments and the application of liquid biopsies for lncRNA detection in melanoma diagnosis and prognosis.
