期刊
CLINICAL MICROBIOLOGY AND INFECTION
卷 22, 期 1, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cmi.2015.09.027
关键词
Capsule deficiency; epidemiology; Haemophilus influenzae; Hib; NTHi; serotype
资金
- Robert Koch-Institute
- Federal Ministry of Health [1369-237]
Among invasive Haemophilus influenzae, unencapsulated strains have largely surpassed the previously predominant serotype b (Hib) because of Hib vaccination. Isolates without the genomic capsule (cap) locus are designated non-typeable H. influenzae (NTHi). They are different from capsule-deficient variants that show deletion of the capsule transport gene bexA within the cap locus. The frequency of capsule-deficient variants in invasive disease is unknown. We analysed 783 unencapsulated invasive isolates collected over 5 years in Germany and found no single capsule-deficient isolate. Invasive unencapsulated strains in Germany were exclusively NTHi. A negative serotyping result by slide agglutination was therefore highly predictive for NTHi. (C) 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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