Article
Polymer Science
Thien Bui-Thuan Do, Tien Ngoc-Thuy Nguyen, Minh Hieu Ho, Nghi Thi-Phuong Nguyen, Thai Minh Do, Dai Tan Vo, Ha Thi-Ngoc Hua, Thang Bach Phan, Phong A. Tran, Hoai Thi-Thu Nguyen, Toi Van Vo, Thi-Hiep Nguyen
Summary: The study revealed that the PCLGelAg membrane was most effective in wound healing and preventing infection, serving as a practical solution for treating severe burn injuries and other infection-related skin complications.
Article
Materials Science, Multidisciplinary
Armin Amirsadeghi, Arman Jafari, Seyyedeh-Sara Hashemi, Aboozar Kazemi, Younes Ghasemi, Amin Derakhshanfar, Mohammad-Ali Shahbazi, Seyyed Vahid Niknezhad
Summary: Novel sprayable antibacterial dressings were developed by in-situ formation of Ag-nanoparticles using Persian gum as a carbohydrate polymer. The dressings showed good sprayability, antibacterial activity, and biocompatibility, indicating high potential for wound repair.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Nandini Sarviya, Urbashi Mahanta, Alexander Dart, Jyotsnendu Giri, Atul Suresh Deshpande, Mudrika Khandelwal, Mrinal Bhave, Peter Kingshott
Summary: A three-layer polymer nanofiber mesh with antibacterial properties has been developed using electrospinning. The mesh is capable of killing bacteria and has cytocompatibility, making it suitable for treating severe skin wounds. The second layer of the mesh contains silver nanoparticles for antibacterial activity, while the third layer acts as a hydrophilic, non-adhesive barrier to aid in wound healing. The study emphasizes the importance of optimizing the properties of antibacterial meshes to achieve a balance between high antibacterial activity and low toxicity.
APPLIED SURFACE SCIENCE
(2023)
Article
Chemistry, Applied
Xiangyan Chen, Hongjin Li, Xiaoni Qiao, Tianze Jiang, Xue Fu, Yue He, Xia Zhao
Summary: Marine agarose oligosaccharides and silver nanoparticles combined with antimicrobial peptides form a novel composite nanomaterial, which shows significant promoting effects on wound healing with strong antimicrobial activities and good biocompatibility.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Textiles
T. Hemamalini, J. Vrishni Ritvic, R. Premitha, A. K. Divya Dharshini, V. R. Giri Dev
Summary: By topically applying silver on cationic cellulosic substrates using the electrospraying process, better bonding of silver nanoparticles is ensured, resulting in long-term durability and excellent antimicrobial activity of the developed wound dressing.
JOURNAL OF NATURAL FIBERS
(2022)
Article
Polymer Science
Nafise Amiri, Sahand Ghaffari, Ida Hassanpour, Taesik Chae, Reza Jalili, Ruhangiz Taghi Kilani, Frank Ko, Aziz Ghahary, Dirk Lange
Summary: A silver nanoparticle-based hydrogel composite has been created to prevent infection, promote tissue repair, and fill cavities in wounds that are difficult to reach with other dressings.
Article
Materials Science, Multidisciplinary
Xianhua Xie, Xin Jin, Binbin He, Yang Zou, Jumin Yang, Changjun Liu, Xiaoling Kong, Wenguang Liu, Wei Wang
Summary: This report introduces a hydrogel dressing with antibacterial and anti-inflammatory activities designed for diabetic wounds. The dressing is formed through in situ crosslinking of gelatin methacrylate and a hyperbranched terpolymer, and it exhibits strong antimicrobial and anti-inflammatory properties.
APPLIED MATERIALS TODAY
(2022)
Article
Polymer Science
Xuefei Chen, Qianqian Zhang, Yi Wang, Jie Meng, Meiqin Wu, Huaizhong Xu, Lei Du, Xiaohua Yang
Summary: In this study, tannic acid was successfully loaded into poly(caprolactone) fibers via electrospinning, resulting in uniform and continuous nanofibers. The addition of tannic acid improved the mechanical properties of the scaffolds and enhanced their hydrophilicity and water absorption capacity, which contribute to wound healing acceleration.
Article
Nanoscience & Nanotechnology
Yun Zhu, Li Liu, Shaoqing Chen, Dan Han, Cheng Wang
Summary: Wound infection, especially chronic ones, can lead to the emergence of antibiotic-resistant bacteria and cause physical and mental burden on patients. This study developed an agarose-hyaluronic acid hydrogel that could potentially serve as an antibacterial wound dressing, promoting healing while maintaining antibacterial efficacy.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Jian Lin, Tianpeng Shi, Yi Wang, Zhiqi He, Zhixiang Mu, Xiaojun Cai, Hui Deng, Jianliang Shen, Fen Liu
Summary: In this study, pH-sensitive CHX subset of CD-MSN@HA@GelMA hydrogels were constructed, which enable ultra-long-acting drug release and sustained antibacterial properties. The combination of beta-CD and MSN gradually releases active molecules, making them ideal anti-infection materials for wound dressing.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zheng Chen, Jinpeng Yao, Jiulong Zhao, Shige Wang
Summary: In this study, a multifunctional COP hydrogel composed of CMCS, OD, and γ-PGA was prepared for antimicrobial and hemostasis of diffuse wounds. The COP hydrogel exhibited significant antibacterial effects, inhibited bacterial growth, and promoted wound healing. It also showed superior hemostasis ability in a rat tail diffuse hemorrhage wound model. Therefore, the multifunctional COP hydrogel is expected to have important applications in wound hemostasis and healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Sibusiso Alven, Buhle Buyana, Zizo Feketshane, Blessing Atim Aderibigbe
Summary: Nanofibrous scaffolds loaded with silver nanoparticles show promising biological and mechanical outcomes in wound healing, with good antibacterial and bioactive properties.
Article
Polymer Science
Irina Popescu, Marieta Constantin, Gheorghe Solcan, Daniela Luminita Ichim, Delia Mihaela Rata, Loredana Horodincu, Carmen Solcan
Summary: In this study, a composite hydrogel based on chitosan (CS) and polyvinyl alcohol (PVA) embedding silver nanoparticles (AgNPs) with antibacterial properties and ibuprofen (Ib) as an anti-inflammatory agent was developed. The hydrogel displayed good mechanical properties, high swelling degree, sustained drug delivery, and showed strong antibacterial activity. In vivo experiments demonstrated that the hydrogel accelerated wound healing process by activating downstream cascades and supporting the healing process of inflammation and promoting cell migration and proliferation.
Article
Chemistry, Applied
Chennan Liu, Junhong Ling, Li-Ye Yang, Xiao-kun Ouyang, Nan Wang
Summary: The development of a new type of dressing to combat bacterial resistance is of great importance. A carbon nitride-polydopamine-silver complex (C3N4-PDA-Ag) was prepared using C3N4 and silver nanoparticles (Ag NPs) to achieve a synergistic antimicrobial effect. The C3N4-PDA-Ag complex was further modified with chitosan (CS) to form a C3N4-PDA-Ag@CS film. The results showed that the C3N4-PDA-Ag@CS film exhibited superior antibacterial activity and biocompatibility, and promoted wound healing in infected mice.
CARBOHYDRATE POLYMERS
(2023)
Review
Polymer Science
Jie Liu, Wenqi Jiang, Qianyue Xu, Yongjie Zheng
Summary: Antibacterial hydrogel is widely used in biomedical, intelligent textiles, cosmetics, and other fields, especially in medical dressings. It has the characteristics of absorbing wound liquid, controlling drug release, and its preparation method is simple with easily accessible materials.
Article
Chemistry, Physical
Sivaram Nallamolu, Vijaya Ratna Jayanti, Mallikarjun Chitneni, Liew Yun Khoon, Shikha Sood, Yassine Riadi, Prashant Kesharwani
Summary: The study successfully synthesized a highly solubilized and biocompatible formulation of RES, using SMEDDS technology to overcome issues related to poor water solubility and low bioavailability.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2022)
Review
Instruments & Instrumentation
Senitta Stephen, Bapi Gorain, Hira Choudhury, Bappaditya Chatterjee
Summary: Mesoporous silica nanoparticles (MSN) offer advantages such as high drug loading efficiency and suitability for functionalization, making them attractive for delivering therapeutic agents in the treatment of various diseases. Recent research has expanded their application to deliver a range of compounds, from small chemicals to large peptides or proteins, for combating complex diseases.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Neurosciences
Rohit Kumar Verma, Manisha Pandey, Pooja Chawla, Hira Choudhury, Jayashree Mayuren, Subrat Kumar Bhattamisra, Bapi Gorain, Maria Abdul Ghafoor Raja, Muhammad Wahab Amjad, Syed Obaidur Rahman
Summary: The treatment of Alzheimer's disease is challenging, mainly due to the difficulty of early diagnosis. Researchers have explored the use of artificial intelligence and technical tools to address this issue, but more data and research are needed.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2022)
Review
Environmental Sciences
Sima Singh, Arshid Numan, Dinesh Sharma, Rahul Shukla, Amit Alexander, Gaurav Kumar Jain, Farhan Jalees Ahmad, Prashant Kesharwani
Summary: The outbreak of the COVID-19 pandemic in 2019 and 2020 has led to a new era of communicable infectious diseases, with the emergence of Hantavirus infection posing a new public health emergency. Hantavirus, a zoonotic pathogen, causes two major clinical manifestations - HFRS and HCPS. Despite the lack of effective treatments or vaccines, public awareness and precautionary measures can help reduce the spread of the virus.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Review
Instruments & Instrumentation
Akanksha R. Singh, Prasanna Kumar Desu, Ramya Krishna Nakkala, Vanitha Kondi, Sushma Devi, Mohammad Sarwar Alam, Hinna Hamid, Rajani B. Athawale, Prashant Kesharwani
Summary: Nanotechnology has opened up new possibilities in the field of nutraceuticals and food industries, offering enhanced properties and applications for nanomaterials. The small size and unique properties of nanomaterials have led to advancements in bioavailability, solubility, stability, and targeted drug delivery in the development of nano-based nutraceuticals, highlighting the potential benefits and future prospects in improving treatment strategies and quality of life in the health sectors.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Environmental Sciences
Sulagna Dutta, Bapi Gorain, Hira Choudhury, Shubhadeep Roychoudhury, Pallav Sengupta
Summary: Untainted environment promotes health, but environmental contaminants from human activities can have detrimental effects on female reproductive health, potentially leading to reproductive issues, infertility, and serious illnesses. Therefore, further research and management efforts are necessary to reduce the negative impacts of heavy metal exposure on female fertility.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Bapi Gorain, Manisha Pandey, Ng Hui Leng, Cho Wei Yan, Kuek Wee Nie, Simran Jeet Kaur, Vincent Marshall, Sreenivas Patro Sisinthy, Jithendra Panneerselvam, Nagashekhara Molugulu, Prashant Kesharwani, Hira Choudhury
Summary: Management of chronic wounds has significant social and economic implications, and traditional medicines combined with nanotechnology offer new opportunities for wound healing.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Shadab Md, Nabil A. Alhakamy, Priyanka Sharma, Mohammad Shahnawaze Ansari, Bapi Gorain
Summary: Chemotherapy is a crucial treatment for cancer, but its clinical application is limited to patients with multidrug resistance. Co-administration of natural P-gp inhibitors with chemotherapeutics has the potential to enhance the efficacy of chemotherapy against MDR cancer. The use of nanotechnology for co-delivery of therapeutic components could improve the anticancer potential of chemotherapeutic agents.
JOURNAL OF DRUG TARGETING
(2022)
Review
Health Care Sciences & Services
Maha Ali Alghamdi, Antonino N. Fallica, Nicola Virzi, Prashant Kesharwani, Valeria Pittala, Khaled Greish
Summary: Personalized medicine and nanomedicine are both new concepts in medical practice. Personalized medicine aims to customize therapeutic management based on a patient's personal attributes, while nanomedicine applies nanotechnology advances in medicine for diagnosis and treatment. The integration of these two fields can provide more effective treatment options tailored to individual patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Chemistry, Analytical
Vanshikha Singh, Afsana Sheikh, Mohammed A. S. Abourehab, Prashant Kesharwani
Summary: Immunotherapy, especially the use of anti-PD-1 monoclonal antibody Dostarlimab, has shown promising results in various cancer treatments, with complete cure observed in colorectal cancer patients. This review emphasizes the mechanism of action of immunotherapy and discusses the ongoing clinical trials and combination therapies involving Dostarlimab to provide insights for future clinicians and researchers.
Review
Biochemistry & Molecular Biology
Neha Jain, Manisha Pandey, Palak Sharma, Gaurav Gupta, Bapi Gorain, Kamal Dua
Summary: The use of nanotechnology in treating various disorders has been proven effective. Plant-derived edible nanoparticles (PDNPs) are predicted to be potential therapeutic agents in treating diseases or delivering drugs. PDNPs structurally resemble exosomes extracted from mammals and selectively target cancer cells via unique endocytic pathways. They can be produced in large quantities, are non-toxic, and have tissue-specific targeting abilities.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Education, Scientific Disciplines
Sook Yee Gan, Subrat Kumar Bhattamisra, Mohd Zulkefeli, Ket Li Ho
Summary: This study aimed to evaluate the effectiveness of assessment rubrics in measuring and enhancing student research performance. The results showed that most supervisors found assessment rubrics to be easier, accurate, unbiased, and consistent for scoring, and they helped identify students' strengths and weaknesses in research. About 80.5% of students ranked the rubrics highly, indicating that they were motivated to improve their research performance. Ultimately, the effectiveness of assessment rubrics in improving research performance depends on students' attitudes towards self-regulation and supervisors' commitment to project supervision.
PHARMACY EDUCATION
(2023)
Review
Engineering, Biomedical
Amir R. Afshari, Mehdi Sanati, Prashant Kesharwani, Amirhossein Sahebkar
Summary: Standard cancer chemotherapeutics often lose effectiveness and produce adverse effects due to resistance mechanisms. Curcumin, when combined with traditional chemotherapeutics, has been found to enhance cancer treatment effectiveness and reduce resistance. However, limited bioavailability requires co-delivery strategies for Cur and conventional pharmaceuticals in clinical settings.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Materials Science, Biomaterials
Hira Choudhury, Manisha Pandey, Raxshanaa Mohgan, Jim Sii Jack Jong, Roshini Nicole David, Wan Yi Ngan, Tze Liang Chin, Shereen Ting, Prashant Kesharwani, Bapi Gorain
Summary: Brain tumor is a deadly form of cancer with high mortality and morbidity rates. Macromolecule-based therapies, such as nucleic acids and peptides, have shown promise in brain tumor treatment. However, delivering these macromolecules across the blood-brain barrier without altering their characteristics is a challenge. Nanotechnology offers targeted delivery of therapeutics, and dendrimers have been identified as potential drug delivery platforms due to their size, structure, solubility, and loading capacity. This review focuses on the therapeutic applications of dendrimers in brain tumor treatment.
BIOMATERIALS ADVANCES
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)