期刊
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
卷 16, 期 3, 页码 163-168出版社
CIG MEDIA GROUP, LP
DOI: 10.1016/j.clml.2015.11.016
关键词
Acute myeloid leukemia; Clofarabine; Induction therapy; Intensive chemotherapy; Propensity matching
资金
- NIH/NCI [P30CA016672]
We conducted a propensity score-matched comparison of AML patients ages >= 60 treated with induction chemotherapy by clofarabine plus low dose cytarabine (CLDA) versus idarubicin and cytarabine (IA). There was no statistically significant differences in treatment response, overall survival or early mortality rate between the two induction regimens but CLDA was associated with less toxicities and had longer remission duration. Introduction: Most patients with acute myeloid leukemia (AML) age >= 60 years are not offered intensive induction because of high mortality. Phase 2 studies of clofarabine plus low-dose cytarabine (CLDA) as frontline therapy for elderly AML patients demonstrated high response and acceptable toxicity. Patients and Methods: We hypothesized that induction therapy with CLDA provides equivalent outcomes to but is less toxic than intensive induction in these patients. To test this hypothesis, we conducted a propensity score-matched comparison of AML patients age >= 60 years given induction CLDA versus idarubicin and cytarabine (IA). Ninety-five patients in both groups were matched according to their propensity score. Results: We did not observe statistically significant differences in response, overall survival, or mortality rate between the two induction regimens. However, CLDA produced significantly fewer grade 3 or worse toxicities (46% for CLDA vs. 62% for IA; P = .03). Furthermore, among responders, the median response duration was significantly longer with CLDA when we censored patients who underwent stem cell transplantation (15.9 months for CLDA vs. 7.0 months for IA; P = .033). Conclusion: Compared with intensive induction, CLDA offers equivalent responses and survival but less toxicity in clinically well-matched cohorts of elderly AML patients. Prospective randomized trials to confirm these findings are warranted. (C) 2016 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据