Article
Nutrition & Dietetics
Jing Yu, Qianqian Li, Jun Wu, Xiaotong Yang, Shiping Yang, Wei Zhu, Yang Liu, Wei Tang, Shaoping Nie, Amira Hassouna, William Lindsey White, Yu Zhao, Jun Lu
Summary: Fucoidan is a multifunctional marine carbohydrate polymer extracted from Undaria pinnatifida grown in Weihai, China, with differences in chemical composition and antioxidant capacity between fractions. The 10k fraction exhibited the lowest sulfation degree but significantly higher primary antioxidant ability compared to 300k. This suggests that fucoidan extracted from U. pinnatifida in Weihai could be a valuable nutraceutical resource.
FRONTIERS IN NUTRITION
(2021)
Article
Food Science & Technology
Yihui Qi, Lilong Wang, Ying You, Xiaona Sun, Chengrong Wen, Yinghuan Fu, Shuang Song
Summary: In this study, a photocatalytic method was successfully used to degrade fucoidan, a sulfated polysaccharide. The degradation process did not strip the sulfate groups, but resulted in a reduction in the galactose/fucose ratio. Additionally, sulfated oligosaccharides were identified in the degradation products. The degraded products showed similar anticoagulant activity to the original polysaccharide.
Article
Biochemistry & Molecular Biology
Martin Pacesa, Chun-Han Lin, Antoine Clery, Aakash Saha, Pablo R. Arantes, Katja Bargsten, Matthew J. Irby, Frederic H. -T. Allain, Giulia Palermo, Peter Cameron, Paul D. Donohoue, Martin Jinek
Summary: The crystallographic structures of Cas9 bound to off-target substrates reveal that noncanonical base-pairing interactions within the guide:off-target heteroduplex enable off-target binding. Single-nucleotide deletions in off-target substrates are accommodated by base skipping or multiple noncanonical base pairs. PAM-distal mismatches result in duplex unpairing and induce a conformational change in the Cas9 REC lobe. These insights contribute to the improved rational design of guide RNAs and off-target prediction algorithms.
Article
Biochemistry & Molecular Biology
Rosalina Ariesta Laeliocattleya, Yunianta Yunianta, Yenny Risjani, Siti Narsito Wulan
Summary: This study investigated the effect of fucoidan on the Wnt/beta-Catenin pathway. Through molecular docking and in-vitro experiments, it was found that fucoidan showed a favorable binding affinity for Frizzled-8 and LRP6 receptors and reduced the interaction between Wnt agonists and these receptors. Fucoidan also effectively inhibited beta-catenin production and demonstrated antiproliferative effects against breast cancer cells.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Akanksha Dubey, Jayanthi Sivaraman
Summary: Inflammation is a preliminary immune response to harmful stimuli, and lipoxygenases are involved in inflammatory reactions. Fucoidan, a sulphated polysaccharide, is being studied for its potential in treating inflammatory diseases. This study investigated the inhibitory effects of fucoidan on lipoxygenase and found that it has anti-inflammatory potentials.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Materials Science, Biomaterials
Nanhee Song, Miran Park, Nuri Kim, Yujin Lee, Eunkyeong Jung, Dongwon Lee
Summary: Compared to normal cells, cancer cells are more susceptible to insults of prooxidants that generate reactive oxygen species (ROS) or scavenge antioxidants such as glutathione (GSH). This study reports the use of rationally designed F-ssPBCA nanoparticles as a tumor-targeting prooxidant, which generates ROS and scavenges GSH simultaneously to cooperatively amplify oxidative stress and induce immunogenic cell death (ICD). Animal studies showed that these nanoparticles effectively accumulate in tumors and suppress tumor growth. The results demonstrate the potential of prooxidant-mediated oxidative stress elevation as a highly effective strategy to selectively kill cancer cells and induce ICD.
BIOMATERIALS SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Noormand Chaloshtori, Mehdi Tabarsa, Hassan Ahmadi Gavlighi, Sangguan You
Summary: A sequential extraction process was used to isolate fucoidan and alginate from brown seaweed Cystoseira indica. The study showed that acid concentrations and temperatures had effects on the sensory, structural, and immunostimulatory properties of fucoidans and the subsequent production of Na+-alginates. The amounts and composition of isolated fucoidans and Na+-alginates varied depending on the extraction conditions.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Ping Zou, Xia Yang, Yuan Yuan, Changliang Jing, Jianmin Cao, Ying Wang, Lin Zhang, Chengsheng Zhang, Yiqiang Li
Summary: A fucoidan extracted from Macrocystis pyrifera showed potential as a plant stimulator to enhance salt resistance, with optimal activity observed at concentrations of 0.5 and 1 mg/ml.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Hyo Geun Lee, Thilina U. Jayawardena, N. M. Liyanage, Kyung-Mo Song, Yun-Sang Choi, You-Jin Jeon, Min-Cheol Kang
Summary: In this study, the potential antioxidant abilities of low-molecular weight fucoidans from enzyme-assisted hydrolysates of Sargassum autumnale were investigated. The results showed that a specific fucoidan fraction (SAPF3) possessed strong antioxidant properties and could be a potential alternative to antioxidant agents in the functional food industry.
Review
Chemistry, Medicinal
Yani Li, Eileen McGowan, Size Chen, Jerran Santos, Haibin Yin, Yiguang Lin
Summary: Fucoidans, extracted from brown seaweed, are fucose-rich sulfated polysaccharides with various beneficial biological activities. They have been recognized for their immunomodulatory effects, especially in cancer immunotherapy. Fucoidans can activate cytotoxic T lymphocytes and have strong antitumor properties, making them promising agents for cancer treatment.
Article
Engineering, Biomedical
Ying Wang, Chuanjiang Jian, Yiqing Long, Xiaowen Xu, Yang Song, Zongning Yin
Summary: In this study, a platelet-targeted and H2O2-triggered nanosystem was developed for specific delivery of therapeutic polymers and probes to platelet-rich arterial thrombus. The system could be activated by H2O2 to produce fluorescent CyOH molecules, enabling photoacoustic imaging of thrombosed tissues. Additionally, CyBA/PFM NPs effectively eliminated ROS within the occlusion site and suppressed thrombus formation. This system has great potential for H2O2-correlated cardiovascular diseases due to its theranostic capabilities and acceptable biosafety.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Medicinal
Ling Qin, Hui Xu, Yingying He, Chen Liang, Kai Wang, Junhan Cao, Changfeng Qu, Jinlai Miao
Summary: An immunomodulatory polysaccharide (DAP4) was extracted from Durvillaea antarctica, which was identified as a fucoidan. DAP4 showed excellent immunomodulatory activity, promoting the proliferation of spleen lymphocytes, increasing NO production, enhancing phagocytic activity of macrophages, and improving the vitality of NK cells.
Article
Environmental Sciences
Fang Li, Hanchang Sun, Yang Li, Die He, Chaoying Ren, Chengke Zhu, Guangjun Lv
Summary: This study investigated the effects of fucoidan supplementation on growth performance, biochemical indices, immunity, digestive enzyme activity, antioxidant capacity, and liver histological structure in juvenile common carp. The results showed that a dose of 1666.67-1757 mg/kg of fucoidan led to the best growth performance. Fucoidan supplementation improved immune function, reduced lipid peroxidation, but a higher dose of fucoidan induced inflammation and metabolic disorders.
FRONTIERS IN MARINE SCIENCE
(2023)
Review
Chemistry, Medicinal
Heitor Gomes de Araujo-Filho, Jucilene F. dos Santos, Mikaella T. B. Carvalho, Laurent Picot, Ingrid Fruitier-Arnaudin, Hugo Groult, Lucindo J. Quintans-Junior, Jullyana S. S. Quintans
Summary: Limonene (LIM), a monoterpene abundant in Citrus fruits peels, has shown potential as a natural anticancer compound by inhibiting tumor initiation, growth, and angiogenesis, as well as inducing cancer cells apoptosis.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sijie Wei, Lihua Geng, Haoyu Yu, Jing Wang, Yang Yue, Quanbin Zhang, Ning Wu
Summary: This study investigated the anti-fibrosis activity of a fucoidan from Costaria costata. The results showed that the fucoidan could inhibit TGF-beta 1-induced epithelial-mesenchymal transition and inflammation in lung cells both in vitro and in vivo, suggesting its potential as a therapeutic agent for pulmonary fibrosis.
Article
Chemistry, Medicinal
Zhen Lin, Yu Zhang, Fangping Li, Xiaohui Tan, Ping Luo, Huazhong Liu
Article
Biochemistry & Molecular Biology
Zhen Lin, Fangping Li, Yu Zhang, Xiaohui Tan, Ping Luo, Huazhong Liu
Summary: This study used network pharmacological approaches to investigate the potential pharmacological activity of astaxanthin in steroid hormone metabolism, identifying its therapeutic effects on depression, insulin resistance, and endometriosis. The results suggest that astaxanthin may treat these diseases by regulating hormone metabolism.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Chemistry, Medicinal
Yu Zhang, Xiaohui Tan, Zhen Lin, Fangping Li, Chunyan Yang, Haiying Zheng, Lingyu Li, Huazhong Liu, Jianghua Shang
Summary: The study demonstrated that fucoidan (FPS) effectively inhibits the expression induction of urate transporters URAT1 and GLUT9 induced by uric acid, through repressing the activation of NF-kappa B, JNK, and PI3K/Akt signal pathways.
Article
Chemistry, Multidisciplinary
Zhen Lin, Huazhong Liu, Chunyan Yang, Haiying Zheng, Yu Zhang, Weiming Su, Jianghua Shang
Summary: The study revealed that Curcumin can induce apoptosis and autophagy in buffalo granulosa cells, possibly through the IKK/NF-κB pathway. Autophagy inhibitors increased the apoptosis rate, while the autophagosome degradation inhibitor had no effect.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhen Lin, Ping Luo, Dongmin Huang, Yulian Wu, Fangping Li, Huazhong Liu
Summary: The study reveals that exposure to ACR leads to impairment of oxidative-reductive balance, energy metabolism, lipid metabolism, nucleotide metabolism, and ribosome function in yeast cells. In response to acute ACR damage, yeast cells exhibit upregulation of glutathione synthesis, acceleration of protein degradation, and initiation of autophagy flux.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Zhen Lin, Xiaohui Tan, Fangping Li, Yu Zhang, Ping Luo, Xuan Lin, Huazhong Liu
Summary: This study prepared SIP binding proteins from mouse liver using superparamagnetic nanometer beads to explore the interactive molecules of squid ink polysaccharides (SIP) and found that SIP reduced the K-m value of aldehyde oxidase in mouse liver.
